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    • 8. 发明申请
    • APPARATUS AND METHOD FOR SAFEGUARDING THE OPERATION OF A FLUID DELIVERY DEVICE
    • 用于保护流体输送装置的操作的装置和方法
    • WO2011007282A1
    • 2011-01-20
    • PCT/IB2010/052988
    • 2010-06-30
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.HIJLKEMA, MarkusNISATO, GiovanniKASSIES, Roelf
    • HIJLKEMA, MarkusNISATO, GiovanniKASSIES, Roelf
    • A61M5/30
    • A61M5/30A61M5/204A61M5/365A61M2205/18A61M2205/3306A61M2205/52
    • The apparatus allows the detection of light bubbles in the area of the pressurized fluid chamber or the nozzle of the micro-jet to detect bubbles by light scattering. Light is sent through the area of interest and detected behind it by a light detector. If the light intensity drops correspondingly a drop in the detector current is detected. This is indicative of unwanted bubbles. In this case the actuation of the electromechanical actuator to generate micro-jets may be stopped, alternatively or in additional signal may be output in order to inform a user to replace a fluid reservoir, or to simply issue an alarm. The fluid delivery device may comprise a durable and a disposable section, wherein the active parts such as power source, light source and light detector are integrated in the durable section and the disposable section comprises a nozzle and the fluid chamber which presents significant advantages, as the contact interface to the skin is frequently replaced and thus hygienic conditions are easy to maintain.
    • 该装置允许在加压流体室的区域或微喷嘴的喷嘴的区域中检测光气泡,以通过光散射来检测气泡。 光通过感兴趣的区域发送并通过光检测器检测到。 如果光强度相应降低,则检测器电流的下降。 这表示不需要的气泡。 在这种情况下,可以停止用于产生微射流的机电致动器的致动,或者可选地输出附加信号,以通知用户更换流体储存器,或简单地发出报警。 流体输送装置可以包括耐用和一次性部分,其中诸如动力源,光源和光检测器的有源部件集成在耐用部分中,并且一次性部分包括喷嘴和流体室,其具有显着的优点,如 经常更换与皮肤的接触界面,因此卫生条件易于维护。
    • 9. 发明申请
    • DETECTING A TEMPORAL ALTERATION OF AN OPTICAL PROPERTY OF A SUBCUTANEOUS LAYER FOR DRUG DELIVERY
    • 检测用于药物递送的半成品层的光学性质的时间变化
    • WO2010150154A1
    • 2010-12-29
    • PCT/IB2010/052741
    • 2010-06-17
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.NISATO, GiovanniKASSIES, Roelf
    • NISATO, GiovanniKASSIES, Roelf
    • A61M5/30A61M5/168
    • A61M5/30A61M5/16836A61M2005/1726A61M2205/3306A61M2205/587
    • Arrangement for detecting a temporal alteration of an optical property of a subcutaneous layer in vivo, drug delivery device (400) comprising the arrangement and method for drug delivery are described. For an optimized control of drug delivery by a transdermal drug delivery device an optical feedback control is described, which allows to detect the alteration of an optical property of a subcutaneous layer caused by an injected fluid from a fluid jet; and to control an actuator of the micro- jet pump in response to the fluid administered under the skin of a subject. If no drug is delivered transdermally the injection speed may be increased and the frequency as well as the injection speed may be controlled in dependence of each other following lookup tables that are generated during calibration of the device. A drug delivery device and a method for drug delivery make use of the optical detection for in situ and real time monitoring of injected substances.
    • 描述了用于检测体内皮下层的光学性质的时间变化的布置,包括药物递送的方法和装置的药物递送装置(400)。 为了通过透皮药物递送装置优化的药物递送控制,描述了光学反馈控制,其允许检测由来自流体射流的注射流体引起的皮下层的光学性质的改变; 并且响应于在受试者的皮肤下施用的流体来控制微喷射泵的致动器。 如果没有药物经皮递送,则可以增加注射速度,并且可以根据在设备校准期间产生的查找表之间的彼此依赖于控制频率以及注射速度。 药物递送装置和药物递送方法利用光学检测用于原位和实时监测注射物质。