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1. 发明授权

US08548545B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08548545B2
公开(公告)日：2013-10-01
申请号：US13458544
申请日：2012-04-27
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施例提供了一种测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

2. 发明申请

US20120029326A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120029326A1
公开(公告)日：2012-02-02
申请号：US13267625
申请日：2011-10-06
申请人： Tatsurou KAWAMURA , Masahiko Shioi , Masaru Minamiguchi
发明人： Tatsurou KAWAMURA , Masahiko Shioi , Masaru Minamiguchi
IPC分类号： A61B5/1455
CPC分类号： G01N21/658 , A61B5/14532 , A61B5/14558 , A61B5/6861
摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation (III). [Math. 3] R(t)=Am·sin(t)+D (III) R(t): received signal Am: amplitude t: time D: a constant number
摘要翻译：本发明的目的是提供一种用于测量生物体中包含的生物体的浓度的方法，其中抑制了由反射光和中断成分引起的精度的劣化。线性偏振光通过调制其调制方向连续地发射到植入皮肤中的粒子碎片。颗粒上产生生物物质的表面增强拉曼散射光。基于接收到的信号计算生物物质的浓度。接收信号满足下式（III）。 [数学。 3] R（t）= Am·sin（t）+ D（III）R（t）：接收信号Am：幅度t：时间D：常数

3. 发明申请

US20110001976A1 METHOD AND APPARATUS FOR BIOGENIC SUBSTANCE CONCENTRATION MEASUREMENT 有权
标题翻译：用于生物物质浓度测量的方法和装置
公开(公告)号：US20110001976A1
公开(公告)日：2011-01-06
申请号：US12828775
申请日：2010-07-01
申请人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

4. 发明授权

US08509868B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08509868B2
公开(公告)日：2013-08-13
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

5. 发明申请

US20120265038A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120265038A1
公开(公告)日：2012-10-18
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

6. 发明授权

US07884934B2 Method and apparatus for biogenic substance concentration measurement 有权
标题翻译：生物来源物质浓度测定方法和装置
公开(公告)号：US07884934B2
公开(公告)日：2011-02-08
申请号：US12828775
申请日：2010-07-01
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01J4/00 , G01N21/00
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

7. 发明授权

US08735170B2 Method for measuring concentration of antigen contained in test solution 有权
标题翻译：测定溶液中含有的抗原浓度的方法
公开(公告)号：US08735170B2
公开(公告)日：2014-05-27
申请号：US13483790
申请日：2012-05-30
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N33/566 , G01N33/551 , G01N33/553 , G01N21/64
CPC分类号： G01N33/551 , G01N21/21 , G01N21/553 , G01N21/648 , G01N33/553
摘要： A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.
摘要翻译：一种生物来源物质浓度测量装置，包括：用于通过使用生物源物质浓度测量用的细胞测量第一基板和第二基板的光学特性的光学测量装置，其包括：第一基板，多个第一金属纳米棒，用特异性结合试验物质的物质进行了改性，被固定成使其长轴在同一方向上排列; 并且其上固定有多个第二金属纳米棒的第二基板，每个第二金属纳米棒被阻挡物质改性，使得其长轴垂直于第一基板上的第一金属纳米棒的长轴取向，并且计算一种具有高精度的光学性质的生物物质浓度。

8. 发明申请

US20120288960A1 METHOD FOR MEASURING CONCENTRATION OF ANTIGEN CONTAINED IN TEST SOLUTION 有权
标题翻译：用于测量测试溶液中含有抗原浓度的方法
公开(公告)号：US20120288960A1
公开(公告)日：2012-11-15
申请号：US13483790
申请日：2012-05-30
申请人： Masaru MINAMIGUCHI , Tatsurou KAWAMURA , Masahiko SHIOI , Atsushi MATSUBARA
发明人： Masaru MINAMIGUCHI , Tatsurou KAWAMURA , Masahiko SHIOI , Atsushi MATSUBARA
IPC分类号： G01N21/75 , B82Y15/00
CPC分类号： G01N33/551 , G01N21/21 , G01N21/553 , G01N21/648 , G01N33/553
摘要： A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.
摘要翻译：一种生物来源物质浓度测量装置，包括：用于通过使用生物源物质浓度测量用的细胞测量第一基板和第二基板的光学特性的光学测量装置，其包括：第一基板，多个第一金属纳米棒，用特异性结合试验物质的物质进行了改性，被固定成使其长轴在同一方向上排列; 并且其上固定有多个第二金属纳米棒的第二基板，每个第二金属纳米棒被阻挡物质改性，使得其长轴垂直于第一基板上的第一金属纳米棒的长轴取向，并且计算一种具有高精度的光学性质的生物物质浓度。

9. 发明授权

US08515508B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08515508B2
公开(公告)日：2013-08-20
申请号：US13267625
申请日：2011-10-06
申请人： Tatsurou Kawamura , Masahiko Shioi , Masaru Minamiguchi
发明人： Tatsurou Kawamura , Masahiko Shioi , Masaru Minamiguchi
IPC分类号： A61B5/1455
CPC分类号： G01N21/658 , A61B5/14532 , A61B5/14558 , A61B5/6861
摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation: R(t)=Am ·sin(ωt)+D, where R(t): received signal, Am: amplitude, t: time, D: a constant number, and ω: angular speed.
摘要翻译：本发明的目的是提供一种用于测量生物体中包含的生物物质的浓度的方法，其中抑制了由于反射光和中断成分引起的精度的劣化。线性偏振光通过调制其调制方向连续地发射到植入皮肤的粒子芯片上。颗粒上产生生物物质的表面增强拉曼散射光。基于接收到的信号计算生物物质的浓度。接收信号满足下列公式：R（t）= Am·sin（omegat）+ D，其中R（t）：接收信号，Am：幅度，t：时间，D：常数，ω：角速度。

10. 发明申请

US20120215078A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120215078A1
公开(公告)日：2012-08-23
申请号：US13458544
申请日：2012-04-27
申请人： Tatsurou KAWAMURA , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou KAWAMURA , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1459
CPC分类号： A61B5/14532 , A61B5/1455
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

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