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1. 发明申请

WO2011007282A1 APPARATUS AND METHOD FOR SAFEGUARDING THE OPERATION OF A FLUID DELIVERY DEVICE 审中-公开
标题翻译：用于保护流体输送装置的操作的装置和方法
公开(公告)号：WO2011007282A1
公开(公告)日：2011-01-20
申请号：PCT/IB2010/052988
申请日：2010-06-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HIJLKEMA, Markus , NISATO, Giovanni , KASSIES, Roelf
发明人： HIJLKEMA, Markus , NISATO, Giovanni , KASSIES, Roelf
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/204 , A61M5/365 , A61M2205/18 , A61M2205/3306 , A61M2205/52
摘要： The apparatus allows the detection of light bubbles in the area of the pressurized fluid chamber or the nozzle of the micro-jet to detect bubbles by light scattering. Light is sent through the area of interest and detected behind it by a light detector. If the light intensity drops correspondingly a drop in the detector current is detected. This is indicative of unwanted bubbles. In this case the actuation of the electromechanical actuator to generate micro-jets may be stopped, alternatively or in additional signal may be output in order to inform a user to replace a fluid reservoir, or to simply issue an alarm. The fluid delivery device may comprise a durable and a disposable section, wherein the active parts such as power source, light source and light detector are integrated in the durable section and the disposable section comprises a nozzle and the fluid chamber which presents significant advantages, as the contact interface to the skin is frequently replaced and thus hygienic conditions are easy to maintain.
摘要翻译：该装置允许在加压流体室的区域或微喷嘴的喷嘴的区域中检测光气泡，以通过光散射来检测气泡。光通过感兴趣的区域发送并通过光检测器检测到。如果光强度相应降低，则检测器电流的下降。这表示不需要的气泡。在这种情况下，可以停止用于产生微射流的机电致动器的致动，或者可选地输出附加信号，以通知用户更换流体储存器，或简单地发出报警。流体输送装置可以包括耐用和一次性部分，其中诸如动力源，光源和光检测器的有源部件集成在耐用部分中，并且一次性部分包括喷嘴和流体室，其具有显着的优点，如经常更换与皮肤的接触界面，因此卫生条件易于维护。

2. 发明申请

WO2010007589A1 MEDICAL DEVICE AND METHOD FOR MONITORING STATUS INFORMATION 审中-公开
标题翻译：用于监测状态信息的医疗装置和方法
公开(公告)号：WO2010007589A1
公开(公告)日：2010-01-21
申请号：PCT/IB2009/053102
申请日：2009-07-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61B5/00
CPC分类号： A61B5/00 , A61B5/1101 , A61B5/1118 , A61B5/1124 , A61B5/681 , A61B2560/0276 , A61B2562/0219
摘要： Medical device (21) and method for monitoring one or more parameters wherein a patient is provided with such a medical device (21) comprising at least one sensor, a fastening band (27) and at least one light emitting element (28) configured to display light as a signal coding for status information relating to the monitored parameter. The medical device (21) can for example be worn as a watch.
摘要翻译：医疗设备（21）和用于监测一个或多个参数的方法，其中患者设置有包括至少一个传感器的该医疗设备（21），紧固带（27）和至少一个发光元件（28）显示光作为编码与被监视参数有关的状态信息的信号。医疗装置（21）例如可以作为手表佩戴。

3. 发明申请

WO2009141776A2 DEVICE FOR NEEDLELESS TRANSDERMAL DELIVERY OF MEDICATION 审中-公开
标题翻译：用于不需要递送药物的设备
公开(公告)号：WO2009141776A2
公开(公告)日：2009-11-26
申请号：PCT/IB2009/052029
申请日：2009-05-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61M5/30
CPC分类号： A61M5/30
摘要： The invention relates to a device for needleless transdermal drug delivery. The device according to the invention comprises an actuator (104) and a support (102) which has a support stiffness. The actuator (104) has a driver part (106) and a support part (108), which support part (106) is connected to the support and which driver part (108) is displaceable with regard to the support part (106) along an axis of displacement (110). The device according to the invention is characterized in that the support stiffness provides a substantially zero displacement of the actuator's support part (106) along the driver's axis of displacement (110) during a displacement of the driver part (108) along said axis with regard to the support part (106).
摘要翻译：本发明涉及无针透皮药物递送装置。根据本发明的装置包括具有支撑刚度的致动器（104）和支撑件（102）。致动器（104）具有驱动器部分（106）和支撑部分（108），支撑部分（106）连接到支撑件，并且驱动器部件（108）可相对于支撑部件（106）沿着位移轴（110）。根据本发明的装置的特征在于，在驱动器部件（108）沿着所述轴线的位移期间，支撑刚度提供致动器的支撑部件（106）沿着驱动器的位移轴线（110）的基本上零位移，到支撑部分（106）。

4. 发明申请

WO2008020378A3 INK JET DEVICE FOR PRODUCING A BIOLOGICAL ASSAY SUBSTRATE BY RELEASING A PLURALITY OF SUBSTANCES ONTO THE SUBSTRATE, AND METHOD FOR PRODUCING SUCH A SUBSTRATE 审中-公开
标题翻译：用于通过将大量物质释放到基底上来生产生物测定基底的墨水装置，以及用于生产这种基底的方法
公开(公告)号：WO2008020378A3
公开(公告)日：2008-06-26
申请号：PCT/IB2007053181
申请日：2007-08-10
申请人： KONINKL PHILIPS ELECTRONICS NV , PIERIK ANKE , DIJKSMAN JOHAN F , VERNHOUT MARTIN M , VAN DEN BESSELAAR LEONARDUS J , VAN DAM DIRKJAN B , NISATO GIOVANNI , IMMINK ALBERT H J
发明人： PIERIK ANKE , DIJKSMAN JOHAN F , VERNHOUT MARTIN M , VAN DEN BESSELAAR LEONARDUS J , VAN DAM DIRKJAN B , NISATO GIOVANNI , IMMINK ALBERT H J
IPC分类号： B01J19/00
CPC分类号： B41J29/393 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00536 , B01J2219/00542 , B01J2219/00547 , B01J2219/0056 , B01J2219/00567 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00641 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00693 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B01L3/0268 , B01L3/545 , B01L2200/143 , B01L2300/021 , B01L2300/022 , B82Y30/00 , G01N35/00732
摘要： The invention provides an ink jet device and method for producing a biological assay substrate (41) by releasing a plurality of substances onto the substrate (41) The device comprises at least a print head and a plurality of substance containers (60, 61, 62) connectable thereto, and mounting means (55) for the containers, whereby at least part of the containers (60, 61, 62) is provided with identification means (63) The device further comprises reading means to read information contained in the identification means (63).
摘要翻译：本发明提供一种通过将多种物质释放到基底（41）上来生产生物测定基底（41）的喷墨装置和方法。该装置包括至少一个打印头和多个物质容器（60,61,62 ）和用于容器的安装装置（55），由此至少一部分容器（60,61,62）设置有识别装置（63）。该装置还包括读取装置，用于读取包含在识别装置（63）。

5. 发明申请

WO2008023300A1 DRUG DELIVERY DEVICE WITH PIEZOELECTRIC ACTUATOR 审中-公开
标题翻译：具有压电致动器的药物递送装置
公开(公告)号：WO2008023300A1
公开(公告)日：2008-02-28
申请号：PCT/IB2007/053199
申请日：2007-08-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NISATO, Giovanni , RUBINGH, Jan-Eric, J. M. , DIJKSMAN, Johan, F. , TIMMERMANS, Henry, M.J.M. , MEUWESE, Mark, T.
发明人： NISATO, Giovanni , RUBINGH, Jan-Eric, J. M. , DIJKSMAN, Johan, F. , TIMMERMANS, Henry, M.J.M. , MEUWESE, Mark, T.
IPC分类号： A61M5/30 , A61K9/00 , A61M5/142
CPC分类号： A61M5/30 , A61K9/0009 , A61K9/0019 , A61K9/0021 , A61K9/0024 , A61K9/0097 , A61M5/142 , A61M5/14276 , A61M5/204 , A61M2205/0288
摘要： The invention refers to an electrically actuated, needle-free injection device. The main field of application is drug delivery. The device is based on a piezoelectric actuator (11). The device enables controlled, continuous, tuneable drug delivery. The device enables painless injection, personalized and programmable dosage profiles. The device is designed, both to pierce the epidermis for trans-epidermal drug delivery and to deliver controlled amounts of fluid (transdermal, electronic pill and implantable drug delivery). This type of device enables personalized drug delivery and is an enabling component for closed-loop drug delivery systems.
摘要翻译：本发明涉及电致动的无针注射装置。主要应用领域为药物输送。该装置基于压电致动器（11）。该装置可实现受控，连续，可调药物输送。该设备可实现无痛注射，个性化和可编程的剂量分布。该设备被设计为刺穿表皮进行反式表皮药物递送并输送受控量的流体（透皮，电子药片和可植入药物递送）。这种类型的装置能够实现个性化的药物递送，并且是闭环药物递送系统的有用组件。

6. 发明申请

WO2010150154A1 DETECTING A TEMPORAL ALTERATION OF AN OPTICAL PROPERTY OF A SUBCUTANEOUS LAYER FOR DRUG DELIVERY 审中-公开
标题翻译：检测用于药物递送的半成品层的光学性质的时间变化
公开(公告)号：WO2010150154A1
公开(公告)日：2010-12-29
申请号：PCT/IB2010/052741
申请日：2010-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf
发明人： NISATO, Giovanni , KASSIES, Roelf
IPC分类号： A61M5/30 , A61M5/168
CPC分类号： A61M5/30 , A61M5/16836 , A61M2005/1726 , A61M2205/3306 , A61M2205/587
摘要： Arrangement for detecting a temporal alteration of an optical property of a subcutaneous layer in vivo, drug delivery device (400) comprising the arrangement and method for drug delivery are described. For an optimized control of drug delivery by a transdermal drug delivery device an optical feedback control is described, which allows to detect the alteration of an optical property of a subcutaneous layer caused by an injected fluid from a fluid jet; and to control an actuator of the micro- jet pump in response to the fluid administered under the skin of a subject. If no drug is delivered transdermally the injection speed may be increased and the frequency as well as the injection speed may be controlled in dependence of each other following lookup tables that are generated during calibration of the device. A drug delivery device and a method for drug delivery make use of the optical detection for in situ and real time monitoring of injected substances.
摘要翻译：描述了用于检测体内皮下层的光学性质的时间变化的布置，包括药物递送的方法和装置的药物递送装置（400）。为了通过透皮药物递送装置优化的药物递送控制，描述了光学反馈控制，其允许检测由来自流体射流的注射流体引起的皮下层的光学性质的改变; 并且响应于在受试者的皮肤下施用的流体来控制微喷射泵的致动器。如果没有药物经皮递送，则可以增加注射速度，并且可以根据在设备校准期间产生的查找表之间的彼此依赖于控制频率以及注射速度。药物递送装置和药物递送方法利用光学检测用于原位和实时监测注射物质。

7. 发明申请

WO2010007565A3 DRUG DELIVERY GARMENT 审中-公开
公开(公告)号：WO2010007565A3
公开(公告)日：2010-01-21
申请号：PCT/IB2009/053005
申请日：2009-07-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61K9/70 , A61M5/145 , A61B1/00 , A61D1/00
摘要： Drug delivery device comprising a garment, such as a sock, T-shirt, or underpants, comprising at least one pocket encasing at least one drug dispenser with an outlet, such as a jet nozzle, in line with an opening in the pocket. The garment is at least partly made of a stretchable fabric. When worn, the outlet can face the skin of a patient and drug delivery can take place.

8. 发明申请

WO2008142640A1 WEARABLE DRUG DELIVERY DEVICE 审中-公开
标题翻译：耐磨药物输送装置
公开(公告)号：WO2008142640A1
公开(公告)日：2008-11-27
申请号：PCT/IB2008/051974
申请日：2008-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , RUBINGH, Jan-Eric, J., M.
发明人： NISATO, Giovanni , RUBINGH, Jan-Eric, J., M.
IPC分类号： A61M5/30 , A61M5/178 , A61M5/31 , A61M5/28
CPC分类号： A61M5/30 , A61M5/1782 , A61M5/3129 , A61M2005/3022 , A61M2205/7536 , A61M2209/045
摘要： In order to provide a wearable drug delivery device for long term administration of drugs not employing a needle or canula, it is suggested according to the present invention that a wearable drug delivery device comprises a tubular reservoir (1) having an outlet end from which a drug may be expelled and a second end, a high-speed jet pump (2) for transdermal, needle-less micro- jet drug delivery, being connected to the outlet end of the tubular reservoir, a venting valve, being connected to the second end of the reservoir.
摘要翻译：为了提供用于长期施用不使用针或套管的药物的可穿戴药物递送装置，根据本发明，建议可穿戴药物递送装置包括具有出口端的管状储存器（1），管状贮存器可以排出药物，并且第二端，用于透皮的无针喷射药物输送的高速喷射泵（2）连接到管状储存器的出口端，排气阀连接到第二水库末端。

9. 发明申请

WO2007148256A3 IONTOPHORETIC ELECTROTRANSPORT DEVICE 审中-公开
标题翻译：静电电动装置
公开(公告)号：WO2007148256A3
公开(公告)日：2008-03-27
申请号：PCT/IB2007052197
申请日：2007-06-11
申请人： KONINKL PHILIPS ELECTRONICS NV , NISATO GIOVANNI , PONJEE MARC WILHELMUS GIJSBERT , JOHNSON MARK THOMAS
发明人： NISATO GIOVANNI , PONJEE MARC WILHELMUS GIJSBERT , JOHNSON MARK THOMAS
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport device for transdermal drug delivery has a number of electrodes and driving circuitry for supplying driving signals to the number of electrodes. The electrodes are connected to the driving circuitry in rows and colums. The driving circuitry has row driving circuitry for supplying a row signal to a row of electrodes, and column driving circuitry for supplying a column signal to a column of electrodes. A predetermined electrode is individually addressable by supplying a row signal to a corresponding row of electrodes and a column signal to a corresponding column of electrodes.
摘要翻译：用于透皮药物递送的电输送装置具有多个电极和用于向电极数提供驱动信号的驱动电路。电极以行和列连接到驱动电路。驱动电路具有用于向一行电极提供行信号的行驱动电路和用于向列电极提供列信号的列驱动电路。通过向对应的电极列提供行信号和列信号，预定电极可单独寻址。

10. 发明申请

WO2005036509A3 ELECTROLUMINESCENT DISPLAY PANEL 审中-公开
标题翻译：电致发光显示面板
公开(公告)号：WO2005036509A3
公开(公告)日：2005-07-14
申请号：PCT/IB2004051993
申请日：2004-10-06
申请人： KONINKL PHILIPS ELECTRONICS NV , DUINEVELD PAULUS C , DECRE MICHEL M J , NISATO GIOVANNI
发明人： DUINEVELD PAULUS C , DECRE MICHEL M J , NISATO GIOVANNI
IPC分类号： H01L27/32 , H01L51/40 , H01L51/56
CPC分类号： H01L51/0004 , H01L27/3211 , H01L51/56
摘要： The invention relates to an electroluminescent display panel (2) comprising a substrate and a plurality of display pixels (3) including an electroluminescent material defined on or over said substrate. The display panel (2) further includes at least one microcontact printed hydrophobic layer (11) between adjacent display pixels (3). The invention further relates to a method for manufacturing such a display panel. The method avoids the need to apply photoresist barriers for containing the liquid electroluminescent material.
摘要翻译：本发明涉及一种电致发光显示面板（2），其包括基板和多个显示像素（3），其包括限定在所述基板上或上方的电致发光材料。显示面板（2）还包括在相邻显示像素（3）之间的至少一个微接触印刷疏水层（11）。本发明还涉及一种用于制造这种显示面板的方法。该方法避免了需要使用用于容纳液体电致发光材料的光致抗蚀剂阻挡层。

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