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1. 发明申请

WO2007068251A1 METHOD AND SYSTEM FOR MEASUREMENT OF NITRITE AND NITRIC OXIDE RELEASE 审中-公开
标题翻译：硝酸和氮氧化物释放的测量方法和系统
公开(公告)号：WO2007068251A1
公开(公告)日：2007-06-21
申请号：PCT/DK2006/000714
申请日：2006-12-13
申请人： Millimed A/S , NIELSEN, Kent Hoier , LARSSON, Lars Niklas
发明人： NIELSEN, Kent Hoier , LARSSON, Lars Niklas
IPC分类号： G01N33/49 , G01N33/00 , G01N21/76
CPC分类号： G01N33/0037 , G01N21/76 , Y02A50/245 , Y10T436/173076
摘要： A method for combined measurement of release of nitrite (NO 2 ") and nitric oxide (NO) from a probe containing nitric oxide, such as an intravascular medical device immersed in an aqueous solution within a first vessel, comprises conveying nitric oxide (NO) released directly from the probe to a nitric oxide analysis apparatus. Nitrite is removed from a first vessel, which may e.g. comprise a head-space chamber, and transferred to a purge vessel where NO 2 " is transformed to nitric oxide (NO), which is conveyed to the nitric oxide analysis apparatus. A selector valve arranged upstream of the nitric oxide analysis apparatus is operated to selectively allow one of the directly released nitric oxide (NO) and the nitrite- derived nitric oxide (NO) into the apparatus. Directly released nitric oxide may be continuously flushed away from the first vessel.
摘要翻译：一种从含有一氧化氮的探针（例如浸入第一容器内的水溶液中的血管内医疗装置）组合测量亚硝酸盐（NO 2 N 2）和一氧化氮（NO）的释放的方法，包括将从探针直接释放的一氧化氮（NO）输送到一氧化氮分析装置，从第一容器中除去亚硝酸盐，其可以例如包括顶空室，并转移到清除容器中，其中NO 2 / SUB>转化为一氧化氮（NO），将其输送到一氧化氮分析装置。操作设置在一氧化氮分析装置上游的选择阀，以选择性地允许直接释放的一氧化氮（NO）和来自亚硝酸盐的一氧化氮（NO）中的一种进入装置。直接释放的一氧化氮可以从第一容器连续冲洗掉。

2. 发明申请

WO2007085254A1 MEDICAL DEVICE WITH PH DEPENDENT DRUG RELEASE 审中-公开
标题翻译：具有PH依赖性药物释放的医疗装置
公开(公告)号：WO2007085254A1
公开(公告)日：2007-08-02
申请号：PCT/DK2007/000030
申请日：2007-01-24
申请人： MILLIMED A/S , NIELSEN, Kent Hoier , LARSSON, Lars Niklas , POULSEN, Frederik, Enemark , PETERSEN, Steen, Guldager , JENSEN, Christian , ULRICH, Finn Munk
发明人： NIELSEN, Kent Hoier , LARSSON, Lars Niklas , POULSEN, Frederik, Enemark , PETERSEN, Steen, Guldager , JENSEN, Christian , ULRICH, Finn Munk
IPC分类号： A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/602 , C08L79/02
摘要： The invention provides intravascular devices coated with a first domain comprising an alkali formulation of polyethylenimine diazeniumdiolate . The alkali ensures stabilisation of the polyethylenimine diazeniumdiolate during processing of the medical device, whilst allowing controlled release of nitric oxide upon use. The invention also provides medical devices coated with a first domain of polyethylenimine diazeniumdiolate, and an outer-layer which prevents or hinders the release of polyethylenimine diazeniumdiolate upon use in the body, particularly from the alkali first domain. In a preferred embodiment a balloon is coated with linear poly (ethylenimine) diazeniumdiolate (L-PEI-NONO) embedded in polyurethane (PU) and provided with a top coat of poly acrylic acid and PU.
摘要翻译：本发明提供涂覆有第一结构域的血管内装置，所述第一结构域包含聚乙烯亚胺二氮烯鎓二醇的碱配制剂。该碱确保了在处理医疗装置期间聚乙烯亚胺二氮烯鎓二醇的稳定化，同时允许一氧化氮在使用时受控释放。本发明还提供涂覆有聚乙烯亚胺二氮烯鎓二醇盐的第一结构域的医疗装置，以及防止或阻碍聚乙烯亚胺二氮烯鎓二硫酸盐在体内使用，特别是从碱第一区域释放的外层。在一个优选实施方案中，气球用嵌入聚氨酯（PU）中的线性聚（亚乙基亚胺）二氮烯二醇二（L-PEI-NONO）涂覆并提供有聚丙烯酸和PU的顶涂层。

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