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1. 发明申请

US20110213129A1 Diagnostics and treatments of periodontal disease 审中-公开
标题翻译：牙周病的诊断和治疗
公开(公告)号：US20110213129A1
公开(公告)日：2011-09-01
申请号：US13064286
申请日：2011-03-16
申请人： Eric Charles Reynolds , Peter Singh Bhogal , Nada Slakeski
发明人： Eric Charles Reynolds , Peter Singh Bhogal , Nada Slakeski
IPC分类号： C07K16/40
CPC分类号： C12N9/52 , A61K8/64 , A61K38/00 , A61K39/00 , A61Q11/00 , C07K16/1203 , G01N33/56955
摘要： This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell association protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
摘要翻译：本发明涉及牙龈卟啉单胞菌PrtR-PrtK细胞表面蛋白，特别涉及包含PrtR和PrtK蛋白的多聚细胞关联蛋白复合物。因此，本发明提供了用于提高针对牙龈卟啉单胞菌的抗体应答的基本上纯化的抗原复合物。复合物包含精氨酸特异性和赖氨酸特异性硫醇内肽酶的至少一种多聚体蛋白质复合物，其各自含有至少一个粘附素结构域，所述复合物具有大于约200kDa的分子量。本发明还涉及基于用于检测，预防和治疗牙龈卟啉菌相关牙周病的所述复合物的药物组合物和相关剂。

2. 发明授权

US06511666B1 Diagnostics and treatments of periodontal disease 有权
标题翻译：牙周病的诊断和治疗
公开(公告)号：US06511666B1
公开(公告)日：2003-01-28
申请号：US09066330
申请日：1998-09-15
申请人： Eric Charles Reynolds , Peter Singh Bhogal , Nada Slakeski
发明人： Eric Charles Reynolds , Peter Singh Bhogal , Nada Slakeski
IPC分类号： A61K3902
CPC分类号： C12N9/52 , A61K38/00
摘要： This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. There is provided a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain. The complex has a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
摘要翻译：本发明涉及牙龈卟啉单胞菌PrtR-PrtK细胞表面蛋白，特别是包含PrtR和PrtK蛋白的多聚细胞相关蛋白复合物。提供了用于提高针对牙龈卟啉单胞菌的抗体应答的基本上纯化的抗原复合物。复合物包含至少一种含有至少一个粘附素结构域的精氨酸特异性和赖氨酸特异性硫醇内肽酶的多聚体蛋白复合物。络合物的分子量大于约200kDa。本发明还涉及基于用于检测，预防和治疗牙龈卟啉菌相关牙周病的所述复合物的药物组合物和相关剂。

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