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1. 发明申请

WO2010035174A1 MAGNETIC-LABEL SENSOR AND CARTRIDGE 审中-公开
标题翻译：磁性标签传感器和盒子
公开(公告)号：WO2010035174A1
公开(公告)日：2010-04-01
申请号：PCT/IB2009/054046
申请日：2009-09-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN ZON, Hans , OVSYANKO, Mikhail, M. , NIEUWENHUIS, Jeroen, H.
发明人： VAN ZON, Hans , OVSYANKO, Mikhail, M. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01N21/552 , G01N15/1463 , G01N2015/1493
摘要： A cartridge (1,3) for a magnetic-label sensor, in particular for a magnetic-label biosensor, comprises a sensor area (4), a fluid channel (2) in contact with said sensor area and first (A) and second (Bl, B2) reservoirs in fluid communication with said fluid channel. The first reservoir comprises a first type of magnetic particles (8) and the second reservoir comprises a second type of magnetic particles (8a). The first type of magnetic particles are functionalized for binding with said sensor area, whereas the second type of magnetic particles are non- functionalized for binding with said sensor area. The magnetic particles (8, 8a) are manipulated using magnet (13). Detection is based on frustrated total internal reflection (FTIR) is hereby light from laser/LED (II) is reflected at sensor area (4) and detected by photodetector/CCD(12).
摘要翻译：用于磁标签传感器的磁带（1,3），特别是用于磁标签生物传感器，包括传感器区域（4），与所述传感器区域接触的流体通道（2）和第一（A）和第二（B1，B2）与所述流体通道流体连通的储存器。第一储存器包括第一类型的磁性颗粒（8），第二储存器包括第二类型的磁性颗粒（8a）。第一类型的磁性颗粒被功能化用于与所述传感器区域结合，而第二类型的磁性颗粒是非功能化的，用于与所述传感器区域结合。使用磁体（13）来操纵磁性颗粒（8,8a）。检测是基于沮丧的全内反射（FTIR）因此来自激光/ LED（II）被反射在传感器区域（4）处并由光电检测器/ CCD（12）检测。

2. 发明申请

WO2009087519A3 WETTING DETECTION AND REMOVAL 审中-公开
标题翻译：湿度检测和去除
公开(公告)号：WO2009087519A3
公开(公告)日：2009-11-26
申请号：PCT/IB2008055405
申请日：2008-12-18
申请人： KONINKL PHILIPS ELECTRONICS NV , NIEUWENHUIS JEROEN H
发明人： NIEUWENHUIS JEROEN H
IPC分类号： F25D21/02 , G01J5/58 , G01N21/35
CPC分类号： G01N21/15 , G01J5/02 , G01J5/026 , G01J5/60 , G01N21/3554 , G01N21/552 , G01N2021/158 , G01N2021/3595
摘要： An optical biosensor device for detecting the wetting of a sensor surface and/or means for removing wetting of an entrance and/or exit window of the light detection path comprising an infrared (IR) light source for emitting IR light having a first wavelength with a high absorption coefficient for a predetermined liquid.
摘要翻译：一种用于检测传感器表面的润湿的光学生物传感器装置和/或用于去除光检测路径的入口和/或出射窗口的润湿的装置，包括用于发射具有第一波长的IR光的红外（IR）光源，对于预定液体的高吸收系数。

3. 发明申请

WO2009125339A3 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 审中-公开
公开(公告)号：WO2009125339A3
公开(公告)日：2009-10-15
申请号：PCT/IB2009/051454
申请日：2009-04-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
发明人： SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
IPC分类号： G01N21/25 , G01N21/41
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (Ll) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.

4. 发明申请

WO2009125339A2 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 审中-公开
标题翻译：小样本容量光学检测的载体
公开(公告)号：WO2009125339A2
公开(公告)日：2009-10-15
申请号：PCT/IB2009051454
申请日：2009-04-07
申请人： KONINKL PHILIPS ELECTRONICS NV , SCHLEIPEN JOHANNES J H B , EVERS TOON H , NIEUWENHUIS JEROEN H , DITTMER WENDY U , BRULS DOMINIQUE M , PRINS MENNO W J , NEIJZEN JACOBUS H M , BOURQUIN YANNYK P J
发明人： SCHLEIPEN JOHANNES J H B , EVERS TOON H , NIEUWENHUIS JEROEN H , DITTMER WENDY U , BRULS DOMINIQUE M , PRINS MENNO W J , NEIJZEN JACOBUS H M , BOURQUIN YANNYK P J
IPC分类号： G01N21/25 , G01N21/41
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (Ll) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及用于在样本室（2）中的样本（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻样品室（2）中并且用于从源自样品室（2）的光中收集输出光束（L2）的光学结构（50）来自输入光束。优选地，光学结构（50）包括载体（11）的表面（12）中的凹槽，其中输入光束以短距离穿过样本传输。光学结构（50）也可以用于润湿检测。

5. 发明申请

WO2009069009A1 OPTICAL DETECTION OF PARTICLES IN A MAGNETIC BIOSENSOR USING A WAVEGUIDE 审中-公开
标题翻译：使用波导的磁性生物传感器中的颗粒的光学检测
公开(公告)号：WO2009069009A1
公开(公告)日：2009-06-04
申请号：PCT/IB2008/050412
申请日：2008-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
发明人： JOHNSON, Mark, T. , IMMINK, Albert, H., J. , DE BOER, Dirk, K., G. , PRINS, Menno, W., J. , NIEUWENHUIS, Jeroen, H. , VERSCHUREN, Coen, A.
IPC分类号： G01N21/55 , G01N33/543 , G01N33/487
CPC分类号： G01N27/745 , G01N21/552 , G01N21/7703 , G01N33/54333 , G01N33/54373
摘要： The present invention provides a biosensor device comprising a sensor surface and an optical wave guide having an input, an output and first and second surfaces, said optical wave guide (5) being adapted to direct light entering the optical wave guide (5) through the input (20) to the output (21) via multiple reflections on said first and second surfaces (22, 23) including at least one reflection onsaid first surface (22) under an angle fulfilling the condition of total internal reflection, wherein the sensor surface is adjacent to the first surface of total internal reflection.
摘要翻译：本发明提供了一种生物传感器装置，其包括具有输入，输出和第一和第二表面的传感器表面和光波导，所述光波导（5）适于将进入光波导（5）的光引导通过通过在所述第一和第二表面（22,23）上的多个反射将输入（20）输入（20），所述第一和第二表面（22,23）包括在满足全内反射条件的角度下的至少一个反射的第一表面（22），其中传感器表面与全内反射的第一表面相邻。

6. 发明申请

WO2008120169A1 SENSOR DEVICE WITH MAGNETIC WASHING MEANS 审中-公开
标题翻译：具有磁性清洗装置的传感器装置
公开(公告)号：WO2008120169A1
公开(公告)日：2008-10-09
申请号：PCT/IB2008/051200
申请日：2008-03-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen, H. , VAN LANKVELT, Petrus, J., W.
发明人： NIEUWENHUIS, Jeroen, H. , VAN LANKVELT, Petrus, J., W.
IPC分类号： G01N35/00 , G01R33/12 , G01N33/543 , G01N15/06
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2400/043 , G01N15/06 , G01N15/0656 , G01N27/745 , G01N35/0098 , G01R33/12 , G01R33/1269
摘要： The invention relates to a sensor device, particularly a magnetic sensor device (200), for detecting magnetic particles (2) in a sensitive region (202) of a sample chamber (201). Magnetic particles (1) can be moved with the help of magnetic forces from the sensitive region (202) into a dump region (203), which is arranged such that the magnetic particles (1) cannot return to the sensitive region (202) by pure sedimentation. The separation between the sensitive and the dump region can optionally be enforced by a barrier (204).
摘要翻译：本发明涉及一种用于检测样品室（201）的敏感区域（202）中的磁性颗粒（2）的传感器装置，特别是磁性传感器装置（200）。磁性颗粒（1）可以借助于来自敏感区域（202）的磁力移动到倾倒区域（203）中，磁性颗粒（1）被布置成使得磁性颗粒（1）不能通过以下方式返回到敏感区域（202）：纯沉淀。敏感和倾倒区域之间的分离可以选择性地由障碍物（204）来执行。

7. 发明申请

WO2010133997A1 DIAGNOSTIC DEVICE WITH SAMPLE APPLICATION DETECTOR 审中-公开
标题翻译：具有样品应用检测器的诊断装置
公开(公告)号：WO2010133997A1
公开(公告)日：2010-11-25
申请号：PCT/IB2010/052015
申请日：2010-05-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , IMMINK, Albert, H., J. , NIEUWENHUIS, Jeroen, H. , MAAS, Joost, H.
发明人： IMMINK, Albert, H., J. , NIEUWENHUIS, Jeroen, H. , MAAS, Joost, H.
IPC分类号： B01L3/00 , G01N33/487
CPC分类号： B01L3/5027 , B01L2200/0605 , B01L2300/0627 , B01L2300/0645 , B01L2300/0681 , B01L2300/168
摘要： The present invention relates to cartridges (1) for diagnostic devices comprising a sample fluid application region (2), a reaction chamber (4) and a channel (3) connecting the application region to the reaction chamber. The device further comprises sensors (5, 6, 7) to detect the application of a sample and to detect the filling of the reaction chamber.
摘要翻译：本发明涉及用于诊断装置的药筒（1），其包括样品流体施用区域（2），反应室（4）和将施用区域连接到反应室的通道（3）。该装置还包括用于检测样品的应用并检测反应室的填充的传感器（5,6,7）。

8. 发明申请

WO2010049883A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：WO2010049883A1
公开(公告)日：2010-05-06
申请号：PCT/IB2009/054740
申请日：2009-10-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NEIJZEN, Jacobus, H., M. , WIMBERGER-FRIEDL, Reinhold , MAAS, Joost, H. , NIEUWENHUIS, Jeroen, H. , BRULS, Dominique, M. , IMMINK, Albert, H., J. , OVSYANKO, Mikhail, M.
发明人： NEIJZEN, Jacobus, H., M. , WIMBERGER-FRIEDL, Reinhold , MAAS, Joost, H. , NIEUWENHUIS, Jeroen, H. , BRULS, Dominique, M. , IMMINK, Albert, H., J. , OVSYANKO, Mikhail, M.
IPC分类号： G01N33/543 , G01N35/00 , G01R33/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

9. 发明申请

WO2009115951A1 CARTRIDGE FOR ASSAYS WITH MAGNETIC PARTICLES 审中-公开
标题翻译：用于磁性颗粒测定的盒子
公开(公告)号：WO2009115951A1
公开(公告)日：2009-09-24
申请号：PCT/IB2009/051021
申请日：2009-03-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
发明人： SIJBERS, Mara, J., J. , VAN LANKVELT, Petrus, J., W. , DE THEIJE, Femke, K. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , B03C1/282 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N27/745 , G01N33/54373 , G01N33/946 , G01N33/948 , G01N33/9486
摘要： The invention relates to a cartridge (100) and a corresponding sensor device for the detection of target components in a liquid sample. The cartridge (100) comprises a sample chamber(SC), at least two reservoirs(131, 132) that can be furnished with magnetic particles(MP, MP'), and at least two corresponding sensitive zones (121, 122) in which solved magnetic particles and/or target components can be detected. When a magnetic actuation field(B) of a given configuration is established in the sample chamber, the magnetic particles of different reservoirs migrate predominantly to different sensitive zones. Thus a mixing of magnetic particles can be avoided.
摘要翻译：本发明涉及一种用于检测液体样品中的目标组分的盒（100）和相应的传感器装置。盒（100）包括样品室（SC），至少两个可以配备有磁性颗粒（MP，MP'）和至少两个对应的敏感区域（121,122）的储存器（131,132），其中可以检测到溶解的磁性颗粒和/或目标成分。当在样品室中建立给定构造的磁致动场（B）时，不同储层的磁性颗粒主要迁移到不同的敏感区域。因此，可以避免磁性颗粒的混合。

10. 发明申请

WO2009027935A9 BIOCHEMICAL SENSOR CARTRIDGE 审中-公开
公开(公告)号：WO2009027935A9
公开(公告)日：2009-03-05
申请号：PCT/IB2008/053453
申请日：2008-08-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen, H. , PELSSERS, Eduard, G. M. , REIJNDORP, Jochem , IMMINK, Albert, H., J. , MATTERS, Marco , MEUFFELS, Maria, E., H., G.
发明人： NIEUWENHUIS, Jeroen, H. , PELSSERS, Eduard, G. M. , REIJNDORP, Jochem , IMMINK, Albert, H., J. , MATTERS, Marco , MEUFFELS, Maria, E., H., G.
IPC分类号： A61B10/00 , B01L3/00
摘要： The invention relates to a (bio-)chemical sensor cartridge (100) for the examination of samples like blood or saliva, which comprises a sample collection element (e.g. a swab (120)), a sensor element (130) for sensing a parameter of interest, a sample transportation mechanism (110) for transferring the sample from the sample collection element (120) to the sensor element (130), and a connector (140) for linking the device to an external reader. The sample transportation mechanism (110) may particularly comprise a reservoir (111) with a buffer liquid that can be transferred via the sample collection element (120) to the sensor element (130). Moreover, the cartridge preferably consists of two parts (101, 102) that can reversibly be connected.

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