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1. 发明授权

US07888536B2 Selective and specific preparation of discrete PEG compounds 有权
标题翻译：离散PEG化合物的选择性和具体制备
公开(公告)号：US07888536B2
公开(公告)日：2011-02-15
申请号：US11203950
申请日：2005-08-15
申请人： Paul D. Davis , Edward C. Crapps
发明人： Paul D. Davis , Edward C. Crapps
IPC分类号： C07C43/11
CPC分类号： C07C41/16 , C07C247/04 , C07C319/12 , C08G65/331 , C08L71/02 , Y02P20/55 , C07C323/12 , C07C43/164 , C07C43/1785 , C07C43/11
摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.
摘要翻译：本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法对于商业制造dPEG有用。保护群体和功能团体可以设计成大规模净化实际的现实。新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。

2. 发明授权

US08637711B2 Selective and specific preparation of discrete PEG compounds 有权
标题翻译：离散PEG化合物的选择性和具体制备
公开(公告)号：US08637711B2
公开(公告)日：2014-01-28
申请号：US13014789
申请日：2011-01-27
申请人： Paul D. Davis , Edward C. Crapps
发明人： Paul D. Davis , Edward C. Crapps
IPC分类号： C07C43/11
CPC分类号： C07C41/16 , C07C247/04 , C07C319/12 , C08G65/331 , C08L71/02 , Y02P20/55 , C07C323/12 , C07C43/164 , C07C43/1785 , C07C43/11
摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commercial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.
摘要翻译：本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法可用于商业制造dPEG。保护群体和功能团体可以设计成大规模净化实际的现实。新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。

3. 发明申请

US20110124844A1 Selective and Specific Preparation of Discrete Peg Compounds 有权
标题翻译：离散聚合物的选择性和特异性制备
公开(公告)号：US20110124844A1
公开(公告)日：2011-05-26
申请号：US13014789
申请日：2011-01-27
申请人： Paul D. Davis , Edward C. Crapps
发明人： Paul D. Davis , Edward C. Crapps
IPC分类号： C07C41/01 , C07C41/26 , C07C247/10 , C07C303/30 , C07C319/12 , C07D309/12 , C07K14/00 , C07K1/113 , C07C323/52
CPC分类号： C07C41/16 , C07C247/04 , C07C319/12 , C08G65/331 , C08L71/02 , Y02P20/55 , C07C323/12 , C07C43/164 , C07C43/1785 , C07C43/11
摘要： Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods which can be used to build up larger dPEG compounds (a) containing a wider range of utility to make useful homo- and heterofunctional and branched species, and (b) under reaction configurations and conditions that are milder, more efficient, more diverse in terms of incorporating useful functionality, more controllable, and more versatile then any conventional method reported in the art to date. In addition, the embodiments of the invention allow for processes that allow for significantly improving the ability to purify the intermediates or final product mixtures, making these methods useful for commerial manufacturing dPEGs. Protecting groups and functional groups can be designed to make purification at large scale a practical reality. The novel dPEG products form the compositional and material basis for making other novel compounds of valuable application in the fields of diagnostics and therapeutics, amongst others.
摘要翻译：本发明的方面涉及选择性地且具体地制备离散聚乙烯化合物至预定数量的环氧乙烷单元的新方法。可用于建立较大的dPEG化合物的方法（a），其具有更广泛的用途以实现有用的同功和异功能和支链物质，以及（b）在温和，更有效，更多样化的反应配置和条件下迄今为止本领域所报道的任何常规方法，结合有用的功能，更可控和更通用的术语。此外，本发明的实施方案允许允许显着提高纯化中间体或最终产物混合物的能力的方法，使得这些方法对于商业制造dPEG有用。保护群体和功能团体可以设计成大规模净化实际的现实。新型dPEG产品形成了其他新型化合物在诊断和治疗领域的有价值应用的组成和物质基础。

4. 发明授权

US5185447A Polycyclic ketones and preparative methods therefor 失效
标题翻译：多环酮及其制备方法
公开(公告)号：US5185447A
公开(公告)日：1993-02-09
申请号：US827429
申请日：1992-01-29
申请人： Edward C. Crapps
发明人： Edward C. Crapps
IPC分类号： C07C49/675 , C07D221/16 , C07D471/04
CPC分类号： C07D471/04 , C07C49/675 , C07D221/16
摘要： Ketones having formulas (1)-(3) are provided by improved methods which involve the treatment of compounds having formulas (9)-(11) with aqueous base. ##STR1## wherein R.sub.x is NO.sub.2.
摘要翻译：具有式（1） - （3）的酮通过改进的方法提供，其涉及用碱水溶液处理具有式（9） - （11）的化合物。（1）（2）或（3）（9）（10）或（11）其中Rx为NO2。

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