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1. 发明申请

US20050171342A1 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof 审中-公开
标题翻译：生物活性化合物的缀合物，其制备和使用方法，其制剂和药物应用
公开(公告)号：US20050171342A1
公开(公告)日：2005-08-04
申请号：US10504787
申请日：2003-02-14
申请人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurent Barker
发明人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurent Barker
IPC分类号： A61K47/48 , A61K49/00 , C07H19/00 , C07H21/00
CPC分类号： A61K49/0004 , A61K47/54 , A61K47/545 , A61K47/549
摘要： This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
摘要翻译：本发明的特征在于下式的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> T - （ - LC） -line-formula description =“In-line Formulas”end =“tail”？> T是转运载体，L是分子量高达240道尔顿的键或接头，C是非抗生素治疗剂， m是1,2,3,4,5,6,7或8，其中转运蛋白具有至少2的免疫选择性比，所述转运载体通过所述键或所述非抗生素治疗剂共价结合，接头，并且化合物的免疫选择性比至少为2。

2. 发明授权

US08643938B2 Microcapsule, system comprising microcapsules, method for changing the state of at least one such microcapsule and apparatus therefor 失效
标题翻译：微胶囊，包含微胶囊的系统，改变至少一种这样的微胶囊的状态的方法及其装置
公开(公告)号：US08643938B2
公开(公告)日：2014-02-04
申请号：US13003452
申请日：2009-07-08
申请人： Simona Margutti , Florian Rothfuss , Karola Rath , Simon Voigt
发明人： Simona Margutti , Florian Rothfuss , Karola Rath , Simon Voigt
IPC分类号： G02B26/00
CPC分类号： G02F1/167 , C08K9/10 , C09D7/70
摘要： The invention relates to a microcapsule, a system comprising microcapsules, and a corresponding method and apparatus, the microcapsule (11) comprising a core (12) which is encapsulated by an envelope (14) and in which at least one particle (16) having a motion component (17) and an indication component (18) is provided, the substance of the core (12) being capable of being transferred, at least for a short time, by an input of energy from a solid state or higher-viscosity state to a low-viscosity state, the at least one particle (16) being capable of undergoing a change in its position and/or orientation due to an input of energy occurring during the low-viscosity state of the substance of the core (12), and the substance of the core (12) reverting back, upon completion of the energy input, to the solid state or higher-viscosity state, thereby immobilizing the at least one particle (16) in its new position and/or orientation.
摘要翻译：本发明涉及一种微胶囊，一种包含微胶囊的体系，以及相应的方法和装置，所述微胶囊（11）包括被封套（14）包封的芯体（12），其中至少一个颗粒（16）具有提供运动部件（17）和指示部件（18），所述芯部（12）的物质能够至少在短时间内通过来自固体或更高粘度的能量的输入状态为低粘度状态，所述至少一个颗粒（16）能够由于在芯（12）的物质的低粘度状态期间发生的能量的输入而发生其位置和/或取向的变化），并且在能量输入完成时，芯（12）的物质回复到固态或更高粘度状态，从而将至少一个颗粒（16）固定在其新位置和/或取向。

3. 发明授权

US07579324B2 Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof 失效
标题翻译：生物活性化合物的缀合物，其制备和使用方法，其制剂和药物应用
公开(公告)号：US07579324B2
公开(公告)日：2009-08-25
申请号：US10367105
申请日：2003-02-14
申请人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurence Barker
发明人： Michael Burnet , Jan-Hinrich Guse , Hans-Jurgen Gutke , Albert Beck , Georgia Tsotsou , Irina Droste-Borel , Jeannette Reichert , Kattie Luyten , Maximilian Busch , Michael Wolff , Moussa Khobzaoui , Simona Margutti , Thomas Meindl , Gene Kim , Laurence Barker
IPC分类号： A01N43/04 , A61K31/70 , C07H17/08
CPC分类号： A61K49/0004 , A61K47/54 , A61K47/545 , A61K47/549
摘要： This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
摘要翻译：本发明的特征在于下列化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> T - （ - LC）m，<？in-line-formula description =“ T是一个转运载体，L是分子量高达240道尔顿的键或接头，C是非抗生素治疗剂，m是1,2,3 ，4,5,6,7或8，其中转运载体具有至少2的免疫选择性比，转运载体通过键或接头与非抗生素治疗剂共价结合，并且该化合物具有免疫选择性比至少为2。

4. 发明申请

US20110180745A1 MICROCAPSULE, SYSTEM COMPRISING MICROCAPSULES, METHOD FOR CHANGING THE STATE OF AT LEAST ONE MICROCAPSULE AND APPARATUS THEREFOR 失效
标题翻译： MICROCAPSULE，包含微阵列的系统，用于改变至少一个微阵列的状态的方法及其装置
公开(公告)号：US20110180745A1
公开(公告)日：2011-07-28
申请号：US13003452
申请日：2009-07-08
申请人： Simona Margutti , Florian Rothfuss , Karola Rath , Simon Voigt
发明人： Simona Margutti , Florian Rothfuss , Karola Rath , Simon Voigt
IPC分类号： G02B5/23 , G02B1/02 , H01F1/00
CPC分类号： G02F1/167 , C08K9/10 , C09D7/70
摘要： The invention relates to a microcapsule, a system comprising microcapsules, and a corresponding method and apparatus, the microcapsule (11) comprising a core (12) which is encapsulated by an envelope (14) and in which at least one particle (16) having a motion component (17) and an indication component (18) is provided, the substance of the core (12) being capable of being transferred, at least for a short time, by an input of energy from a solid state or higher-viscosity state to a low-viscosity state, the at least one particle (16) being capable of undergoing a change in its position and/or orientation due to an input of energy occurring during the low-viscosity state of the substance of the core (12), and the substance of the core (12) reverting back, upon completion of the energy input, to the solid state or higher-viscosity state, thereby immobilising the at least one particle (16) in its new position and/or orientation. (Cf. FIG. 1).
摘要翻译：本发明涉及一种微胶囊，一种包含微胶囊的体系，以及相应的方法和装置，所述微胶囊（11）包括被封套（14）包封的芯体（12），其中至少一个颗粒（16）具有提供运动部件（17）和指示部件（18），所述芯部（12）的物质能够至少在短时间内通过来自固体或更高粘度的能量的输入状态为低粘度状态，所述至少一个颗粒（16）能够由于在芯（12）的物质的低粘度状态期间发生的能量的输入而发生其位置和/或取向的变化），并且核（12）的物质在能量输入完成时回复到固态或更高粘度状态，从而将至少一个颗粒（16）固定在其新位置和/或取向。（参见图1）。

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