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1. 发明授权

US07495022B2 α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors 有权
标题翻译： α，β-不饱和异羟肟酸衍生物及其作为组蛋白脱乙酰酶抑制剂的用途
公开(公告)号：US07495022B2
公开(公告)日：2009-02-24
申请号：US10510630
申请日：2003-04-10
申请人： Dae-Kee Kim , Ju Young Lee , Nam Kyu Lee , Jae-Sun Kim , Junwon Lee , Suk Ho Lee , Jin Young Choi , Je Ho Ryu , Nam Ho Kim , Guang-Jin Im , Tae Kon Kim , Jung-Woo Seo , Young-Jue Bang
发明人： Dae-Kee Kim , Ju Young Lee , Nam Kyu Lee , Jae-Sun Kim , Junwon Lee , Suk Ho Lee , Jin Young Choi , Je Ho Ryu , Nam Ho Kim , Guang-Jin Im , Tae Kon Kim , Jung-Woo Seo , Young-Jue Bang
IPC分类号： A61K31/19 , C07D207/32
CPC分类号： C07D213/82 , C07C259/06 , C07C317/44 , C07D213/38 , C07D213/71 , C07D213/81 , C07D215/48 , C07D215/54 , C07D295/155
摘要： Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.
摘要翻译：公开了抑制组蛋白脱乙酰酶的药剂。更具体地，本发明涉及用于抗癌剂或其它治疗剂的新型异羟肟酸衍生物或其药学上可接受的盐，基于其组蛋白脱乙酰酶抑制活性。

2. 发明申请

US20050124679A1 Alpha, beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors 有权
标题翻译： α，β-不饱和异羟肟酸衍生物及其作为组蛋白脱乙酰酶抑制剂的用途
公开(公告)号：US20050124679A1
公开(公告)日：2005-06-09
申请号：US10510630
申请日：2003-04-10
申请人： Dae-Kee Kim , Ju Young Lee , Nam Kyu Lee , Jae-Sun Kim , Junwon Lee , Suk Ho Lee , Jin Young Choi , Nam Ho Kim , Guang-Jin Im , Tae Kon Kim , Tae Kon Kim , Jung-Woo Seo , Young-Jue Bang
发明人： Dae-Kee Kim , Ju Young Lee , Nam Kyu Lee , Jae-Sun Kim , Junwon Lee , Suk Ho Lee , Jin Young Choi , Nam Ho Kim , Guang-Jin Im , Tae Kon Kim , Tae Kon Kim , Jung-Woo Seo , Young-Jue Bang
IPC分类号： C07D401/04 , C07C259/06 , C07C317/44 , C07D213/38 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D295/155 , A61K31/40 , A61K31/19 , C07C259/04 , C07D207/30
CPC分类号： C07D213/82 , C07C259/06 , C07C317/44 , C07D213/38 , C07D213/71 , C07D213/81 , C07D215/48 , C07D215/54 , C07D295/155
摘要： Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.
摘要翻译：公开了抑制组蛋白脱乙酰酶的药剂。更具体地，本发明涉及用于抗癌剂或其它治疗剂的新型异羟肟酸衍生物或其药学上可接受的盐，基于其组蛋白脱乙酰酶抑制活性。

3. 发明授权

US07442714B2 Amlodipine gentisate and a method of its preparation 失效
标题翻译：氨氯地平龙胆和其制备方法
公开(公告)号：US07442714B2
公开(公告)日：2008-10-28
申请号：US10583438
申请日：2004-12-15
申请人： Jae-Sun Kim , Jin Young Choi , Je Ho Ryu , Nam Kyu Lee , Jeong-soo Jang , Woo Jae Jang , Key An Um , Do Seung Kum
发明人： Jae-Sun Kim , Jin Young Choi , Je Ho Ryu , Nam Kyu Lee , Jeong-soo Jang , Woo Jae Jang , Key An Um , Do Seung Kum
IPC分类号： A61K31/44 , C07D213/80
CPC分类号： C07D211/90
摘要： The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.
摘要翻译：本发明涉及一种氨氯地平龙胆酸的酸性盐及其制备方法。更具体地说，本发明涉及通过使氨氯地平和龙胆酸反应制备的下式1的氨氯地平结晶酸盐，其可用于治疗心血管疾病，并且具有毒性低，稳定性优异的药物血液中的功效和持久的浓度。

4. 发明授权

US07772400B2 Optical resolution method of amlodipine 失效
标题翻译：氨氯地平的光学拆分方法
公开(公告)号：US07772400B2
公开(公告)日：2010-08-10
申请号：US11792281
申请日：2005-12-02
申请人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
发明人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
IPC分类号： C07D213/803
CPC分类号： C07D211/90
摘要： The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.
摘要翻译：本发明涉及通过使用异丙醇溶剂和光学活性的O，O-二苯甲酰基酒石酸作为手性试剂来旋光拆分氨氯地平的方法。更具体地说，本发明涉及一种方法，其包括（a）通过使（R，S） - 氨氯地平与光学活性的O，O-二苯甲酰基酒石酸盐反应获得（R） - 或（S） - 氨氯地平二苯甲酰酒石酸盐或其溶剂合物异丙醇溶剂中的酸，和（b）用碱处理（R） - 或（S） - 氨氯地平盐，从而得到光学活性的氨氯地平。

5. 发明申请

US20080249314A1 Optical Resolution Method of Amlodipine 失效
标题翻译：氨氯地平的光学分辨方法
公开(公告)号：US20080249314A1
公开(公告)日：2008-10-09
申请号：US11792281
申请日：2005-12-02
申请人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
发明人： Jae-Sun Kim , Jin Young Choi , Nam Ho Kim , Nam Kyu Lee
IPC分类号： C07D213/803
CPC分类号： C07D211/90
摘要： The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)— or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)— or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.
摘要翻译：本发明涉及通过使用异丙醇溶剂和光学活性的O，O-二苯甲酰基酒石酸作为手性试剂来旋光拆分氨氯地平的方法。更具体地说，本发明涉及一种方法，其包括（a）通过使（R，S） - 氨氯地平与光学活性的O，O-二苯甲酰基酒石酸盐反应获得（R） - 或（S） - 氨氯地平二苯甲酰酒石酸盐或其溶剂合物异丙醇溶剂中的酸，和（b）用碱处理（R） - 或（S） - 氨氯地平盐，从而得到光学活性的氨氯地平。

6. 发明授权

US08302035B2 Method for verifying optical proximity correction 有权
标题翻译：验证光学邻近校正的方法
公开(公告)号：US08302035B2
公开(公告)日：2012-10-30
申请号：US12825835
申请日：2010-06-29
申请人： Jin Young Choi
发明人： Jin Young Choi
IPC分类号： G06F17/50
CPC分类号： G03F1/36
摘要： A method for verifying an optical proximity correction includes: performing an optical proximity correction on a target pattern layout; performing a primary verification on the target pattern layout which has undergone the optical proximity correction; performing a secondary verification on defect weak points detected in the primary verification; and performing an additional optical proximity correction on hot spot points which are detected in the secondary verification and which may be generated as defects when transferred to a real wafer.
摘要翻译：一种用于验证光学邻近校正的方法包括：对目标图案布局执行光学邻近校正; 对经过光学邻近校正的目标图案布局进行初步验证; 对主要验证中检测到的缺陷弱点进行二次验证; 以及在二次验证中检测到的热点上执行附加的光学邻近校正，并且当传送到真实晶片时可能被产生为缺陷。

7. 发明申请

US20100078598A1 CONDUCTIVE POLYMER COMPOSITION FOR RADIOGRAPHIC IMAGING 审中-公开
标题翻译：用于放射成像的导电聚合物组合物
公开(公告)号：US20100078598A1
公开(公告)日：2010-04-01
申请号：US12524400
申请日：2008-01-25
申请人： Suck Hyun Lee , Dong Jin Woo , Jin Young Choi
发明人： Suck Hyun Lee , Dong Jin Woo , Jin Young Choi
IPC分类号： H01B1/12
CPC分类号： C08L101/12 , C08K5/0008 , C08L79/02
摘要： The present invention provides a conductive polymer composition for radiographic imaging prepared by mixing a photosensitive compound, such as a carbon nanotube, a photodegradable dopant, a photocuririg agent, an organic electron acceptor including a halogen atom, a Lewis basic dopant, and a pseudodopant, with a conductive polymer, the conductive polymer composition for radiographic imaging showing an electrical resistance variation amplified by radiation. When a photosensitive compound is mixed with a conductive polymer in accordance with the present invention, it is possible to effectively amplify the electrical resistance variation of the thus obtained composition by radiation, and thus it is possible to effectively detect and record radiation of low dose. That is, when the amplified electrical resistance variation is processed into an electrical signal, it is possible to facilitate the detection and recording of radiation, i.e., high-energy light, such as X-rays, gamma-rays, electron beams, and neutron beams.
摘要翻译：本发明提供了一种用于放射线成像的导电聚合物组合物，其通过将诸如碳纳米管的光敏化合物，可光降解的掺杂剂，光质量试剂，包含卤素原子的有机电子受体，路易斯碱性掺杂剂和假型聚糖混合而制备，使用导电聚合物，用于放射照相成像的导电聚合物组合物显示通过辐射放大的电阻变化。当根据本发明将光敏化合物与导电聚合物混合时，可以通过辐射有效地放大由此获得的组合物的电阻变化，因此可以有效地检测和记录低剂量的辐射。也就是说，当放大的电阻变化被处理成电信号时，有可能促进辐射的检测和记录，例如高能量光，例如X射线，γ射线，电子束和中子梁。

8. 发明申请

US20120064606A1 METHOD FOR PRODUCING HIGH CONCENTRATE LACTIC ACID BACTERIA WITH MEMBRANE BIOREACTOR AND FREEZE-DRIED, LACTIC ACID BACTERIA POWDER 审中-公开
标题翻译：用膜生物反应器和冷冻干燥的酸性细菌粉生产高浓度酸性细菌的方法
公开(公告)号：US20120064606A1
公开(公告)日：2012-03-15
申请号：US13147237
申请日：2009-07-07
申请人： Young Chai Cho , Il Seong Jung , Tae Man Jung , Sil Ho Choi , Jin Young Choi
发明人： Young Chai Cho , Il Seong Jung , Tae Man Jung , Sil Ho Choi , Jin Young Choi
IPC分类号： C12N1/20
CPC分类号： C12N1/02 , C12M29/04 , C12M47/10
摘要： The present invention relates to a method for producing lactic acid bacteria of a high concentration continuously using a membrane bioreactor. Specifically, the present invention relates to a method for producing lactic acid bacteria of a high concentration in a membrane bioreactor that comprises the steps of cultivating lactic acid bacteria in a membrane bioreactor including a membrane for product separation and a medium supply apparatus; supplying culture media to the bioreactor through the medium supply apparatus; continuously separating and discharging culture filtrate through the membrane for product separation; and recycling lactic acid bacteria continuously to the bioreactor. Additionally, the present invention relates to a method for producing lactic acid bacteria powder by freeze drying the bacteria produced in the membrane bioreactor using a freeze drying preservative composition. The lactic acid bacteria obtained through the membrane bioreactor is obtained in pellet form with a centrifugal separator, and is subjected to freeze-drying using the composition for freeze drying preservative containing certain amounts of trehalose, maltodextrin, starch and sodium carboxy methyl cellulose to form lactic acid powder. The lactic acid bacteria that have been converted into powder by such method exhibit superior stability chemically and physically compared to lactic acid bacteria powder that has been subjected to simple freeze drying.
摘要翻译：本发明涉及使用膜生物反应器连续生产高浓度乳酸菌的方法。具体而言，本发明涉及膜生物反应器中高浓度的乳酸菌的制造方法，其特征在于，包括在包含产品分离用膜的膜生物反应器和培养基供给装置中培养乳酸菌的工序; 通过介质供应装置向生物反应器供应培养基; 通过膜分离和排出培养滤液，用于产品分离; 并将乳酸菌连续循环到生物反应器。另外，本发明涉及使用冷冻干燥防腐剂组合物冷冻干燥膜生物反应器中生成的细菌来生产乳酸菌粉末的方法。通过膜生物反应器获得的乳酸菌用离心分离器以颗粒形式获得，并使用含有一定量海藻糖，麦芽糖糊精，淀粉和羧甲基纤维素钠的冷冻干燥防腐剂组合物进行冷冻干燥以形成乳酸酸粉。通过这种方法转化为粉末的乳酸菌与经过简单冷冻干燥的乳酸菌粉相比，表现出优异的化学稳定性和稳定性。

9. 发明授权

US08064027B2 Preventing wiring corrosion in LCDs 有权
标题翻译：防止LCD中的布线腐蚀
公开(公告)号：US08064027B2
公开(公告)日：2011-11-22
申请号：US12001609
申请日：2007-12-11
申请人： Jin Young Choi , Dong Hwan Kim , Jin Jeon , Yong Gi Park
发明人： Jin Young Choi , Dong Hwan Kim , Jin Jeon , Yong Gi Park
IPC分类号： G02F1/1345 , G02F1/1339
CPC分类号： G02F1/1345 , G02F2001/136254
摘要： A display device includes a display panel having a display region and a peripheral region. Signal lines disposed in the peripheral region provide an image display signal to the display region. A test pad portion is disposed in the peripheral region and connected to at least some of the signal lines. The test pad portion includes a test pad, an extension line extending from the test pad, and a bridge wire connecting the extension line to an associated signal line. The bridge wire is formed of a corrosion resistant material. The signal line is protected from corrosion by connecting the signal line to the test pad portion via the bridge wire, which prevents corrosion of the test pad from spreading to the signal line. The bridge wire can be protected from corrosion by disposing it under a sealing member of the panel.
摘要翻译：显示装置包括具有显示区域和周边区域的显示面板。设置在周边区域中的信号线向显示区域提供图像显示信号。测试焊盘部分设置在外围区域中并且连接到至少一些信号线。测试焊盘部分包括测试焊盘，从测试焊盘延伸的延伸线以及将延伸线连接到相关信号线的桥接线。桥接线由耐腐蚀材料形成。通过桥接线将信号线连接到测试焊盘部分，防止信号线受到腐蚀，防止测试焊盘腐蚀到信号线上。桥接线可以通过将其布置在面板的密封构件下而免受腐蚀。

10. 发明申请

US20060136251A1 System and method for providing electronic business-card service using open service interface 有权
公开(公告)号：US20060136251A1
公开(公告)日：2006-06-22
申请号：US11253379
申请日：2005-10-19
申请人： Ki Soon Sung , Yoo Mi Park , Yong Joo Lee , Jin Young Choi , Young Il Choi , Byung Sun Lee , Kyung Pyo Jun
发明人： Ki Soon Sung , Yoo Mi Park , Yong Joo Lee , Jin Young Choi , Young Il Choi , Byung Sun Lee , Kyung Pyo Jun
IPC分类号： G06Q99/00
CPC分类号： G06Q10/107 , H04L67/24
摘要： Provided are a system and method for providing an electronic business card service using an open service interface. In the system, a business card information register receives electronic business card information from terminals of presentities who provide an electronic business card, and publishes it on an open service gateway, each of the electronic business card information including identification information and status information of each of the terminals and the terminals being connected to a convergence network; a watcher register receiving identification information of a terminal of a watcher who desires to use the electronic business card information and registers it to the open service gateway; and a business card information providing unit obtaining status information of a terminal of a specified presentity from the open service gateway and transmits it together with identification information of the terminal of the specified presentity to the terminal of the watcher, upon a request for electronic business card information of the specified presentity.

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