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1. 发明申请

WO2012161539A3 SIRNA FOR INHIBITING THE EXPRESSION OF BHRF1 AND COMPOSITION COMPRISING SAME 审中-公开
标题翻译： SIRNA用于抑制BHRF1的表达和包含其的组合物
公开(公告)号：WO2012161539A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012004135
申请日：2012-05-24
申请人： CATHOLIC UNIV IND ACAD COOP , LEE SUK-KYEONG , SHIN HEE-JONG
发明人： LEE SUK-KYEONG , SHIN HEE-JONG
IPC分类号： C12N15/113 , A61K31/7105 , A61K48/00 , A61P35/00
CPC分类号： A61K31/713 , C12N15/1131 , C12N2310/14
摘要： The present invention relates to an siRNA which inhibits the expression of BHRF1 in the Epstein-Bar virus (EBV), and to a compound for inhibiting resistance to anticancer medications using the siRNA. More particularly, the present invention relates to an siRNA which inhibits the expression of BHRF1, and to a composition for inhibiting resistance to anticancer medications for the treatment of EBV-positive stomach cancer, comprising the siRNA. Further, the present invention relates to a composition for the treatment of EBV-positive stomach cancer, comprising the siRNA and the anti-cancer agent.
摘要翻译：本发明涉及抑制EB病毒（EBV）中BHRF1表达的siRNA和使用siRNA抑制抗癌药物抗性的化合物。更具体地说，本发明涉及抑制BHRF1表达的siRNA，以及涉及用于抑制抗癌药物治疗EBV阳性胃癌抗性的组合物，其包含该siRNA。此外，本发明涉及用于治疗EBV阳性胃癌的组合物，其包含siRNA和抗癌剂。

2. 发明申请

WO2012141536A2 COMPOSITION FOR REGENERATING CONNECTIVE TISSUE, AND METHOD FOR REGENERATING CONNECTIVE TISSUE 审中-公开
标题翻译：用于再生连接组织的组合物和用于再生连接组织的方法
公开(公告)号：WO2012141536A2
公开(公告)日：2012-10-18
申请号：PCT/KR2012002835
申请日：2012-04-13
申请人： CATHOLIC UNIV IND ACAD COOP , KIM SEOK-JUNG
发明人： KIM SEOK-JUNG
IPC分类号： A61K31/55 , A61K31/728 , A61P7/00 , A61P7/02
CPC分类号： A61K31/55 , A61K31/728
摘要： The present invention relates to a composition for regenerating connective tissue and to a method for regenerating connective tissue, and more particularly, to a composition for regenerating connective tissue and to a method for regenerating a connective tissue, wherein the composition is formed by mixing hyarulonic acid and fibrinogen with atelocollagen or a myelocyte, and injected into the damaged portion of connective tissue, to thereby regenerate the connective tissue of the damaged portion. The composition for regenerating connective tissue according to the present invention may effectively regenerate a damaged portion of connective tissue, and specifically may exhibit activity in regenerating cartilage having a low regenerative capacity. Further, the composition of the present invention uses a natural material and therefore is harmless to the human body. The composition of the present invention may regenerate tissue-engineered cartilage that is similar to natural cartilage, and therefore may be valuably used as a therapeutic agent for cartilage which can effectively repair damaged cartilage tissue.
摘要翻译：本发明涉及一种用于再生结缔组织的组合物和一种用于再生结缔组织的方法，更具体地，涉及一种用于再生结缔组织的组合物和一种再生结缔组织的方法，其中该组合物通过将hyarulonic acid 和纤维蛋白原与成纤维细胞或骨髓细胞，并注射到结缔组织的损伤部分，从而再生损伤部分的结缔组织。根据本发明的用于再生结缔组织的组合物可以有效地再生结缔组织的损伤部分，并且具体可能表现出在再生能力低的软骨再生中的活性。此外，本发明的组合物使用天然材料，因此对人体无害。本发明的组合物可以再生类似于天然软骨的组织工程化软骨，因此可以有价值地用作可有效修复受损软骨组织的软骨治疗剂。

3. 发明申请

WO2012134187A2 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MACULAR DEGENERATION 审中-公开
标题翻译：用于预防或治疗黄斑变性的药物组合物
公开(公告)号：WO2012134187A2
公开(公告)日：2012-10-04
申请号：PCT/KR2012002310
申请日：2012-03-29
申请人： KOREA RES INST CHEM TECH , CATHOLIC UNIV IND ACAD COOP , YI KYU-YANG , YOO SUNG-EUN , KIM NACK-JEONG , SUH JEE-HEE , JOO CHOUN-KI , CHOI JUN-SUB , YANG JAE-SIK , LEE GEUN-HYEOG , CHO YUN-SEOK , PARK JIN-HA , LEE HYE-SUNG
发明人： YI KYU-YANG , YOO SUNG-EUN , KIM NACK-JEONG , SUH JEE-HEE , JOO CHOUN-KI , CHOI JUN-SUB , YANG JAE-SIK , LEE GEUN-HYEOG , CHO YUN-SEOK , PARK JIN-HA , LEE HYE-SUNG
IPC分类号： A61K31/4164 , A61K31/35 , A61P27/02
CPC分类号： A61K9/0048 , A61K31/4178
摘要： The present invention relates to a pharmaceutical composition for preventing or treating macular degeneration. The pharmaceutical composition of the present invention contains, as an active ingredient, benzopyrane derivatives substituted with secondary amines including imidazole, or the pharmaceutically acceptable salts thereof. The pharmaceutical composition of the present invention may be used in the form of eye drops.
摘要翻译：本发明涉及用于预防或治疗黄斑变性的药物组合物。本发明的药物组合物含有用包括咪唑的仲胺取代的苯并吡喃衍生物或其药学上可接受的盐作为活性成分。本发明的药物组合物可以以滴眼剂的形式使用。

4. 发明申请

WO2011065753A3 FLOW CYTOMETRY METHOD THROUGH THE CONTROL OF FLUORESCENCE INTENSITIES 审中-公开
标题翻译：通过控制荧光强度的流式细胞计数方法
公开(公告)号：WO2011065753A3
公开(公告)日：2011-11-17
申请号：PCT/KR2010008366
申请日：2010-11-24
申请人： CATHOLIC UNIV IND ACAD COOP , HAN KYUNG JA
发明人： HAN KYUNG JA
IPC分类号： G01N33/533 , C12Q1/04 , G01N33/52 , G06F19/00
CPC分类号： G01N33/56972
摘要： The present invention provides a new flow cytometry method comprising: performing a necessary control of the cell populations targeted by an antibody to which fluorescent pigments of the same color are conjugated such that the cell populations show different fluorescent intensities according to the type of an antibody. In contrast to conventional flow cytometry methods where the categorization of positive and negative expressions of only one target can be made by using one antibody for each single color, the method of the present invention allows the categorization of positive and negative expressions of a plurality of targets using only one color, by controlling various types of antibodies to which fluorescent pigments of the same color are conjugated in such a manner that the antibodies show different fluorescent intensities from each other, or by varying the amount of an antibody to which a fluorescent pigment is conjugated according to the type of an antibody. Accordingly, even with the existing flow cytometer for distinguishing a limited number of colors, it becomes possible to categorize various cell populations that are to be clinically checked.
摘要翻译：本发明提供了一种新的流式细胞术方法，包括：对由相同颜色的荧光颜料共轭的抗体靶向的细胞群进行必要的控制，使得细胞群体根据抗体的类型显示不同的荧光强度。与常规的流式细胞术方法相比，仅通过使用一种抗体对每种单一颜色进行仅一个靶标的阳性和阴性表达的分类，本发明的方法允许将多个靶标的阳性和阴性表达分类仅使用一种颜色，通过控制相同颜色的荧光颜料的各种类型的抗体以使得抗体彼此显示不同的荧光强度或通过改变荧光颜料的抗体的量来共轭根据抗体的类型缀合。因此，即使现有的用于区分有限数量的颜色的流式细胞仪，可以对待临床检查的各种细胞群进行分类。

5. 发明申请

WO2010128787A9 GADOLINIUM COMPLEX, METHOD FOR PREPARING SAME, AND MRI CONTRAST AGENT COMPRISING SAME 审中-公开
标题翻译： GADOLINIUM复合物，其制备方法以及包含该复合物的MRI造影剂
公开(公告)号：WO2010128787A9
公开(公告)日：2011-05-12
申请号：PCT/KR2010002819
申请日：2010-05-04
申请人： CATHOLIC UNIV IND ACAD COOP , NA KUN , YIM HYEON A
发明人： NA KUN , YIM HYEON A
IPC分类号： C07F5/00 , A61K49/06
CPC分类号： A61K49/128 , C08B37/0018
摘要： The present invention provides a gadolinium complex in which gadolinium is coordinated with and covalently bonded to diethylenetriamine pentaacetic acid (DTPA) dianhydride of a pullulan-DTPA conjugate prepared by ester-bonding pullulan to DTPA, to a method for preparing same, to an MRI contrast agent composition containing the complex, and to a method for providing information for diagnosing a disease using the complex as an MRI contrast agent. The gadolinium-DTPA complex in which pullulan is ester-bonded to DTPA according to the present invention has a prolonged in vivo half-life, less toxicity, and a signal with a higher strength for providing a clearer MRI when compared with conventional gadolinium-DTPA complexes. Therefore, the gadolinium-DTPA complex of the present invention can not only be advantageously used as an MRI contrast agent but also produces MRI images in which a liver disease portion and a normal tissue portion can be discriminated, and can thus be used as an MRI contrast agent for the liver.
摘要翻译：本发明提供了一种钆配合物，其中钆与将普鲁兰多糖与DTPA酯键合制备的普鲁兰多糖-DTPA缀合物的二亚乙基三胺五乙酸（DTPA）二酐配位并共价键合至其制备方法，MRI对比包含该复合物的药物组合物，以及使用该复合物作为MRI造影剂提供用于诊断疾病的信息的方法。根据本发明的其中支链淀粉与DTPA酯键结合的钆-DTPA复合物与常规钆-DTPA相比具有延长的体内半衰期，更小的毒性和更高强度的信号以提供更清晰的MRI 复合物。因此，本发明的钆DTPA复合物不仅可以有利地用作MRI造影剂，而且还可以产生其中肝脏疾病部分和正常组织部分可以被区分的MRI图像，因此可以用作MRI 造影剂为肝脏。

6. 发明申请

WO2011049291A2 MESENCHYMAL STEM CELL INCORPORATING A NUCLEOTIDE SEQUENCE CODING TGF?, AND USES THEREOF 审中-公开
标题翻译：包含核苷酸序列编码TGFβ的间充质干细胞及其用途
公开(公告)号：WO2011049291A2
公开(公告)日：2011-04-28
申请号：PCT/KR2010005771
申请日：2010-08-27
申请人： CATHOLIC UNIV IND ACAD COOP , CHO SEOK GOO , PARK MIN JUNG , PARK HYUN SIL , CHO MI LA
发明人： CHO SEOK GOO , PARK MIN JUNG , PARK HYUN SIL , CHO MI LA
IPC分类号： C12N5/071 , A61K35/12 , A61P37/00 , C12N15/12
CPC分类号： C07K14/495 , A61K35/28 , A61K38/00 , C12N5/0663 , C12N2501/15 , C12N2510/00 , A61K2300/00
摘要： One or more specific examples of the present invention relate to a mesenchymal stem cell incorporating a nucleotide sequence coding TGFß, and to the uses thereof.
摘要翻译：本发明的一个或多个具体实施例涉及掺入编码TGFβ的核苷酸序列的间充质干细胞及其用途。

7. 发明申请

WO2014046474A3 COMPOSITION COMPRISING METFORMIN AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：包含METFORMIN作为活性成分的组合物用于预防或治疗炎性肠病
公开(公告)号：WO2014046474A3
公开(公告)日：2014-05-22
申请号：PCT/KR2013008428
申请日：2013-09-17
申请人： CATHOLIC UNIV IND ACAD COOP
发明人： CHO MI-LA , LEE SEON-YEONG , YANG EUN-JI , SON HYE-JIN , KIM EUN-KYUNG , RYU JUN-GEOL
IPC分类号： A61K31/155 , A61P1/00 , A61P29/00
CPC分类号： A61K31/155 , A61K2300/00
摘要： The present invention relates to a composition comprising metformin as an active ingredient for preventing or treating inflammatory bowel disease. The metformin compound or the metformin-etanercept (product name: Enbrel) composite according to the present invention may have excellent effects of maintaining the thickness of the small intestine and length of the large intestine normal, inhibiting or decreasing the activity of IL-17 and TNF-a, and promoting or increasing the activity of IFNr, and therefore can be effectively used as a pharmaceutical composition for preventing or treating autoimmune diseases including inflammatory bowel disease.
摘要翻译：本发明涉及包含二甲双胍作为用于预防或治疗炎症性肠病的活性成分的组合物。根据本发明的二甲双胍化合物或二甲双胍 - 依那西普（产品名称：Enbrel）复合物可具有维持小肠厚度和大肠正常长度，抑制或降低IL-17活性和 TNF-α，以及促进或增加IFNτ的活性，因此可以有效地用作预防或治疗包括炎症性肠病的自身免疫性疾病的药物组合物。

8. 发明申请

WO2013100724A1 COMPOUND FOR ORGANIC LIGHT-EMITTING DEVICE HAVING DOUBLE CORE STRUCTURE AND ORGANIC LIGHT-EMITTING DEVICE USING SAME 审中-公开
标题翻译：用于具有双重核心结构的有机发光装置和使用其的有机发光装置的化合物
公开(公告)号：WO2013100724A1
公开(公告)日：2013-07-04
申请号：PCT/KR2012011785
申请日：2012-12-28
申请人： CATHOLIC UNIV IND ACAD COOP
发明人： PARK JONG WOOK , PARK YOUNG IL , KIM BEOM JIN
IPC分类号： C09K11/06 , C07C15/20 , H01L51/50
CPC分类号： C07C15/38 , C07C211/54 , C07C211/61 , C07C2603/24 , C07C2603/50 , C07D251/24 , C09B1/00 , C09B3/14 , C09B57/001 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , H01L51/0054 , H01L51/0058 , H01L51/5012 , H05B33/10
摘要： The present invention relates to a compound for an organic light-emitting device having a double core structure in molecules thereof, and to a light-emitting device using the compound. The present invention provides a compound for an organic light-emitting device having a double core (A-B) structure in molecules thereof expressed by the following chemical formula 1. The double core structure is configured in that light-emitting materials having superior light-emitting efficiency are combined to form a double core, and has structural characteristics in that two cores (A-B) of an aromatic ring having a planar structure are combined at a twisted angle, and thus may exhibit high stability in a solution process and a long service life of the device due to high light-emitting efficiency and improved solubility. Further, a device using, as a light-emitting layer, the compound for an organic light-emitting device according to the present invention may exhibit high light-emitting efficiency and long service life as compared with cases using conventional compounds having a single core. Chemical formula 1 : Ar1-(A-B)-Ar2 (where A, B, Ar1 or Ar2 is as defined in the specification).
摘要翻译：本发明涉及一种其分子中具有双核结构的有机发光器件的化合物，以及使用该化合物的发光器件。本发明提供一种具有由以下化学式1表示的分子中具有双核（AB）结构的有机发光器件的化合物。双芯结构被配置为具有优异的发光效率的发光材料结合形成双芯，具有结构特征，即具有平面结构的芳香环的两个核（AB）以扭转角度组合，因此可能在溶液过程中表现出高稳定性和长的使用寿命该器件由于发光效率高，溶解度提高。此外，与使用具有单个核心的常规化合物的情况相比，使用根据本发明的用于有机发光器件的化合物作为发光层的器件可以表现出高的发光效率和长的使用寿命。化学式1：Ar1-（A-B）-Ar2（其中A，B，Ar1或Ar2如说明书中所定义）。

9. 发明申请

WO2012134180A3 EMOTION CLASSIFICATION METHOD FOR ANALYZING INHERENT EMOTIONS IN A SENTENCE, AND EMOTION CLASSIFICATION METHOD FOR MULTIPLE SENTENCES USING CONTEXT INFORMATION 审中-公开
标题翻译：用于分析声音中的实际情绪的情绪分类方法，以及使用上下文信息的多种语音的情感分类方法
公开(公告)号：WO2012134180A3
公开(公告)日：2013-01-10
申请号：PCT/KR2012002295
申请日：2012-03-28
申请人： CATHOLIC UNIV IND ACAD COOP , KANG HANG BONG
发明人： KANG HANG BONG
IPC分类号： G06F17/27 , G06F17/28
CPC分类号： G06F17/2765
摘要： According to the emotion classification method for analyzing inherent emotions in a sentence proposed by the present invention, emotional characteristics of words constituting a sentence are extracted and inherent emotions in the sentence are classified using an emotion sorter. Thus, opinion-mining can be automatized via an automatic analysis of a sentence that contains a mood, opinion, and the like which can be collected online, marketing strategies can be quickly established via such opinion-mining, the evaluations of a company, brand, product, service and the like may be automatically analyzed, and a mood analysis may be automatically performed in a variety of fields, such as product evaluation surveys, public opinion surveys, and customer preference analyses.
摘要翻译：根据用于分析本发明提出的句子中的内在情绪的情感分类方法，提取构成句子的单词的情感特征，并且使用情感分类器对句子中的内在情绪进行分类。因此，通过自动分析包含可以在线收集的情绪，意见等的句子，可以自动化意见挖掘，可以通过这种意见挖掘，公司评估，品牌快速建立营销策略，产品，服务等可以自动分析，并且可以在诸如产品评估调查，民意调查和客户偏好分析的各种领域中自动执行情绪分析。

10. 发明申请

WO2012064146A3 ANTICANCER COMPOSITION CONTAINING GKN 1 审中-公开
标题翻译：含有GKN的ANTICANCER组合物1
公开(公告)号：WO2012064146A3
公开(公告)日：2012-08-23
申请号：PCT/KR2011008605
申请日：2011-11-11
申请人： CATHOLIC UNIV IND ACAD COOP , PARK WON SANG , YOON JUNG HWAN
发明人： PARK WON SANG , YOON JUNG HWAN
IPC分类号： A61K38/16 , A61K38/17 , A61P35/00
CPC分类号： A61K38/1709 , G01N33/5008 , G01N33/57446 , G01N2500/10
摘要： The present invention relates to an anticancer composition containing an active ingredient consisting of GKN 1, and more specifically relates to an anticancer composition containing an active ingredient consisting of GKN 1 protein or an expression vector comprising the GKN 1 gene which has an outstanding anticancer activity. The GKN 1 according to the present invention is advantageous in that it can beneficially be used as a composition for anticancer therapy because it features not only outstanding activity in suppressing the occurrence of cancer cells but also outstanding activity in suppressing cancer cell metastasis during overexpression.
摘要翻译：本发明涉及含有由GKN1组成的活性成分的抗癌组合物，更具体地说，涉及含有由GKN1蛋白组成的活性成分或含有优异抗癌活性的GKN1基因的表达载体的抗癌组合物。根据本发明的GKN1的优点在于，它可以有益地用作抗癌治疗的组合物，因为它不仅具有抑制癌细胞发生的突出活性，而且具有在过表达时抑制癌细胞转移的突出活性。

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