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    • 5. 发明申请
    • USE OF A NITROSOUREA DERIVATIVE FOR PREVENTION OR TREATMENT OF ACUTE ALLOGRAFT REJECTION
    • 使用NITROSOUREA衍生物预防或治疗急性乙型肝炎病毒
    • WO0038668A3
    • 2000-12-07
    • PCT/US9930985
    • 1999-12-28
    • SOUTHERN RES INSTBLATTER HERBERT MKAHN DONALD RPIPER JAMES RSECRIST JOHN A IIISTRUCK ROBERT FTEMPLE CARROLL
    • BLATTER HERBERT MKAHN DONALD RPIPER JAMES RSECRIST JOHN A IIISTRUCK ROBERT FTEMPLE CARROLL
    • A61K31/175A61K31/45A61K31/17A61K31/445A61K31/4468A61P37/06
    • A61K31/175A61K31/45Y10S514/885
    • A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulae (I), (II), (III), (IV), (V), (VI), and (VII) is administered to the organ donor, wherein Y is (a); X is F or Cl; R1 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R2 is a straight or branched alkyl group having from 1 to 7 carbon atoms; R3 is H or a straight or branched alkyl group having from 1 to 7 carbon atoms; Z is H, OH, or a straight or branched alkyl group including from 1 to 7 carbon atoms; and in Formula (II), the OH groups may be substituted anywhere except where Y is present and are not on the same carbon atom; in Formula (III), the OH group may be substituted anywhere except where Y is present; in Formula (IV), the OH group may be substituted anywhere except where Y is present; in Formula (V), Z may be substituted anywhere except at C-1, C-6, and C-4 if Z is OH; in Formula (VI), Z may be substituted anywhere except at C-1, C-3, and C-5 if Z is OH; and in Formula (VII), Z may be at C-1, C-2, and C-3 except not on C-1 if Z is OH.
    • 在收获器官之前处理器官供体以减少受体中的移植物排斥的方法。 降低至少一种选自具有式(I),(II),(III),(IV),(V),(VI)和(VII)的化合物的化合物的移植排斥反应的量) 给予器官供体,其中Y为(a); X是F或Cl; R1是具有1至7个碳原子的直链或支链烷基; R2是具有1至7个碳原子的直链或支链烷基; R3是H或具有1至7个碳原子的直链或支链烷基; Z是H,OH或包含1至7个碳原子的直链或支链烷基; 在式(II)中,除了存在Y并且不在相同碳原子上之外,OH基团可以被取代; 在式(III)中,除了存在Y之外,OH基团可以被取代; 在式(IV)中,除了存在Y之外,OH基团可以被取代; 在式(Ⅴ)中,如果Z是OH,则Z可以在C-1,C-6和C-4之外的任何地方被取代; 在式(VI)中,Z可以在C 1,C 3和C 5上的任何地方被取代,如果Z是OH; 并且在式(VII)中,Z可以是C-1,C-2和C-3,但如果Z是OH,则不在C-1上。