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1. 发明授权

US09045523B2 Compounds 有权
标题翻译：化合物
公开(公告)号：US09045523B2
公开(公告)日：2015-06-02
申请号：US12596068
申请日：2007-11-14
申请人： Michael Peter Seed , Michael Burnet , Hans Hurgen Gutke
发明人： Michael Peter Seed , Michael Burnet , Hans Hurgen Gutke
IPC分类号： A01N43/04 , A61K31/70 , C07K9/00 , C07H13/04 , C07H15/04
CPC分类号： C07K9/005 , C07H5/06 , C07H5/08 , C07H13/04 , C07H15/04
摘要： The present invention is directed to sulphated compounds comprising at least one glycosidic amine group, and polysaccharide, oligosaccharide, peptide and protein derivatives comprising such compounds, and mixtures thereof. The present invention is also directed to methods of synthesizing such compounds. Such compounds may bind to a range of proteins, find application in methods of modifying, or testing for a modification in the level of a cytokine in vivo, ex vivo or in vitro, and find application in the treatment and/or prevention of inflammation, an inflammatory disorder, a proliferative disorder, an immune disorder, an angiogenesis-dependent disorder, a sensitivity disorder, an adverse endocrine reaction, a degenerative disorder, wound healing, depression, and other diseases and disorders.
摘要翻译：本发明涉及包含至少一种糖苷基的硫酸化合物，以及包含这些化合物的多糖，寡糖，肽和蛋白质衍生物及其混合物。本发明还涉及合成这些化合物的方法。这样的化合物可以结合一系列蛋白质，在体内，离体或体外在应用于修饰或测试细胞因子水平的修饰的方法中应用，并且可用于治疗和/或预防炎症，炎症性疾病，增殖性疾病，免疫疾病，血管发生依赖性病症，敏感性障碍，不良内分泌反应，退行性病症，伤口愈合，抑郁症和其它疾病和病症。

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