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1. 发明授权

US07772400B2 Optical resolution method of amlodipine 失效
标题翻译：氨氯地平的光学拆分方法
公开(公告)号：US07772400B2
公开(公告)日：2010-08-10
申请号：US11792281
申请日：2005-12-02
申请人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
发明人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
IPC分类号： C07D213/803
CPC分类号： C07D211/90
摘要： The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.
摘要翻译：本发明涉及通过使用异丙醇溶剂和光学活性的O，O-二苯甲酰基酒石酸作为手性试剂来旋光拆分氨氯地平的方法。更具体地说，本发明涉及一种方法，其包括（a）通过使（R，S） - 氨氯地平与光学活性的O，O-二苯甲酰基酒石酸盐反应获得（R） - 或（S） - 氨氯地平二苯甲酰酒石酸盐或其溶剂合物异丙醇溶剂中的酸，和（b）用碱处理（R） - 或（S） - 氨氯地平盐，从而得到光学活性的氨氯地平。

2. 发明申请

US20090145708A1 SHOCK ABSORBER 审中-公开
标题翻译：减震器
公开(公告)号：US20090145708A1
公开(公告)日：2009-06-11
申请号：US12328688
申请日：2008-12-04
申请人： Nam Ho Kim
发明人： Nam Ho Kim
IPC分类号： F16F9/34
CPC分类号： F16F9/5126
摘要： Disclosed herein is a shock absorber for damping vibration transmitted to a vehicle according to a road state. The shock absorber includes a cylinder and a piston valve disposed within the cylinder and connected to a piston rod to divide the cylinder into a first chamber and a second chamber. The piston rod includes a hollow chamber formed within the piston rod, first and second orifices formed in upper and lower ends of the hollow chamber and connected to the first and second chambers, respectively, a floating piston disposed within the hollow chamber to move up and down and to divide the hollow chamber into upper and lower chambers, and a moving mechanism formed in the hollow chamber to move an operating fluid to upper and lower portions of the floating piston. The shock absorber can change a damping force according to a displacement of the piston rod, thereby improving driving comfort and stability of the vehicle.
摘要翻译：本文公开了一种用于根据道路状况阻尼传递到车辆的振动的减震器。该减震器包括一气缸和一活塞阀，该气缸和一活塞阀设置在气缸内并与活塞杆连接，将气缸分成第一腔室和第二腔室。活塞杆包括形成在活塞杆内的中空室，分别形成在中空室的上端和下端并分别连接到第一和第二腔的第一和第二孔，设置在中空室内的浮动活塞向上移动，并且将中空室分成上下室，以及形成在中空室中的移动机构，以将工作流体移动到浮动活塞的上部和下部。减震器可以根据活塞杆的位移改变阻尼力，从而提高车辆的行驶舒适性和稳定性。

3. 发明申请

US20080306277A1 Process for Preparation of Chiral Amlodipine Gentisate 审中-公开
标题翻译：手性氨氯地平龙胆酸的制备方法
公开(公告)号：US20080306277A1
公开(公告)日：2008-12-11
申请号：US12090264
申请日：2006-10-17
申请人： Jae-Sun Kim , Nam Ho Kim , Nam Kyu Lee
发明人： Jae-Sun Kim , Nam Ho Kim , Nam Kyu Lee
IPC分类号： C07D211/90
CPC分类号： C07D211/90
摘要： The present invention relates to a process for the preparation of optically pure amlodipine gentisate, more particularly to a continuous process for the preparation of optically pure amlodipine gentisate with good yield and high optical purity. The processes can be preformed by first reacting racemic (R,S)-amlodipine and optically pure O,O′-dibenzoyltartaric acid in the presence of a solvent including isopropanol to prepare (R)- or (S)-amlodipine dibenzoyltartarate diastereomer or a solvate thereof, treating the prepared amlodipine diastereomeric salt or a solvate thereof with a base and then finally adding gentisic acid.
摘要翻译：本发明涉及一种制备光学纯氨氯地平龙胆酸盐的方法，更具体地说，涉及一种以高产率和高光学纯度制备光学纯氨氯地平龙胆酸盐的连续方法。该方法可以通过在包含异丙醇的溶剂的存在下首先使外消旋（R，S） - 氨氯地平和光学纯的O，O-二苯甲酰基酒石酸反应来制备（R） - 或（S） - 氨氯地平二苯甲酰三酸盐非对映异构体或溶剂合物，用碱处理制备的氨氯地平非对映体盐或其溶剂合物，然后最后加入龙胆酸。

4. 发明申请

US20060199617A1 Apparatus and method for illuminating a key pad of a mobile communication terminal 审中-公开
标题翻译：用于照亮移动通信终端的键盘的装置和方法
公开(公告)号：US20060199617A1
公开(公告)日：2006-09-07
申请号：US11369479
申请日：2006-03-06
申请人： Nam-Ho Kim , Guk-Chan Lim
发明人： Nam-Ho Kim , Guk-Chan Lim
IPC分类号： H04B1/38 , H04M1/00
CPC分类号： H04M1/22 , H04M1/0241
摘要： An apparatus and method is provided for allowing an improved power key function of a mobile communication terminal that enhances user convenience by providing an independent backlight function for the power key when a mobile communication terminal is opened while in a power OFF state. By providing an independent backlight function for a power key of the mobile communication terminal, the present invention facilitates illuminating the power key when the mobile communication terminal is opened and in a power OFF state.
摘要翻译：提供了一种装置和方法，用于当移动通信终端在断电状态下打开时，通过提供用于电源键的独立背光功能来提高移动通信终端的电力键功能，从而增强用户便利性。通过为移动通信终端的电源键提供独立的背光功能，本发明便于在移动通信终端被打开并处于断电状态时照亮电源键。

5. 发明授权

US06999604B1 Apparatus and method for detecting a moving object in a sequence of color frame images 失效
标题翻译：用于检测彩色帧图像序列中的移动物体的装置和方法
公开(公告)号：US06999604B1
公开(公告)日：2006-02-14
申请号：US09744250
申请日：1998-08-07
申请人： Hyoung Gon Kim , Sang Chul Ahn , Nam Ho Kim
发明人： Hyoung Gon Kim , Sang Chul Ahn , Nam Ho Kim
IPC分类号： G06K9/00
CPC分类号： H04N19/543 , G06T7/254 , G06T9/001
摘要： An apparatus and method for detecting a moving object in a sequence of color frame images is provided. The apparatus comprises a color normalizer for normalizing color components of the color frame image to produce a normalized frame image; a color transformer coupled to the color normalizer for color transforming the normalized frame image to a color transformed frame image; the color transformed frame image having intensity levels such that colors corresponding to said moving object are emphasized; a frame delay coupled to the color transformer for delaying the color transformed frame image by one frame; and a motion detector coupled to the color transformer and the frame delay for detecting the motion of the moving object and further intensifying the intensity levels of the color transformed frame image based on the detected motion.
摘要翻译：提供了一种用于检测彩色帧图像序列中的移动物体的装置和方法。该装置包括用于对彩色图像的颜色分量进行归一化以产生标准化的帧图像的色彩归一化器; 耦合到所述颜色归一化器的颜色变换器，用于将所述归一化帧图像颜色变换为颜色变换的帧图像; 所述颜色变换的帧图像具有强调级别，使得对应于所述移动对象的颜色被强调; 帧延迟，耦合到色变换器，用于将彩色变换的帧图像延迟一帧; 以及运动检测器，其耦合到所述颜色变换器和所述帧延迟，用于检测所述运动对象的运动，并且基于检测到的运动进一步增强所述颜色变换的帧图像的强度水平。

6. 发明授权

US08791152B2 Stable pharmaceutical composition containing docetaxel and a method of manufacturing the same 失效
标题翻译：含有多西紫杉醇的稳定的药物组合物及其制造方法
公开(公告)号：US08791152B2
公开(公告)日：2014-07-29
申请号：US12301700
申请日：2007-05-22
申请人： Nam Ho Kim , Jin Young Lee , Jae-Sun Kim , Nam Kyu Lee , Woo Jae Jang , Joon Gyo Oh , Yoon-Jung Lee , Woong Sik Kim , Jin-Heung Sung , Key An Um
发明人： Nam Ho Kim , Jin Young Lee , Jae-Sun Kim , Nam Kyu Lee , Woo Jae Jang , Joon Gyo Oh , Yoon-Jung Lee , Woong Sik Kim , Jin-Heung Sung , Key An Um
IPC分类号： A61K31/335
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/337 , A61K31/724 , A61K47/10 , A61K47/32 , A61K47/38 , A61K47/40 , A61K2300/00
摘要： The present invention relates to a stable pharmaceutical composition for injection containing docetaxel and a method of preparing the same. More particularly, the present invention relates to a pharmaceutical composition for injection containing docetaxel having better storage stability than conventional medications, which is prepared by dissolving docetaxel, a water-insoluble compound, in distilled water after mixing it with cyclodextrin (CD) and a water-soluble polymer such as hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) and lyophilizing the mixture, and a method of preparing the same.
摘要翻译：本发明涉及含有多西紫杉醇的稳定的注射用药物组合物及其制备方法。更具体地说，本发明涉及含有多西紫杉醇的药物组合物，其具有比常规药物更好的储存稳定性，其通过将多巴紫杉醇，水不溶性化合物与环糊精（CD）和水混合后在蒸馏水中溶解而制备可溶性聚合物如羟丙基甲基纤维素（HPMC），聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP），并将混合物冷冻干燥及其制备方法。

7. 发明申请

US20130159607A1 MEMORY SYSTEM AND A PROGRAMMING METHOD THEREOF 有权
标题翻译：存储器系统及其编程方法
公开(公告)号：US20130159607A1
公开(公告)日：2013-06-20
申请号：US13535934
申请日：2012-06-28
申请人： Yoon-Young Kyung , Nam-Ho Kim , Hyun Jin Choi
发明人： Yoon-Young Kyung , Nam-Ho Kim , Hyun Jin Choi
IPC分类号： G06F12/02
CPC分类号： G11C16/3404 , G06F12/0246 , G11C5/147 , G11C7/04 , G11C11/5628 , G11C16/0483 , G11C16/10 , G11C29/028
摘要： A method of programming a storage device includes determining, at a controller of the storage device, that a first program mode of a plurality of program modes is to be entered in response to first information, wherein the first information includes a parameter associated with temperature, power consumption or input/output workload, and changing, using the controller, a program ratio of a first programming and a second programming of the storage device in the first program mode.
摘要翻译：一种对存储设备进行编程的方法包括：在所述存储设备的控制器处，确定要响应于第一信息输入多个节目模式的第一节目模式，其中所述第一信息包括与温度相关联的参数，功率消耗或输入/输出工作量，以及使用所述控制器，在所述第一编程模式中改变所述存储设备的第一编程和所述第二编程的编程比率。

8. 发明授权

US07550521B2 Toughening of thermosets 失效
标题翻译：热固性增韧
公开(公告)号：US07550521B2
公开(公告)日：2009-06-23
申请号：US10519251
申请日：2003-06-27
申请人： Ho Sung Kim , Nam Ho Kim
发明人： Ho Sung Kim , Nam Ho Kim
IPC分类号： C08L63/00 , C08J9/00 , C08J7/00 , B32B27/38
CPC分类号： C08J9/32 , B29C70/66 , C08J2203/22 , C08J2363/00 , C08K7/22
摘要： A method of manufacturing thermosets such as epoxy resins includes adding expandable hollow microspheres, which expand with temperature as shown in the accompanying graph, to the base thermoset components in the liquid phase and applying heat treatment to the mixture so formed causing the micropsheres to expand during or after curing of the thermoset. This results in a toughening mechanism caused by compressive residual stress around the microspheres which significantly increases the specific fracture energy of the epoxy resin.
摘要翻译：制造诸如环氧树脂的热固性材料的方法包括将如附图所示的随温度膨胀的可膨胀中空微球体添加到液相中的基础热固性组分，并对如此形成的混合物进行热处理，导致微球体膨胀或固化后的热固性材料。这导致由微球附近的压缩残余应力引起的增韧机理，这显着增加了环氧树脂的特定断裂能。

9. 发明授权

US07495022B2 α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors 有权
标题翻译： α，β-不饱和异羟肟酸衍生物及其作为组蛋白脱乙酰酶抑制剂的用途
公开(公告)号：US07495022B2
公开(公告)日：2009-02-24
申请号：US10510630
申请日：2003-04-10
申请人： Dae-Kee Kim , Ju Young Lee , Nam Kyu Lee , Jae-Sun Kim , Junwon Lee , Suk Ho Lee , Jin Young Choi , Je Ho Ryu , Nam Ho Kim , Guang-Jin Im , Tae Kon Kim , Jung-Woo Seo , Young-Jue Bang
发明人： Dae-Kee Kim , Ju Young Lee , Nam Kyu Lee , Jae-Sun Kim , Junwon Lee , Suk Ho Lee , Jin Young Choi , Je Ho Ryu , Nam Ho Kim , Guang-Jin Im , Tae Kon Kim , Jung-Woo Seo , Young-Jue Bang
IPC分类号： A61K31/19 , C07D207/32
CPC分类号： C07D213/82 , C07C259/06 , C07C317/44 , C07D213/38 , C07D213/71 , C07D213/81 , C07D215/48 , C07D215/54 , C07D295/155
摘要： Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.
摘要翻译：公开了抑制组蛋白脱乙酰酶的药剂。更具体地，本发明涉及用于抗癌剂或其它治疗剂的新型异羟肟酸衍生物或其药学上可接受的盐，基于其组蛋白脱乙酰酶抑制活性。

10. 发明授权

US06962911B2 Pyrrolopyrimidinone derivatives, process of preparation and use 有权
公开(公告)号：US06962911B2
公开(公告)日：2005-11-08
申请号：US10204327
申请日：2001-02-15
申请人： Dae-Kee Kim , Ju Young Lee , Do Hyun Ryu , Nam Kyu Lee , Suk Ho Lee , Nam-Ho Kim , Jae-Sun Kim , Je Ho Ryu , Jin-Young Choi , Guang-Jin Im , Won-Son Choi , Tae Kon Kim , Hoon Cha
发明人： Dae-Kee Kim , Ju Young Lee , Do Hyun Ryu , Nam Kyu Lee , Suk Ho Lee , Nam-Ho Kim , Jae-Sun Kim , Je Ho Ryu , Jin-Young Choi , Guang-Jin Im , Won-Son Choi , Tae Kon Kim , Hoon Cha
IPC分类号： A61K31/51 , A61K31/519 , A61K31/551 , A61P1/04 , A61P9/00 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/10 , A61P15/14 , A61P27/02 , A61P29/00 , A61P37/08 , A61P43/00 , C07D207/00 , C07D207/34 , C07D239/00 , C07D487/04 , A61P27/06
CPC分类号： C07D487/04 , C07D207/34
摘要： The invention relates to a series of pyrrolopyrimidinone derivatives of the formula (1): wherein R1 is H; C1-C3 alkyl optionally substituted with one or more fluoro atoms; or C3-C6 cycloalkyl; R2 is H; a halogen atom; C1-C6 alkyl optionally substituted with OH, C1-C3 alkoxy, C3-C6 cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6 alkenyl; or C2-C6 alkynyl; R3 is H; C1-C6 alkyl optionally substituted with OH, C1-C3 alkoxy, C3-C6 cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6 alkenyl; or C2-C6 alkynyl; R4 is C1-C6 alkyl optionally substituted with C3-C6 cycloalkyl or with one or more fluoro atoms; C2-C6 alkenyl; C2-C6 alkynyl; or C3-C6 cycloalkyl; and R5 is SO2NR6R7; NHSO2NR6R7; NHCOCONR6R7; NHSO2R8; NHCOR8; or phenyl or heterocyclyl either of which is optionally substituted with one or more fluoro atoms or C1-C3 alkyl.

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