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1. 发明授权

US5332739A Pyrimidinedione derivatives and antiarrhythmic agents containing same 失效
标题翻译：嘧啶二酮衍生物和含有它们的抗心律失常药
公开(公告)号：US5332739A
公开(公告)日：1994-07-26
申请号：US971059
申请日：1992-11-02
申请人： Tsutomu Katakami , Tatsuro Yokoyama , Michihiko Miyamoto , Haruki Mori , Nobuya Kawauchi , Tadahito Nobori , Joji Kamiya , Masaaki Ishii
发明人： Tsutomu Katakami , Tatsuro Yokoyama , Michihiko Miyamoto , Haruki Mori , Nobuya Kawauchi , Tadahito Nobori , Joji Kamiya , Masaaki Ishii
IPC分类号： C07D239/54 , A61K31/505 , A61P9/00 , A61P9/06 , C07D239/545 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/50 , C07D239/42 , C07D403/04
CPC分类号： C07D239/545 , C07D401/12
摘要： Pyrimidinedione derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R.sup.3, R.sup.4, X.sup.1, X.sup.2 and X.sup.3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.
摘要翻译：其中R1和R2彼此连接以形成亚烷基链，从而形成杂环结构，其中A，R 3，R 4，X 1，X 2和X 3分别是取代基，并且n 2或3具有其中苯基部分和嘧啶二酮部分通过包含烷基链和具有两个氮原子的杂环的结构连接的基本主链。这些化合物可用于治疗心律失常。

2. 发明授权

US6118007A Preparation process of nitroguanidine derivatives 失效
标题翻译：硝基胍衍生物的制备方法
公开(公告)号：US6118007A
公开(公告)日：2000-09-12
申请号：US46588
申请日：1998-03-24
申请人： Koichi Ebihara , Tatsuo Kaiho , Michihiko Miyamoto , Daisuke Ura
发明人： Koichi Ebihara , Tatsuo Kaiho , Michihiko Miyamoto , Daisuke Ura
IPC分类号： C07D277/28 , C07D277/32 , C07D407/06 , C07D417/06 , C07D263/30 , C07D333/22
CPC分类号： C07D277/32 , C07D407/06 , C07D417/06
摘要： A process, as a substitute for hydrolysis, for preparing a nitroguanidine derivative represented by the following formula (2): ##STR1## wherein A represents a substituted or unsubstituted aromatic or non-aromatic hydrocarbon ring, a substituted or unsubstituted aromatic or non-aromatic heterocycle, a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl or alkynyl group; and R.sub.2 represents a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl, alkenyl or alkynyl group, which comprises reacting a compound represented by the following formula (1): ##STR2## wherein R.sub.1 represents a substituted or unsubstituted, linear or cyclic C.sub.1-10 alkyl group and A and R.sub.2 have the same meanings as defined above, with ammonia, a primary amine or a secondary amine, or a salt thereof.
摘要翻译：用于制备由下式（2）表示的硝基胍衍生物的方法作为水解的替代方法：其中A表示取代或未取代的芳族或非芳族烃环，取代或未取代的芳族或非芳族杂环，氢原子或取代或未取代的烷基，烯基或炔基; R 2表示氢原子，取代或未取代的C 1-6烷基，烯基或炔基，其包括使下式（1）表示的化合物：其中R 1表示取代或未取代的直链或环状C 1-10烷基基团和A和R 2具有与上述相同的含义，与氨，伯胺或仲胺或其盐。

3. 发明授权

US5770683A Preparation process of polyhydroxycarboxylic acid 失效
标题翻译：聚羟基羧酸的制备方法
公开(公告)号：US5770683A
公开(公告)日：1998-06-23
申请号：US546311
申请日：1995-10-20
申请人： Yasunori Yoshida , Michihiko Miyamoto , Shoji Obuchi , Kan Ideda , Masahiro Ohta
发明人： Yasunori Yoshida , Michihiko Miyamoto , Shoji Obuchi , Kan Ideda , Masahiro Ohta
IPC分类号： C08G63/06 , C08G63/91
CPC分类号： C08G63/912 , C08G63/06
摘要： A preparation process of polyhydroxycarboxylic acid comprising conducting dehydration polycondensation of hydroxycarboxylic acid or an oligomer of the same in a reaction mixture containing said hydroxycarboxylic acid or the oligomer of the same and an organic solvent substantially in the absence of water to give polyhydroxycarboxylic acid having an weight average molecular weight of 50,000 or more, successively mixing the reaction mixture containing said polyhydroxycarboxylic acid with at least one binder selected from the group consisting of (1) polyisocyanate compound, (2) polybasic acid anhydride, (3) cyclic imino ester, (4) cyclic imino ether, (5) aromatic hydroxycarboxylic acid, (6) polyamino compound, (7) polyhydric alcohol, (8) epoxy compound, (9) polyfunctional aziridine compound, (10) lactam, (11) lactone, and (12) diethylene glycol bischloroforate, and reacting to obtain polyhydroxycarboxylic acid having a weight average molecular weight of 100,000 or more the polyhydroxycarboxylic acid which is obtained by the process has a weight average molecular weight of 100,000 or more, has satisfactory mechanical strength in the form of molded articles and is useful as a degradable polymer for substituting medical materials and general purpose resins.
摘要翻译：一种聚羟基羧酸的制备方法，其包括在含有羟基羧酸或其低聚物的反应混合物中进行羟基羧酸或其低聚物的脱水缩聚，基本上不存在水，得到具有重量的多羟基羧酸将（1）多异氰酸酯化合物，（2）多元酸酐，（3）环状亚氨基酯，（4）的多元酸酐，（4））环状亚氨基醚，（5）芳族羟基羧酸，（6）聚氨基化合物，（7）多元醇，（8）环氧化合物，（9）多官能氮丙啶化合物，（10）内酰胺，（11）内酯和（12 ）二甘醇双氯氟酸盐，并且反应得到重均分子量为100,000以上的聚羟基
羧酸通过该方法获得的氧酸的重均分子量为100,000以上，成型品的机械强度良好，作为用于代替医用材料和通用树脂的可降解聚合物是有用的。

4. 发明授权

US5629321A Bicyclic compound and platelet aggregation inhibitor containing the same 失效
标题翻译：双环化合物和含有其的血小板聚集抑制剂
公开(公告)号：US5629321A
公开(公告)日：1997-05-13
申请号：US544583
申请日：1995-10-18
申请人： Kunio Okumura , Isao Yokoyama , Toshiyuki Shimazaki , Michihiko Miyamoto , Hiroyuki Yamashita , Kenji Kibayashi , Takanori Yutaka , Kouhei Yazawa
发明人： Kunio Okumura , Isao Yokoyama , Toshiyuki Shimazaki , Michihiko Miyamoto , Hiroyuki Yamashita , Kenji Kibayashi , Takanori Yutaka , Kouhei Yazawa
IPC分类号： C07C237/40 , C07C251/48 , C07C255/54 , C07C255/57 , C07C255/58 , C07C257/18 , C07C279/18 , C07D217/14 , C07D311/58 , A61K31/19 , A61K31/35 , A61K31/47 , C07C63/36 , C07D217/16 , C07D309/22
CPC分类号： C07D311/58 , C07C237/40 , C07C251/48 , C07C255/54 , C07C255/57 , C07C255/58 , C07C257/18 , C07C279/18 , C07D217/14
摘要： The invention relates to a novel compound which is represented by the formula (1) and has an excellent platelet aggregation inhibiting action based on fibrinogen antagonism. The platelet aggregation inhibitor containing the compound of the formula (1) as an effective ingredient are effective for prevention and curing of thrombosis and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.
摘要翻译：本发明涉及一种由式（1）表示的新型化合物，其具有基于纤维蛋白原拮抗作用的优异的血小板聚集抑制作用。含有式（1）化合物作为有效成分的血小板聚集抑制剂可有效预防和治愈经皮腔内冠状动脉血管成形术或经皮腔内冠状动脉再通后的血栓形成和再狭窄。

5. 发明授权

US5308848A Pyrimidinedione derivatives and antiarrythmic agents containing the same 失效
标题翻译：嘧啶二酮衍生物和含有它们的抗焦虑剂
公开(公告)号：US5308848A
公开(公告)日：1994-05-03
申请号：US927738
申请日：1992-08-12
申请人： Michihiko Miyamoto , Tsutomu Katakami , Nobuya Kawauchi , Tadahito Nobori , Joji Kamiya , Masaaki Ishii
发明人： Michihiko Miyamoto , Tsutomu Katakami , Nobuya Kawauchi , Tadahito Nobori , Joji Kamiya , Masaaki Ishii
IPC分类号： C07D239/54 , C07D239/545 , C07D401/12 , A61K31/505 , C07D239/10
CPC分类号： C07D239/545 , C07D401/12
摘要： A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a linking structure comprising an alkyl chain containing two nitrogen atoms. This linking structure is represented by ##STR1## [wherein A is --(CH.sub.2).sub.n --, --CO-- or --O--(CH.sub.2).sub.m --; each of R.sup.1 and R.sup.2 is independently a hydrogen atom or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.1 and R.sup.2 may be so linked with each other as to make an alkylene chain and thus form a heterocyclic structure; R.sup.5 is a halogen atom, a hydroxyl group, a lower alkyloxycarbonyl group, a lower alkyloxy group which may be substituted by a lower alkyloxy group, or a lower alkyl group which may be substituted by a hydroxyl group, or R.sup.5 may be so linked with R.sup.1 as to make an alkylene chain and thus form a heterocyclic structure; n is 0, 1, 2 or 3 (when R.sup.5 is the hydroxyl group, n.noteq.0); m is 0, 1, 2 or 3; and k is 0, 1, 2 or 3 (however, a compound in which A is --O--(CH.sub.2).sub.m -- and R.sup.5 is the hydroxyl group is excluded from the pyrimidinedione derivative)]. The pyrimidinedione derivative and its acid addition salt are useful for a medical treatment of cardiac arrhythmias.
摘要翻译：嘧啶二酮衍生物化合物具有其中苯基部分和嘧啶二酮部分通过包含含有两个氮原子的烷基链的连接结构连接的碱性主链。该连接结构由表示，其中A是 - （CH 2）n - ， - CO-或-O-（CH 2）m - ; R 1和R 2各自独立地为氢原子或可以被羟基取代的低级烷基，或者R 1和R 2可以相互连接形成亚烷基链，从而形成杂环结构; R5是卤素原子，羟基，低级烷氧基羰基，可被低级烷氧基取代的低级烷氧基或可被羟基取代的低级烷基，或R5可以与 R1形成亚烷基链，从而形成杂环结构; n是0,1,2或3（当R5是羟基时，n是等于0）; m为0,1,2或3; 并且k为0,1,2或3（然而，其中A为-O-（CH 2）m - 且R 5为羟基的化合物不包括在嘧啶二酮衍生物中]]。嘧啶二酮衍生物及其酸加成盐可用于治疗心律失常。

6. 发明授权

US5008267A Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same 失效
标题翻译：嘧啶二酮化合物，其制备方法和含有它们的抗焦虑剂
公开(公告)号：US5008267A
公开(公告)日：1991-04-16
申请号：US425730
申请日：1989-10-24
申请人： Tsutomu Katakami , Tatsuro Yokoyama , Michihiko Miyamoto , Haruki Mori , Nobuya Kawauchi , Tadahito Nobori , Kunio Sannohe , Joji Kamiya , Masaaki Ishii , Kanji Yoshihara
发明人： Tsutomu Katakami , Tatsuro Yokoyama , Michihiko Miyamoto , Haruki Mori , Nobuya Kawauchi , Tadahito Nobori , Kunio Sannohe , Joji Kamiya , Masaaki Ishii , Kanji Yoshihara
IPC分类号： C07D239/54 , C07D239/545 , C07D401/12 , C07D403/12
CPC分类号： C07D239/545 , C07D401/12 , C07D403/12 , Y10S514/821
摘要： A pyrimidinedione derivative compound has a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain containing at least two nitrogen atoms. The pyrimidinedione derivative is useful for a medical treatment of cardiac arrhythmias.
摘要翻译：嘧啶二酮衍生物化合物具有碱性主链，其中苯基部分和嘧啶二酮部分通过包含至少两个氮原子的烷基链的结构连接。嘧啶二酮衍生物可用于治疗心律失常。

7. 发明授权

US5917010A Preparation process of aliphatic polyester 失效
标题翻译：脂肪族聚酯的制备方法
公开(公告)号：US5917010A
公开(公告)日：1999-06-29
申请号：US917378
申请日：1997-08-26
申请人： Kenichi Goto , Yukiko Mori , Michihiko Miyamoto
发明人： Kenichi Goto , Yukiko Mori , Michihiko Miyamoto
IPC分类号： C08G63/06 , C08G63/16 , C08G63/60 , C08G63/81 , C08F6/00 , B01J49/00
CPC分类号： C08G63/81 , C08G63/06 , C08G63/16 , C08G63/60
摘要： The invention relates to a preparation process of aliphatic polyester, comprising using an ion exchange resin as a drying agent and after the dehydration polycondensation reaction, regenerating and drying the used ion exchange resin and repeatedly using said ion exchange resin in the next dehydration polycondensation reaction, in a process for preparing aliphatic polyester from one or more aliphatic compound (A) by heating in an organic solvent in the presence of a catalyst, distilling a generated water containing organic solvent out of the reaction system, treating the distilled organic solvent with a drying agent, and returning the treated solvent to the reaction system to progress a dehydration polycondensation reaction. The process of the invention enables one to steadily and efficiently prepare in industry an aliphatic polyester having an excellent color tone, high molecular weight and high quality.
摘要翻译：本发明涉及一种脂肪族聚酯的制备方法，其包括使用离子交换树脂作为干燥剂，在脱水缩聚反应后，再次干燥所使用的离子交换树脂，并在下一次脱水缩聚反应中反复使用所述离子交换树脂，在通过在有机溶剂中在催化剂存在下加热制备脂族聚酯的方法中，将产生的含有机溶剂的水从反应体系中蒸馏出来，用干燥法处理蒸馏的有机溶剂并将处理过的溶剂返回到反应体系中进行脱水缩聚反应。本发明的方法使得能够稳定且有效地在工业上制备具有优异色调，高分子量和高质量的脂族聚酯。

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