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1. 发明申请

US20110097387A1 PARTICULATE DRUG CARRIERS AS DESENSITIZING AGENTS 有权
标题翻译：颗粒状药物作为脱敏剂
公开(公告)号：US20110097387A1
公开(公告)日：2011-04-28
申请号：US12746656
申请日：2008-12-07
申请人： Yechezkel Barenholz , Janos Szebeni , Miklos Toth , Laszlo Rosivall
发明人： Yechezkel Barenholz , Janos Szebeni , Miklos Toth , Laszlo Rosivall
IPC分类号： A61K9/127 , A61K31/35 , A61K9/14 , B82Y5/00
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/337 , A61K31/475 , A61K31/555 , A61K31/704
摘要： The present invention provides methods for desensitization for prevention or diminishing hypersensitivity reactions including C activation-related pseudoallergy (CARPA) and other reactions to particulate medicines. The desensitization is performed via pretreatment using a drug-free vehicle or carrier to eliminate or diminish the clinical symptoms of hypersensitivity.
摘要翻译：本发明提供了用于预防或减少包括C活化相关假性反应（CARPA）和其他对颗粒药物的反应的超敏反应的脱敏的方法。通过使用无药物载体或载体的预处理来进行脱敏以消除或减少超敏反应的临床症状。

2. 发明授权

US4364931A Composite insect attractant for male white-line dart moths and a process for preparing the active ingredients thereof 失效
标题翻译：用于雄性白线飞蛾的复合昆虫引诱剂及其活性成分的制备方法
公开(公告)号：US4364931A
公开(公告)日：1982-12-21
申请号：US220113
申请日：1980-12-24
申请人： Csaba Szantay , Lajos Novak , Miklos Toth , Jozsef Jakab , Attila Kis-Tamas , Istvan Ujvari
发明人： Csaba Szantay , Lajos Novak , Miklos Toth , Jozsef Jakab , Attila Kis-Tamas , Istvan Ujvari
IPC分类号： C07D471/04 , A01N37/02 , A61K31/519 , A61P29/00 , C07C29/147 , C07C69/145 , C07D303/42 , A01N17/14
CPC分类号： A01N37/02 , C07C29/147 , C07C67/08 , C07C67/293 , C07C67/343 , C07D303/42
摘要： The invention relates to a composite insect attractant for male white-line dart moths [Scotia segetum] containing 7[Z]-dodecen-l-ol acetate of the formula [I] ##STR1## and 9[Z]-tetradecen-l-ol acetate of the formula [II] ##STR2## as active agents in a weight ratio of I to II of [50-99]:[50-1], optionally along with a liquid or solid adjuvant.Another object of the invention is an insect trap containing said composition and a process for attracting and trapping male white-line dart moths as well as a process for disrupting their mating by air permeation technique. The invention relates further to a novel process for the preparation of the active ingredients of the composition.
摘要翻译：本发明涉及含有式[I]图7（I）的7 [Z] - 十一碳烯-1-醇乙酸酯和9 [Z]十四碳烯的男性白线镖飞蛾（Scotia segetum）的复合昆虫引诱剂（II）的1-乙酸乙酯作为活性剂，其重量比为[50-99]的I至II：[50-1]，任选与液体或固体佐剂一起使用。本发明的另一个目的是含有所述组合物的昆虫陷阱和用于吸引和捕获雄性白线飞镖的方法以及通过空气渗透技术破坏它们的交配的方法。本发明进一步涉及用于制备组合物的活性成分的新方法。

3. 发明授权

US09078812B2 Particulate drug carriers as desensitizing agents 有权
标题翻译：颗粒状药物载体作为脱敏剂
公开(公告)号：US09078812B2
公开(公告)日：2015-07-14
申请号：US12746656
申请日：2008-12-07
申请人： Yechezkel Barenholz , Janos Szebeni , Miklos Toth , Laszlo Rosivall
发明人： Yechezkel Barenholz , Janos Szebeni , Miklos Toth , Laszlo Rosivall
IPC分类号： A61K9/14 , A61K9/00 , A61K9/127 , A61K31/337 , A61K31/475 , A61K31/555 , A61K31/704
CPC分类号： A61K9/0019 , A61K9/1271 , A61K31/337 , A61K31/475 , A61K31/555 , A61K31/704
摘要： The present invention provides methods for desensitization for prevention or diminishing hypersensitivity reactions including C activation-related pseudoallergy (CARPA) and other reactions to particulate medicines. The desensitization is performed via pretreatment using a drug-free vehicle or carrier to eliminate or diminish the clinical symptoms of hypersensitivity.
摘要翻译：本发明提供了用于预防或减少包括C活化相关假性反应（CARPA）和其他对颗粒药物的反应的超敏反应的脱敏的方法。通过使用无药物载体或载体的预处理来进行脱敏，以消除或减少超敏反应的临床症状。

4. 发明授权

US4243660A Composite insect attractant for male cabbage moths and a process for preparing its active agents 失效
标题翻译：用于大白菜蛾的复合昆虫引诱剂及其活性剂的制备方法
公开(公告)号：US4243660A
公开(公告)日：1981-01-06
申请号：US31583
申请日：1979-04-19
申请人： Csaba Szantay , Lajos Novak , Miklos Toth , Jozsef Balla , Bela Stefko , Attila Kis-Tamas
发明人： Csaba Szantay , Lajos Novak , Miklos Toth , Jozsef Balla , Bela Stefko , Attila Kis-Tamas
IPC分类号： A01N37/02 , A01N49/00 , C07C29/10 , C07C41/30 , C07C43/15 , C07C43/17 , C07C69/145 , C07D309/12 , C07F9/54 , A01N25/00 , A01N37/06
CPC分类号： C07D309/12 , A01N37/02 , C07C29/10 , C07C41/30 , C07C43/15 , C07C43/17 , C07C67/08 , C07C67/293 , C07C69/145 , C07F9/5407
摘要： The invention relates to a composite insect attractant for male cabbage moths (Mamestra brassicae) containing (Z)-11-hexadecenyl acetate and (Z)-11-heptadecenyl acetate as active agents in a weight ratio of 70 to 90:80 to 1, optionally along with a liquid or solid adjuvant. An insect trap can contain the composition which is used for attracting and trapping cabbage moth. Their mating is disrupted by air permeation techniques. (Z)-11-heptadecenyl acetate is a synergistically active new compound. The composition according to the invention produces a significantly stronger stimulating reaction on male cabbage moths than the known sex lure compositions.
摘要翻译：本发明涉及含有（Z）-11-十六碳烯基乙酸酯和（Z）-11-十七碳烯酸乙酯作为活性剂的重量比为70至90:80至1的男性白菜蛾（Mamestra brassicae）的复合昆虫引诱剂，任选地与液体或固体佐剂一起。昆虫陷阱可以包含用于吸引和捕获白菜蛾的组合物。它们的交配被空气渗透技术所破坏。（Z）-11-十七碳烯酸乙酯是协同活性的新化合物。根据本发明的组合物比已知的性诱剂组合物对雄性白菜蛾产生显着更强的刺激反应。

5. 发明授权

US5077043A Hyphantria cunea sex pheromones and attractant compositions including the pheromones 失效
标题翻译： Hyphantria cunea性信息素和引诱剂组合物，包括信息素
公开(公告)号：US5077043A
公开(公告)日：1991-12-31
申请号：US535637
申请日：1990-06-11
申请人： Miklos Toth , Hans-Rudolf Buser , Heinrich Arn , Kenji Mori , Yasuo Ninomiya , Tetsuo Omata , Shuji Senda , Tadashi Takeuchi , Masakazu Aburatani
发明人： Miklos Toth , Hans-Rudolf Buser , Heinrich Arn , Kenji Mori , Yasuo Ninomiya , Tetsuo Omata , Shuji Senda , Tadashi Takeuchi , Masakazu Aburatani
IPC分类号： A01N43/04 , A01N43/20 , C07C47/21 , C07D303/04 , C07D303/14
CPC分类号： A01N43/20 , C07D303/04 , C07D303/14
摘要： The present invention provides mainly (3Z,6Z)-cis-9,10-epoxy-1,3,6-heneicosatriene (formula 1) and (3Z, 6Z)-cis-9,10-epoxy-1,3,6-elcosatriene (formula 2) which are Hyphantria cunea sex pheromones. The invention provides attractant components having high attraction effect for Hyphantria cunea, that is, Hyphantria cumea sex pheromones having high attraction activity and the intermediates which can selectively synthesize such pheromones with great ease.Furthermore, the invention provides attractant compositions with high attraction effect for Hyphantria cunea including such above noted pheromones.Consequently, this invention is completed. ##STR1##
摘要翻译：本发明主要提供（3Z，6Z） - 顺-9,10-环氧-1,3,6 - 二十碳三烯（式1）和（3Z，6Z） - 顺式-9,10-环氧-1,3,6 - 三氯三烯（式2），它们是Hyphantria cunea性信息素。本发明提供了具有高吸引力的吸引效果的吸引成分，即具有高吸附活性的Hyphantria cumea性信息素和可以非常容易地选择性合成这种信息素的中间体。此外，本发明提供具有高吸引力效果的引诱剂组合物，其包括上述信息素。因此，本发明完成。（公式1）（公式2）

6. 发明授权

US4696899A Process for the preparation of human leukocyte and human gamma interferon 失效
标题翻译：人类白细胞和人γ干扰素的制备方法
公开(公告)号：US4696899A
公开(公告)日：1987-09-29
申请号：US681451
申请日：1984-12-10
申请人： Miklos Toth , Valeria Endresz , Ilona Beladi , Sandor Toth
发明人： Miklos Toth , Valeria Endresz , Ilona Beladi , Sandor Toth
IPC分类号： C12P21/00 , A61K35/14 , A61K38/21 , A61P43/00 , C07K1/14 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/57 , C07K16/00 , C12P21/02 , C12R1/91 , A61K45/02
CPC分类号： C07K14/555 , Y10S435/811
摘要： The invention relates to a process for the preparation of .alpha.- and .gamma.-interferon by isolating the buffy coat fraction of blood, removing the erythrocytes, suspending the leukocytes in a suitable nutrient medium and treating with an .alpha.-interferon inducer and with a .gamma.-interferon inducer, which comprises producing .alpha.-interferon and .gamma.-interferon one after the other in the same leukocyte culture by pre-treating the suspension obtained after the separation of the leukocyte/buffy coat/fraction of blood, removal of the erythrocytes and suspending the leukocytes in a suitable nutrient medium with - or .beta.-interferon, contacting with an .alpha.-interferon inducer, separating the liquid containing the .alpha.-interferon from the cells, if desired recovering the -interferon, washing and suspending the cells in a suitable nutrient medium, treating with a mitogenic agent, separating the liquid comprising .alpha.-interferon from the cells and if desired recovering .alpha.-interferon and if desired making .alpha.-interferon free of .alpha.-interferon.The advantage of the process is that .alpha.- and .gamma.-interferon are produced from the same leukocyte culture in two steps. This makes the process more economical and enables an effective utilization of the limitedly available leukocytes.
摘要翻译：本发明涉及通过分离血液的血沉棕黄层级分，去除红细胞，将白细胞悬浮在合适的营养培养基中并用α-干扰素诱导剂和γ-干扰素诱导剂进行处理的方法来制备α-和γ-干扰素，干扰素诱导剂，其包括通过预处理在分离白细胞/血沉棕黄层/血液部分之后获得的悬浮液，在相同的白细胞培养物中逐渐生成α-干扰素和γ-干扰素，去除红细胞并悬浮在具有β-干扰素的合适营养培养基中的白细胞与α-干扰素诱导剂接触，如果需要，将含有α-干扰素的液体与细胞分离，如果需要，则回收 - 干扰素，洗涤并将细胞悬浮在合适的营养培养基用有丝分裂剂处理，将含有α-干扰素的液体与细胞分离，并且如果需要，可以回收α-inter feron，如果需要，制造不含α-干扰素的α-干扰素。该方法的优点是α-和γ-干扰素是在两个步骤中由相同的白细胞培养产生的。这使得该方法更经济并能有效利用有限可用的白细胞。

7. 发明专利

DE633406C 未知
公开(公告)号：DE633406C
公开(公告)日：1936-07-27
申请号：DET0042930
申请日：1933-08-15
申请人： MIKLOS TOTH DIPL ING
IPC分类号： G02B13/20

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