专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997046531A1 PYRIDINE DERIVATIVE, COMPOSITION AND METHOD FOR TREATING CANCER 审中-公开
标题翻译：吡啶衍生物，组合物和治疗癌症的方法
公开(公告)号：WO1997046531A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009428
申请日：1997-06-03
申请人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SOUTHERN RESEARCH INSTITUTE , JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDECINE , HARTMAN, Neil , STRUCK, Robert, F. , O'REILLY, Seamus , STRONG, John, M. , ROWINSKY, Eric, K. , COLLINS, Jerry, M.
发明人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SOUTHERN RESEARCH INSTITUTE , JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDECINE
IPC分类号： C07D213/69
CPC分类号： C07D213/69
摘要： Substantially pure 3,5-dichloro-2-methoxy-4-hydroxy-6-(trichloromethyl)pyridine or 4-demethylpenclomedine (formula I), acid addition salts thereof, pharmaceutical compositions containing the aforesaid compound, and a method of using the compound in the treatment of cancer in a mammal are disclosed.
摘要翻译：基本上纯的3,5-二氯-2-甲氧基-4-羟基-6-（三氯甲基）吡啶或4-去甲基宁烯醇（式I），其酸加成盐，含有上述化合物的药物组合物，以及使用该化合物在哺乳动物的癌症治疗中被公开。

2. 发明专利

IL184940A DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION THEREOF 未知
公开(公告)号：IL184940A
公开(公告)日：2012-12-31
申请号：IL18494007
申请日：2007-07-30
申请人： SOUTHERN RES INST , STRUCK ROBERT F
发明人： STRUCK ROBERT F
摘要： Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.

3. 发明申请

WO2006083930A3 DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF 审中-公开
公开(公告)号：WO2006083930A3
公开(公告)日：2006-08-10
申请号：PCT/US2006/003496
申请日：2006-02-01
申请人： SOUTHERN RESEARCH INSTITUTE , STRUCK, Robert, F.
发明人： STRUCK, Robert, F.
IPC分类号： C07D213/24 , C07D213/30 , A61K31/44
摘要： Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.

4. 发明申请

WO2006083930A2 DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF 审中-公开
标题翻译： 4-去甲基联苯胺的衍生物，其用途及其制备方法
公开(公告)号：WO2006083930A2
公开(公告)日：2006-08-10
申请号：PCT/US2006003496
申请日：2006-02-01
申请人： SOUTHERN RES INST , STRUCK ROBERT F
发明人： STRUCK ROBERT F
IPC分类号： C07D213/69 , A61K31/44
CPC分类号： C07D213/69
摘要： Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided.
摘要翻译：提供4-去甲基中间体的硫代碳酸酯和硫代氨基甲酸酯衍生物以及含有它们的药物组合物，并用于治疗癌症。还提供了制备衍生物的方法。

5. 发明申请

WO0038668A3 USE OF A NITROSOUREA DERIVATIVE FOR PREVENTION OR TREATMENT OF ACUTE ALLOGRAFT REJECTION 审中-公开
标题翻译：使用NITROSOUREA衍生物预防或治疗急性乙型肝炎病毒
公开(公告)号：WO0038668A3
公开(公告)日：2000-12-07
申请号：PCT/US9930985
申请日：1999-12-28
申请人： SOUTHERN RES INST , BLATTER HERBERT M , KAHN DONALD R , PIPER JAMES R , SECRIST JOHN A III , STRUCK ROBERT F , TEMPLE CARROLL
发明人： BLATTER HERBERT M , KAHN DONALD R , PIPER JAMES R , SECRIST JOHN A III , STRUCK ROBERT F , TEMPLE CARROLL
IPC分类号： A61K31/175 , A61K31/45 , A61K31/17 , A61K31/445 , A61K31/4468 , A61P37/06
CPC分类号： A61K31/175 , A61K31/45 , Y10S514/885
摘要： A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulae (I), (II), (III), (IV), (V), (VI), and (VII) is administered to the organ donor, wherein Y is (a); X is F or Cl; R1 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R2 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R3 is H or a straight or branched alkyl group having from 1 to 7 carbon atoms; Z is H, OH, or a straight or branched alkyl group including from 1 to 7 carbon atoms; and in Formula (II), the OH groups may be substituted anywhere except where Y is present and are not on the same carbon atom; in Formula (III), the OH group may be substituted anywhere except where Y is present; in Formula (IV), the OH group may be substituted anywhere except where Y is present; in Formula (V), Z may be substituted anywhere except at C-1, C-6, and C-4 if Z is OH; in Formula (VI), Z may be substituted anywhere except at C-1, C-3, and C-5 if Z is OH; and in Formula (VII), Z may be at C-1, C-2, and C-3 except not on C-1 if Z is OH.
摘要翻译：在收获器官之前处理器官供体以减少受体中的移植物排斥的方法。降低至少一种选自具有式（I），（II），（III），（IV），（V），（VI）和（VII）的化合物的化合物的移植排斥反应的量）给予器官供体，其中Y为（a）; X是F或Cl; R1是具有1至7个碳原子的直链或支链烷基; R2是具有1至7个碳原子的直链或支链烷基; R3是H或具有1至7个碳原子的直链或支链烷基; Z是H，OH或包含1至7个碳原子的直链或支链烷基; 在式（II）中，除了存在Y并且不在相同碳原子上之外，OH基团可以被取代; 在式（III）中，除了存在Y之外，OH基团可以被取代; 在式（IV）中，除了存在Y之外，OH基团可以被取代; 在式（Ⅴ）中，如果Z是OH，则Z可以在C-1，C-6和C-4之外的任何地方被取代; 在式（VI）中，Z可以在C 1，C 3和C 5上的任何地方被取代，如果Z是OH; 并且在式（VII）中，Z可以是C-1，C-2和C-3，但如果Z是OH，则不在C-1上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式