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1. 发明申请

WO2008055718A3 MEDICAL DEVICE CAPABLE OF RELEASING NO 审中-公开
公开(公告)号：WO2008055718A3
公开(公告)日：2008-05-15
申请号：PCT/EP2007/057779
申请日：2007-07-27
申请人： Millimed A/S , NIELSEN, Kent, Høier , POULSEN, Frederik, Enemark , JENSEN, Christian , LARSSON, Lars, Niklas , PETERSEN, Steen, Guldager , ULRICH, Finn, Munk
发明人： NIELSEN, Kent, Høier , POULSEN, Frederik, Enemark , JENSEN, Christian , LARSSON, Lars, Niklas , PETERSEN, Steen, Guldager , ULRICH, Finn, Munk
IPC分类号： A61L31/10 , A61L31/16 , A61L29/08 , A61L29/16
摘要： The present invention relates to the introducer sheath equipment used during the Seldinger technique and related surgical techniques. The introducer sheaths or parts thereof comprise reactive nitrogen adducts which release reactive nitrogen species such as nitric oxide and nitroxyl during use for the prevention of mechanically induced vasospasm. The introducer sheaths are particularly useful for entry via access other than the femoral artery, such as via transradial access. In a preferred embodiement, the sheaths are coated with a linear' poly (ethyleneimine) diazeniumdiolate (L-PEI-NONO) embedded in polyurethane (PU).

2. 发明申请

WO1994020627A1 MANNOSE OR XYLOSE BASED POSITIVE SELECTION 审中-公开
标题翻译： MANNOSE或基于XYLOSE的积极选择
公开(公告)号：WO1994020627A1
公开(公告)日：1994-09-15
申请号：PCT/EP1994000575
申请日：1994-02-28
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , BOJSEN, Kirsten , DONALDSON, Iain , HALDRUP, Anna , JOERSBOE, Morten , KREIBERG, Jette, Dina , NIELSEN, John , OKKELS, Finn, Thyge , PETERSEN, Steen, Guldager
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/82
CPC分类号： C07H15/203 , C07H15/26 , C07H17/02 , C07H19/16 , C07H19/20 , C12N5/0025 , C12N9/90 , C12N9/92 , C12N15/65 , C12N15/8209 , C12N15/8245 , C12Y503/01008
摘要： The present invention provides a method for identifying or selecting from a population of eukaryotic cells cultivated on or in a medium containing at least one compound, cells which have a metabolic advantage as a result of having being transformed, wherein: (i) the cells are transformed with a nucleotide sequence or a co-introduced nucleotide sequence one of which comprises a region which: (a) encodes a protein which is involved in the metabolism of the compound, and/or (b) regulates the activity of the protein; and (ii) the compound is mannose or xylose or a derivative or a precursor of these, or a substrate of the protein, or is capable of being metabolized by the transformed cells into such a substrate, with the proviso that the compound is not mannos when the proteine is mannose 6 phosphate isomerase. The invention also includes a method according to the preceding paragraph wherein the compounds are are not so limited with the proviso that an agent which reduces the toxicity to the cells of the compound is added to the medium. It is preferred that where a toxicity-reducing agent has been added to the culture medium, the compound is mannose and the nucleotide or co-introduced nucleotide sequence encodes mannose-6-phosphate isomerase.
摘要翻译：本发明提供了鉴定或选择培养在含有至少一种化合物的培养基中的真核细胞群体的方法，所述培养基具有作为转化结果具有代谢优势的细胞，其中：（i）细胞是用核苷酸序列或共同引入的核苷酸序列转化，其中之一包含以下区域：（a）编码参与化合物代谢的蛋白质和/或（b）调节蛋白质的活性; 和（ii）化合物是甘露糖或木糖或其衍生物或前体，或蛋白质的底物，或能够被转化的细胞代谢成这样的底物，条件是该化合物不是甘露糖当蛋白为甘露糖6磷酸异构酶时。本发明还包括根据前述段落的方法，其中化合物不限于此，条件是向培养基中加入降低化合物细胞毒性的试剂。优选的是，当向培养基中加入毒性降低剂时，化合物是甘露糖，核苷酸或共同引入的核苷酸序列编码甘露糖-6-磷酸异构酶。

3. 发明申请

WO2008055718A2 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2008055718A2
公开(公告)日：2008-05-15
申请号：PCT/EP2007057779
申请日：2007-07-27
申请人： MILLIMED AS , NIELSEN KENT HOEIER , POULSEN FREDERIK ENEMARK , JENSEN CHRISTIAN , LARSSON LARS NIKLAS , PETERSEN STEEN GULDAGER , ULRICH FINN MUNK
发明人： NIELSEN KENT HOEIER , POULSEN FREDERIK ENEMARK , JENSEN CHRISTIAN , LARSSON LARS NIKLAS , PETERSEN STEEN GULDAGER , ULRICH FINN MUNK
IPC分类号： A61L29/16
CPC分类号： A61L29/16 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/114 , C08L79/02
摘要： The present invention relates to the introducer sheath equipment used during the Seldinger technique and related surgical techniques. The introducer sheaths or parts thereof comprise reactive nitrogen adducts which release reactive nitrogen species such as nitric oxide and nitroxyl during use for the prevention of mechanically induced vasospasm. The introducer sheaths are particularly useful for entry via access other than the femoral artery, such as via transradial access.
摘要翻译：本发明涉及在Seldinger技术和相关手术技术期间使用的引导器护套设备。引导器鞘或其部分包括活性氮加合物，其在使用期间释放反应性氮物质如一氧化氮和硝酰基，以防止机械诱导的血管痉挛。导引鞘对于通过除股动脉以外的通路是特别有用的，例如通过经桡侧通路。

4. 发明申请

WO2003090939A1 METHOD AND APPARATUS FOR PLASMA DEPOSITION OF CHEMICALLY REACTIVE GROUPS ON SUBSTRATES CHEMICALLY REACTIVE SUBSTRATES OBTAINABLE BY THE METHOD AND USE THEREOF 审中-公开
标题翻译：用于等离子体沉积在基板上的化学反应性基团的方法和装置可通过其方法和使用获得化学反应性基板
公开(公告)号：WO2003090939A1
公开(公告)日：2003-11-06
申请号：PCT/DK2003/000272
申请日：2003-04-25
申请人： NKT RESEARCH & INNOVATION A/S , CHRISTENSEN, Søren, Flygenring , PETERSEN, Steen, Guldager
发明人： CHRISTENSEN, Søren, Flygenring , PETERSEN, Steen, Guldager
IPC分类号： B05D7/24
CPC分类号： H01J37/32082 , B05D1/62 , C03C17/3405 , C23C16/30
摘要： The present invention relates to a method and apparatus for plasma deposition of a chemically reactive group (Y-Z) on a substrate, chemically reactive substrates, and use thereof, e.g. for immobilisation of biomolecules; the method comprising: (a) providing at least one precursor (A-X (Y)) for the chemically reactive group; (b) providing at least one donor (D(Z)), said at least one donor comprising at least one addition group (Z), optionally said at least one addition group (Z) being comprised in said precursor (A-X (Y)) and optionally said at least one donor (D(Z)) is not being provided; (c) providing a substrate (M); (d) providing a gas plasma, said gas plasma having a pressure and an energy to form at least one activated carrier group (B); and (e) reacting said substrate (M), said at least one precursor (A-X (Y)), said at least one donor (D(Z)) in said gas plasma so that said chemically reactive group (Y-Z) is bound to said substrate, either directly (M-Y-Z) or via said at least one activated carrier group (M-B-Y-Z), and so that when exposed to a substance which chemically reacts with said chemically reactive group, said substance binds thereto.
摘要翻译：本发明涉及用于在衬底上等离子体沉积化学反应性基团（Y-Z）的方法和装置，化学反应性底物及其用途，例如，用于固定生物分子; 该方法包括：（a）为化学反应性基团提供至少一种前体（A-X（Y））; （B）提供至少一个供体（D（Z）），所述至少一个供体包含至少一个加成基团（Z），任选地所述至少一种加成基团（Z）包含在所述前体（AX（Y））和任选地所述至少一个供体（D（Z）））; （c）提供衬底（M）; （d）提供气体等离子体，所述气体等离子体具有压力和能量以形成至少一个活化载体组（B）; 和（e）使所述底物（M），所述至少一种前体（AX（Y）），所述至少一种供体（D（Z））在所述气体等离子体中反应，使得所述化学反应性基团（YZ）所述底物直接（MYZ）或通过所述至少一种活化的载体基团（MBYZ），并且当暴露于与所述化学反应性基团发生化学反应的物质时，所述物质与其结合。

5. 发明申请

WO2007085254A1 MEDICAL DEVICE WITH PH DEPENDENT DRUG RELEASE 审中-公开
标题翻译：具有PH依赖性药物释放的医疗装置
公开(公告)号：WO2007085254A1
公开(公告)日：2007-08-02
申请号：PCT/DK2007/000030
申请日：2007-01-24
申请人： MILLIMED A/S , NIELSEN, Kent Hoier , LARSSON, Lars Niklas , POULSEN, Frederik, Enemark , PETERSEN, Steen, Guldager , JENSEN, Christian , ULRICH, Finn Munk
发明人： NIELSEN, Kent Hoier , LARSSON, Lars Niklas , POULSEN, Frederik, Enemark , PETERSEN, Steen, Guldager , JENSEN, Christian , ULRICH, Finn Munk
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/602 , C08L79/02
摘要： The invention provides intravascular devices coated with a first domain comprising an alkali formulation of polyethylenimine diazeniumdiolate . The alkali ensures stabilisation of the polyethylenimine diazeniumdiolate during processing of the medical device, whilst allowing controlled release of nitric oxide upon use. The invention also provides medical devices coated with a first domain of polyethylenimine diazeniumdiolate, and an outer-layer which prevents or hinders the release of polyethylenimine diazeniumdiolate upon use in the body, particularly from the alkali first domain. In a preferred embodiment a balloon is coated with linear poly (ethylenimine) diazeniumdiolate (L-PEI-NONO) embedded in polyurethane (PU) and provided with a top coat of poly acrylic acid and PU.
摘要翻译：本发明提供涂覆有第一结构域的血管内装置，所述第一结构域包含聚乙烯亚胺二氮烯鎓二醇的碱配制剂。该碱确保了在处理医疗装置期间聚乙烯亚胺二氮烯鎓二醇的稳定化，同时允许一氧化氮在使用时受控释放。本发明还提供涂覆有聚乙烯亚胺二氮烯鎓二醇盐的第一结构域的医疗装置，以及防止或阻碍聚乙烯亚胺二氮烯鎓二硫酸盐在体内使用，特别是从碱第一区域释放的外层。在一个优选实施方案中，气球用嵌入聚氨酯（PU）中的线性聚（亚乙基亚胺）二氮烯二醇二（L-PEI-NONO）涂覆并提供有聚丙烯酸和PU的顶涂层。

6. 发明申请

WO2004088710A2 METHOD AND APPARATUS FOR GAS PLASMA TREATMENT WITH CONTROLLED EXTENT OF GAS PLASMA, AND USE THEREOF 审中-公开
标题翻译：气体等离子体等离子体处理气体等离子体处理方法及装置及其应用
公开(公告)号：WO2004088710A2
公开(公告)日：2004-10-14
申请号：PCT/DK2004/000240
申请日：2004-04-02
申请人： NKT RESEARCH & INNOVATION A/S , CHRISTENSEN, Søren, Flygenring , OVERBY, Bent , CARLSEN, René , PETERSEN, Steen, Guldager , BERENDSEN, Christianus, Wilhelmus, Johannes
发明人： CHRISTENSEN, Søren, Flygenring , OVERBY, Bent , CARLSEN, René , PETERSEN, Steen, Guldager , BERENDSEN, Christianus, Wilhelmus, Johannes
IPC分类号： H01J37/32
CPC分类号： H01J37/3244 , H01J37/32431 , H01J37/32568 , H01J37/32935
摘要： A method of controlling the extent of gas plasma, the method comprising: (A) providing a gas zone (110), said gas zone comprising a gas having a pressure; said gas comprising at least one gas component allowing generation of a plasma; (B) generating a plasma in said gas zone by supplying a potential difference between at least two electrodes (150); said at least two electrodes being configured to wholly or partly encompass said gas zone; and (C) controlling the extent of said generated plasma by controlling at least one of: said gas, said pressure, said potential difference, and said configuration of said at least two electrodes; a plasma treatment apparatus comprising at least one plasma measuring means (160) for measuring the extent of the plasma, and at least one controlling means (180, 191, 131) for controlling the extent of the plasma; and use of the method and apparatus in plasma treatment and/or plasma-assisted surface modification of electrodes and/or substrates.
摘要翻译：一种控制气体等离子体的程度的方法，所述方法包括：（A）提供气体区域（110），所述气体区域包括具有压力的气体; 所述气体包括允许产生等离子体的至少一种气体成分; （B）通过在至少两个电极（150）之间提供电位差来产生所述气体区域中的等离子体; 所述至少两个电极构造成完全或部分地包围所述气体区域; 以及（C）通过控制所述气体，所述压力，所述电位差和所述至少两个电极的所述构造中的至少一个来控制所述产生的等离子体的程度; 一种等离子体处理装置，包括用于测量等离子体的程度的至少一个等离子体测量装置（160）和用于控制等离子体的程度的至少一个控制装置（180,191,131）以及在电极和/或基板的等离子体处理和/或等离子体辅助表面改性中使用该方法和装置。

7. 发明申请

WO1997020937A2 MODIFICATION PROCESS 审中-公开
标题翻译：修改过程
公开(公告)号：WO1997020937A2
公开(公告)日：1997-06-12
申请号：PCT/EP1996005581
申请日：1996-12-02
申请人： DANISCO A/S , JORSBOE, Morten , BRUNSTEDT, Janne , PETERSEN, Steen, Guldager
发明人： DANISCO A/S
IPC分类号： C12N15/56
CPC分类号： C12N9/2408 , C08B37/0096 , C12N9/90 , C12N15/8245
摘要： An in vivo modification process is described. The in vivo modification process affects the mannose-to-galactose ratio of either an organism (or part thereof) capable of producing a mannose/galactose containing compound or of a mannose/galactose containing compound thereof.
摘要翻译：描述体内修饰方法。体内修饰方法影响能够产生含有甘露糖/半乳糖的化合物或其含有甘露糖/半乳糖的化合物的生物体（或其部分）的甘露糖与半乳糖的比例。

8. 发明申请

WO2008055719A3 MEDICAL DEVICE CAPABLE OF RELEASING NO 审中-公开
标题翻译：可释放的医疗器械
公开(公告)号：WO2008055719A3
公开(公告)日：2009-02-26
申请号：PCT/EP2007057781
申请日：2007-07-27
申请人： ARSENAL MEDICAL INC , NIELSEN KENT HOEIER , POULSEN FREDERIK ENEMARK , JENSEN CHRISTIAN , LARSSON LARS NIKLAS , PETERSEN STEEN GULDAGER , ULRICH FINN MUNK
发明人： NIELSEN KENT HOEIER , POULSEN FREDERIK ENEMARK , JENSEN CHRISTIAN , LARSSON LARS NIKLAS , PETERSEN STEEN GULDAGER , ULRICH FINN MUNK
IPC分类号： A61L31/10 , A61L29/08 , A61L29/16 , A61L31/16
CPC分类号： A61L29/16 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/114 , C08L79/02
摘要： The invention provides a medical device for intravascular use, comprising a base material which is at least in part, coated with a coating system comprising a polymer mixture, wherein said polymer mixture comprises at least one reactive nitrogen species (RNS) adduct, wherein said adduct is capable of releasing said reactive nitrogen species under physiological conditions; and a hydrophilic polymer or hydrophilic polymer blend, wherein the reactive nitrogen species adduct and the hydrophilic polymer or polymer blend form a homogeneous phase. In a preferred embodiement, the medical device is coated with a linear poly (ethyleneimine) diazeniumdiolate (L-PEI-NONO) embedded in polyure thane (PU).
摘要翻译：本发明提供了一种用于血管内使用的医疗装置，其包括至少部分地涂覆有包含聚合物混合物的涂层系统的基材，其中所述聚合物混合物包含至少一种反应性氮物质（RNS）加合物，其中所述加合物能够在生理条件下释放所述活性氮物质; 和亲水性聚合物或亲水性聚合物共混物，其中反应性氮物质加合物和亲水性聚合物或聚合物共混物形成均相。在优选的实施方案中，医疗装置涂覆有嵌入聚氨酯（PU）中的线性聚（亚乙基亚胺）二氮烯二硫氰酸酯（L-PEI-NONO）。

9. 发明申请

WO2008055719A2 COATING SYSTEM 审中-公开
标题翻译：涂装系统
公开(公告)号：WO2008055719A2
公开(公告)日：2008-05-15
申请号：PCT/EP2007/057781
申请日：2007-07-27
申请人： Millimed A/S , NIELSEN, Kent Høier , POULSEN, Frederik Enemark , JENSEN, Christian , LARSSON, Lars Niklas , PETERSEN, Steen Guldager , ULRICH, FInn Munk
发明人： NIELSEN, Kent Høier , POULSEN, Frederik Enemark , JENSEN, Christian , LARSSON, Lars Niklas , PETERSEN, Steen Guldager , ULRICH, FInn Munk
IPC分类号： A61L31/10 , A61L31/16 , A61L29/08 , A61L29/16
CPC分类号： A61L29/16 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/114 , C08L79/02
摘要： The invention provides a medical device for intravascular use, comprising a base material which is at least in part, coated with a coating system comprising a polymer mixture, wherein said polymer mixture comprises at least one reactive nitrogen species (RNS) adduct, wherein said adduct is capable of releasing said reactive nitrogen species under physiological conditions; and a hydrophilic polymer or hydrophilic polymer blend, wherein the reactive nitrogen species adduct and the hydrophilic polymer or polymer blend form a homogeneous phase.
摘要翻译：本发明提供了一种用于血管内使用的医疗装置，其包括至少部分地涂覆有包含聚合物混合物的涂层系统的基材，其中所述聚合物混合物包含至少一种反应性氮物质（RNS）加合物，其中所述加合物能够在生理条件下释放所述活性氮物质; 和亲水性聚合物或亲水性聚合物共混物，其中反应性氮物质加合物和亲水性聚合物或聚合物共混物形成均相。

10. 发明申请

WO2004088710A3 METHOD AND APPARATUS FOR GAS PLASMA TREATMENT WITH CONTROLLED EXTENT OF GAS PLASMA, AND USE THEREOF 审中-公开
标题翻译：气体等离子体等离子体处理气体等离子体处理方法及装置及其应用
公开(公告)号：WO2004088710A3
公开(公告)日：2005-12-08
申请号：PCT/DK2004000240
申请日：2004-04-02
申请人： NKT RES & INNOVATION AS , CHRISTENSEN SOEREN FLYGENRING , OVERBY BENT , CARLSEN RENE , PETERSEN STEEN GULDAGER , BERENDSEN CHRISTIANUS WILHELMU
发明人： CHRISTENSEN SOEREN FLYGENRING , OVERBY BENT , CARLSEN RENE , PETERSEN STEEN GULDAGER , BERENDSEN CHRISTIANUS WILHELMU
IPC分类号： H01J37/32
CPC分类号： H01J37/3244 , H01J37/32431 , H01J37/32568 , H01J37/32935
摘要： A method of controlling the extent of gas plasma, the method comprising: (A) providing a gas zone (110), said gas zone comprising a gas having a pressure; said gas comprising at least one gas component allowing generation of a plasma; (B) generating a plasma in said gas zone by supplying a potential difference between at least two electrodes (150); said at least two electrodes being configured to wholly or partly encompass said gas zone; and (C) controlling the extent of said generated plasma by controlling at least one of: said gas, said pressure, said potential difference, and said configuration of said at least two electrodes; a plasma treatment apparatus comprising at least one plasma measuring means (160) for measuring the extent of the plasma, and at least one controlling means (180, 191, 131) for controlling the extent of the plasma; and use of the method and apparatus in plasma treatment and/or plasma-assisted surface modification of electrodes and/or substrates.
摘要翻译：一种控制气体等离子体的程度的方法，所述方法包括：（A）提供气体区域（110），所述气体区域包括具有压力的气体; 所述气体包括允许产生等离子体的至少一种气体成分; （B）通过在至少两个电极（150）之间提供电位差来产生所述气体区域中的等离子体; 所述至少两个电极构造成完全或部分地包围所述气体区域; 以及（C）通过控制所述气体，所述压力，所述电位差和所述至少两个电极的所述构造中的至少一个来控制所述产生的等离子体的程度; 一种等离子体处理装置，包括用于测量等离子体的程度的至少一个等离子体测量装置（160）和用于控制等离子体的程度的至少一个控制装置（180,191,131）以及在电极和/或基板的等离子体处理和/或等离子体辅助表面改性中使用该方法和装置。

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