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1. 发明申请

WO1998002163A1 PURIFIED COMPOSITIONS OF 10-PROPARGYL-10-DEAZAAMINOPTERIN AND METHODS OF USING SAME IN THE TREATMENT OF TUMORS 审中-公开
标题翻译： 10-PROPARGYL-10-DEAZAAMINOPTERIN的纯化组合物及其在肿瘤治疗中的使用方法
公开(公告)号：WO1998002163A1
公开(公告)日：1998-01-22
申请号：PCT/US1997011982
申请日：1997-07-16
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , SRI INTERNATIONAL , SOUTHERN RESEARCH INSTITUTE , SIROTNAK, Francis, M. , PIPER, James, R. , DeGRAW, Joseph, I. , COLWELL, William, T.
发明人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , SRI INTERNATIONAL , SOUTHERN RESEARCH INSTITUTE
IPC分类号： A61K31/505
CPC分类号： C07D475/08 , A61K31/505 , A61K31/519 , A61K31/555 , A61K33/24 , A61K2300/00 , A61K31/475 , A61K31/335
摘要： Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propragyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.
摘要翻译：在异种移植模型中测试的高度纯化的10-炔丙基-10-脱氮基喋呤（10-炔丙基-10dAM）组合物对于人类肿瘤的功效显示出远优于甲氨蝶呤（“MTX”），并且甚至优于较新的临床候选人艾曲汀（ “EDX”）。此外，10-propragyl-10dAM显示出令人惊奇的治愈肿瘤的能力，使得在治疗停止后数周没有肿瘤生长迹象。因此，含有10-炔丙基-10dAM的高度纯化的组合物可用于治疗人类肿瘤，特别是人类乳腺肿瘤和人类肺癌。

2. 发明专利

CA2001458A1 5-METHYL-5-DEAZA-10-PROPARGYLAMINOPTERIN 未知
公开(公告)号：CA2001458A1
公开(公告)日：1991-02-14
申请号：CA2001458
申请日：1989-10-25
申请人： PIPER JAMES R , MONTGOMERY JOHN A , SIROTNAK FRANCIS M
发明人： PIPER JAMES R , MONTGOMERY JOHN A , SIROTNAK FRANCIS M
IPC分类号： C07D475/08 , A61K31/505 , A61K31/519 , A61P35/00 , C07D471/04
摘要： 5-Methyl-5-deaza-10-propargylaminopterin is disclosed as a potent antineoplastic agent.

3. 发明申请

WO2003030620A3 IMAGING MICROARRAYS 审中-公开
公开(公告)号：WO2003030620A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032523
申请日：2002-10-11
申请人： VYSIS, INC. , PIPER, James, R.
发明人： PIPER, James, R.
IPC分类号： G01N33/48
摘要： A method of obtaining a corrected image of a microarray includes acquiring an image of a microarray including a target spot, and processing the image to correct for background noise and chip misalignment. The method also includes analyzing the image to identify a target patch, edit debris, and correct for ratio bias; and detecting single copy number variation in the target spot using an objective statistical analysis that includes a t-value statistical analysis. The method provides statistically robust computational processes for accurately detecting genomic variation at the single copy level.

4. 发明申请

WO03030620A2 IMAGING MICROARRAYS 审中-公开
标题翻译：成像微观
公开(公告)号：WO03030620A2
公开(公告)日：2003-04-17
申请号：PCT/US0232523
申请日：2002-10-11
申请人： VYSIS INC , PIPER JAMES R
发明人： PIPER JAMES R
IPC分类号： G06F19/20 , G06T5/00 , G06T7/00
CPC分类号： G06T5/002 , G06F19/20 , G06T7/0012 , G06T7/11 , G06T7/143 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072
摘要： A method of obtaining a corrected image of a microarray includes acquiring an image of a microarray including a target spot, and processing the image to correct for background noise and chip misalignment. The method also includes analyzing the image to identify a target patch, edit debris, and correct for ratio bias; and detecting single copy number variation in the target spot using an objective statistical analysis that includes a t-value statistical analysis. The method provides statistically robust computational processes for accurately detecting genomic variation at the single copy level.
摘要翻译：获得微阵列的校正图像的方法包括获取包括目标斑点的微阵列的图像，以及处理图像以校正背景噪声和芯片未对准。该方法还包括分析图像以识别目标贴片，编辑碎片并纠正比率偏差; 并使用包括t值统计分析的客观统计分析来检测目标点中的单拷贝数变化。该方法提供统计上鲁棒的计算过程，用于准确检测单拷贝水平的基因组变异。

5. 发明申请

WO0038668A3 USE OF A NITROSOUREA DERIVATIVE FOR PREVENTION OR TREATMENT OF ACUTE ALLOGRAFT REJECTION 审中-公开
标题翻译：使用NITROSOUREA衍生物预防或治疗急性乙型肝炎病毒
公开(公告)号：WO0038668A3
公开(公告)日：2000-12-07
申请号：PCT/US9930985
申请日：1999-12-28
申请人： SOUTHERN RES INST , BLATTER HERBERT M , KAHN DONALD R , PIPER JAMES R , SECRIST JOHN A III , STRUCK ROBERT F , TEMPLE CARROLL
发明人： BLATTER HERBERT M , KAHN DONALD R , PIPER JAMES R , SECRIST JOHN A III , STRUCK ROBERT F , TEMPLE CARROLL
IPC分类号： A61K31/175 , A61K31/45 , A61K31/17 , A61K31/445 , A61K31/4468 , A61P37/06
CPC分类号： A61K31/175 , A61K31/45 , Y10S514/885
摘要： A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulae (I), (II), (III), (IV), (V), (VI), and (VII) is administered to the organ donor, wherein Y is (a); X is F or Cl; R1 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R2 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R3 is H or a straight or branched alkyl group having from 1 to 7 carbon atoms; Z is H, OH, or a straight or branched alkyl group including from 1 to 7 carbon atoms; and in Formula (II), the OH groups may be substituted anywhere except where Y is present and are not on the same carbon atom; in Formula (III), the OH group may be substituted anywhere except where Y is present; in Formula (IV), the OH group may be substituted anywhere except where Y is present; in Formula (V), Z may be substituted anywhere except at C-1, C-6, and C-4 if Z is OH; in Formula (VI), Z may be substituted anywhere except at C-1, C-3, and C-5 if Z is OH; and in Formula (VII), Z may be at C-1, C-2, and C-3 except not on C-1 if Z is OH.
摘要翻译：在收获器官之前处理器官供体以减少受体中的移植物排斥的方法。降低至少一种选自具有式（I），（II），（III），（IV），（V），（VI）和（VII）的化合物的化合物的移植排斥反应的量）给予器官供体，其中Y为（a）; X是F或Cl; R1是具有1至7个碳原子的直链或支链烷基; R2是具有1至7个碳原子的直链或支链烷基; R3是H或具有1至7个碳原子的直链或支链烷基; Z是H，OH或包含1至7个碳原子的直链或支链烷基; 在式（II）中，除了存在Y并且不在相同碳原子上之外，OH基团可以被取代; 在式（III）中，除了存在Y之外，OH基团可以被取代; 在式（IV）中，除了存在Y之外，OH基团可以被取代; 在式（Ⅴ）中，如果Z是OH，则Z可以在C-1，C-6和C-4之外的任何地方被取代; 在式（VI）中，Z可以在C 1，C 3和C 5上的任何地方被取代，如果Z是OH; 并且在式（VII）中，Z可以是C-1，C-2和C-3，但如果Z是OH，则不在C-1上。

6. 发明授权

US3690370A Cooling system 失效
标题翻译：冷却系统
公开(公告)号：US3690370A
公开(公告)日：1972-09-12
申请号：US3690370D
申请日：1970-02-11
申请人： PIPER JAMES R
发明人： PIPER JAMES R
IPC分类号： F24F5/00 , B60H1/00
CPC分类号： F24F5/0007
摘要： A series-loop cooling system for cooling individually several zones within a building or several buildings includes a closed circuit having for each zone and within series in the circuit the heat exchange coil of a heat exchange unit which utilizes and incorporates the standard structural members of a building or of several buildings. A cooling medium is circulated continually through the circuit and the heat exchange coil of each heat exchange unit and thermostatically controlled fans in each heat exchange unit are adapted to pass air over the heat exchange coils and distribute the same into the temperature controlled zones.
摘要翻译：用于单独地冷却建筑物或几栋建筑物内的几个区域的串联回路冷却系统包括一个闭合回路，该闭合回路具有对于每个区域并在该回路内的串联的热交换单元的热交换盘管中，其利用并结合了一个建筑物或几栋建筑物。冷却介质通过电路连续循环，每个热交换单元的热交换线圈和每个热交换单元中的恒温控制风扇适于将空气传递到热交换盘管上并将其分配到温度受控区域中。

7. 发明授权

US3655127A Heating system 失效
标题翻译：加热系统
公开(公告)号：US3655127A
公开(公告)日：1972-04-11
申请号：US3655127D
申请日：1970-02-11
申请人： PIPER JAMES R
发明人： PIPER JAMES R
IPC分类号： F24D3/08 , F24D3/10
CPC分类号： F24D3/10 , F24D3/08
摘要： A series-loop heating system provides heat for a plurality of controlled temperature zones within a large building or several buildings and utilizes and incorporates within the system both the domestic hot water system and the standard structural members normally associated with such a building or buildings. The heating system includes a normally closed circuit with a plurality of heat exchange coils connected to the circuit in series through which the domestic hot water is continually circulated. Each controlled temperature zone includes at least one heat exchange unit and each heat exchange unit includes one of the heat exchange coils over which air is passed when heating the zone.
摘要翻译：串联回路加热系统为大型建筑物或多个建筑物内的多个受控温度区域提供热量，并利用并结合在系统内的家用热水系统和通常与这种建筑物相关联的标准结构构件。加热系统包括常闭电路，其中多个热交换线圈串联连接到家用热水继续循环。每个受控温度区包括至少一个热交换单元，并且每个热交换单元包括加热该区域时空气通过的一个热交换盘管。

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