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1. 发明申请

US20070239270A1 Mitral Valve Annuloplasty Device with Vena Cava Anchor 有权
标题翻译：二尖瓣瓣膜成形术与腔静脉栓塞
公开(公告)号：US20070239270A1
公开(公告)日：2007-10-11
申请号：US11279352
申请日：2006-04-11
申请人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
发明人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： The present invention relates to a medical device and uses thereof that supports or changes the shape of tissue near a vessel in which the device is placed. The present invention is particularly useful in reducing mitral valve regurgitation by changing the shape of or supporting a mitral valve annulus. The device includes a support structure, a proximal anchor adapted to be positioned in a superior vena cava, and a distal anchor adapted to be positioned in a coronary sinus. The support structure engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed.
摘要翻译：本发明涉及一种医疗装置及其用途，其用于支撑或改变其中放置该装置的血管附近的组织的形状。本发明特别可用于通过改变二尖瓣环的形状或支撑二尖瓣环来减少二尖瓣反流。该装置包括支撑结构，适于定位在上腔静脉中的近端锚，以及适于定位在冠状窦中的远侧锚。支撑结构接合血管壁以改变邻近其中放置血管内支持物的血管的组织的形状。

2. 发明申请

US20080015407A1 Device and Method for Modifying the Shape of a Body Organ 审中-公开
公开(公告)号：US20080015407A1
公开(公告)日：2008-01-17
申请号：US11782527
申请日：2007-07-24
申请人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
发明人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
IPC分类号： A61F2/00
CPC分类号： A61F2/2451
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

3. 发明申请

US20080015680A1 Device and Method for Modifying the Shape of a Body Organ 审中-公开
标题翻译：修饰身体器官形状的装置和方法
公开(公告)号：US20080015680A1
公开(公告)日：2008-01-17
申请号：US11782508
申请日：2007-07-24
申请人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
发明人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
IPC分类号： A61F2/06
CPC分类号： A61F2/2451
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
摘要翻译：血管内支持装置包括支撑件或再生线，近端锚和远端锚。支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。锚固件可以锁定到位以将支撑件固定在容器内。

4. 发明申请

US20080015679A1 Device and Method for Modifying the Shape of a Body Organ 审中-公开
公开(公告)号：US20080015679A1
公开(公告)日：2008-01-17
申请号：US11782490
申请日：2007-07-24
申请人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
发明人： Mark Mathis , Gregory Nieminen , Nathan Aronson , Garrett Beget
IPC分类号： A61F2/06
CPC分类号： A61F2/2451
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

5. 发明申请

US20050027351A1 Mitral valve regurgitation treatment device and method 审中-公开
标题翻译：二尖瓣反流治疗装置及方法
公开(公告)号：US20050027351A1
公开(公告)日：2005-02-03
申请号：US10742747
申请日：2003-12-19
申请人： David Reuter , Gregory Nieminen , Nathan Aronson , Lucas Gordon , Garrett Beget , Clif Alferness , Mark Mathis
发明人： David Reuter , Gregory Nieminen , Nathan Aronson , Lucas Gordon , Garrett Beget , Clif Alferness , Mark Mathis
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： A method of treating regurgitation of a mitral valve in a patient's heart. The method includes the steps of: delivering a tissue shaping device to the coronary sinus; and deploying the tissue shaping device to reduce mitral valve regurgitation, the deploying step comprising applying a force through the coronary sinus wall toward the mitral valve solely proximal to a crossover point where a coronary artery passes between a coronary sinus and the mitral valve. The invention is also a set of devices for use in treating mitral valve regurgitation. The set includes a plurality of tissue shaping devices having different lengths, each of the tissue shaping devices being configured to be deliverable to a coronary sinus of a patient within a catheter having an outer diameter no greater than ten french.
摘要翻译：治疗患者心脏二尖瓣反流的方法。该方法包括以下步骤：将组织整形装置递送至冠状窦; 并且展开所述组织整形装置以减少二尖瓣反流，所述展开步骤包括仅通过冠状动脉穿过冠状窦和二尖瓣之间的交叉点向二尖瓣施加穿过冠状窦壁的力。本发明也是用于治疗二尖瓣反流的一组装置。该组包括具有不同长度的多个组织整形装置，每个组织整形装置构造成可输送到具有不超过十个法兰的外径的导管内的患者的冠状窦。

6. 发明申请

US20050137450A1 Tapered connector for tissue shaping device 审中-公开
标题翻译：用于组织成形装置的锥形连接器
公开(公告)号：US20050137450A1
公开(公告)日：2005-06-23
申请号：US10742600
申请日：2003-12-19
申请人： Nathan Aronson , Gregory Nieminen , Mark Mathis
发明人： Nathan Aronson , Gregory Nieminen , Mark Mathis
IPC分类号： A61F2/24 , A61F2/86 , A61F2/04
CPC分类号： A61F2/2451 , A61F2/86
摘要： A tissue shaping device adapted to be disposed in a vessel near a patient's heart to reshape the patient's heart. The tissue shaping device includes a proximal anchor, a distal anchor, and a connector disposed between the proximal anchor and the distal anchor, the connector having a moment of inertia that varies along its length, such as by varying the connector thickness as a function of distance from one of its ends, with the smallest thickness being in the central portion of the connector.
摘要翻译：一种适于被布置在患者心脏附近的容器中以重塑患者心脏的组织成形装置。组织成形装置包括近端锚固件，远侧锚固件和设置在近端锚固件和远端锚固件之间的连接器，所述连接器具有沿其长度变化的惯性矩，例如通过改变连接器厚度作为距离其一端的距离，其中最小的厚度在连接器的中心部分。

7. 发明申请

US20050010240A1 Device and method for modifying the shape of a body organ 有权
标题翻译：用于改变身体器官形状的装置和方法
公开(公告)号：US20050010240A1
公开(公告)日：2005-01-13
申请号：US10840188
申请日：2004-05-05
申请人： Mark Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
发明人： Mark Mathis , David Reuter , Lucas Gordon , Cruz Beeson , Garrett Beget , Frederick Stewart
IPC分类号： A61B17/00 , A61F2/24 , A61B17/08
CPC分类号： A61F2/2451 , A61B2017/00243
摘要： A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
摘要翻译：组织成形装置，其适于部署在内腔中以改变邻近内腔的靶组织的形状。在一个实施例中，该装置包括第一和第二锚固件; 连接器，设置在第一和第二锚固件之间; 以及设置在所述第一和第二锚固件之间的焦偏转器，并且可以适于在所述装置展开在所述内腔中时远离所述内腔轴线延伸并且朝向所述目标组织和/或远离所述内腔轴线延伸并远离所述目标组织。本发明也是改变目标组织形状的方法。该方法包括提供包括近端和远端锚固件的组织成形装置，设置在近端锚固件和远端锚固件之间的连接器以及焦点偏转器的步骤; 将组织成形装置放置在与目标组织相邻的内腔中; 将来自焦偏转器的成形力施加到管腔壁以改变靶组织的形状; 并且扩张近端和远端锚固件以将装置锚定在管腔中。

8. 发明申请

US20060191121A1 Tissue Shaping Device with Integral Connector and Crimp 有权
标题翻译：具有整体连接器和压接的组织整形装置
公开(公告)号：US20060191121A1
公开(公告)日：2006-08-31
申请号：US11383115
申请日：2006-05-12
申请人： Lucas Gordon , Mark Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark Mathis , Nathan Aronson
IPC分类号： B23P13/04 , B23P11/00
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

9. 发明申请

US20050137451A1 Tissue shaping device with integral connector and crimp 有权
标题翻译：具有整体式连接器和压接的组织整形装置
公开(公告)号：US20050137451A1
公开(公告)日：2005-06-23
申请号：US10742742
申请日：2003-12-19
申请人： Lucas Gordon , Mark Mathis , Nathan Aronson
发明人： Lucas Gordon , Mark Mathis , Nathan Aronson
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2451 , Y10T29/49609 , Y10T29/49826 , Y10T29/49947 , Y10T29/49995
摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
摘要翻译：一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

10. 发明申请

US20050216077A1 Fixed length anchor and pull mitral valve device and method 审中-公开
标题翻译：固定长度锚和拉二尖瓣装置及方法
公开(公告)号：US20050216077A1
公开(公告)日：2005-09-29
申请号：US11132788
申请日：2005-05-18
申请人： Mark Mathis , Gregory Nieminen , David Reuter
发明人： Mark Mathis , Gregory Nieminen , David Reuter
IPC分类号： A61B17/00 , A61F2/24 , A61N1/05
CPC分类号： A61F2/2451 , A61B2017/00243 , A61F2/24 , A61F2/2442 , A61F2/2448 , A61F2/246 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2250/0012 , A61F2310/00017 , A61F2310/00023 , A61N1/057 , A61N2001/0585
摘要： A device affects the mitral valve annulus geometry of a heart. The device includes a first anchor configured to be positioned within and anchored to the coronary sinus of the heart adjacent the mitral valve annulus within the heart and a second anchor configured to be positioned within the coronary sinus of the heart proximal to the first anchor and adjacent the mitral valve annulus within the heart. The second anchor, when deployed, anchors against distal movement and is moveable in a proximal direction. The device further includes a connecting member having a fixed length permanently attached to the first and second anchors. As a result, when the first and second anchors are within the coronary sinus with the first anchor anchored in the coronary sinus, the second anchor may be displaced proximally to affect the geometry of the mitral valve annulus and released to maintain the effect on the mitral valve geometry.
摘要翻译：一个装置影响心脏的二尖瓣环几何形状。该装置包括第一锚定构件，其构造成定位在心脏内邻近心脏二尖瓣环的心脏的冠状窦内并且锚固在心脏周围的第二锚定件上，第二锚固件构造成定位在靠近第一锚固件的心脏的冠状窦内，心脏内的二尖瓣环。当第二锚固件被展开时，锚固件抵靠远端运动并且可沿近端方向移动。该装置还包括具有固定长度的连接构件，该固定长度永久地附接到第一和第二锚固件。结果，当第一和第二锚固件位于冠状窦内时，第一锚固件锚固在冠状窦中时，第二锚固件可以向近侧位移以影响二尖瓣环的几何形状并被释放以维持对二尖瓣的作用阀几何。

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