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1. 发明申请

WO2012091452A2 BIOCOMPATIBLE AGENT FOR DISPERSING NANOPARTICLES INTO AN AQUEOUS MEDIUM USING MUSSEL ADHESIVE PROTEIN-MIMETIC POLYMER 审中-公开
标题翻译：使用MUSSEL粘合蛋白 - 模拟聚合物将纳米颗粒分散到水介质中的生物相容剂
公开(公告)号：WO2012091452A2
公开(公告)日：2012-07-05
申请号：PCT/KR2011010230
申请日：2011-12-28
申请人： HANWHA CHEMICAL CORP , HYEON TAEGHWAN , NA KUN , LING DAISHUN , PARK WOORAM
发明人： HYEON TAEGHWAN , NA KUN , LING DAISHUN , PARK WOORAM
IPC分类号： C08G73/00 , A61K49/06 , C08G65/08 , C08G73/04
CPC分类号： C08G73/024 , A61K8/91 , A61K49/1857 , A61K49/1887 , C08G73/02 , C08G81/00 , C08G2261/128 , C08L71/02 , C08L2205/03 , C08L79/02
摘要： Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine-graft-(polyethyleneglycol;polyDOPA) PEI-graft-(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.
摘要翻译：本发明提供将纳米粒子分散在水性介质中的贻贝粘附性模拟蛋白质分散稳定剂，包含通过分散稳定剂分散并稳定的纳米粒子的胶体溶液以及包含该胶体溶液的造影剂。更具体地说，贻贝粘附蛋白 - 模拟物分散稳定剂是聚乙烯亚胺 - 接枝 - （聚乙二醇;聚DOPA）PEI-接枝 - （PEG; PDOPA）。接枝聚合物由两部分组成。一种是聚乙二醇接枝的聚乙二醇，其对水性介质具有亲和性，另一种是聚DOPA，其对纳米颗粒的表面具有亲和性。由于这些特性，稳定剂显示纳米颗粒在水性介质中的稳定分散。

2. 发明申请

WO2011059216A9 MEDICAL STENT COATED WITH PHOTOSENSITIZER, AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：用光敏剂包衣的医疗用品及其制备方法
公开(公告)号：WO2011059216A9
公开(公告)日：2011-08-04
申请号：PCT/KR2010007890
申请日：2010-11-09
申请人： CATHOLIC UNIV IND ACAD COOP , NA KUN
发明人： NA KUN
IPC分类号： A61L27/34 , A61F2/82 , A61L27/04 , A61L27/54 , A61L27/58
CPC分类号： A61L31/10 , A61L31/16
摘要： The present invention relates to a medical stent coated with a photosensitizer, and a preparation method thereof, and more specifically, to a composition for coating a stent for photodynamic therapy, comprising a photosensitizer, a non-degradable polymer and an organic solvent, a medical stent coated with a photosensitizer, comprising a layer coated with the coating composition, a preparation method of the stent, and photodynamic therapy using the stent. A medical stent coated with the coating composition according to the present invention, is prepared by dissolving a photosensitizer and a non-degradable polymer in an organic solvent; coating a stent with a coating solvent where the photosensitizer and the non-degradable polymer are dissolved; and volatilizing the coating solvent. Excellent treatment effects can be induced in vivo even after a long time since a photosensitizer, which is a pharmaceutically active material, is adhered to a stent for a long time by a non-degradable polymer, and a patient can be up and around outside after operation since only target cells can be selectively treated according to whether light is irradiated, in vivo side effects are small compared with known photodynamic therapy through transdermal or oral administration and it is possible to repeatedly carry out operations several times.
摘要翻译：本发明涉及一种涂有光敏剂的医用支架及其制备方法，更具体地说，涉及用于光动力治疗用支架涂敷用组合物，其包含光敏剂，不可降解聚合物和有机溶剂，医用用光敏剂涂覆的支架，包括涂覆有涂层组合物的层，支架的制备方法和使用该支架的光动力学治疗。通过将光敏剂和不可降解聚合物溶解在有机溶剂中来制备涂覆有根据本发明的涂料组合物的医用支架; 用溶解有光敏剂和不可降解聚合物的涂布溶剂涂覆支架; 并挥发涂布溶剂。由于作为药物活性物质的光敏剂通过不可降解聚合物长时间粘附在支架上，所以即使经过长时间也可以在体内诱导出优异的治疗效果，患者可以在不可降解的聚合物之后向上和向外外因为只要靶细胞能够根据是否照射光被选择性地进行治疗，与通过透皮或口服给药的已知的光动力疗法相比，体内副作用小，并且可以反复进行多次操作。

3. 发明申请

WO2012002715A3 TEMPERATURE-SENSITIVE BIOACTIVE MATERIAL CARRIER AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：温度敏感的生物活性物质载体及其制备方法
公开(公告)号：WO2012002715A3
公开(公告)日：2012-05-03
申请号：PCT/KR2011004732
申请日：2011-06-29
申请人： CATHOLIC UNIV IND ACAD COOP , NA KUN , JUNG YOUNG SEOK
发明人： NA KUN , JUNG YOUNG SEOK
IPC分类号： A61K47/48 , A61K47/30 , A61K47/36
CPC分类号： A61K9/4816 , A61K38/47 , A61K41/0028 , A61K47/36 , A61K47/593 , A61K47/61 , A61L27/26 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/62 , C08L67/04 , C08L5/08
摘要： The present invention relates to a temperature-sensitive bioactive material carrier and to a method for preparing same. More particularly, the present invention relates to a temperature-sensitive bioactive material carrier and to a method for preparing same, wherein the carrier comprises a biodegradable amphiphilic block copolymer, wherein said coplymer comprises polysaccharides or both polysaccharides and succinic anhydrides as a hydrophilic block, and polylactides as a nonionic block. The hydrophilic polymer/polylactide copolymer according to the present invention forms stable composites in in-vivo conditions through ionic bonding or temperature-sensitive hydrophobic bonding to bioactive materials such as proteins, polynucléotides, or the like, thus enabling the easy in vivo delivery of bioactive material, and therefore can be used as an in vivo drug delivery system.
摘要翻译：温度敏感性生物活性物质载体及其制备方法本发明涉更具体地说，本发明涉及温度敏感的生物活性物质载体及其制备方法，其中载体包含生物可降解的两性嵌段共聚物，其中所述共聚物包含多糖或者作为亲水嵌段的多糖和琥珀酸酐二者，以及聚丙交酯作为非离子嵌段。根据本发明的亲水性聚合物/聚丙交酯共聚物通过离子键或温度敏感的疏水键与生物活性物质如蛋白质，多核苷酸等形成在体内条件下的稳定复合物，因此能够容易地体内递送生物活性材料，因此可以用作体内药物递送系统。

4. 发明申请

WO2011059216A3 MEDICAL STENT COATED WITH PHOTOSENSITIZER, AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：包含光敏剂的医用支架及其制备方法
公开(公告)号：WO2011059216A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007890
申请日：2010-11-09
申请人： CATHOLIC UNIV IND ACAD COOP , NA KUN
发明人： NA KUN
IPC分类号： A61L27/34 , A61F2/82 , A61L27/04 , A61L27/54 , A61L27/58
CPC分类号： A61L31/10 , A61L31/16
摘要： The present invention relates to a medical stent coated with a photosensitizer, and a preparation method thereof, and more specifically, to a composition for coating a stent for photodynamic therapy, comprising a photosensitizer, a non-degradable polymer and an organic solvent, a medical stent coated with a photosensitizer, comprising a layer coated with the coating composition, a preparation method of the stent, and photodynamic therapy using the stent. A medical stent coated with the coating composition according to the present invention, is prepared by dissolving a photosensitizer and a non-degradable polymer in an organic solvent; coating a stent with a coating solvent where the photosensitizer and the non-degradable polymer are dissolved; and volatilizing the coating solvent. Excellent treatment effects can be induced in vivo even after a long time since a photosensitizer, which is a pharmaceutically active material, is adhered to a stent for a long time by a non-degradable polymer, and a patient can be up and around outside after operation since only target cells can be selectively treated according to whether light is irradiated, in vivo side effects are small compared with known photodynamic therapy through transdermal or oral administration and it is possible to repeatedly carry out operations several times.
摘要翻译：本发明涉及一种涂覆有光敏剂的医用支架及其制备方法，更具体地，涉及一种用于光动力治疗的支架涂覆用组合物，其包含光敏剂，不可降解聚合物和有机溶剂，医疗覆盖有光敏剂的支架，该支架包括涂覆有涂层组合物的层，支架的制备方法以及使用该支架的光动力治疗。用根据本发明的涂层组合物涂覆的医用支架是通过将光敏剂和不可降解的聚合物溶解在有机溶剂中而制备的; 用溶解光敏剂和不可降解聚合物的涂布溶剂涂覆支架; 并挥发涂布溶剂。由于作为药物活性物质的光敏剂通过不可降解的聚合物长时间地附着在支架上，并且患者可以在不久之后在患者体内外周围上升，所以即使长时间后也能够在体内诱导优异的治疗效果因为只有靶细胞能够根据是否受到光照而被选择性地处理，所以与已知的通过透皮或口服给药的光动力疗法相比，体内副作用小，并且可以重复进行多次操作。

5. 发明申请

WO2010128787A2 GADOLINIUM COMPLEX, METHOD FOR PREPARING SAME, AND MRI CONTRAST AGENT COMPRISING SAME 审中-公开
标题翻译：甘油复合物，其制备方法和包括其的MRI对比剂
公开(公告)号：WO2010128787A2
公开(公告)日：2010-11-11
申请号：PCT/KR2010002819
申请日：2010-05-04
申请人： CATHOLIC UNIV IND ACAD COOP , NA KUN , YIM HYEON A
发明人： NA KUN , YIM HYEON A
IPC分类号： C07F5/00 , A61K49/06
CPC分类号： A61K49/128 , C08B37/0018
摘要： The present invention provides a gadolinium complex in which gadolinium is coordinated with and covalently bonded to diethylenetriamine pentaacetic acid (DTPA) dianhydride of a pullulan-DTPA conjugate prepared by ester-bonding pullulan to DTPA, to a method for preparing same, to an MRI contrast agent composition containing the complex, and to a method for providing information for diagnosing a disease using the complex as an MRI contrast agent. The gadolinium-DTPA complex in which pullulan is ester-bonded to DTPA according to the present invention has a prolonged in vivo half-life, less toxicity, and a signal with a higher strength for providing a clearer MRI when compared with conventional gadolinium-DTPA complexes. Therefore, the gadolinium-DTPA complex of the present invention can not only be advantageously used as an MRI contrast agent but also produces MRI images in which a liver disease portion and a normal tissue portion can be discriminated, and can thus be used as an MRI contrast agent for the liver.
摘要翻译：本发明提供了一种钆配合物，其中钆与通过酯键合支链淀粉制备的DTPA制备的支链淀粉-DTPA缀合物的二亚乙基三胺五乙酸（DTPA）二酐配位并共价键合到其制备方法，与MRI对比含有复合物的药剂组合物，以及使用该复合物作为MRI造影剂提供用于诊断疾病的信息的方法。根据本发明的支链淀粉与DTPA酯键合的钆-DTPA复合物与常规的钆-DTPA相比具有延长的体内半衰期，较少的毒性，以及具有较高强度的信号以提供更清晰的MRI 复合物。因此，本发明的钆-DTPA复合物不仅可以有利地用作MRI造影剂，而且可以产生可以区分肝脏疾病部分和正常组织部分的MRI图像，因此可以用作MRI 造影剂用于肝脏。

6. 发明申请

WO2006049463A1 HEMOSTATIC AGENT INTERNALLY APPLIED THROUGH ENDOSCOPE AND APPLICATION METHOD THEREOF 审中-公开
标题翻译：通过内窥镜应用的止血药物及其应用方法
公开(公告)号：WO2006049463A1
公开(公告)日：2006-05-11
申请号：PCT/KR2005/003730
申请日：2005-11-04
申请人： NA, Kun , LEE, Don Haeng
发明人： NA, Kun , LEE, Don Haeng
IPC分类号： A61K31/74
CPC分类号： A61K31/74
摘要： Provided is a hemostatic agent for internal body use, which can be applied onto a bleeding lesion of the gastrointestinal tract by an endoscopic hemostatic method, and a method of applying the hemostatic agent onto the bleeding lesion. The coating agent is a polymer solution prepared by dissolving a cationic or an anionic reaction product into a polysaccharide solution. The coating agent hemostatic agent for stopping bleeding from a lesion of a mucous membrane by being applied onto the lesion of the mucous membrane through an endoscope, comprising a coating agent as a polymer solution prepared by dissolving a cationic or an anionic reaction product into a polysaccharide solution, wherein the coating agent has adherence high enough to flowthrough an endoscope catheter, biocompatibility, and bioadherence induced by the interaction with mucous membrane due to hydrogen bonds, ion bonds or hydrophobic bonds. According to the hemostatic agent and method thereof, since the hemostatic agent is applied onto an ulcer through an endoscope, the ulcer can be completely covered with the hemostatic agent. As a result, bleeding from the ulcer can be totally stopped and there is no major probability of rebleeding. Further, since the hemostatic agent contains the supplement, the ulcer can be cured by the medical effect and growth factor of the supplement.
摘要翻译：本发明提供一种用于体内止血剂的止血剂，其可以通过内窥式止血方法施用于胃肠道的出血性病变，以及将止血剂施用于出血性病变的方法。涂层剂是通过将阳离子或阴离子反应产物溶解在多糖溶液中制备的聚合物溶液。用于通过内窥镜施用于粘膜损伤上止血的涂剂止血剂，其包含作为通过将阳离子或阴离子反应产物溶解于多糖而制备的聚合物溶液的包衣剂溶液，其中涂层剂具有足够高的穿过内窥镜导管的粘附性，由于氢键，离子键或疏水键与粘膜的相互作用诱导的生物相容性和生物相容性。根据止血剂及其方法，由于止血剂通过内窥镜施用于溃疡，所以可以用止血剂完全覆盖溃疡。结果，溃疡出血可以完全停止，再出血的可能性不大。此外，由于止血剂含有补充剂，因此可以通过补充剂的医疗效果和生长因子来治愈溃疡。

7. 发明申请

WO2012087040A3 CONJUGATE FOR PHOTODYNAMIC DIAGNOSIS OR THERAPY AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：共轭用于光动力学诊断或治疗以及制备相同的方法
公开(公告)号：WO2012087040A3
公开(公告)日：2012-10-04
申请号：PCT/KR2011009967
申请日：2011-12-21
申请人： PANAXEM CO LTD , NA KUN , LI FANG YUAN , BAE BYOUNG CHAN
发明人： NA KUN , LI FANG YUAN , BAE BYOUNG CHAN
IPC分类号： A61K31/695 , A61K31/315 , A61K31/702 , A61K49/06 , A61K49/10 , A61K49/12 , C09B47/04
CPC分类号： A61K47/4823 , A61K41/0071 , A61K49/0036 , A61K49/0054
摘要： The present invention relates to a conjugate of acetylated biocompatible polysaccharide and phthalocyanine compound for photodynamic diagnosis or therapy and to a method for preparing the same, and more particularly, to a conjugate for photodynamic diagnosis or therapy and to a method for preparing the same, in which biocompatible polysaccharide is acetylated and a phthalocyanine compound is bound to the acetylated polysaccharide. The conjugate for photodynamic diagnosis or therapy according to the present invention is characterized in that the polysaccharide is acetylated to improve solubility in a solvent and thus enable various chemical modifications, and the conjugate may specifically target tumor cells, has superior cancer cell selecting and accumulating capacity, and has excellent effects of killing cancer cells when near infrared ray is irradiated. The conjugate of the present invention may not show cytotoxicity for cells other than cancer cells even when near infrared ray is irradiated, and thus exhibits superior in vivo stability, and therefore, may be valuably used in disease diagnosis or therapy using photodynamics.
摘要翻译：本发明涉及用于光动力学诊断或治疗的乙酰化生物相容性多糖和酞菁化合物的缀合物及其制备方法，更具体地涉及用于光动力学诊断或治疗的缀合物及其制备方法，该生物相容性多糖被乙酰化并且酞菁化合物与乙酰化多糖结合。根据本发明的用于光动力学诊断或治疗的缀合物的特征在于多糖被乙酰化以提高在溶剂中的溶解度并因此能够进行各种化学修饰，并且该缀合物可以特异性靶向肿瘤细胞，具有优异的癌细胞选择和积聚能力并且在接近红外线照射时具有杀死癌细胞的优异效果。本发明的缀合物即使在照射近红外线时也不显示对癌细胞以外的细胞的细胞毒性，因此显示优异的体内稳定性，因此可以有价值地用于疾病诊断或使用光动力学的治疗。

8. 发明申请

WO2012091452A3 BIOCOMPATIBLE AGENT FOR DISPERSING NANOPARTICLES INTO AN AQUEOUS MEDIUM USING MUSSEL ADHESIVE PROTEIN-MIMETIC POLYMER 审中-公开
公开(公告)号：WO2012091452A3
公开(公告)日：2012-07-05
申请号：PCT/KR2011/010230
申请日：2011-12-28
申请人： HANWHA CHEMICAL CORPORATION , HYEON, Taeghwan , NA, Kun , LING, Daishun , PARK, Wooram
发明人： HYEON, Taeghwan , NA, Kun , LING, Daishun , PARK, Wooram
IPC分类号： C08G73/00 , C08G73/04 , C08G65/08 , A61K49/06
摘要： Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine- graft -(polyethyleneglycol;polyDOPA) PEI- graft -(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.

9. 发明申请

WO2009102121A3 SOLID LIPID NANOPARTICLES FOR DRUG DELIVERY, A PRODUCTION METHOD THEREFOR, AND AN INJECTABLE PREPARATION COMPRISING THE NANOPARTICLES 审中-公开
标题翻译：用于药物递送的固体脂质纳米颗粒及其生产方法和包含纳米颗粒的可注射制剂
公开(公告)号：WO2009102121A3
公开(公告)日：2009-10-22
申请号：PCT/KR2009000530
申请日：2009-02-04
申请人： MECOX CUREMED CO LTD , NA KUN , JIN SANG-WOO , LEE DON-HAENG , HAHM KI-BAIK , SHINN HYUN-CHUL , CHUNG GREGORY-JY
发明人： NA KUN , JIN SANG-WOO , LEE DON-HAENG , HAHM KI-BAIK , SHINN HYUN-CHUL , CHUNG GREGORY-JY
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61K47/30
CPC分类号： A61K9/5123 , A61K9/5146 , A61K47/10 , A61K47/46
摘要： The present invention provides solid lipid nanoparticles for drug delivery, which take the form of a shell made of a poloxamer and, present within the shell, a nanolipid core comprising a lipid matrix of a mixture of cacao powder and a drug. The invention also provides a production method for the same, and an injectable preparation comprising the solid lipid nanoparticles.
摘要翻译：本发明提供用于药物递送的固体脂质纳米粒子，其采用由泊洛沙姆制成的壳的形式，并且存在于壳内的纳米脂质核包含可可粉和药物的混合物的脂质基质。本发明还提供了其制备方法，以及包含该固体脂质纳米颗粒的可注射制剂。

10. 发明申请

WO2010128787A9 GADOLINIUM COMPLEX, METHOD FOR PREPARING SAME, AND MRI CONTRAST AGENT COMPRISING SAME 审中-公开
标题翻译： GADOLINIUM复合物，其制备方法以及包含该复合物的MRI造影剂
公开(公告)号：WO2010128787A9
公开(公告)日：2011-05-12
申请号：PCT/KR2010002819
申请日：2010-05-04
申请人： CATHOLIC UNIV IND ACAD COOP , NA KUN , YIM HYEON A
发明人： NA KUN , YIM HYEON A
IPC分类号： C07F5/00 , A61K49/06
CPC分类号： A61K49/128 , C08B37/0018
摘要： The present invention provides a gadolinium complex in which gadolinium is coordinated with and covalently bonded to diethylenetriamine pentaacetic acid (DTPA) dianhydride of a pullulan-DTPA conjugate prepared by ester-bonding pullulan to DTPA, to a method for preparing same, to an MRI contrast agent composition containing the complex, and to a method for providing information for diagnosing a disease using the complex as an MRI contrast agent. The gadolinium-DTPA complex in which pullulan is ester-bonded to DTPA according to the present invention has a prolonged in vivo half-life, less toxicity, and a signal with a higher strength for providing a clearer MRI when compared with conventional gadolinium-DTPA complexes. Therefore, the gadolinium-DTPA complex of the present invention can not only be advantageously used as an MRI contrast agent but also produces MRI images in which a liver disease portion and a normal tissue portion can be discriminated, and can thus be used as an MRI contrast agent for the liver.
摘要翻译：本发明提供了一种钆配合物，其中钆与将普鲁兰多糖与DTPA酯键合制备的普鲁兰多糖-DTPA缀合物的二亚乙基三胺五乙酸（DTPA）二酐配位并共价键合至其制备方法，MRI对比包含该复合物的药物组合物，以及使用该复合物作为MRI造影剂提供用于诊断疾病的信息的方法。根据本发明的其中支链淀粉与DTPA酯键结合的钆-DTPA复合物与常规钆-DTPA相比具有延长的体内半衰期，更小的毒性和更高强度的信号以提供更清晰的MRI 复合物。因此，本发明的钆DTPA复合物不仅可以有利地用作MRI造影剂，而且还可以产生其中肝脏疾病部分和正常组织部分可以被区分的MRI图像，因此可以用作MRI 造影剂为肝脏。

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