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    • 3. 发明授权
    • Diagnostics and treatments of periodontal disease
    • 牙周病的诊断和治疗
    • US06511666B1
    • 2003-01-28
    • US09066330
    • 1998-09-15
    • Eric Charles ReynoldsPeter Singh BhogalNada Slakeski
    • Eric Charles ReynoldsPeter Singh BhogalNada Slakeski
    • A61K3902
    • C12N9/52A61K38/00
    • This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. There is provided a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain. The complex has a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
    • 本发明涉及牙龈卟啉单胞菌PrtR-PrtK细胞表面蛋白,特别是包含PrtR和PrtK蛋白的多聚细胞相关蛋白复合物。 提供了用于提高针对牙龈卟啉单胞菌的抗体应答的基本上纯化的抗原复合物。 复合物包含至少一种含有至少一个粘附素结构域的精氨酸特异性和赖氨酸特异性硫醇内肽酶的多聚体蛋白复合物。 络合物的分子量大于约200kDa。 本发明还涉及基于用于检测,预防和治疗牙龈卟啉菌相关牙周病的所述复合物的药物组合物和相关剂。
    • 5. 发明申请
    • THERMALLY INSULATED PIPE FOR USE AT VERY HIGH TEMPERATURES
    • 热绝缘管用于非常高的温度
    • US20100154917A1
    • 2010-06-24
    • US12376982
    • 2007-08-03
    • Maurice BatallasPeter Singh
    • Maurice BatallasPeter Singh
    • F16L9/14F16L59/14
    • F16L59/029F16L59/143
    • The present invention provides an insulated pipe comprising a pipe and a composite insulation system, said composite insulation system comprising: (a) a first insulation layer comprising a first insulation material having a thermal conductivity k-factor value of less than 0.023 W/m-K at 38° C.; and (b) at least one additional insulation layer comprising an insulation material having a thermal conductivity k-factor greater than that of the first insulation material and a maximum operating temperature limit less than that of the first insulation layer. The composite insulation system is bonded to an exterior surface of the pipe with the first insulation layer facing towards said exterior surface of the pipe. At least one of said first insulation layer or said at least one additional layer extends continuously about the exterior surface of the pipe. The present invention further provides an insulated pipe for use in an undersea pipeline and an insulated pipe for use in a subterranean pipeline.
    • 本发明提供了一种包括管和复合绝缘系统的绝缘管,所述复合绝缘系统包括:(a)第一绝缘层,其包括第一绝缘材料,其具有小于0.023W / mK的热导率k因子值 38℃。 和(b)至少一个额外的绝缘层,其包括具有大于第一绝缘材料的热导率k因子的绝缘材料,并且最大工作温度极限小于第一绝缘层的最大工作温度极限。 复合绝缘系统结合到管的外表面,第一绝缘层面向管的所述外表面。 所述第一绝缘层或所述至少一个附加层中的至少一个围绕管的外表面连续延伸。 本发明还提供一种用于海底管道的绝缘管和用于地下管线的绝缘管。