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1. 发明申请

WO1994013671A1 ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES 审中-公开
标题翻译：抗真菌三氮唑酮衍生物
公开(公告)号：WO1994013671A1
公开(公告)日：1994-06-23
申请号：PCT/EP1993003320
申请日：1993-11-25
申请人： JANSSEN PHARMACEUTICA N.V. , JANSSENS, Frans, Eduard , LACRAMPE, Jean, Fernand, Armand , PILATTE, Isabelle, Noelle, Constance
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Antiallergic triazolobenzazepines of formula (I), wherein each of the dotted lines independently represents an optional bond; R represents hydrogen, halo, c1-4alkyl, hydroxy or C1-4alkyloxy; R represents hydrogen, halo, C1-4alkyl, hydroxy or C1-4alkyloxy; R represents hydrogen, C1-4alkyl or halo; -B D- is a bivalent radical of formula -C(R ) N- (a-1); or -N C(R )- (a-2); R and R represent hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C1-4alkyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R also represents phenyl or pyridinyl; L represents hydrogen; C1-6alkyl; substituted C1-6alkyl, C3-6alkenyl; C3-6alkenyl substituted with aryl or, L represents a radical of formula -Alk-Y-Het (b-1), -Alk-NH-CO-Het (b-2) or -Alk-Het (b-3). Compositions comprising said compounds, processes of preparing the same, and intermediates in the preparation thereof.
摘要翻译：式（I）的抗过敏三唑并苯并吖庚因，其中每个虚线独立地表示任选的键; R 1表示氢，卤素，C 1-4烷基，羟基或C 1-4烷氧基; R 2表示氢，卤素，C 1-4烷基，羟基或C 1-4烷氧基; R 3表示氢，C 1-4烷基或卤素; -B-D是式-C（R 4）N-（a-1）的二价基团。或-N-C（R 5） - （a-2）; R 4和R 5代表氢，C 1-4烷基，被羟基羰基或C 1-4烷氧基羰基取代的乙烯基，被羟基羰基或C 1-4烷氧基羰基取代的C 1-4烷基，羟基C 1-4烷基，甲酰基或羟基羰基; R 5也表示苯基或吡啶基; L表示氢; C1-6烷基; 取代的C 1-6烷基，C 3-6烯基; 由芳基取代的C 3-6链烯基，或L表示式-Alk-Y-Het 1（b-1），-Alk-NH-CO-Het 2（b-2）或-Alk-Het （b-3）。包含所述化合物的组合物，其制备方法以及其制备中的中间体。

2. 发明申请

WO2008107478A8 QUINOLINONE DERIVATIVES AS PARP AND TANK INHIBITORS 审中-公开
标题翻译：喹诺酮衍生物作为PARP和油墨抑制剂
公开(公告)号：WO2008107478A8
公开(公告)日：2008-10-23
申请号：PCT/EP2008052764
申请日：2008-03-07
申请人： JANSSEN PHARMACEUTICA NV , VIALARD JORGE EDUARDO , ANGIBAUD PATRICK RENE , MEVELLEC LAURENCE ANNE , MEYER CHRISTOPHE , FREYNE EDDY JEAN EDGARD , PILATTE ISABELLE NOELLE CONSTANCE , ROUX BRUNO , PASQUIER ELISABETH THERESE JEANNE , BOURDREZ XAVIER MARC , ADELINET CHRISTOPHE DENIS , MARCONNET-DECRANE LAURENCE FRANCOISE BERNADETTE , MACRITCHIE JACQUELINE ANNE , DUFFY JAMES EDWARD STEWART , OWENS ANDREW PATE , STORCK PIERRE-HENRI , PONCELET VIRGINIE SOPHIE
发明人： VIALARD JORGE EDUARDO , ANGIBAUD PATRICK RENE , MEVELLEC LAURENCE ANNE , MEYER CHRISTOPHE , FREYNE EDDY JEAN EDGARD , PILATTE ISABELLE NOELLE CONSTANCE , ROUX BRUNO , PASQUIER ELISABETH THERESE JEANNE , BOURDREZ XAVIER MARC , ADELINET CHRISTOPHE DENIS , MARCONNET-DECRANE LAURENCE FRACOISE BERNADETTE , MACRITCHIE JACQUELINE ANNE , DUFFY JAMES EDWARD STEWART , OWENS ANDREW PATE , STORCK PIERRE-HENRI , PONCELET VIRGINIE SOPHIE
IPC分类号： C07D215/22 , A61K31/4704
CPC分类号： C07D215/227 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention provides compounds of Formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , n, m and X have defined meanings.
摘要翻译：本发明提供式（I）化合物，其作为PARP抑制剂的用途以及包含所述化合物的药物组合物，其中R 1，R 2，R 2， R 4，R 4，R 5，R 6，R 7，n，m和 X已经定义了含义。

3. 发明申请

WO1994013681A1 ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES 审中-公开
标题翻译：抗坏血酸（PYRROLO，THIENO或FURANO）亚胺衍生物
公开(公告)号：WO1994013681A1
公开(公告)日：1994-06-23
申请号：PCT/EP1993003322
申请日：1993-11-25
申请人： JANSSEN PHARMACEUTICA N.V. , JANSSENS, Frans, Eduard , LACRAMPE, Jean, Fernand, Armand , PILATTE, Isabelle, Noelle, Constance
发明人： JANSSEN PHARMACEUTICA N.V.
IPC分类号： C07D495/14
CPC分类号： C07D487/14 , C07D491/14 , C07D495/14
摘要： Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; -E-G- is a bivalent radical of formula -X-C(R ) CH- (a-1); or -CH C(R )-X- (a-2); X represents O, S or NR ; R represents hydrogen, C1-6alkyl or C1-4alkylcarbonyl; -B D- is a bivalent radical of formula -C(R ) N- (b-1); or -N C(R )- (b-2); L represents hydrogen; C1-6alkyl; substituted C1-6alkyl; C3-6alkenyl; C3-6alkenyl substituted with aryl; or, L represents a radical of formula -Alk-Y-Het (c-1), -Alk-NH-CO-Het (c-2) or -Alk-Het (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.
摘要翻译：式（I）的抗过敏三唑（吡咯，噻吩或呋喃）吖庚因，其药学上可接受的加成盐和立体化学异构形式，其中每个虚线独立地表示任选的键; -E-G-是式-X-C（R 1）符号CH-（a-1）的二价基团。或-CH = C（R 2）-X-（a-2）; X表示O，S或NR 3; R 3表示氢，C 1-6烷基或C 1-4烷基羰基; -B-D是式-C（R 4）符号N-（b-1）的二价基团。或-N-C（R 5） - （b-2）; L表示氢; C1-6烷基; 取代的C 1-6烷基; C3-6alkenyl; 被芳基取代的C 3-6烯基; 或者，L表示式-Alk-Y-Het1（c-1），-Alk-NH-CO-Het2（c-2）或-Alk-Het3（c- 3）。包含所述化合物的组合物，其制备方法及其制备中的中间体。

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