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1. 发明授权

US08143294B2 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors 有权
标题翻译： 2-硫烷基取代的咪唑衍生物及其作为细胞因子抑制剂的用途
公开(公告)号：US08143294B2
公开(公告)日：2012-03-27
申请号：US12347498
申请日：2008-12-31
申请人： Michael Burnet , Stefan Laufer , Pierre Koch
发明人： Michael Burnet , Stefan Laufer , Pierre Koch
IPC分类号： C07D401/04 , A61K31/4439
CPC分类号： C07D401/04
摘要： The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof.
摘要翻译：本发明涉及式I的2-硫代取代的咪唑衍生物及其使用方法。

2. 发明申请

US20110028417A1 Macrocyclic Compounds and Methods of Use Thereof 失效
标题翻译：大环化合物及其使用方法
公开(公告)号：US20110028417A1
公开(公告)日：2011-02-03
申请号：US12847740
申请日：2010-07-30
申请人： Hans-Jurgen Gutke , Michael Burnet , Jan-Hinrich Guse
发明人： Hans-Jurgen Gutke , Michael Burnet , Jan-Hinrich Guse
IPC分类号： A61K31/7052 , C07H17/00 , A61P31/12 , A61P31/04 , A61P9/00 , A61P3/00 , A61P37/00 , A61P29/00
CPC分类号： C07H17/08
摘要： The invention features novel macrocyclic compounds, methods of making the compounds, pharmaceutical compositions including the compounds, and methods of treatment using the compounds.
摘要翻译：本发明的特征在于新颖的大环化合物，制备化合物的方法，包括该化合物的药物组合物以及使用该化合物的治疗方法。

3. 发明授权

US07767797B1 Macrocyclic compounds and methods of use thereof 有权
标题翻译：大环化合物及其使用方法
公开(公告)号：US07767797B1
公开(公告)日：2010-08-03
申请号：US11241514
申请日：2005-09-30
申请人： Hans-Jurgen Gutke , Michael Burnet , Jan-Hinrich Guse
发明人： Hans-Jurgen Gutke , Michael Burnet , Jan-Hinrich Guse
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： The invention features novel macrocyclic compounds, methods of making the compounds, pharmaceutical compositions including the compounds, and methods of treatment using the compounds.
摘要翻译：本发明的特征在于新颖的大环化合物，制备化合物的方法，包括该化合物的药物组合物以及使用该化合物的治疗方法。

4. 发明授权

US08461120B2 Macrocyclic compounds pounds and methods of use thereof 失效
标题翻译：大环化合物磅及其使用方法
公开(公告)号：US08461120B2
公开(公告)日：2013-06-11
申请号：US12847740
申请日：2010-07-30
申请人： Hans-Jurgen Gutke , Michael Burnet , Jan-Hinrich Guse
发明人： Hans-Jurgen Gutke , Michael Burnet , Jan-Hinrich Guse
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The invention features novel macrocyclic compounds, methods of making the compounds, pharmaceutical compositions including the compounds, and methods of treatment using the compounds.
摘要翻译：本发明的特征在于新颖的大环化合物，制备化合物的方法，包括该化合物的药物组合物以及使用该化合物的治疗方法。

5. 发明申请

US20070149409A1 Pesticide formulations with substituted biopolymers and organic polymers for improving residual activity, droplet size, adherence and rainfastness on leaves and reduction in soil leaching 审中-公开
标题翻译：具有取代的生物聚合物和有机聚合物的农药制剂，用于改善残留活性，液滴尺寸，粘附和叶片耐雨性和减少土壤浸出
公开(公告)号：US20070149409A1
公开(公告)日：2007-06-28
申请号：US11476479
申请日：2006-06-27
申请人： Michael Burnet , Jonathan Gressel
发明人： Michael Burnet , Jonathan Gressel
IPC分类号： A01N25/10 , A01N25/08
CPC分类号： A01N25/10 , A01N25/02 , A01N25/24
摘要： Functionalized polymers are mixed with pesticides to form semi-stable complexes with desirable field properties: reduced leaching in soil, improved leaf retention (rainfastness), selective unloading to roots and convenient packaging and application. Pesticides that may be so complexed include herbicides, insecticides (including compounds controlling non-insect arthropods and nematodes), bacteriocides, rodenticides, and fungicides. Polymers with which they may be complexed include derivatives of carbohydrates, amides, imines, alkanes, vinyls, styrenes or glycols. The polymers may be functionalized with chemical groups that exhibit ionic (amines, carboxyls), hydrophobic, complexing (e.g. metal chelating) and ligand binding interactions. The variously functionalized polymers may be mixed, grafted, or fused to obtain optimal properties. The polymer/pesticide formulations may be applied as granules, as suspensions or solutions in sprays, as foams, or as coats for seeds and fertilizers. The formulations may be applied to foliage, soil, irrigation water, construction materials (plastics, wood), seeding materials, grains, and buildings.
摘要翻译：官能化聚合物与农药混合以形成具有所需场性质的半稳定配合物：减少土壤浸出，提高叶片保持力（耐雨性），选择性卸载至根部，方便包装和施用。可能如此复杂的农药包括除草剂，杀虫剂（包括控制非昆虫节肢动物和线虫的化合物），杀菌剂，杀鼠剂和杀真菌剂。它们可能复合的聚合物包括碳水化合物，酰胺，亚胺，烷烃，乙烯基，苯乙烯或二醇的衍生物。可以用显示离子（胺，羧基），疏水性，络合（例如金属螯合）和配体结合相互作用的化学基团官能化聚合物。各种官能化聚合物可以混合，接枝或熔融以获得最佳性能。聚合物/农药制剂可以作为颗粒剂，作为喷雾剂中的悬浮液或溶液，泡沫或作为种子和肥料的涂层施用。制剂可以应用于叶子，土壤，灌溉水，建筑材料（塑料，木材），播种材料，谷物和建筑物。

6. 发明申请

US20050171342A1 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof 审中-公开
标题翻译：生物活性化合物的缀合物，其制备和使用方法，其制剂和药物应用
公开(公告)号：US20050171342A1
公开(公告)日：2005-08-04
申请号：US10504787
申请日：2003-02-14
申请人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurent Barker
发明人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurent Barker
IPC分类号： A61K47/48 , A61K49/00 , C07H19/00 , C07H21/00
CPC分类号： A61K49/0004 , A61K47/54 , A61K47/545 , A61K47/549
摘要： This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
摘要翻译：本发明的特征在于下式的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> T - （ - LC） -line-formula description =“In-line Formulas”end =“tail”？> T是转运载体，L是分子量高达240道尔顿的键或接头，C是非抗生素治疗剂， m是1,2,3,4,5,6,7或8，其中转运蛋白具有至少2的免疫选择性比，所述转运载体通过所述键或所述非抗生素治疗剂共价结合，接头，并且化合物的免疫选择性比至少为2。

7. 发明申请

US20090270462A1 2-SULFANYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS 有权
标题翻译： 2-SULFANYL取代的咪唑衍生物及其作为细胞因子抑制剂的用途
公开(公告)号：US20090270462A1
公开(公告)日：2009-10-29
申请号：US12347498
申请日：2008-12-31
申请人： Michael Burnet , Stefan Laufer , Pierre Koch
发明人： Michael Burnet , Stefan Laufer , Pierre Koch
IPC分类号： A61K31/4439 , C07D401/04 , C07K2/00 , A61P17/06 , C12N9/99
CPC分类号： C07D401/04
摘要： The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof.
摘要翻译：本发明涉及式I的2-硫代取代的咪唑衍生物及其使用方法。

8. 发明申请

US20090093014A1 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof 失效
标题翻译：生物活性化合物的缀合物，其制备和使用方法，其制剂和药物应用
公开(公告)号：US20090093014A1
公开(公告)日：2009-04-09
申请号：US12157937
申请日：2008-06-12
申请人： Michael Burnet , Jan-Hinrich Guse , Gene Kim , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Laurence Barker , Michael Wolff , Hans-Jurgen Gutke
发明人： Michael Burnet , Jan-Hinrich Guse , Gene Kim , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Laurence Barker , Michael Wolff , Hans-Jurgen Gutke
IPC分类号： C12Q1/02 , C12N5/06
CPC分类号： B82Y5/00 , A61K47/552 , A61K47/556 , A61K47/67 , A61K49/0004 , G01N33/5047 , G01N33/5094
摘要： This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.
摘要翻译：本发明的特征在于鉴定可用于增强治疗剂功效的化合物的方法。该方法包括在血细胞中孵育化合物; 将免疫细胞与红细胞分离; 并测定免疫细胞中化合物的浓度与红细胞中化合物浓度之比; 其中所述化合物包含转运载体和治疗剂，其中所述转运载体通过键或接头共价键合到所述治疗剂。

9. 发明授权

US06310271B1 Polynucleotides encoding choline monooxygenase and plants transformed therewith 失效
标题翻译：编码胆碱单加氧酶的多核苷酸和用其转化的植物
公开(公告)号：US06310271B1
公开(公告)日：2001-10-30
申请号：US09004393
申请日：1998-01-08
申请人： Andrew D. Hanson , Bala Rathinasabapathi , Michael Burnet
发明人： Andrew D. Hanson , Bala Rathinasabapathi , Michael Burnet
IPC分类号： C12N1529
CPC分类号： C12N9/0006 , C12N15/8243 , C12N15/8273
摘要： A full length choline monooxygenase (CMO) cDNA was cloned from spinach and used to transform plants which do not naturally express CMO. A method is presented to improve stress tolerance of crops following engineering of CMO and BADH in plants that lack glycine betaine accumulation. Also provided are fragments useful as probes to isolate other CMO-type genes, and antisense sequences which inhibit the production of CMO. Reduction of glycine betaine as a consequence of antisense expression of CMO in species naturally accumulating glycine betaine, improves the transgenic plant's tolerance toward pathogens and pests and/or enhances its nutritional quality.
摘要翻译：从菠菜中克隆全长胆碱单加氧酶（CMO）cDNA，用于转化不自然表达CMO的植物。提出了一种在缺乏甘氨酸甜菜碱积累的植物中提高CMO和BADH工程后作物胁迫耐受性的方法。还提供了可用作分离其他CMO型基因的探针的片段和抑制CMO产生的反义序列。由于CMO在天然存在甘氨酸甜菜碱的物种中反义表达的结果，甘氨酸甜菜碱的降低，改善了转基因植物对病原体和害虫的耐受性和/或增强了其营养品质。

10. 发明授权

US09045523B2 Compounds 有权
标题翻译：化合物
公开(公告)号：US09045523B2
公开(公告)日：2015-06-02
申请号：US12596068
申请日：2007-11-14
申请人： Michael Peter Seed , Michael Burnet , Hans Hurgen Gutke
发明人： Michael Peter Seed , Michael Burnet , Hans Hurgen Gutke
IPC分类号： A01N43/04 , A61K31/70 , C07K9/00 , C07H13/04 , C07H15/04
CPC分类号： C07K9/005 , C07H5/06 , C07H5/08 , C07H13/04 , C07H15/04
摘要： The present invention is directed to sulphated compounds comprising at least one glycosidic amine group, and polysaccharide, oligosaccharide, peptide and protein derivatives comprising such compounds, and mixtures thereof. The present invention is also directed to methods of synthesizing such compounds. Such compounds may bind to a range of proteins, find application in methods of modifying, or testing for a modification in the level of a cytokine in vivo, ex vivo or in vitro, and find application in the treatment and/or prevention of inflammation, an inflammatory disorder, a proliferative disorder, an immune disorder, an angiogenesis-dependent disorder, a sensitivity disorder, an adverse endocrine reaction, a degenerative disorder, wound healing, depression, and other diseases and disorders.
摘要翻译：本发明涉及包含至少一种糖苷基的硫酸化合物，以及包含这些化合物的多糖，寡糖，肽和蛋白质衍生物及其混合物。本发明还涉及合成这些化合物的方法。这样的化合物可以结合一系列蛋白质，在体内，离体或体外在应用于修饰或测试细胞因子水平的修饰的方法中应用，并且可用于治疗和/或预防炎症，炎症性疾病，增殖性疾病，免疫疾病，血管发生依赖性病症，敏感性障碍，不良内分泌反应，退行性病症，伤口愈合，抑郁症和其它疾病和病症。

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