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1. 发明授权

US07884934B2 Method and apparatus for biogenic substance concentration measurement 有权
标题翻译：生物来源物质浓度测定方法和装置
公开(公告)号：US07884934B2
公开(公告)日：2011-02-08
申请号：US12828775
申请日：2010-07-01
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01J4/00 , G01N21/00
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

2. 发明授权

US08735170B2 Method for measuring concentration of antigen contained in test solution 有权
标题翻译：测定溶液中含有的抗原浓度的方法
公开(公告)号：US08735170B2
公开(公告)日：2014-05-27
申请号：US13483790
申请日：2012-05-30
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N33/566 , G01N33/551 , G01N33/553 , G01N21/64
CPC分类号： G01N33/551 , G01N21/21 , G01N21/553 , G01N21/648 , G01N33/553
摘要： A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.
摘要翻译：一种生物来源物质浓度测量装置，包括：用于通过使用生物源物质浓度测量用的细胞测量第一基板和第二基板的光学特性的光学测量装置，其包括：第一基板，多个第一金属纳米棒，用特异性结合试验物质的物质进行了改性，被固定成使其长轴在同一方向上排列; 并且其上固定有多个第二金属纳米棒的第二基板，每个第二金属纳米棒被阻挡物质改性，使得其长轴垂直于第一基板上的第一金属纳米棒的长轴取向，并且计算一种具有高精度的光学性质的生物物质浓度。

3. 发明申请

US20110001976A1 METHOD AND APPARATUS FOR BIOGENIC SUBSTANCE CONCENTRATION MEASUREMENT 有权
标题翻译：用于生物物质浓度测量的方法和装置
公开(公告)号：US20110001976A1
公开(公告)日：2011-01-06
申请号：US12828775
申请日：2010-07-01
申请人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

4. 发明授权

US08509868B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08509868B2
公开(公告)日：2013-08-13
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

5. 发明申请

US20120265038A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120265038A1
公开(公告)日：2012-10-18
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

6. 发明授权

US08548545B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08548545B2
公开(公告)日：2013-10-01
申请号：US13458544
申请日：2012-04-27
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施例提供了一种测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

7. 发明授权

US08515508B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08515508B2
公开(公告)日：2013-08-20
申请号：US13267625
申请日：2011-10-06
申请人： Tatsurou Kawamura , Masahiko Shioi , Masaru Minamiguchi
发明人： Tatsurou Kawamura , Masahiko Shioi , Masaru Minamiguchi
IPC分类号： A61B5/1455
CPC分类号： G01N21/658 , A61B5/14532 , A61B5/14558 , A61B5/6861
摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation: R(t)=Am ·sin(ωt)+D, where R(t): received signal, Am: amplitude, t: time, D: a constant number, and ω: angular speed.
摘要翻译：本发明的目的是提供一种用于测量生物体中包含的生物物质的浓度的方法，其中抑制了由于反射光和中断成分引起的精度的劣化。线性偏振光通过调制其调制方向连续地发射到植入皮肤的粒子芯片上。颗粒上产生生物物质的表面增强拉曼散射光。基于接收到的信号计算生物物质的浓度。接收信号满足下列公式：R（t）= Am·sin（omegat）+ D，其中R（t）：接收信号，Am：幅度，t：时间，D：常数，ω：角速度。

8. 发明授权

US07790470B2 Stirring method, cell, and measuring apparatus using the same 有权
标题翻译：搅拌方法，电池和使用其的测量装置
公开(公告)号：US07790470B2
公开(公告)日：2010-09-07
申请号：US10588546
申请日：2005-03-23
申请人： Akihito Kamei , Fumihisa Kitawaki , Tatsurou Kawamura , Hiroshi Nakayama , Nobuyuki Shigetou
发明人： Akihito Kamei , Fumihisa Kitawaki , Tatsurou Kawamura , Hiroshi Nakayama , Nobuyuki Shigetou
IPC分类号： G01N1/00 , G01N33/00 , G01N21/00 , G01N15/06 , G01N33/53
CPC分类号： B01F5/0057 , B01F1/0022 , B01F5/0206 , B01F2215/0037 , G01N21/03 , G01N21/76 , G01N2035/00544 , Y10T436/25
摘要： A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.
摘要翻译：能够迅速且容易地搅拌液体样品和试剂的方法包括以下步骤（A）和（B）。在步骤（A）中，使用包括：具有多个颗粒的液体样品保留部分的细胞; 将液体试样供给口从液体试样供给口供给到液体试样保持部。在步骤（B）中，液体样品和能够特异性结合分析物的特异性结合物质由于由液体样品供应而导致的液体样品流动引起的颗粒运动而被搅拌至获得液体混合物。至少颗粒表面的电荷和特定结合物质的电荷在液体混合物中具有相同的极性。

9. 发明申请

US20060288253A1 Biological information utilization system, biological information utilization method, program and recording medium 审中-公开
标题翻译：生物信息利用系统，生物信息利用方法，程序和记录介质
公开(公告)号：US20060288253A1
公开(公告)日：2006-12-21
申请号：US10559872
申请日：2004-06-10
申请人： Tatsurou Kawamura , Akihito Kamei
发明人： Tatsurou Kawamura , Akihito Kamei
IPC分类号： G06F11/00
CPC分类号： G06F19/3418 , G06Q50/24 , G16H10/20 , G16H10/60
摘要： In a vital data utilization system, measurement systems include a measurement unit for measuring the vital data of subjects, a clock unit for detecting each measurement time at which vital data is measured and a communication unit for sending the vital data including measurement time to a server, a server includes a communication unit for receiving sets of vital data from measurement systems, a vital data storage unit in which vital data are stored, a value-added information making unit for making the value-added information indicating the changes over time of average values of subjects' vital data in a predetermined geographical area based on the vital data stored in the vital data storage unit and a communication unit for providing the made value-added information to the measurement systems and the PCs of service destinations, and PCs output the provided value-added information.
摘要翻译：在重要的数据利用系统中，测量系统包括用于测量被摄体的重要数据的测量单元，用于检测测量重要数据的每个测量时间的时钟单元和用于将包括测量时间的重要数据发送到服务器的通信单元服务器包括用于从测量系统接收重要数据集的通信单元，其中存储重要数据的重要数据存储单元，增值信息制造单元，用于使增值信息指示随时间变化的增长信息基于存储在重要数据存储单元中的重要数据的预定地理区域中的受试者的重要数据的值以及用于将所提供的增值信息提供给测量系统和服务目的地的PC的通信单元，并且PC输出提供增值信息。

10. 发明申请

US20060281195A1 Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same 有权
公开(公告)号：US20060281195A1
公开(公告)日：2006-12-14
申请号：US11507011
申请日：2006-08-21
申请人： Akihito Kamei , Nobuyuki Shigetoh , Tatsurou Kawamura
发明人： Akihito Kamei , Nobuyuki Shigetoh , Tatsurou Kawamura
IPC分类号： C12M1/34 , G01N33/551
CPC分类号： G01N33/53 , G01N33/54333
摘要： A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the sample and a magnetic particle on which a specific coupling substance for specifically coupling with the subject substance is immobilized; (b) measuring an optical characteristic of the reaction system; and (c) removing, from the reaction system, an agglutination complex including the subject substance, the specific coupling substance and the magnetic particle by utilizing magnetic force.

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