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1. 发明申请

US20050236554A1 Optical interrogation system and method for 2-D sensor arrays 失效
标题翻译： 2-D传感器阵列的光学询问系统和方法
公开(公告)号：US20050236554A1
公开(公告)日：2005-10-27
申请号：US11100199
申请日：2005-04-05
申请人： Norman Fontaine , Eric Mozdy , Po Yuen
发明人： Norman Fontaine , Eric Mozdy , Po Yuen
IPC分类号： H01L27/00
CPC分类号： G01N21/6452 , G01N21/253 , G01N21/553 , G01N21/6456 , G01N21/7743
摘要： An optical interrogation system and method are described herein that can interrogate a two-dimensional (2D) array of optical sensors (e.g., grating coupled waveguide sensors) located in a 2D specimen plate (e.g., microplate). In one embodiment, the optical interrogation system has a launch system which directs an array of light beams towards the array of sensors in the two-dimensional specimen plate. The optical interrogation system also has a receive system that includes a Keplerian beam expander (used in reverse as a beam condenser) which receives an array of light beams output from the array of sensors and directs each received light beam to a unique region on the detection plane of a small area detector (e.g., CCD camera). In addition, the optical interrogation system has a processor that analyzes changes in the position or shape of each detected light beam to determine if a binding event (bio-chemical interaction) or a mass transport (cell-based assay) occurred, or to determine the rate of binding (kinetics) that occurred on each sensor.
摘要翻译：本文描述了可以询问位于2D样本板（例如微板）中的光学传感器（例如，光栅耦合波导传感器）的二维（2D）阵列的光学询问系统和方法。在一个实施例中，光学询问系统具有发射系统，该发射系统将光束阵列引向二维样本板中的传感器阵列。光学询问系统还具有接收系统，其包括开普勒光束扩展器（反向用作光束聚光器），其接收从传感器阵列输出的光束阵列，并将每个接收的光束引导到检测上的唯一区域平面的小区域检测器（例如CCD摄像机）。此外，光学询问系统具有处理器，其分析每个检测到的光束的位置或形状的变化，以确定是否发生结合事件（生物化学相互作用）或质量传输（基于细胞的测定）或确定在每个传感器上发生的结合速率（动力学）。

2. 发明授权

US07571151B1 Data analysis tool for analyzing data stored in multiple text files 失效
标题翻译：用于分析存储在多个文本文件中的数据的数据分析工具
公开(公告)号：US07571151B1
公开(公告)日：2009-08-04
申请号：US11303621
申请日：2005-12-15
申请人： Norman Fontaine
发明人： Norman Fontaine
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30569 , Y10S707/99931 , Y10S707/99942
摘要： A system for organizing data in multiple text data files and for automatically parsing data directly into named variables within a single, user-configurable graphical user interface (GUI) or workspace. Results organization, analysis algorithms, and file viewing all take place from within the workspace. No apriori knowledge of the dimensionality or length of data is required. Results may readily be placed into reports. Multiple data files may be processed using batch commands. Metafile capability is provided wherein data within a first level file may be the name of another data file allowing cascaded processing of data files. This unification of a user-configurable workspace, an integrated file viewing method and a parsing method minimizes distraction to a researcher allowing him or her to focus on analysis of experimental data rather than on the mechanics of data processing. The system of methods interacts with third party data analysis application software packages.
摘要翻译：用于在多个文本数据文件中组织数据并在单个用户可配置的图形用户界面（GUI）或工作空间内自动将数据解析为命名变量的系统。结果组织，分析算法和文件查看全部从工作区内进行。不需要知道数据的维度或长度。结果可能很容易被放入报告。可以使用批处理命令处理多个数据文件。提供了元文件能力，其中第一级文件中的数据可以是允许数据文件的级联处理的另一数据文件的名称。用户可配置的工作空间的统一，集成文件查看方法和解析方法最大限度地减少了研究者的注意力，允许他或她专注于实验数据的分析，而不是数据处理的机制。方法系统与第三方数据分析应用软件包进行交互。

3. 发明申请

US20080063569A1 System and method for self-referencing a sensor in a micron-sized deep flow chamber 失效
标题翻译：用于在微米级深流动室中自我参考传感器的系统和方法
公开(公告)号：US20080063569A1
公开(公告)日：2008-03-13
申请号：US11900263
申请日：2007-09-11
申请人： Norman Fontaine , Prantik Mazumder , Mark Quesada , Eric Mozdy , Po Yuen
发明人： Norman Fontaine , Prantik Mazumder , Mark Quesada , Eric Mozdy , Po Yuen
IPC分类号： G01N21/01
CPC分类号： G01N21/7743 , G01N21/05 , G01N21/276 , G01N21/553 , G01N2021/0346 , G01N2021/058 , G01N2201/108 , G01N2201/1211 , G01N2201/1217 , G01N2201/127 , G01N2201/12723 , G01N2201/128 , Y10T436/117497 , Y10T436/2575
摘要： A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
摘要翻译：本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

4. 发明申请

US20050099622A1 Arrayed sensor measurement system and method 失效
标题翻译：阵列传感器测量系统及方法
公开(公告)号：US20050099622A1
公开(公告)日：2005-05-12
申请号：US11019439
申请日：2004-12-21
申请人： Stephen Caracci , Norman Fontaine , Eric Mozdy , Po Yuen
发明人： Stephen Caracci , Norman Fontaine , Eric Mozdy , Po Yuen
IPC分类号： G01N21/25 , G02B27/10 , G01J3/50
CPC分类号： G01N21/253 , G01N2201/04 , G01N2201/10 , G02B27/1086
摘要： Optical interrogation systems and methods are described herein that are capable of measuring the angles (or changes in the angles) at which light reflects, transmits, scatters, or is emitted from an array of sensors or specimens that are distributed over a large area 2-dimensional array. In one embodiment of the present invention, the optical interrogation system has a far-field diffraction measurement configuration so it can simultaneously receive the light from sensors in all or a sub-section of a sensor array at a detector. In another embodiment of the present invention, the optical interrogation system incorporates an anamorphic optical receive system that enables parallel detection of angular responses from the sensors in the 2D array. In yet another embodiment of the present invention, the optical interrogation system incorporates an angular measurement system which measures the change in angular tilt of the sensor plane when the sensor array is moved or removed and then replaced in the measurement system. Several other embodiments of optical interrogation systems and methods are also described herein. A significant advantage of the present invention is that the system has no critical moving or scanning parts, which are frequently the source of measurement sensitivity limitations.
摘要翻译：本文描述了光学询问系统和方法，其能够测量光从其分布在大面积上的传感器或样本阵列2反射，透射，散射或发射的角度（或角度变化）维数组。在本发明的一个实施例中，光学询问系统具有远场衍射测量配置，因此它可以在检测器处同时从传感器阵列的全部或子部分接收来自传感器的光。在本发明的另一实施例中，光学询问系统包括变形光学接收系统，其能够并行地检测来自2D阵列中的传感器的角度响应。在本发明的另一个实施例中，光学询问系统包括角度测量系统，该系统测量当传感器阵列移动或移除并随后在测量系统中被更换时传感器平面的角度倾斜度的变化。本文还描述了光询问系统和方法的其他几个实施例。本发明的显着优点是该系统没有关键的移动或扫描部件，其经常是测量灵敏度限制的来源。

5. 发明申请

US20060106557A1 System and method for self-referencing a sensor in a micron-sized deep flow chamber 失效
标题翻译：用于在微米级深流动室中自我参考传感器的系统和方法
公开(公告)号：US20060106557A1
公开(公告)日：2006-05-18
申请号：US10993565
申请日：2004-11-18
申请人： Norman Fontaine , Prantik Mazumder , Mark Quesada , Eric Mozdy , Po Yuen
发明人： Norman Fontaine , Prantik Mazumder , Mark Quesada , Eric Mozdy , Po Yuen
IPC分类号： G01R35/00
CPC分类号： G01N21/7743 , G01N21/05 , G01N21/276 , G01N21/553 , G01N2021/0346 , G01N2021/058 , G01N2201/108 , G01N2201/1211 , G01N2201/1217 , G01N2201/127 , G01N2201/12723 , G01N2201/128 , Y10T436/117497 , Y10T436/2575
摘要： A system and method are described herein for self-referencing a sensor that is used to detect a biomolecular binding event and/or kinetics which occur in a sample solution flowing along side a reference solution in a micron-sized deep flow channel.
摘要翻译：本文描述了一种系统和方法，用于自我参考用于检测在微米尺寸深流动通道中沿着参考溶液侧流动的样品溶液中发生的生物分子结合事件和/或动力学的传感器。

6. 发明申请

US20060229818A1 Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate 失效
标题翻译：用于消除位于微板中的基于波导光栅的生物传感器与所得微板之间的串扰的方法
公开(公告)号：US20060229818A1
公开(公告)日：2006-10-12
申请号：US11101096
申请日：2005-04-07
申请人： Ye Fang , Ann Ferrie , Norman Fontaine , Anthony Frutos , Eric Mozdy , Chuan-Che Wang , Po Yuen
发明人： Ye Fang , Ann Ferrie , Norman Fontaine , Anthony Frutos , Eric Mozdy , Chuan-Che Wang , Po Yuen
IPC分类号： G06F19/00
CPC分类号： G01N21/7743 , G01N21/253
摘要： The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods include (1) physically deteriorating/removing the waveguide film between individual biosensors; (2) chemically depositing highly absorbing materials within the waveguide film between individual biosensors; (3) patterning disordered (scattering) regions between the diffraction gratings that define individual biosensors; (4) using a specific mask and depositing individual patches of waveguide film, where each patch defines at least one biosensor. Each of these methods and several other methods described herein prevent the propagation of light between individual sensing regions, thereby eliminating optical crosstalk between the biosensors. The present invention also includes the resulting microplate.
摘要翻译：本发明包括几种用于修改制造光学感测微板的当前工艺的方法，其使用连续波导膜来减少/消除结合在孔内的生物传感器之间的串扰。所述方法包括（1）在各个生物传感器之间物理劣化/去除波导膜; （2）在各个生物传感器之间在波导膜内化学沉积高吸收材料; （3）在限定单个生物传感器的衍射光栅之间图形化无序（散射）区域; （4）使用特定掩模并沉积波导膜的各个贴片，其中每个贴片限定至少一个生物传感器。这些方法和本文所描述的其它方法中的每一种都防止光在各个感测区域之间的传播，从而消除了生物传感器之间的光学串扰。本发明还包括所得到的微孔板。

7. 发明申请

US20060223051A1 System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors 审中-公开
标题翻译：使用波导光栅传感器进行G蛋白偶联受体（GPCR）细胞测定的系统和方法
公开(公告)号：US20060223051A1
公开(公告)日：2006-10-05
申请号：US11100262
申请日：2005-04-05
申请人： Ye Fang , Ann Ferrie , Norman Fontaine , Joydeep Lahiri , Po Yuen
发明人： Ye Fang , Ann Ferrie , Norman Fontaine , Joydeep Lahiri , Po Yuen
IPC分类号： G01N33/53 , C12Q1/00
CPC分类号： G01N33/5041 , G01N21/4788 , G01N21/553 , G01N2333/726 , G01N2500/10
摘要： The present invention includes a system and method that uses optical LID biosensors to monitor in real time agonist-induced GPCR signaling events within living cells. Particularly, the present invention includes a system and method for using an optical LID biosensor to screen compounds against a target GPCR within living cells based on the mass redistribution due to agonist-induced GPCR activation. In an extended embodiment, the present invention discloses different ways for self-referencing the optical LID biosensor to eliminate unwanted sensitivity to ambient temperature, pressure fluctuations, and other environmental changes. In yet another extended embodiment, the present invention discloses different ways for screening multiple GPCRs in a single type of cell or multiple GPCRs in multiple types of cells within a single medium solution. In still yet another extended embodiment, the present invention discloses different ways to confirm the physiological or pharmacological effect of a compound against a specific GPCR within living cells.
摘要翻译：本发明包括使用光学LID生物传感器实时监测活细胞内激动剂诱导的GPCR信号事件的系统和方法。特别地，本发明包括使用光学LID生物传感器基于由于激动剂诱导的GPCR活化导致的质量再分布来筛选活细胞内的靶GPCR的化合物的系统和方法。在扩展实施例中，本发明公开了用于自参考光学LID生物传感器以消除对环境温度，压力波动和其他环境变化的不期望的灵敏度的不同方式。在又一个扩展的实施方案中，本发明公开了在单一培养基溶液中的多种类型的细胞中单种类型细胞或多种GPCR筛选多种GPCR的不同方式。在又一个延伸的实施方案中，本发明公开了确定化合物对活细胞内特异性GPCR的生理或药理作用的不同方式。

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