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1. 发明申请

US20170313656A1 Branched Discrete PEG Constructs 审中-公开
公开(公告)号：US20170313656A1
公开(公告)日：2017-11-02
申请号：US15630986
申请日：2017-06-23
申请人： Paul D. Davis , D. Scott Wilbur
发明人： Paul D. Davis , D. Scott Wilbur
IPC分类号： C07D209/60 , C07K16/30 , C07K14/605 , C07D403/14 , C07D257/02 , C07D209/48 , C07D207/404 , C07C331/28 , C07C317/44 , C07C279/24 , C07C271/16 , C07C235/48 , C07C235/08 , A61K51/10 , C07K16/40 , C07C2603/18
CPC分类号： C07D209/60 , A61K47/60 , A61K51/106 , C07C235/08 , C07C235/48 , C07C271/16 , C07C279/24 , C07C317/44 , C07C331/28 , C07C2603/18 , C07D207/404 , C07D209/48 , C07D257/02 , C07D403/14 , C07K14/605 , C07K16/3069 , C07K16/40
摘要： Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.

2. 发明申请

US20130052130A1 Branched Discreet PEG Constructs 审中-公开
标题翻译：分支的谨慎的PEG构造
公开(公告)号：US20130052130A1
公开(公告)日：2013-02-28
申请号：US13600188
申请日：2012-08-30
申请人： Paul D. Davis , D. Scott Wilbur
发明人： Paul D. Davis , D. Scott Wilbur
IPC分类号： C07D209/48 , C07C271/16 , C07D207/452 , C07K16/00 , C07D403/14 , C07C235/08 , C07C235/74 , C07K14/605 , A61K51/10 , C07D257/02 , C07K16/10 , B82Y99/00
CPC分类号： C07D209/60 , A61K47/60 , A61K51/106 , C07C235/08 , C07C235/48 , C07C271/16 , C07C279/24 , C07C317/44 , C07C331/28 , C07C2603/18 , C07D207/404 , C07D209/48 , C07D257/02 , C07D403/14 , C07K14/605 , C07K16/3069 , C07K16/40
摘要： Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.
摘要翻译：公开了一般和基本上纯的支链离散聚乙二醇构建体，其可用于连接多种生物活性基团，例如优先定位剂，以及用于诊断的生物制剂如酶。影像学，治疗学，神经学和其他应用专用的部分。在其最简单的中间状态下，分支离散的聚乙二醇构造物在一端被化学反应性部分终止，A是与生成A生物材料反应的基团，A是生物反应性基团，其连接到支链核心（BC），其连接至少两个dPEG链，由实线表示，具有端基，其可以是带电荷的，非反应性的或可反应的部分，并且含有约2至64个dPEG残基。

3. 发明授权

US5573343A Hydrostatic release device 失效
标题翻译：静电释放装置
公开(公告)号：US5573343A
公开(公告)日：1996-11-12
申请号：US418003
申请日：1995-04-06
申请人： Paul D. Davis , Thomas S. Floate
发明人： Paul D. Davis , Thomas S. Floate
IPC分类号： B63B22/14 , B63C9/22 , B63B23/70
CPC分类号： B63B22/14 , B63C9/22 , Y10T403/11 , Y10T403/22 , Y10T403/595
摘要： The application describes a hydrostatic release device, suitable for releasing life-saving equipment carried on a ship or aircraft when the ship or aircraft sinks or ditches in the sea. A change in ambient pressure is detected by a pressure sensor which opens a liquid-filled chamber and thereby releases a hydrostatic pressure behind a reciprocable member. This reciprocable member then allows release of a release means. The release means can comprise a link prevented from longitudinal movement by an abutment and normally constrained against lateral movement by the reciprocable member. Thus removal of the reciprocable member away from the link enables transverse movement of the link clear of the fixed abutment. Such an arrangement provides a particularly simple and inexpensive release means.
摘要翻译：该应用描述了一种静电释放装置，适用于当船舶或飞机在海中沉没或沟渠时释放船上或飞机上携带的救生设备。通过压力传感器检测环境压力的变化，所述压力传感器打开充满液体的室，从而在可往复运动的构件之后释放静水压力。然后，该往复件可释放释放装置。释放装置可以包括阻止由邻接部纵向运动的连杆，并且通常受到可往复运动的构件的横向运动的约束。因此，可往复运动的构件远离链节的移除使得连杆的横向移动远离固定的基台。这种布置提供了特别简单且便宜的释放装置。

4. 发明授权

US4940645A Imaging material employing photosensitive microcapsules containing tertiary amines as coinitiators 失效
标题翻译：使用含有叔胺作为共引发剂的光敏微胶囊的成像材料
公开(公告)号：US4940645A
公开(公告)日：1990-07-10
申请号：US300168
申请日：1989-01-19
申请人： Paul D. Davis , Gary F. Hillenbrand , Paul C. Adair
发明人： Paul D. Davis , Gary F. Hillenbrand , Paul C. Adair
IPC分类号： G03F7/00
CPC分类号： G03F7/002 , Y10S430/117 , Y10S430/12 , Y10S430/122 , Y10S430/127
摘要： Imaging materials employing photosensitive microcapsules having improved film speed are disclosed wherein the microcapsules contain a photoinitiator system including an absorber, a coinitiator and an autoxidizer; the absorber is a compound such as an aromatic ketone, the coinitiator and the autoxidizer are different but may be compounds such as N,N-dialkylanilines; the coinitiator and autoxidizer are selected such that free radical generation and oxygen consumption occur with optimum efficiency thereby providing an imaging material having high film speed.
摘要翻译：公开了使用具有改进的膜速度的光敏微胶囊的成像材料，其中微胶囊含有包含吸收剂，共引发剂和自动氧化剂的光引发剂体系; 吸收剂是诸如芳香酮的化合物，共引发剂和自动氧化剂是不同的，但可以是化合物如N，N-二烷基苯胺; 选择共引发剂和自动氧化剂，使得以最佳效率发生自由基产生和氧气消耗，从而提供具有高膜速度的成像材料。

5. 发明授权

US5230982A Photoinitiator compositions containing disulfides and photohardenable compositions containing the same 失效
标题翻译：含有二硫化物的光引发剂组合物和含有它们的可光硬化组合物
公开(公告)号：US5230982A
公开(公告)日：1993-07-27
申请号：US795282
申请日：1991-11-19
申请人： Paul D. Davis , Jacqueline G. Truini , David A. Hutchings
发明人： Paul D. Davis , Jacqueline G. Truini , David A. Hutchings
IPC分类号： G03F7/00 , G03F7/031
CPC分类号： G03F7/031 , G03F7/002 , Y10S430/121
摘要： A photohardenable composition comprising a free radical addition polymerizable or crosslinkable compound, an ionic dye/reactive counter ion complex capable of absorbing actinic radiation and producing free radicals which initiate free radical polymerization or crosslinking of the polymerizable or crosslinkable compound, and a disulfide represented by the structure ##STR1## wherein X is selected from the group consisting of S and O except in a specific case in which the disulfide is derived from one or more tetrazolyl groups; n represents 0 or 1; A represents the residue of the ring containing the N, C and X atoms, the ring containing five or six members and, in addition, said ring members may be fused to an aromatic ring; and R.sup.5 is an aromatic radical selected from the group consisting of (i) phenyl, (ii) benzothiazolyl, (iii) benzoxazolyl, (iv) tetrazolyl, (v) pyridinyl, (vi) pyrimidinyl, (vii) thiazolyl, (viii) oxazolyl, (ix) quinazolinyl, and (x) thiadiazolyl, each of which may have a substituent on one or more C or N atoms of the ring.
摘要翻译：一种可光硬化组合物，其包含可自由基加成聚合的或可交联的化合物，能够吸收光化辐射的离子染料/反应性抗衡离子络合物，并产生引发可聚合或可交联化合物的自由基聚合或交联的自由基，结构其中X选自S和O，除了二硫化物衍生自一个或多个四唑基的特定情况; n表示0或1; A表示含有N，C和X原子的环的残基，所述环含有五个或六个成员，此外，所述环成员可以与芳环稠合; （ⅰ）苯基，（ⅱ）苯并噻唑基，（ⅲ）苯并恶唑基，（ⅳ）四唑基，（ⅴ）吡啶基，（vi）嘧啶基，（i）噻唑基，（ii）（ix）喹唑啉基和（x）噻二唑基，其各自可以在环的一个或多个C或N原子上具有取代基。

6. 发明授权

US4954415A Photoinitiator compositions containing O-acylthiohydroxamate or an N-alkoxypyridinethione and photohardenable compositions containing the same 失效
标题翻译：包含O-酰基硫代羟基甲酸酯或N-烷氧基吡啶硫酮的光引发剂组合物和含有它们的可光硬化组合物
公开(公告)号：US4954415A
公开(公告)日：1990-09-04
申请号：US321256
申请日：1989-03-09
申请人： Paul D. Davis , Gary B. Schuster , Jacqueline G. Truini , Al Fentiman
发明人： Paul D. Davis , Gary B. Schuster , Jacqueline G. Truini , Al Fentiman
IPC分类号： G03F7/004 , G03F7/00 , G03F7/031
CPC分类号： G03F7/002 , G03F7/031 , Y10S430/116 , Y10S430/121
摘要： A photoinitiator composition comprising a compound which absorbs actinic radiation and directly or indirectly generates free radicals, and an O-acylthiohydroxamate compound or an N-alkoxypyridine thione; photohardenable compositions containing that photoinitiator composition; and photosensitive materials employing same.

7. 发明授权

US4788125A Imaging materials employing microparticles including a silver initiator 失效
标题翻译：使用包含银引发剂的微粒的成像材料
公开(公告)号：US4788125A
公开(公告)日：1988-11-29
申请号：US46380
申请日：1987-05-04
申请人： Paul D. Davis , Joseph G. O'Connor
发明人： Paul D. Davis , Joseph G. O'Connor
IPC分类号： G03F7/00 , G03F7/028 , G03C1/40 , G03C1/00
CPC分类号： G03F7/0285 , G03F7/002 , Y10S430/136
摘要： An imaging material comprising a support and a layer of photosensitive microparticles on one surface of said support, said microparticles including an image-forming agent and a photosensitive composition containing a polymer which is capable of undergoing cationically-initiated depolymerization and a photoinitiator including a silver halide and an organo silver salt, wherein, after exposing said microparticle to radiation, said microparticles, directly or with additional processing, release said image-forming agent or become permeable to a developer which reacts with said image-forming agent to form a visible image.
摘要翻译：一种在所述载体的一个表面上包含支持体和感光性微粒层的成像材料，所述微粒包括成像剂和含有能够进行阳离子引发解聚的聚合物的光敏组合物和包含卤化银的光引发剂和有机银盐，其中，在将所述微粒暴露于辐射之后，所述微粒直接或通过附加处理，释放所述成像剂或使其与所述图像形成剂反应形成可见图像的显影剂变得透气。

8. 发明授权

US08637711B2 Selective and specific preparation of discrete PEG compounds 有权
标题翻译：离散PEG化合物的选择性和具体制备
公开(公告)号：US08637711B2
公开(公告)日：2014-01-28
申请号：US13014789
申请日：2011-01-27
申请人： Paul D. Davis , Edward C. Crapps
发明人： Paul D. Davis , Edward C. Crapps
IPC分类号： C07C43/11
CPC分类号： C07C41/16 , C07C247/04 , C07C319/12 , C08G65/331 , C08L71/02 , Y02P20/55 , C07C323/12 , C07C43/164 , C07C43/1785 , C07C43/11
摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commercial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.
摘要翻译：本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法可用于商业制造dPEG。保护群体和功能团体可以设计成大规模净化实际的现实。新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。

9. 发明申请

US20110124844A1 Selective and Specific Preparation of Discrete Peg Compounds 有权
标题翻译：离散聚合物的选择性和特异性制备
公开(公告)号：US20110124844A1
公开(公告)日：2011-05-26
申请号：US13014789
申请日：2011-01-27
申请人： Paul D. Davis , Edward C. Crapps
发明人： Paul D. Davis , Edward C. Crapps
IPC分类号： C07C41/01 , C07C41/26 , C07C247/10 , C07C303/30 , C07C319/12 , C07D309/12 , C07K14/00 , C07K1/113 , C07C323/52
CPC分类号： C07C41/16 , C07C247/04 , C07C319/12 , C08G65/331 , C08L71/02 , Y02P20/55 , C07C323/12 , C07C43/164 , C07C43/1785 , C07C43/11
摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.
摘要翻译：本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法对于商业制造dPEG有用。保护群体和功能团体可以设计成大规模净化实际的现实。新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。

10. 外观设计

USD295196S Game board 失效
公开(公告)号：USD295196S
公开(公告)日：1988-04-12
申请号：US734882
申请日：1985-05-16
申请人： Paul D. Davis
设计人： Paul D. Davis

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