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1. 发明申请

WO2010007589A1 MEDICAL DEVICE AND METHOD FOR MONITORING STATUS INFORMATION 审中-公开
标题翻译：用于监测状态信息的医疗装置和方法
公开(公告)号：WO2010007589A1
公开(公告)日：2010-01-21
申请号：PCT/IB2009/053102
申请日：2009-07-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61B5/00
CPC分类号： A61B5/00 , A61B5/1101 , A61B5/1118 , A61B5/1124 , A61B5/681 , A61B2560/0276 , A61B2562/0219
摘要： Medical device (21) and method for monitoring one or more parameters wherein a patient is provided with such a medical device (21) comprising at least one sensor, a fastening band (27) and at least one light emitting element (28) configured to display light as a signal coding for status information relating to the monitored parameter. The medical device (21) can for example be worn as a watch.
摘要翻译：医疗设备（21）和用于监测一个或多个参数的方法，其中患者设置有包括至少一个传感器的该医疗设备（21），紧固带（27）和至少一个发光元件（28）显示光作为编码与被监视参数有关的状态信息的信号。医疗装置（21）例如可以作为手表佩戴。

2. 发明申请

WO2009141776A2 DEVICE FOR NEEDLELESS TRANSDERMAL DELIVERY OF MEDICATION 审中-公开
标题翻译：用于不需要递送药物的设备
公开(公告)号：WO2009141776A2
公开(公告)日：2009-11-26
申请号：PCT/IB2009/052029
申请日：2009-05-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61M5/30
CPC分类号： A61M5/30
摘要： The invention relates to a device for needleless transdermal drug delivery. The device according to the invention comprises an actuator (104) and a support (102) which has a support stiffness. The actuator (104) has a driver part (106) and a support part (108), which support part (106) is connected to the support and which driver part (108) is displaceable with regard to the support part (106) along an axis of displacement (110). The device according to the invention is characterized in that the support stiffness provides a substantially zero displacement of the actuator's support part (106) along the driver's axis of displacement (110) during a displacement of the driver part (108) along said axis with regard to the support part (106).
摘要翻译：本发明涉及无针透皮药物递送装置。根据本发明的装置包括具有支撑刚度的致动器（104）和支撑件（102）。致动器（104）具有驱动器部分（106）和支撑部分（108），支撑部分（106）连接到支撑件，并且驱动器部件（108）可相对于支撑部件（106）沿着位移轴（110）。根据本发明的装置的特征在于，在驱动器部件（108）沿着所述轴线的位移期间，支撑刚度提供致动器的支撑部件（106）沿着驱动器的位移轴线（110）的基本上零位移，到支撑部分（106）。

3. 发明申请

WO2010007565A3 DRUG DELIVERY GARMENT 审中-公开
公开(公告)号：WO2010007565A3
公开(公告)日：2010-01-21
申请号：PCT/IB2009/053005
申请日：2009-07-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61K9/70 , A61M5/145 , A61B1/00 , A61D1/00
摘要： Drug delivery device comprising a garment, such as a sock, T-shirt, or underpants, comprising at least one pocket encasing at least one drug dispenser with an outlet, such as a jet nozzle, in line with an opening in the pocket. The garment is at least partly made of a stretchable fabric. When worn, the outlet can face the skin of a patient and drug delivery can take place.

4. 发明申请

WO2009153729A1 PARENTERAL MEDICAMENT DELIVERY DEVICE 审中-公开
标题翻译：国家药物递送装置
公开(公告)号：WO2009153729A1
公开(公告)日：2009-12-23
申请号：PCT/IB2009/052547
申请日：2009-06-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61M5/30 , A61M5/52
CPC分类号： A61M5/52 , A61M5/30
摘要： Device for parenteral administration of a medicament, e.g. for transdermal or (sub)cutaneous administration of drugs without the use of a needle. The device (1, 21, 31) comprises a top side (3, 23, 33) with a support surface for supporting a patient's body part, e.g. a lower arm, at least one medicament reservoir (5, 6) with at least one jet dispenser comprising a nozzle (8, 28, 38) at the support surface. The support surface (3, 23, 33) can be curved to guide the body part to be in reach of the jet dispenser nozzle (8, 28, 38). The device can have a grip (25, 35) for further optimizing the positioning of the lower arm.
摘要翻译：用于胃肠外给药的装置，例如药物。用于透皮或（次）皮肤给药，而不使用针头。装置（1,21,31）包括具有用于支撑患者身体部位的支撑表面的顶侧（3,23,33），例如，下臂，至少一个具有至少一个喷射分配器的药剂储存器（5,6），所述至少一个喷射分配器在支撑表面处包括喷嘴（8,28,38）。支撑表面（3,23,33）可以是弯曲的，以将主体部分引导到喷嘴分配器喷嘴（8,28,38）的到达位置。该装置可以具有用于进一步优化下臂定位的把手（25,35）。

5. 发明申请

WO2010038182A2 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO2010038182A2
公开(公告)日：2010-04-08
申请号：PCT/IB2009/054213
申请日：2009-09-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M. , PASTINK, Erik, A.
发明人： KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M. , PASTINK, Erik, A.
IPC分类号： A61M5/00 , A61M5/14 , A61M5/31 , A61M5/142 , A61J1/16
CPC分类号： A61M5/002 , A61M5/1413 , A61M5/14248 , A61M2005/14268 , A61M2005/3125 , A61M2205/12 , A61M2205/6045 , A61M2205/6054 , A61M2205/8243 , A61M2209/045 , A61M2209/086
摘要： A drug delivery system (102) comprising a drug delivery device (108) arranged for accommodating a drug cartridge (106) and a drug cartridge loading device (104) for loading the drug cartridge to the drug delivery device. The drug cartridge loading device is provided with a storing unit (110) for storing a drug cartridge, a receiving unit (112) for receiving the drug delivery device, and a transferring unit (114) for transferring the drug cartridge to the drug delivery device during or after receiving the drug delivery device. The drug delivery system reduces the difficulties associated with the handling of relatively small drug cartridges through providing a drug cartridge loading device.
摘要翻译：药物输送系统（102）包括布置成容纳药物盒（106）的药物输送装置（108）和用于将药物盒装载到药物输送装置的药物盒装载装置（104）。药盒装载装置设置有用于储存药物盒的存储单元（110），用于接收药物递送装置的接收单元（112）和用于将药物盒转移到药物输送装置的转移单元（114）在接收药物递送装置期间或之后。药物递送系统通过提供药物盒装载装置来减少与处理相对小的药物药筒有关的困难。

6. 发明申请

WO2010007574A1 DRUG DELIVERY SYSTEM WITH A FASTENING BAND 审中-公开
标题翻译：带有紧身带的药物输送系统
公开(公告)号：WO2010007574A1
公开(公告)日：2010-01-21
申请号：PCT/IB2009/053030
申请日：2009-07-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： NISATO, Giovanni , KASSIES, Roelf , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61M5/142
CPC分类号： A61M5/30 , A61M5/14244 , A61M2005/3022 , A61M2205/276 , A61M2205/50 , A61M2205/609
摘要： Drug delivery device (1) comprising a fastening band (2) with a case (4) with a display (5) and one or more control keys (6, 7) in communication with a control unit (17), which is programmed to lock the control keys (6, 7). The device comprises an actuator (8, 9) to be used by a user for unlocking the control keys (6, 7), such as a set of two buttons (8, 9) on opposite sides of the case (4) to be actuated by a pinching motion.
摘要翻译：药物输送装置（1）包括具有带有显示器（5）的壳体（4）的紧固带（2）和与控制单元（17）连通的一个或多个控制键（6,7），其被编程为锁定控制键（6,7）。该装置包括用于使用户解锁控制键（6,7）的致动器（8,9），例如在壳体（4）的相对侧上的一组两个按钮（8,9），以使其成为通过夹持动作来驱动。

7. 发明申请

WO2010007573A1 MEDICAL DEVICE COMPRISING A REMOTE CONTROL 审中-公开
标题翻译：包含远程控制的医疗设备
公开(公告)号：WO2010007573A1
公开(公告)日：2010-01-21
申请号：PCT/IB2009/053029
申请日：2009-07-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
发明人： KASSIES, Roelf , NISATO, Giovanni , VAN MENSVOORT, Wilhelmus, H., N., M.
IPC分类号： A61M5/142
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2205/3523 , A61M2209/01
摘要： Medical device (11) comprising a remote control (1, 30, 40) having a flat foldable sheath (3, 41), with a display (10, 37, 46), an input interface (7, 34, 35, 47, 52), and an antenna (33, 51). The sheath (3, 41) encases a power module (38, 48), a central control unit (31, 49) and wireless communication circuitry (32). The remote control (1, 40) can have the shape of a pocket size bill fold, having two or more panels (42, 43, 44) connected at their adjacent edges by a flexible interconnect (45).
摘要翻译：医疗设备（11）包括具有平面可折叠护套（3,41）的遥控器（1,30,40），具有显示器（10,37,46），输入接口（7,34,35,47） 52）和天线（33,51）。护套（3,41）包围电源模块（38,48），中央控制单元（31,49）和无线通信电路（32）。遥控器（1,40）可以具有口袋尺寸纸币折叠的形状，其具有通过柔性互连（45）在其相邻边缘处连接的两个或更多个面板（42,43,44）。

8. 发明申请

WO2011007282A1 APPARATUS AND METHOD FOR SAFEGUARDING THE OPERATION OF A FLUID DELIVERY DEVICE 审中-公开
标题翻译：用于保护流体输送装置的操作的装置和方法
公开(公告)号：WO2011007282A1
公开(公告)日：2011-01-20
申请号：PCT/IB2010/052988
申请日：2010-06-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HIJLKEMA, Markus , NISATO, Giovanni , KASSIES, Roelf
发明人： HIJLKEMA, Markus , NISATO, Giovanni , KASSIES, Roelf
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/204 , A61M5/365 , A61M2205/18 , A61M2205/3306 , A61M2205/52
摘要： The apparatus allows the detection of light bubbles in the area of the pressurized fluid chamber or the nozzle of the micro-jet to detect bubbles by light scattering. Light is sent through the area of interest and detected behind it by a light detector. If the light intensity drops correspondingly a drop in the detector current is detected. This is indicative of unwanted bubbles. In this case the actuation of the electromechanical actuator to generate micro-jets may be stopped, alternatively or in additional signal may be output in order to inform a user to replace a fluid reservoir, or to simply issue an alarm. The fluid delivery device may comprise a durable and a disposable section, wherein the active parts such as power source, light source and light detector are integrated in the durable section and the disposable section comprises a nozzle and the fluid chamber which presents significant advantages, as the contact interface to the skin is frequently replaced and thus hygienic conditions are easy to maintain.
摘要翻译：该装置允许在加压流体室的区域或微喷嘴的喷嘴的区域中检测光气泡，以通过光散射来检测气泡。光通过感兴趣的区域发送并通过光检测器检测到。如果光强度相应降低，则检测器电流的下降。这表示不需要的气泡。在这种情况下，可以停止用于产生微射流的机电致动器的致动，或者可选地输出附加信号，以通知用户更换流体储存器，或简单地发出报警。流体输送装置可以包括耐用和一次性部分，其中诸如动力源，光源和光检测器的有源部件集成在耐用部分中，并且一次性部分包括喷嘴和流体室，其具有显着的优点，如经常更换与皮肤的接触界面，因此卫生条件易于维护。

9. 发明申请

WO2010150154A1 DETECTING A TEMPORAL ALTERATION OF AN OPTICAL PROPERTY OF A SUBCUTANEOUS LAYER FOR DRUG DELIVERY 审中-公开
标题翻译：检测用于药物递送的半成品层的光学性质的时间变化
公开(公告)号：WO2010150154A1
公开(公告)日：2010-12-29
申请号：PCT/IB2010/052741
申请日：2010-06-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NISATO, Giovanni , KASSIES, Roelf
发明人： NISATO, Giovanni , KASSIES, Roelf
IPC分类号： A61M5/30 , A61M5/168
CPC分类号： A61M5/30 , A61M5/16836 , A61M2005/1726 , A61M2205/3306 , A61M2205/587
摘要： Arrangement for detecting a temporal alteration of an optical property of a subcutaneous layer in vivo, drug delivery device (400) comprising the arrangement and method for drug delivery are described. For an optimized control of drug delivery by a transdermal drug delivery device an optical feedback control is described, which allows to detect the alteration of an optical property of a subcutaneous layer caused by an injected fluid from a fluid jet; and to control an actuator of the micro- jet pump in response to the fluid administered under the skin of a subject. If no drug is delivered transdermally the injection speed may be increased and the frequency as well as the injection speed may be controlled in dependence of each other following lookup tables that are generated during calibration of the device. A drug delivery device and a method for drug delivery make use of the optical detection for in situ and real time monitoring of injected substances.
摘要翻译：描述了用于检测体内皮下层的光学性质的时间变化的布置，包括药物递送的方法和装置的药物递送装置（400）。为了通过透皮药物递送装置优化的药物递送控制，描述了光学反馈控制，其允许检测由来自流体射流的注射流体引起的皮下层的光学性质的改变; 并且响应于在受试者的皮肤下施用的流体来控制微喷射泵的致动器。如果没有药物经皮递送，则可以增加注射速度，并且可以根据在设备校准期间产生的查找表之间的彼此依赖于控制频率以及注射速度。药物递送装置和药物递送方法利用光学检测用于原位和实时监测注射物质。

10. 发明申请

WO2009136304A2 DISPOSABLE DRUG CARTRIDGE 审中-公开
标题翻译：不可多得的药盒
公开(公告)号：WO2009136304A2
公开(公告)日：2009-11-12
申请号：PCT/IB2009/051684
申请日：2009-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KASSIES, Roelf , NISATO, Giovanni , RUBINGH, Jan-Eric, J., M.
发明人： KASSIES, Roelf , NISATO, Giovanni , RUBINGH, Jan-Eric, J., M.
IPC分类号： A61M37/00 , A61M5/30 , A61M5/142
CPC分类号： A61M5/30 , A61M5/14248 , A61M37/00 , A61M2005/14268 , A61M2005/3022 , B05B17/0607 , B05B17/0676
摘要： The present invention concerns a fully disposable medication cartridge concept for variable infusion systems based on needle-less, electrically activated jet-injection. The cartridge comprises medication reservoir, a micro jet pump cavity being in fluid communication with the medication reservoir, a pump membrane connected to the pump cavity, a nozzle for injection of a medication being in fluid communication with the pump cavity, and a connecting element for establishing mechanical contact with a power unit. The cartridge is designed in such a way that a sterile medication is never in contact with the reusable part of the delivery device. This fact ensures that the medication is not contaminated by the reusable part of the device. The pump mechanismofthe device induces a pressure in the pump cavity through the membrane.
摘要翻译：本发明涉及一种基于无针电活化喷射注射的可变输注系统的完全一次性药物盒概念。药筒包括药物储存器，与药物储存器流体连通的微喷射泵腔体，连接到泵腔的泵膜，用于注射与泵腔流体连通的药物的喷嘴，以及用于与动力单元建立机械接触。该盒被设计成使得无菌药物不会与递送装置的可重复使用的部分接触。这个事实确保了药物不被设备的可重复使用部分污染。设备的泵机构通过膜引起泵腔中的压力。

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