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2. 发明申请

WO2005044995A2 USES OF HUMAN PEPTIDE DEFORMYLASE 审中-公开
标题翻译：使用人类胃蛋白酶
公开(公告)号：WO2005044995A2
公开(公告)日：2005-05-19
申请号：PCT/US2004036866
申请日：2004-11-04
申请人： SLOAN KETTERING INST CANCER , SCHEINBERG DAVID A , LEE MONA D , SIROTNAK FRANCIS M , ANTCZAK CHRISTOPHE , BORNMANN WILLIAM G
发明人： SCHEINBERG DAVID A , LEE MONA D , SIROTNAK FRANCIS M , ANTCZAK CHRISTOPHE , BORNMANN WILLIAM G
IPC分类号： C12N20060101 , C12N
CPC分类号： C12N9/80 , A61K38/00 , C12N15/1137 , C12N2310/14 , C12Y305/01088
摘要： This invention provides a substance derived naturally or manufactured through chemical or genetic engineering that is capable of inhibiting the removal of N-formyl group from peptides by peptide deformylase. This invention also provides a nucleic acid molecule encoding the above fragment of human peptide deformylase or its functional equivalent. This invention provides methods of identifying (1) a compound that inhibits peptide deformylase or its functional equivalent, and (2) a compound that inhibits tumor growth. The invention further provides a method of identifying a compound that inhibits tumor growth comprising comparison of the inhibitory concentration or binding affinity of the compound to a bacterial peptide deformylase with a human peptide deformylase, and this inhibitory concentration or binding of the compound to human peptide deformylase indicates a better inhibition of tumor growth. This invention provides a composition comprising an effective amount of the compound identified by the above methods and a suitable carrier.
摘要翻译：本发明提供了一种天然产生的或通过化学或遗传工程制造的物质，其能够通过肽去甲酰化酶抑制从肽中去除N-甲酰基。本发明还提供了编码人肽脱甲酰酶的上述片段或其功能等同物的核酸分子。本发明提供鉴定（1）抑制肽脱甲酰酶或其功能等价物的化合物的方法，和（2）抑制肿瘤生长的化合物。本发明还提供了鉴定抑制肿瘤生长的化合物的方法，其包括将化合物与细菌肽变性酶与人肽脱甲酰酶的抑制浓度或结合亲和性与人肽变性酶的抑制浓度或结合作用表明更好地抑制肿瘤生长。本发明提供了包含有效量的通过上述方法鉴定的化合物和合适的载体的组合物。

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