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1. 发明授权

US08784831B2 P. gingivalis antigenic composition 有权
标题翻译：牙龈卟啉单胞菌抗原组成
公开(公告)号：US08784831B2
公开(公告)日：2014-07-22
申请号：US13566264
申请日：2012-08-03
申请人： Eric Charles Reynolds , Nada Slakeski , Chao Guang Chen , Ian George Barr
发明人： Eric Charles Reynolds , Nada Slakeski , Chao Guang Chen , Ian George Barr
IPC分类号： A61K39/02
CPC分类号： A61K8/64 , A61K39/00 , A61K2039/505 , A61K2800/86 , A61Q11/00 , C07K14/195 , C07K16/12 , C07K16/1257 , C07K2319/00
摘要： The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
摘要翻译：本发明提供一种抗原组合物，该组合物包含至少一种重组蛋白。重组蛋白包含至少一个表位。表位与抗体反应，该抗体与具有SEQ ID NO：1所示序列的多肽具有反应性。 ID。没有。 3或SEQ。 ID。没有。本发明还提供了用于生产重组蛋白的方法和组合物。还提供了用于诊断，治疗和预防牙龈卟啉菌感染的方法。

2. 发明申请

US20080124284A1 Synthetic peptide constructs for the diagnosis and treatment of periodontitis associated with Porphyromonas gingivalis 失效
标题翻译：用于诊断和治疗与牙龈卟啉单胞菌相关的牙周炎的合成肽结构
公开(公告)号：US20080124284A1
公开(公告)日：2008-05-29
申请号：US11731307
申请日：2007-03-30
申请人： Eric Charles Reynolds , Neil Martin O'Brien-Simpson , Nada Slakeski
发明人： Eric Charles Reynolds , Neil Martin O'Brien-Simpson , Nada Slakeski
IPC分类号： A61K8/64 , A61Q11/00 , A61K39/00 , A61K39/395 , A61P31/04 , C07K14/00 , C07K16/00
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K39/0216 , A61K2039/55544 , A61K2039/55566 , A61K2039/6037 , C12N9/52
摘要： The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.
摘要翻译：本发明涉及用于抑制口腔内细菌与牙周病相关的牙龈卟啉单胞菌的致病作用的口腔组合物和免疫原性组合物。

3. 发明申请

US20130164298A1 P. GINGIVALIS ANTIGENIC COMPOSITION 有权
标题翻译： P. GINGIVALIS抗原组合物
公开(公告)号：US20130164298A1
公开(公告)日：2013-06-27
申请号：US13566264
申请日：2012-08-03
申请人： Eric Charles Reynolds , Nada Slakeski , Chao Guang Chen , Ian George Barr
发明人： Eric Charles Reynolds , Nada Slakeski , Chao Guang Chen , Ian George Barr
IPC分类号： C07K16/12 , C07K14/195
CPC分类号： A61K8/64 , A61K39/00 , A61K2039/505 , A61K2800/86 , A61Q11/00 , C07K14/195 , C07K16/12 , C07K16/1257 , C07K2319/00
摘要： The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
摘要翻译：本发明提供一种抗原组合物，该组合物包含至少一种重组蛋白。重组蛋白包含至少一个表位。表位与抗体反应，该抗体与具有SEQ ID NO：1所示序列的多肽具有反应性。 ID。没有。 3或SEQ ID。没有。本发明还提供了用于生产重组蛋白的方法和组合物。还提供了用于诊断，治疗和预防牙龈卟啉菌感染的方法。

4. 发明申请

US20070189982A1 Diagnostics and treatments of Periodontal disease 审中-公开
标题翻译：牙周病的诊断和治疗
公开(公告)号：US20070189982A1
公开(公告)日：2007-08-16
申请号：US11654512
申请日：2007-01-18
申请人： Eric Reynolds , Peter Bhogal , Nada Slakeski
发明人： Eric Reynolds , Peter Bhogal , Nada Slakeski
IPC分类号： A61K39/40 , A61K39/02 , A61K8/96 , C07K16/12
CPC分类号： C12N9/52 , A61K8/64 , A61K38/00 , A61K39/00 , A61Q11/00 , C07K16/1203 , G01N33/56955
摘要： This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis and in particular a multimeric cell association protein complex comprising the PrtR and PrtK proteins. Accordingly the invention provides a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain, the complex having a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
摘要翻译：本发明涉及牙龈卟啉单胞菌PrtR-PrtK细胞表面蛋白，特别涉及包含PrtR和PrtK蛋白的多聚细胞关联蛋白复合物。因此，本发明提供了用于提高针对牙龈卟啉单胞菌的抗体应答的基本上纯化的抗原复合物。复合物包含精氨酸特异性和赖氨酸特异性硫醇内肽酶的至少一种多聚体蛋白质复合物，其各自含有至少一个粘附素结构域，所述复合物具有大于约200kDa的分子量。本发明还涉及基于用于检测，预防和治疗牙龈卟啉菌相关牙周病的所述复合物的药物组合物和相关剂。

5. 发明授权

US08431688B2 Synthetic peptide constructs for the diagnosis and treatment of Periodontitis associated with Porphyromonas gingivalis 有权
标题翻译：用于诊断和治疗与牙龈卟啉单胞菌相关的牙周炎的合成肽构建体
公开(公告)号：US08431688B2
公开(公告)日：2013-04-30
申请号：US12797566
申请日：2010-06-09
申请人： Eric C. Reynolds , Neil Martin O'Brien-Simpson , Nada Slakeski
发明人： Eric C. Reynolds , Neil Martin O'Brien-Simpson , Nada Slakeski
IPC分类号： C07K16/00 , A61K8/64
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K39/0216 , A61K2039/55544 , A61K2039/55566 , A61K2039/6037 , C12N9/52
摘要： The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.
摘要翻译：本发明涉及用于抑制口腔内细菌与牙周病相关的牙龈卟啉单胞菌的致病作用的口腔组合物和免疫原性组合物。

6. 发明授权

US07749502B2 Synthetic peptide constructs for the diagnosis and treatment of periodontitis associated with Porphyromonas gingivalis 失效
标题翻译：用于诊断和治疗与牙龈卟啉单胞菌相关的牙周炎的合成肽结构
公开(公告)号：US07749502B2
公开(公告)日：2010-07-06
申请号：US11731307
申请日：2007-03-30
申请人： Eric C. Reynolds , Neil Martin O'Brien-Simpson , Nada Slakeski
发明人： Eric C. Reynolds , Neil Martin O'Brien-Simpson , Nada Slakeski
IPC分类号： C07K16/00 , A61K8/64
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , A61K39/0216 , A61K2039/55544 , A61K2039/55566 , A61K2039/6037 , C12N9/52
摘要： The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease.
摘要翻译：本发明涉及用于抑制口腔内细菌与牙周病相关的牙龈卟啉单胞菌的致病作用的口腔组合物和免疫原性组合物。

7. 发明授权

US06511666B1 Diagnostics and treatments of periodontal disease 有权
标题翻译：牙周病的诊断和治疗
公开(公告)号：US06511666B1
公开(公告)日：2003-01-28
申请号：US09066330
申请日：1998-09-15
申请人： Eric Charles Reynolds , Peter Singh Bhogal , Nada Slakeski
发明人： Eric Charles Reynolds , Peter Singh Bhogal , Nada Slakeski
IPC分类号： A61K3902
CPC分类号： C12N9/52 , A61K38/00
摘要： This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. There is provided a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain. The complex has a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
摘要翻译：本发明涉及牙龈卟啉单胞菌PrtR-PrtK细胞表面蛋白，特别是包含PrtR和PrtK蛋白的多聚细胞相关蛋白复合物。提供了用于提高针对牙龈卟啉单胞菌的抗体应答的基本上纯化的抗原复合物。复合物包含至少一种含有至少一个粘附素结构域的精氨酸特异性和赖氨酸特异性硫醇内肽酶的多聚体蛋白复合物。络合物的分子量大于约200kDa。本发明还涉及基于用于检测，预防和治疗牙龈卟啉菌相关牙周病的所述复合物的药物组合物和相关剂。

8. 发明授权

US08871213B2 Prevention, treatment and diagnosis of P. gingivalis infection 有权
标题翻译：牙龈卟啉菌感染的预防，治疗和诊断
公开(公告)号：US08871213B2
公开(公告)日：2014-10-28
申请号：US13060653
申请日：2009-08-28
申请人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J Cross , Nada Slakeski
发明人： Eric Charles Reynolds , Neil Martin O'Brien Simpson , Keith J Cross , Nada Slakeski
IPC分类号： A61K38/00 , A61K39/00 , A61K39/38 , A61K39/02 , A61K39/385 , C07K14/195 , C07K16/12 , G01N33/569
CPC分类号： C07K14/195 , A61K39/0216 , A61K2039/505 , A61K2039/53 , A61K2039/55566 , C07K16/1203 , C07K16/1257 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N9/14 , C12N9/52 , C12Y304/21 , C12Y304/21004 , C12Y306/05002 , G01N33/56955 , G01N2333/95
摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
摘要翻译：本发明涉及细胞和体液应答的生成和使用，用于预防和治疗牙龈卟啉单胞菌相关病症和疾病。

9. 发明授权

US08282933B2 P. gingivalis antigenic composition 有权
标题翻译：牙龈卟啉单胞菌抗原组成
公开(公告)号：US08282933B2
公开(公告)日：2012-10-09
申请号：US11729218
申请日：2007-03-27
申请人： Eric C. Reynolds , Nada Slakeski , Guang Gao Chen , George Ian Barr
发明人： Eric C. Reynolds , Nada Slakeski , Guang Gao Chen , George Ian Barr
IPC分类号： A61K39/02
CPC分类号： A61K8/64 , A61K39/00 , A61K2039/505 , A61K2800/86 , A61Q11/00 , C07K14/195 , C07K16/12 , C07K16/1257 , C07K2319/00
摘要： The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
摘要翻译：本发明提供一种抗原组合物，该组合物包含至少一种重组蛋白。重组蛋白包含至少一个表位。表位与抗体反应，该抗体与具有SEQ ID NO：1所示序列的多肽具有反应性。 ID。没有。 3或SEQ。 ID。没有。本发明还提供了用于生产重组蛋白的方法和组合物。还提供了用于诊断，治疗和预防牙龈卟啉菌感染的方法。

10. 发明授权

US07419671B2 P. gingivalis antigenic composition 有权
公开(公告)号：US07419671B2
公开(公告)日：2008-09-02
申请号：US10174695
申请日：2002-06-18
申请人： Eric Charles Reynolds , Nada Slakeski , Chao Guang Chen , Ian George Barr
发明人： Eric Charles Reynolds , Nada Slakeski , Chao Guang Chen , Ian George Barr
IPC分类号： A61K39/02
CPC分类号： A61K8/64 , A61K39/00 , A61K2039/505 , A61K2800/86 , A61Q11/00 , C07K14/195 , C07K16/12 , C07K16/1257 , C07K2319/00
摘要： The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.

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