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1. 发明申请

WO2012091452A3 BIOCOMPATIBLE AGENT FOR DISPERSING NANOPARTICLES INTO AN AQUEOUS MEDIUM USING MUSSEL ADHESIVE PROTEIN-MIMETIC POLYMER 审中-公开
公开(公告)号：WO2012091452A3
公开(公告)日：2012-07-05
申请号：PCT/KR2011/010230
申请日：2011-12-28
申请人： HANWHA CHEMICAL CORPORATION , HYEON, Taeghwan , NA, Kun , LING, Daishun , PARK, Wooram
发明人： HYEON, Taeghwan , NA, Kun , LING, Daishun , PARK, Wooram
IPC分类号： C08G73/00 , C08G73/04 , C08G65/08 , A61K49/06
摘要： Provided are a mussel adhesive protein-mimetic dispersion stabilizing agent to disperse nanoparticles in an aqueous medium, a colloidal solution including nanoparticles dispersed and stabilized by the dispersion stabilizing agent, and a contrast agent including the colloidal solution. More particularly, the mussel adhesive protein-mimetic dispersion stabilizer is a polyethyleneimine- graft -(polyethyleneglycol;polyDOPA) PEI- graft -(PEG;PDOPA). The graft polymer is formed of two parts. One is polyethyleneglycol grafted with a polyethyleneime which has an affinity to an aqueous medium, and the other is polyDOPA which has an affinity to the surface of nanoparticles. Because of those characteristics, the stabilizer shows a stable dispersion of nano particles in the aqueous medium.

2. 发明申请

WO2012177039A2 MRI CONTRAST AGENT FOR LYMPHOGRAPHY BASED ON IRON OXIDE NANOPARTICLES AND METHOD FOR IMAGING LYMPH NODE USING THE SAME 审中-公开
标题翻译：基于氧化铁纳米颗粒的MRI对比剂和用于成像使用其的淋巴结的方法
公开(公告)号：WO2012177039A2
公开(公告)日：2012-12-27
申请号：PCT/KR2012/004861
申请日：2012-06-20
申请人： HANWHA CHEMICAL CORPORATION. , PARK, Ju Young , MYEONG, Wan Jae , JEON, Bong-Sik , KIM, Eung Gyu , KWON, Eun Byul , HYEON, Taeghwan , LING, Daishun
发明人： PARK, Ju Young , MYEONG, Wan Jae , JEON, Bong-Sik , KIM, Eung Gyu , KWON, Eun Byul , HYEON, Taeghwan , LING, Daishun
IPC分类号： A61K49/12 , A61K49/08 , A61K49/06
CPC分类号： A61K49/124 , A61K49/1857 , A61K49/186 , B82Y15/00
摘要： Provided are a contrast agent for contrast imaging lymph node, which includes iron oxide nanoparticles dispersed and stabilized in an aqueous medium by a mussel adhesive protein-mimetic copolymer, a method for contrast enhanced lymphography using the foregoing contrast agent, and a method for diagnosis of lymph node cancers using the foregoing contrast agent. Using such a mussel adhesive protein-mimetic copolymer, the surface of iron oxide is modified and dispersed well in water to prepare a colloidal solution, which in turn forms the contrast agent containing the colloidal solution. The inventive contrast agent does not have toxicity and is easily taken up to the lymph node to exhibit excellent contrast imaging effects. The contrast agent of the present invention is useful for diagnosis of metastatic cancers.
摘要翻译：本发明提供对比成像淋巴结造影剂，其包括通过贻贝粘合蛋白模拟共聚物在水性介质中分散和稳定的氧化铁纳米粒子，使用前述造影剂的对比度增强淋巴造影法，以及诊断方法使用上述造影剂的淋巴结癌。使用这种贻贝粘合蛋白模拟共聚物，将氧化铁的表面改性并充分分散在水中以制备胶体溶液，这又形成含有胶体溶液的造影剂。本发明的造影剂不具有毒性，并且容易吸收到淋巴结以显示出优异的对比度成像效果。本发明的造影剂可用于诊断转移性癌症。

3. 发明申请

WO2012108648A2 METHOD OF PREPARING IRON OXIDE NANOPARTICLES COATED WITH HYDROPHILIC MATERIAL, AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：用氢化物质涂覆氧化镍纳米粒子的方法和使用其的磁共振成像对比剂
公开(公告)号：WO2012108648A2
公开(公告)日：2012-08-16
申请号：PCT/KR2012/000845
申请日：2012-02-06
申请人： HANWHA CHEMICAL CORPORATION , HYEON, Taeghwan , PIAO, Yuanzhe , PARK, Yong Il
发明人： HYEON, Taeghwan , PIAO, Yuanzhe , PARK, Yong Il
IPC分类号： A61K49/18 , A61K49/04 , A61K9/28 , A61K9/16 , A61K47/30
CPC分类号： A61K49/1824 , A61K49/186 , A61K49/1863 , B82Y30/00 , C01G49/02 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/51 , C01P2004/64 , C01P2006/42 , C09C1/24 , C09C3/08
摘要： The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects.
摘要翻译：本发明涉及一种制备生物相容性氧化铁纳米粒子的方法，该方法是通过使用具有亲水性材料的盐颗粒进行退火处理和通过包含由其制备的氧化铁纳米粒子的磁共振成像（MRI）造影剂来涂覆具有改善的磁性的氧化铁纳米颗粒。在亲水性材料中，羧甲基葡聚糖（CM-葡聚糖）在稳定退火的氧化铁纳米颗粒方面是最有效的，并且具有对比效果。

4. 发明申请

WO2008093999A1 MRI T1 CONTRASTING AGENT COMPRISING MANGANESE OXIDE NANOPARTICLE 审中-公开
标题翻译： MRI T1对比剂包含锰氧化物纳米颗粒
公开(公告)号：WO2008093999A1
公开(公告)日：2008-08-07
申请号：PCT/KR2008/000574
申请日：2008-01-30
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , AN, Kwangjin , NA, Hyon Bin , LEE, Junghee
发明人： HYEON, Taeghwan , AN, Kwangjin , NA, Hyon Bin , LEE, Junghee
IPC分类号： A61K49/08
CPC分类号： A61K49/08 , A61K49/126 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , B82Y5/00 , Y10T428/2982
摘要： The present invention relates to the use of and method for using MnO nanoparticles as MRI Tl contrasting agents which reduces Tl of tissue. More specifically, the present invention is directed to MRI Tl contrasting agent comprising MnO nanoparticle coated with a biocompatible material bound to a biologically active material such as a targeting agent, for example tumor marker etc., and methods for diagnosis and treatment of tumor etc. using said MRI Tl contrasting agent, thereby obtaining more detailed images than the conventional MRI Tl-weighted images. The MRI Tl contrasting agent of the present invention allows a high resolution anotomic imaging by emphasizing Tl contrast images between tissues based on the difference of accumulation of the contarsting agent in tissues. Also, the MRI Tl contrasting agent of the present invention enables to visualize cellular distibution due to its high intracellular uptake. The MRI Tl contrasting agent of the present invention can be used for target-specific diagnosis and treatment of various diseases such as tumor etc. when targeting agents binding to disease- specific biomarkers are conjugated to the surface of nanoparticles.
摘要翻译：本发明涉及使用MnO纳米颗粒作为降低组织T1的MRI T1对比剂的用途和方法。更具体地，本发明涉及包含结合生物活性物质如靶向剂例如肿瘤标志物等的生物相容性材料的MnO纳米颗粒的MRI Tl造影剂，以及用于诊断和治疗肿瘤等的方法。使用所述MRI T1对比剂，从而获得比常规MRI T1加权图像更详细的图像。本发明的MRI T1造影剂基于组织中对比剂的积累差异，通过强调组织之间的T1对比度图像，可以进行高分辨率的插入成像。此外，本发明的MRI T1对比剂能够由于其高细胞内摄取而可视化细胞分布。当与疾病特异性生物标志物结合的靶向剂与纳米颗粒的表面缀合时，本发明的MRI Tl造影剂可用于靶向特异性诊断和治疗各种疾病如肿瘤等。

5. 发明申请

WO2008048074A1 USE OF CORE-SHELL GOLD NANOPARTICLE WHICH CONTAINS MAGNETIC NANOPARTICLES FOR MRI T2 CONTRAST AGENT, CANCER DIAGNOSTIC AND THERAPY 审中-公开
标题翻译：含有磁性纳米粒子的核心金纳米颗粒用于MRI T2对比剂，癌症诊断和治疗
公开(公告)号：WO2008048074A1
公开(公告)日：2008-04-24
申请号：PCT/KR2007/005154
申请日：2007-10-19
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , KIM, Jae Yoon , CHO, Myung-Haing , KIM, Seong Keun , LEE, Junghee
发明人： HYEON, Taeghwan , KIM, Jae Yoon , CHO, Myung-Haing , KIM, Seong Keun , LEE, Junghee
IPC分类号： A61K49/06 , A61P43/00
CPC分类号： A61K49/1887 , B82Y5/00
摘要： The present invention relates to the use of magnetic gold nanoshells consisted of gold nanoshells embedded with magnetic nanoparticles and spherical silica cores for use in MRI T2 contrast agent, cancer diagnosis and cancer therapy. More particularly, the present invention is directed to the use of an MRI T2 contrast agent using the magnetic properties of the magnetic nanoparticles embedded with the gold nanoshell, a cancer diagnostic agent for treating cancer using the cancer binding properties of target-specific ligands bonded to the surface of the magnetic gold nanoparticles and a therapeutic agent for treating cancer using the heat released form the gold nanoshell absorbed from the energy of near infrared ray range electromagnetic pulses to destroy the cancer cells, and methods for the diagnosis and treatment of cancer using the magnetic gold nanoparticles.
摘要翻译：本发明涉及包含磁性纳米颗粒的金纳米壳和用于MRI T2造影剂，癌症诊断和癌症治疗的球形二氧化硅核心的磁性金纳米壳的应用。更具体地说，本发明涉及使用嵌入有金纳米壳的磁性纳米颗粒的磁特性的MRI T2造影剂，癌症诊断剂使用与靶结合特异性配体结合的癌症结合特性磁性金纳米颗粒的表面和用于治疗癌症的治疗剂，使用从近红外线射线范围电磁脉冲的能量吸收的金纳米壳释放的热量来破坏癌细胞，以及用于诊断和治疗癌症的方法磁性金纳米颗粒。

6. 发明申请

WO2006057533A1 NEW PROCESS FOR LARGE-SCALE PRODUCTION OF MONODISPERSE NANOPARTICLES 审中-公开
标题翻译：用于大规模生产单体纳米粒子的新工艺
公开(公告)号：WO2006057533A1
公开(公告)日：2006-06-01
申请号：PCT/KR2005/004009
申请日：2005-11-26
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , PARK, Jongnam
发明人： HYEON, Taeghwan , PARK, Jongnam
IPC分类号： B22F1/00 , B22F9/00
CPC分类号： G11B5/706 , B22F9/30 , B82Y10/00 , B82Y25/00 , B82Y30/00 , C01B13/32 , C01F17/0043 , C01G1/02 , C01G3/02 , C01G9/02 , C01G23/053 , C01G25/02 , C01G45/02 , C01G49/0072 , C01G49/02 , C01G49/06 , C01G49/08 , C01G51/00 , C01G51/02 , C01G51/04 , C01G53/04 , C01G55/00 , C01P2002/72 , C01P2002/82 , C01P2004/04 , C01P2004/32 , C01P2004/52 , C01P2004/64 , C01P2006/42 , H01F1/0054 , Y10T428/12014
摘要： A process for making nanoparticles of metals, metal aloys, metal oxides and multi-metallic oxides, which comprises the steps of: a) reacting a metal salt dissolved in water with an alkali metal salt of C 4-25 carboxylic acid dissolved in an first solvent selected from the group consisting of C 5-10 aliphatic hydrocarbon and C 6-10 aromatic hydrocarbon to form a metal carboxylate complex and b) heating said metal carboxylate complex dissolved in a second solvent selected from the group consisting of C 6-25 aromatic, C 6-25 ether, C 6-25 aliphatic hydrocarbon and C 6-25 amine to
摘要翻译：一种制备金属，金属合金，金属氧化物和多金属氧化物的纳米颗粒的方法，其包括以下步骤：a）使溶解在水中的金属盐与C 4-25的碱金属盐反应 >羧酸溶解在选自C 5-10 - 脂肪族烃和C 6-10芳族烃的第一溶剂中以形成金属羧酸盐络合物，和b）加热所述金属羧酸盐络合物溶解在选自由C 6-25芳族，C 6〜6-25个醚，C 6〜26-25个碳原子的第二溶剂中， / SUB>脂族烃和C 6-25胺

7. 发明申请

WO2005006471A1 NANOSTRUCTURED CARBON MATERIALS HAVING GOOD CRYSTALLINITY AND LARGE SURFACE AREA SUITABLE FOR ELECTRODES, AND METHOD FOR SYNTHESIZING THE SAME USING CATALYTIC GRAPHITIZATION OF POLYMERIC CARBON PRECURSORS 审中-公开
标题翻译：具有良好结晶性和适用于电极的大面积面积的纳米结构材料及其使用聚合碳前驱体的催化成核合成其方法
公开(公告)号：WO2005006471A1
公开(公告)日：2005-01-20
申请号：PCT/KR2003/001377
申请日：2003-07-10
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , HAN, Sangjin
发明人： HYEON, Taeghwan , HAN, Sangjin
IPC分类号： H01M4/88
CPC分类号： B82Y30/00 , B82Y40/00 , C01B32/162 , H01M4/9083 , H01M4/926 , H01M8/1011 , Y02E60/523
摘要： Methods for synthesizing nanostructured carbon materials having good crystallinity and large surface area using inexpensive metal salts and polymeric carbon precursors are disclosed. A typical synthetic method comprises the formation of nanostructured carbon material-metal-inorganic oxide composite through catalytic graphitization of a polymeric carbon precursor-metal salt-inorganic oxide composite, removal of inorganic oxide using an etchant, and removal of metal through an acid treatment, wherein an inorganic oxide material is added in the reaction mixture to increase the surface area of the nanostructured carbon material and metal was used as a graphitization catalyst. The resultant nanostructured carbon materials have the characteristics of good crystallinity and large surface area, which are excellent for fuel cell electrode applications.
摘要翻译：公开了使用便宜的金属盐和聚合碳前体合成具有良好结晶度和大表面积的纳米结构碳材料的方法。典型的合成方法包括通过聚合碳前体金属盐 - 无机氧化物复合物的催化石墨化，使用蚀刻剂去除无机氧化物和通过酸处理除去金属形成纳米结构碳材料 - 金属 - 无机氧化物复合物，其中在反应混合物中加入无机氧化物材料以增加纳米结构碳材料的表面积，金属用作石墨化催化剂。所得的纳米结构碳材料具有结晶性好，表面积大的特点，对于燃料电池电极应用是极好的。

8. 发明申请

WO2009054695A2 GOETHITE NANOTUBE AND PROCESS FOR PREPARING THEREOF 审中-公开
标题翻译： GOETHITE纳米管及其制备方法
公开(公告)号：WO2009054695A2
公开(公告)日：2009-04-30
申请号：PCT/KR2008/006295
申请日：2008-10-24
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , YU, Taekyung
发明人： HYEON, Taeghwan , YU, Taekyung
IPC分类号： B82B3/00
CPC分类号： D01F9/08 , B01J23/745 , B01J35/0013 , B01J35/002 , B01J37/086 , B01J37/16 , B82Y25/00 , B82Y30/00
摘要： The present invention relates to a goethite nanotube. Particularly, the present invention is directed to goethite nanotubes, which can be used as a catalyst relating to environment or a drug delivery system, and process for preparing the goethite nanotube, and process for preparing magnetite and hematite nanoparticles.
摘要翻译：本发明涉及针铁矿纳米管。特别地，本发明涉及针铁矿纳米管，其可用作与环境或药物递送系统有关的催化剂，以及制备针铁矿纳米管的方法，以及制备磁铁矿和赤铁矿纳米颗粒的方法。

9. 发明申请

WO2009051392A2 BIOCOMPATIBLE SUSPENSION STABILIZER FOR DISPERSING INORGANIC NANOPARTICLES INTO AQUEOUS SOLUTION 审中-公开
标题翻译：用于将无机纳米颗粒分解成水溶液的生物可溶性悬浮稳定剂
公开(公告)号：WO2009051392A2
公开(公告)日：2009-04-23
申请号：PCT/KR2008/006063
申请日：2008-10-15
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , HYEON, Taeghwan , KIM, Sang-Wook , NA, Hyon Bin
发明人： HYEON, Taeghwan , KIM, Sang-Wook , NA, Hyon Bin
IPC分类号： C07F9/53
CPC分类号： C07F9/2408 , C07F9/2458
摘要： The present invention relates to a suspension stabilizer for dispersing inorganic nanoparticles into aqueous medium. More particularly, the present invention is directed to a biocompatible suspension stabilizer which comprises phosphoryl domain having an affinity to the surface of an inorganic nanoparticle and poly(ethylene glycol) having an affinity to the aqueous medium, and which is prepared by reacting a biocompatible poly(ethylene glycol )-derivati zed polymer with phosphine oxide having a leaving group.
摘要翻译：本发明涉及将无机纳米颗粒分散在水介质中的悬浮稳定剂。更具体地说，本发明涉及一种生物相容性悬浮稳定剂，它包括对无机纳米颗粒的表面具有亲和性的磷酸结构域和对水性介质具有亲和性的聚（乙二醇），并且其通过使生物相容性聚（乙二醇） - 具有离去基团的氧化膦的衍生聚合物。

10. 发明申请

WO2008069561A1 METAL OXIDE HOLLOW NANOCAPSULE AND A METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：金属氧化物中空纳米颗粒及其制备方法
公开(公告)号：WO2008069561A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/006269
申请日：2007-12-05
申请人： SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION , HYEON, Taeghwan , PIAO, Yuanzhe , KIM, Jaeyun
发明人： HYEON, Taeghwan , PIAO, Yuanzhe , KIM, Jaeyun
IPC分类号： C01F1/00 , C01G1/02 , B82B3/00 , A61K9/51 , B82B1/00
CPC分类号： C01G49/04 , A61K9/5115 , A61K9/5192 , B82Y30/00 , C01B13/18 , C01F5/06 , C01F7/441 , C01G49/06 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/34 , C01P2004/62 , C01P2004/64 , C01P2004/90 , C01P2006/12 , C01P2006/17
摘要： The present invention relates to a metal oxide hollow nanocapsule which is able to disperse well in aqueous systems and a method for preparing thereof. The method for preparing the iron oxide hollow nanocapsules according to the present invention is characterized by dispersing metal oxyhydroxide in an aqueous solution and coating said metal oxyhydroxide with silica coating layer and administering heat treatment to form a metal oxide layer around the internal hollow space of the silica coating layer and removing said silica to obtain the metal oxide hollow nanocapsule. The iron oxide hollow nanoparticles prepared by the method of the present invention do not only have superior dispers ability in aqueous solutions and uniform size distribution, and said iron oxide hollow nanocapsule can also carry physiologically active materials within the hollow space of said nanocapsule. In addition, the iron oxide hollow nanocapsules of the present invention have a large surface area of at least 100 m2/g and narrow mesopore size distribution which allows physiologically active material carrying capability which brings great expectations for a wide range of industrial uses such as drug delivery vehicles for biomedical applications, gas sensors, lithium ion batteries, etc.
摘要翻译：本发明涉及能够在水性体系中良好分散的金属氧化物中空纳米胶囊及其制备方法。根据本发明的制备氧化铁中空纳米胶囊的方法的特征在于将金属氢氧化物分散在水溶液中并用二氧化硅涂层涂覆所述金属羟基氧化物，并施加热处理以在内部中空空间周围形成金属氧化物层二氧化硅涂层并除去二氧化硅，得到金属氧化物空心纳米胶囊。通过本发明的方法制备的氧化铁中空纳米颗粒不仅在水溶液中具有优异的分散能力和均匀的粒度分布，并且所述氧化铁中空纳米胶囊还可以在所述纳米胶囊的中空空间内承载生理活性材料。此外，本发明的氧化铁中空纳米胶囊具有至少100m 2 / g的大的表面积和窄的中孔尺寸分布，其允许生理活性物质携带能力，这对于广泛的工业用途如药物具有极大的期望用于生物医学应用的输送车辆，气体传感器，锂离子电池等

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