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1. 发明申请

US20110001976A1 METHOD AND APPARATUS FOR BIOGENIC SUBSTANCE CONCENTRATION MEASUREMENT 有权
标题翻译：用于生物物质浓度测量的方法和装置
公开(公告)号：US20110001976A1
公开(公告)日：2011-01-06
申请号：US12828775
申请日：2010-07-01
申请人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

2. 发明授权

US08548545B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08548545B2
公开(公告)日：2013-10-01
申请号：US13458544
申请日：2012-04-27
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施例提供了一种测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

3. 发明申请

US20120029326A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120029326A1
公开(公告)日：2012-02-02
申请号：US13267625
申请日：2011-10-06
申请人： Tatsurou KAWAMURA , Masahiko Shioi , Masaru Minamiguchi
发明人： Tatsurou KAWAMURA , Masahiko Shioi , Masaru Minamiguchi
IPC分类号： A61B5/1455
CPC分类号： G01N21/658 , A61B5/14532 , A61B5/14558 , A61B5/6861
摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation (III). [Math. 3] R(t)=Am·sin(t)+D (III) R(t): received signal Am: amplitude t: time D: a constant number
摘要翻译：本发明的目的是提供一种用于测量生物体中包含的生物体的浓度的方法，其中抑制了由反射光和中断成分引起的精度的劣化。线性偏振光通过调制其调制方向连续地发射到植入皮肤中的粒子碎片。颗粒上产生生物物质的表面增强拉曼散射光。基于接收到的信号计算生物物质的浓度。接收信号满足下式（III）。 [数学。 3] R（t）= Am·sin（t）+ D（III）R（t）：接收信号Am：幅度t：时间D：常数

4. 发明申请

US20090316137A1 LIVING BODY INGREDIENT CONCENTRATION MEASURING INSTRUMENT 有权
标题翻译：生命体成分浓度测量仪器
公开(公告)号：US20090316137A1
公开(公告)日：2009-12-24
申请号：US11915889
申请日：2007-03-08
申请人： Masahiko Shioi
发明人： Masahiko Shioi
IPC分类号： G01N21/35 , G01J3/00
CPC分类号： A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/6817 , G01J1/04 , G01J1/0448 , G01J1/0451 , G01J2003/1213 , G01N21/35
摘要： A device for measuring the concentration of a biological constituent based on infrared radiation emitted by a subject's eardrum with the influence of the eardrum's thickness taken into account is provided.The biological constituent concentration measuring device includes: a detecting section for detecting infrared radiation emitted by an eardrum; an acquisition section for acquiring thickness information about the thickness of the eardrum; and a computing section for figuring out the concentration of the biological constituent based on the infrared radiation detected and the thickness information acquired. The infrared radiation emitted by the eardrum is subject to the influence of the subject's eardrum thickness. Therefore, by calculating the biological constituent concentration based on not only the infrared radiation detected but also the eardrum thickness information, the biological constituent concentration can be measured highly accurately.
摘要翻译：提供了一种用于根据所考虑的鼓膜厚度的影响来测量基于被检体耳膜发射的红外辐射的生物成分浓度的装置。所述生物体成分浓度测定装置包括：检测部，其检测由鼓膜发射的红外线辐射; 用于获取关于所述鼓膜厚度的厚度信息的获取部分; 以及计算部，用于基于所检测的红外辐射和获取的厚度信息来计算生物成分的浓度。由鼓膜发射的红外辐射受到受试者耳膜厚度的影响。因此，通过不仅检测出红外辐射而且基于鼓膜厚度信息计算生物成分浓度，所以可以高精度地测定生物成分浓度。

5. 发明申请

US20090270698A1 BIOINFORMATION MEASUREMENT DEVICE 审中-公开
标题翻译：生物测量装置
公开(公告)号：US20090270698A1
公开(公告)日：2009-10-29
申请号：US12067917
申请日：2006-10-19
申请人： Masahiko Shioi , Yoshiko Miyamoto , Shinji Uchida
发明人： Masahiko Shioi , Yoshiko Miyamoto , Shinji Uchida
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6817
摘要： A bioinformation measurement device that enables further accurate bioinformation measurement is provided. The device includes an insertion portion 104 to be inserted in an ear cavity 200; a first light inlet 105 and a second light inlet 106 provided at the insertion portion 104, for introducing the infrared light irradiated from the ear cavity 200 to the insertion portion 104; an optical guide path provided in the insertion portion 104 for guiding the first infrared light introduced from the first light inlet 105 and the second infrared light introduced from the second light inlet 106; a dispersive element for dispersing the first infrared light and the second infrared light guided by the optical guide path; an infrared ray detector 108 for detecting the first infrared light and the second infrared light dispersed by the dispersive element; and a computing unit for computing bioinformation based on the intensities of the first infrared light and the second infrared light detected by the infrared ray detector 108.
摘要翻译：提供了能够进一步精确的生物信息测量的生物信息测量装置。该装置包括插入耳孔200中的插入部分104; 设置在插入部104处的第一光入口105和第二光入口106，用于将从耳腔200照射的红外光引入插入部104; 设置在插入部104中用于引导从第一光入口105引入的第一红外光和从第二光入口106引入的第二红外光的光导路径; 用于分散由光导路引导的第一红外光和第二红外线的色散元件; 用于检测由色散元件分散的第一红外光和第二红外光的红外线检测器108; 以及计算单元，用于基于由红外线检测器108检测到的第一红外光和第二红外光的强度来计算生物信息。

6. 发明申请

US20090030295A1 INSTRUMENT FOR MEASURING CONCENTRATION OF LIVING BODY INGREDIENT 审中-公开
标题翻译：用于测量生命体成分浓度的仪器
公开(公告)号：US20090030295A1
公开(公告)日：2009-01-29
申请号：US12281809
申请日：2007-03-08
申请人： Masahiko Shioi , Shinji Uchida , Yoshiko Miyamoto
发明人： Masahiko Shioi , Shinji Uchida , Yoshiko Miyamoto
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B1/227 , A61B5/14532 , A61B5/6817 , G01N21/35
摘要： A biological constituent concentration measuring device that can measure a biological constituent concentration highly accurately using a radiation that has come from an eardrum is provided.A measuring device for measuring concentration of a biological constituent includes: an image capturing section for capturing an image of an eardrum; a processing section for generating tilt information concerning tilt of the eardrum based on a first image capturing information obtained by capturing an image of a first area of the eardrum and a second image capturing information obtained by capturing an image of a second area of the eardrum, which is different from the first area; an infrared sensor for sensing infrared radiation that has been radiated from the eardrum; and a computing section for calculating the concentration of a biological constituent based on the infrared radiation sensed and the tilt information.
摘要翻译：提供了可以使用来自鼓膜的辐射高精度地测量生物成分浓度的生物成分浓度测量装置。用于测量生物成分浓度的测量装置包括：用于捕获鼓膜图像的图像捕获部分; 基于通过拍摄耳膜的第一区域的图像获得的第一图像拍摄信息和通过拍摄鼓膜的第二区域的图像而获得的第二图像拍摄信息，生成关于耳膜倾斜的倾斜信息的处理部分，这与第一个区域不同; 用于感测已经从鼓膜辐射的红外辐射的红外传感器; 以及计算部分，用于基于所感测的红外辐射和倾斜信息计算生物成分的浓度。

7. 发明授权

US08509868B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08509868B2
公开(公告)日：2013-08-13
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

8. 发明申请

US20120265038A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120265038A1
公开(公告)日：2012-10-18
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

9. 发明授权

US07884934B2 Method and apparatus for biogenic substance concentration measurement 有权
标题翻译：生物来源物质浓度测定方法和装置
公开(公告)号：US07884934B2
公开(公告)日：2011-02-08
申请号：US12828775
申请日：2010-07-01
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01J4/00 , G01N21/00
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

10. 发明授权

US07684841B2 Living body ingredient concentration measuring instrument 有权
标题翻译：活体成分浓度测定仪
公开(公告)号：US07684841B2
公开(公告)日：2010-03-23
申请号：US11915889
申请日：2007-03-08
申请人： Masahiko Shioi
发明人： Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/6817 , G01J1/04 , G01J1/0448 , G01J1/0451 , G01J2003/1213 , G01N21/35
摘要： A device for measuring the concentration of a biological constituent based on infrared radiation emitted by a subject's eardrum with the influence of the eardrum's thickness taken into account is provided.The biological constituent concentration measuring device includes: a detecting section for detecting infrared radiation emitted by an eardrum; an acquisition section for acquiring thickness information about the thickness of the eardrum; and a computing section for figuring out the concentration of the biological constituent based on the infrared radiation detected and the thickness information acquired. The infrared radiation emitted by the eardrum is subject to the influence of the subject's eardrum thickness. Therefore, by calculating the biological constituent concentration based on not only the infrared radiation detected but also the eardrum thickness information, the biological constituent concentration can be measured highly accurately.
摘要翻译：提供了一种用于根据所考虑的鼓膜厚度的影响来测量基于被检体耳膜发射的红外辐射的生物成分浓度的装置。所述生物体成分浓度测定装置包括：检测部，其检测由鼓膜发射的红外线辐射; 用于获取关于所述鼓膜厚度的厚度信息的获取部分; 以及计算部，用于基于所检测的红外辐射和获取的厚度信息来计算生物成分的浓度。由鼓膜发射的红外辐射受到受试者耳膜厚度的影响。因此，通过不仅检测出红外辐射而且基于鼓膜厚度信息计算生物成分浓度，所以可以高精度地测定生物成分浓度。

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