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1. 发明申请

US20050187187A1 Carboxyl-reduced derivatives of chondroitin sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开
标题翻译：硫酸软骨素的羧基还原的衍生物，其制备，其作为药用产品的用途和含有它们的药物组合物
公开(公告)号：US20050187187A1
公开(公告)日：2005-08-25
申请号：US11016175
申请日：2004-12-17
申请人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
发明人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
IPC分类号： A61K31/737 , C08B37/00
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced and chemoselectively O-sulfated derivatives of chondroitin sulfate of formula (I): in which R1, R2, R3 and R4 are H or SO3M, n is an integer of between 0 and 200, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的硫酸软骨素的羧基还原和化学选择性O-硫酸化衍生物：其中R 1，R 2，R 2， 3和R 4是H或SO 3 M，n是0和200之间的整数，M是碱金属，分离的或作为混合物，其非对映异构体，其制备方法，其作为药用产品的用途和含有它们的药物组合物。

2. 发明申请

US20050203056A1 Carboxyl-reduced derivatives of hyaluronic acid, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开
标题翻译：透明质酸的羧基还原衍生物，其制备方法，作为药物的用途以及含有它们的药物组合物
公开(公告)号：US20050203056A1
公开(公告)日：2005-09-15
申请号：US11015947
申请日：2004-12-17
申请人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
发明人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
IPC分类号： A61K31/728 , C08B37/00
CPC分类号： A61K31/728 , C08B37/00 , C08B37/0072
摘要： The present invention relates to the carboxyl-reduced derivatives of hyaluronic acid of formula (I): in which R or R1 represents H or SO3M, n is an integer of between 0 and 25 000, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的透明质酸的羧基还原衍生物：其中R或R 1表示H或SO 3 M，n是整数为0至25 000，M为与其非对映异构体，分离或混合的碱金属，其制备方法，作为药用产品的用途以及含有它们的药物组合物。

3. 发明申请

US20050164983A1 Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them 审中-公开
标题翻译：硫酸皮肤素的羧基还原衍生物，其制备方法，作为药物的用途以及含有它们的药物组合物
公开(公告)号：US20050164983A1
公开(公告)日：2005-07-28
申请号：US11016501
申请日：2004-12-17
申请人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
发明人： Wolfgang Ulmer , Christian Viskov , Philippe Hubert
IPC分类号： A61K31/737
CPC分类号： C08B37/0069
摘要： The present invention relates to the carboxyl-reduced derivatives of dermatan sulfate of formula (I): in which R1, R2, R3 or R4 represents H or SO3M, n is an integer of between 0 and 150, M is an alkali metal, isolated or as mixtures, to the diastereoisomers thereof, to the process for the preparation thereof, to the uses thereof as a medicinal product and to the pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的硫酸皮肤素的羧基还原衍生物：其中R 1，R 2，R 3，或R 4代表H或SO 3 M，n为0至150的整数，M为与其非对映异构体分离或作为混合物的碱金属，其制备方法，其作为药用产品的用途和含有它们的药物组合物。

4. 发明申请

US20100081629A1 LOW MOLECULAR WEIGHT HEPARINS INCLUDING AT LEAST ONE COVALENT BOND WITH BIOTIN OR A BIOTIN DERIVATIVE, METHOD FOR MAKING SAME AND USE THEREOF 审中-公开
标题翻译：低分子量重量包括至少一种与生物或生物素衍生物的共价键，其制备方法及其用途
公开(公告)号：US20100081629A1
公开(公告)日：2010-04-01
申请号：US12539224
申请日：2009-08-11
申请人： Christian Viskov , Philippe Hubert , Pierre Mourier
发明人： Christian Viskov , Philippe Hubert , Pierre Mourier
IPC分类号： A61K31/727 , C07H1/00
CPC分类号： C08B37/0075 , A61K31/715
摘要： The invention relates to biotinylated low molecular weight heparins comprising constituent polysaccharides having at their reducing ends at least one covalent bond with biotin or a biotin derivative, and also to the process for preparing them, to pharmaceutical compositions containing them and to their therapeutic use.
摘要翻译：本发明涉及生物素化的低分子量肝素，其包含在其还原端与生物素或生物素衍生物具有至少一个共价键的组成多糖，以及其制备方法，含有它们的药物组合物及其治疗用途。

5. 发明申请

US20110071807A1 ANALYSING SPECTRAL DATA FOR THE SELECTION OF A CALIBRATION MODEL 有权
标题翻译：分析用于选择校准模型的光谱数据
公开(公告)号：US20110071807A1
公开(公告)日：2011-03-24
申请号：US12736929
申请日：2009-05-06
申请人： Philippe Hubert , Eric Ziemons , François Moonen
发明人： Philippe Hubert , Eric Ziemons , François Moonen
IPC分类号： G06F17/10
CPC分类号： G01N21/274 , G01N21/3554 , G01N21/359 , G01N2201/129
摘要： The invention relates to a method of analyzing spectral data for the selection of a calibration model, relating spectra of a substance to a physical or chemical parameter of the substance, over a predetermined range of the physical or chemical parameter, comprising the steps: a) capturing spectral data of the substance with respective values of the physical or chemical parameter over the predetermined range, b) creating a plurality of calibration models using the captured spectral data in dependence upon the values of the physical or chemical parameter based on the calibration data using statistical resampling methods, c) calculating tolerance intervals of the results at each reference level for each calibration model, and d) displaying the tolerance intervals at each reference level over the predetermined range for each calibration model. In this way, a possibility for analyzing spectra data is provided which is useful in spectroscopic applications for automated calibration model selection and makes analytical interpretation and evaluation easier and more accurate.
摘要翻译：本发明涉及一种分析用于选择校准模型的光谱数据的方法，所述校准模型在物理或化学参数的预定范围内将物质的光谱与物质的物理或化学参数相关联，包括以下步骤：a）以预定范围的物理或化学参数的相应值捕获物质的光谱数据; b）使用所捕获的光谱数据，根据基于校准数据的物理或化学参数的值，使用所捕获的光谱数据创建多个校准模型，所述校准模型使用统计重采样方法，c）计算每个校准模型的每个参考水平处的结果的容差间隔，以及d）在每个校准模型的预定范围上显示每个参考水平的公差间隔。以这种方式，提供了分析光谱数据的可能性，其在用于自动校准模型选择的光谱应用中是有用的，并且使分析解释和评估更容易和更准确。

6. 发明授权

US4960152A Device for compensating by supplying a measured amount of fluid and its application for replenishing a hydraulic circuit 失效
标题翻译：通过供应测量量的液体进行补偿的装置及其补充液压回路的应用
公开(公告)号：US4960152A
公开(公告)日：1990-10-02
申请号：US348529
申请日：1989-05-08
申请人： Philippe Hubert , Eric Martin
发明人： Philippe Hubert , Eric Martin
IPC分类号： G01F17/00 , B67D7/36 , F04B49/10 , F16N19/00 , G01F13/00
CPC分类号： B67D7/36 , F16N19/006 , G01F13/00 , Y10T137/7339 , Y10T137/8359
摘要： The device includes a main receptacle (1) having an overflow pipe (2) and a secondary receptacle (9) mounted so as to be freely movable in the vertical direction inside the main receptacle (1). The inner space of the secondary receptacle (9) communicates with a drainage pipe (8) for fluid lost by the hydraulic installation. The secondary receptacle (9) floats in the fluid contained in the main receptacle (1). The immersion level of the secondary receptacle (9) increases, depending on the amount of lost fluid received by the secondary receptacle (9), and the supply of fluid from the main receptacle (1) is caused by the immersion of the secondary receptacle (9).
摘要翻译：该装置包括具有溢流管（2）的主容器（1）和安装成可在主容器（1）内沿垂直方向自由移动的次级容器（9）。辅助容器（9）的内部空间与用于由液压装置流体损失的排水管（8）连通。副容器（9）漂浮在容纳在主容器（1）中的流体中。次级容器（9）的浸入水平根据次级容器（9）接收的流体损失量而增加，并且来自主容器（1）的流体的供应是由次级容器（ 9）。

7. 发明授权

US06603005B2 Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them 失效
标题翻译：杂环基烷基哌啶衍生物，它们的制备方法和含有它们的组合物
公开(公告)号：US06603005B2
公开(公告)日：2003-08-05
申请号：US09987386
申请日：2001-11-14
申请人： Eric Baque , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani
发明人： Eric Baque , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani
IPC分类号： C07D47102
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.
摘要翻译：通式（I）的杂环基烷基哌啶衍生物在它们的对映异构体或非对映异构体形式或这些形式的混合物中，和/或在适当时以其顺式或反式或其混合物以及其任何盐。

8. 发明授权

US06903217B2 Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them 失效
标题翻译：杂环基烷基哌啶衍生物，它们的制备方法和含有它们的组合物
公开(公告)号：US06903217B2
公开(公告)日：2005-06-07
申请号：US10607220
申请日：2003-06-27
申请人： Eric Bacqué , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani
发明人： Eric Bacqué , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani
IPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14 , C07D471/02 , C07D215/18 , C07D237/26
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.
摘要翻译：通式（I）的杂环基烷基哌啶衍生物在它们的对映体或非对映异构体形式或这些形式的混合物中，和/或在适当的情况下以其顺式或反式或其混合物以及其任何盐。

9. 发明授权

US08494818B2 Analyzing spectral data for the selection of a calibration model 有权
标题翻译：分析校准模型选择的光谱数据
公开(公告)号：US08494818B2
公开(公告)日：2013-07-23
申请号：US12736929
申请日：2009-05-06
申请人： Philippe Hubert , Eric Ziemons , François Moonen
发明人： Philippe Hubert , Eric Ziemons , François Moonen
IPC分类号： G06F17/10
CPC分类号： G01N21/274 , G01N21/3554 , G01N21/359 , G01N2201/129
摘要： The invention relates to a method of analyzing spectral data for the selection of a calibration model, relating spectra of a substance to a physical or chemical parameter of the substance, over a predetermined range of the physical or chemical parameter, comprising the steps: a) capturing spectral data of the substance with respective values of the physical or chemical parameter over the predetermined range, b) creating a plurality of calibration models using the captured spectral data in dependence upon the values of the physical or chemical parameter based on the calibration data using statistical resampling methods, c) calculating tolerance intervals of the results at each reference level for each calibration model, and d) displaying the tolerance intervals at each reference level over the predetermined range for each calibration model. In this way, a possibility for analyzing spectra data is provided which is useful in spectroscopic applications for automated calibration model selection and makes analytical interpretation and evaluation easier and more accurate.
摘要翻译：本发明涉及一种分析用于选择校准模型的光谱数据的方法，所述校准模型在物理或化学参数的预定范围内将物质的光谱与物质的物理或化学参数相关联，包括以下步骤：a）以预定范围的物理或化学参数的相应值捕获物质的光谱数据; b）使用所捕获的光谱数据，根据基于校准数据的物理或化学参数的值，使用所捕获的光谱数据创建多个校准模型，所述校准模型使用统计重采样方法，c）计算每个校准模型的每个参考水平处的结果的容差间隔，以及d）在每个校准模型的预定范围上显示每个参考水平的公差间隔。以这种方式，提供了分析光谱数据的可能性，其在用于自动校准模型选择的光谱应用中是有用的，并且使分析解释和评估更容易和更准确。

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