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1. 发明申请

US20070154951A1 Biosensor apparatus and method with sample type and volume detection 审中-公开
标题翻译：具有样品类型和体积检测的生物传感器装置和方法
公开(公告)号：US20070154951A1
公开(公告)日：2007-07-05
申请号：US11707376
申请日：2007-02-16
申请人： Mahyar Kermani
发明人： Mahyar Kermani
IPC分类号： G01N33/53 , G01N33/50
CPC分类号： G01N33/54373 , G01N27/3273 , G01R27/2605
摘要： A biosensor apparatus and method with sample type and cell volume detection. The apparatus includes a sine wave generator to apply an AC signal to a biosensor cell containing a sample, a current-to-voltage converter, a phase shifter, a square wave generator, a synchronous demodulator, and a low pass filter which yields a signal proportional to the effective capacitance across the biosensor cell, which is proportional to the volume of the sample. In addition, the current-to-voltage converter yields a signal indicative of the type of sample contained within the biosensor cell. The method includes applying a sine wave to the biosensor cell, shifting the phase of the resultant signal, generating a square wave synchronous with the sine wave, demodulating the resultant signal with the square wave, and filtering the demodulated signal to produce a signal proportional to the effective capacitance across the biosensor cell. The biosensor apparatus and method are capable of determining sample type and measuring glucose levels over a wide range of sample volumes.
摘要翻译：一种具有样品类型和细胞体积检测的生物传感器装置和方法。该装置包括正弦波发生器，用于向包含样本的生物传感器单元施加AC信号，电流 - 电压转换器，移相器，方波发生器，同步解调器和低通滤波器，其产生信号与生物传感器单元上的有效电容成比例，其与样品的体积成比例。此外，电流 - 电压转换器产生指示生物传感器单元中包含的样品类型的信号。所述方法包括对生物传感器单元施加正弦波，移位所得到的信号的相位，产生与正弦波同步的方波，用方波解调所得到的信号，并对解调信号进行滤波以产生与生物传感器电池的有效电容。生物传感器装置和方法能够在宽范围的样品体积上确定样品类型并测量葡萄糖水平。

2. 发明申请

US20060229507A1 Adhesive fluorescence measurement band 审中-公开
标题翻译：粘附荧光测量带
公开(公告)号：US20060229507A1
公开(公告)日：2006-10-12
申请号：US11093960
申请日：2005-03-30
申请人： Mahyar Kermani
发明人： Mahyar Kermani
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/14532 , A61B5/681 , A61B5/6824 , A61B5/6833 , G01N21/6428
摘要： A fluorescence measurement band for use with a fluorescent light-emitting bead implanted within a user's body includes a band configured for secure and removable positioned about a portion of the user's body, a light emitter attached to the band and a light detector attached to the band. The light emitter of the fluorescence measurement band is configured for emitting light that is absorbed by the fluorescent light-emitting bead while the light detector configured for detecting fluorescent light emitted by the fluorescent light-emitting bead.
摘要翻译：用于植入用户体内的荧光发光珠的荧光测量带包括被配置为围绕用户身体的一部分固定和移除的带，连接到该带的光发射器和附接到该带的光检测器。荧光测量带的光发射器被配置为发射由荧光发光珠吸收的光，而被配置为检测由荧光发光珠发射的荧光的光检测器。

3. 发明申请

US20060224055A1 Fluorescence measurement analytical kit 审中-公开
标题翻译：荧光测定分析试剂盒
公开(公告)号：US20060224055A1
公开(公告)日：2006-10-05
申请号：US11093980
申请日：2005-03-30
申请人： Mahyar Kermani , Kimberly Dale
发明人： Mahyar Kermani , Kimberly Dale
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/6833 , G01N21/6428
摘要： A fluorescence measurement analytical kit includes an adhesive fluorescence measurement patch, a fluorescent light-emitting bead and a remote module. The adhesive fluorescence measurement patch has an adhesive sheet configured for removable adhesion to the user's body, a light emitter attached to the adhesive sheet, and a light detector attached to the adhesive sheet. The light emitter is configured for emitting light that is absorbed by the fluorescent light emitting bead while the light detector is configured for detecting fluorescent light emitted by the fluorescent light-emitting bead.
摘要翻译：荧光测量分析试剂盒包括粘附荧光测量贴片，荧光发光珠和远程模块。粘合荧光测量贴片具有被配置为可拆卸地粘附到使用者身体的粘合片，附着在粘合片上的发光体和附着在粘合片上的光检测器。光发射器被配置为发射由荧光发光珠吸收的光，同时光检测器被配置为检测由荧光发光珠发射的荧光。

4. 发明申请

US20070038045A1 Method for monitoring an implanted fluorescent light-emitting bead 审中-公开
标题翻译：用于监测植入的荧光发光珠的方法
公开(公告)号：US20070038045A1
公开(公告)日：2007-02-15
申请号：US11200704
申请日：2005-08-09
申请人： Paul Hayter , Mahyar Kermani
发明人： Paul Hayter , Mahyar Kermani
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/6833 , A61K49/0067
摘要： A method for monitoring a fluorescent light-emitting bead implanted in a user's body includes removably adhering an adhesive plate of a kinematic adhesive fluorescence measurement patch to a user's body. The method also includes attaching an optical plate of the kinematic adhesive fluorescence measurement patch to the adhered adhesive plate in a kinematic manner such that the optical plate is in operative alignment with the fluorescent light-emitting bead and, thereafter, monitoring the fluorescent light-emitting bead by emitting incident light from the light emitter and detecting fluorescent light emitted from the fluorescent light-emitting bead with the light detector. In addition, the method optionally includes detaching the optical plate from the adhered adhesive plate and reattaching the optical plate in a kinematic manner.
摘要翻译：用于监测植入用户体内的荧光发光珠的方法包括将运动粘合剂荧光测量贴片的粘合板可移除地粘附到使用者的身体。该方法还包括以运动学方式将运动粘合剂荧光测量贴片的光学板附着到粘附的粘合板上，使得光学板与荧光发光珠操作对准，然后监测荧光发光通过发射来自发光体的入射光并利用光检测器检测从荧光发光珠发射的荧光。此外，该方法可选地包括从粘附的粘合板上分离光学板并以运动学方式重新附着光学板。

5. 发明申请

US20060178573A1 System and method for piercing dermal tissue 审中-公开
标题翻译：刺穿皮肤组织的系统和方法
公开(公告)号：US20060178573A1
公开(公告)日：2006-08-10
申请号：US10511495
申请日：2004-02-03
申请人： Mahyar Kermani , Borzu Sohrab
发明人： Mahyar Kermani , Borzu Sohrab
IPC分类号： A61B5/05
CPC分类号： A61B5/6843 , A61B5/053 , A61B5/150022 , A61B5/150068 , A61B5/150091 , A61B5/150358 , A61B5/150419 , A61B5/150503 , A61B5/150946 , A61B5/15186 , A61B5/157
摘要： A system for piercing dermal tissue includes a skin-piercing element (e.g., an integrated micro-needle and biosensor medical device), at least one electrical contact (e.g., an electrical skin contact) and a meter configured for measuring an electrical characteristic (e.g., resistance and/or impedance) existent between the skin-piercing element and the electrical contact(s) when the system is in use. The electrical contact(s) can be integrated with a pressure/contact ring of the meter to provide a compact and inexpensive system compatible with integrated micro-needle and biosensor medical devices. Also, a method for piercing dermal tissue that includes contacting dermal tissue (e.g., skin) with at least one electrical contact and inserting a skin-piercing element into the dermal tissue while measuring an electrical characteristic existent between the skin-piercing element and the electrical contact(s).
摘要翻译：用于刺穿真皮组织的系统包括皮肤刺穿元件（例如，集成的微针和生物传感器医疗装置），至少一个电接触（例如，电皮肤接触）和配置用于测量电特性的仪表（例如，，电阻和/或阻抗）存在于皮肤穿孔元件和电触点之间。电触点可以与仪表的压力/接触环一体化，以提供与集成的微针和生物传感器医疗装置兼容的紧凑且便宜的系统。另外，一种刺穿皮肤组织的方法，包括使真皮组织（例如皮肤）与至少一个电接触接触并将皮肤刺穿元件插入真皮组织中，同时测量皮肤刺穿元件与电气之间存在的电特性联系人。

6. 发明申请

US20060224056A1 Method for monitoring an implanted fluorescent light-emitting bead 审中-公开
标题翻译：用于监测植入的荧光发光珠的方法
公开(公告)号：US20060224056A1
公开(公告)日：2006-10-05
申请号：US11093981
申请日：2005-03-30
申请人： Mahyar Kermani , Kimberly Dale
发明人： Mahyar Kermani , Kimberly Dale
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , A61B5/6833 , A61B2562/0233 , A61B2562/043 , G01N21/6428
摘要： A method for monitoring an implanted fluorescent light-emitting bead includes adhering and adhesive fluorescence measurement patch to a user's body. The method also includes monitoring the implanted fluorescent light-emitting bead implanted in the user's by emitting light from a light emitter included in the adhesive fluorescence measurement patch and detecting fluorescent light emitted from the fluorescent light-emitting bead with a light detector included in the adhesive fluorescence measurement patch.
摘要翻译：用于监测植入的荧光发光珠的方法包括将粘附和粘附的荧光测量贴片贴到使用者身上。该方法还包括通过从包含在粘合剂荧光测量贴片中的发光器发射光并监测包含在粘合剂中的光检测器从荧光发光珠发射的荧光，监测植入在使用者中的植入的荧光发光珠子荧光测量贴片。

7. 发明申请

US20060200021A1 Electrically-conductive patterns for monitoring the filling of medical devices 有权
公开(公告)号：US20060200021A1
公开(公告)日：2006-09-07
申请号：US11417344
申请日：2006-05-02
申请人： Robert Shartle , Timothy Ohara , Mahyar Kermani
发明人： Robert Shartle , Timothy Ohara , Mahyar Kermani
IPC分类号： A61B5/05 , G01N33/487
CPC分类号： G01N27/3272
摘要： A flexible diagnostic device has a measurement cell that is sandwiched between the conductive surfaces of two conductive-coated insulating layers. At least one of the conductive surfaces is scored with an insulating pattern, so that the flow of a conductive fluid sample into the cell can be monitored.

8. 发明申请

US20050176153A1 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations 审中-公开
标题翻译：用于确定血细胞比容校正分析物浓度的电化学方法和装置
公开(公告)号：US20050176153A1
公开(公告)日：2005-08-11
申请号：US10979054
申请日：2004-11-01
申请人： Timothy O'hara , Mahyar Kermani
发明人： Timothy O'hara , Mahyar Kermani
IPC分类号： G01N33/483 , A61B5/145 , G01N27/26 , G01N27/327 , G01N27/416 , G01N33/487 , G01N33/66 , G01N33/96 , G01N27/447
CPC分类号： G01N27/3274
摘要： Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physiological sample is introduced into an electrochemical cell having a working and reference electrode. A first electric potential is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second a time-current transient is determined. The preliminary concentration of the analyte is then calculated from the first and/or second time-current transient. This preliminary analyte concentration less a background value is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable γ of the electrochemical cell. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.
摘要翻译：提供了用于确定生理样品中分析物浓度的方法和装置。在本方法中，将生理样品引入具有工作参比电极的电化学电池中。对单元施加第一电位，并测量在一段时间内产生的单元电流以确定第一时间 - 电流瞬变。然后施加相反极性的第二电位，并且确定第二个时间电流瞬变。然后从第一和/或第二时间电流瞬态计算分析物的初步浓度。然后将较少背景值的初步分析物浓度乘以血细胞比容校正因子以获得样品中的分析物浓度，其中血细胞比容校正因子是初步分析物浓度和电化学电池的可变γ的函数。本发明的方法和装置适用于多种样品中多种分析物的测定，特别适用于测定全血或其衍生物中的分析物，其中特别感兴趣的分析物是葡萄糖。

9. 发明申请

US20050161344A1 Passive sample detection to initiate timing of an assay 审中-公开
标题翻译：被动样品检测以启动测定的时间
公开(公告)号：US20050161344A1
公开(公告)日：2005-07-28
申请号：US11085900
申请日：2005-03-21
申请人： Mahyar Kermani , Timothy Ohara , Maria Teodorczyk
发明人： Mahyar Kermani , Timothy Ohara , Maria Teodorczyk
IPC分类号： G01N33/483 , G01N27/28 , G01N27/327 , G01N27/403 , G01N27/416 , G01N27/42 , G01N33/487 , G01N27/26
CPC分类号： G01N27/3273
摘要： The present invention provides methods and systems for passively and automatically detecting the presence of a sample (the “sample detection phase”) upon application of the sample to a biosensor, identifying the sample detection time and then initiating the measurement of a targeted characteristic, e.g., the concentration of one or more analytes, of the sample (the “measurement phase”), immediately upon sample detection. The subject methods and systems do not employ or involve the application of an electrical signal from an external source to the electrochemical cell for purposes of performing the sample detection phase and are, thus, less complicated and involve fewer steps and components.
摘要翻译：本发明提供了将样品应用于生物传感器时被动地自动检测样品（“样品检测阶段”）的方法和系统，识别样品检测时间，然后开始测量目标特征，例如，样品检测后立即对样品的一种或多种分析物（“测量阶段”）的浓度。为了执行样品检测阶段的目的，主题方法和系统不使用或涉及将外部源的电信号施加到电化学电池，并且因此更不复杂并且涉及较少的步骤和组件。

10. 发明授权

US08623660B2 Hand-held test meter with phase-shift-based hematocrit measurement circuit 有权
标题翻译：手持式测试仪，具有基于相移的血细胞比容测量电路
公开(公告)号：US08623660B2
公开(公告)日：2014-01-07
申请号：US13250525
申请日：2011-09-30
申请人： Ulrich Kraft , David Elder , Mahyar Kermani
发明人： Ulrich Kraft , David Elder , Mahyar Kermani
IPC分类号： G01N33/48 , G01N33/66 , G01N27/00 , C12Q1/02 , C12Q1/54
CPC分类号： G01N27/3274 , G01N27/3273 , Y10T436/144444
摘要： A hand-held test meter for use with an analytical test strip in the determination of an analyte in a bodily fluid sample includes a housing; a microcontroller block disposed in the housing; and a phase-shift-based hematocrit measurement block. The phase-shift-based hematocrit measurement block includes a signal generation sub-block, a low pass filter sub-block, an analytical test strip sample cell interface sub-block, a transimpedance amplifier sub-block, and a phase detector sub-block. In addition, the phase-shift-based hematocrit measurement block and microcontroller block are configured to measure the phase shift of a bodily fluid sample in a sample cell of an analytical test strip inserted in the hand-held test meter and the microcontroller block is configured to compute the hematocrit of the bodily fluid sample based on the measured phase shift.
摘要翻译：用于测定体液样品中的分析物的分析测试条的手持式测试仪包括壳体; 布置在所述壳体中的微控制器块; 和基于相移的血细胞比容测量块。基于相移的血细胞比容测量块包括信号生成子块，低通滤波器子块，分析测试条样本单元接口子块，跨阻抗放大器子块和相位检测器子块。此外，基于相移的血细胞比容测量块和微控制器块被配置为测量插入在手持测试仪中的分析测试条的样本池中的体液样本的相移，并且配置微控制器块以根据所测量的相移计算体液样品的血细胞比容。

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