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1. 发明申请

US20050176153A1 Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations 审中-公开
标题翻译：用于确定血细胞比容校正分析物浓度的电化学方法和装置
公开(公告)号：US20050176153A1
公开(公告)日：2005-08-11
申请号：US10979054
申请日：2004-11-01
申请人： Timothy O'hara , Mahyar Kermani
发明人： Timothy O'hara , Mahyar Kermani
IPC分类号： G01N33/483 , A61B5/145 , G01N27/26 , G01N27/327 , G01N27/416 , G01N33/487 , G01N33/66 , G01N33/96 , G01N27/447
CPC分类号： G01N27/3274
摘要： Methods and devices for determining the concentration of an analyte in a physiological sample are provided. In the subject methods, the physiological sample is introduced into an electrochemical cell having a working and reference electrode. A first electric potential is applied to the cell and the resultant cell current over a period of time is measured to determine a first time-current transient. A second electric potential of opposite polarity is then applied and a second a time-current transient is determined. The preliminary concentration of the analyte is then calculated from the first and/or second time-current transient. This preliminary analyte concentration less a background value is then multiplied by a hematocrit correction factor to obtain the analyte concentration in the sample, where the hematocrit correction factor is a function of the preliminary analyte concentration and the variable γ of the electrochemical cell. The subject methods and devices are suited for use in the determination of a wide variety of analytes in a wide variety of samples, and are particularly suited for the determination of analytes in whole blood or derivatives thereof, where an analyte of particular interest is glucose.
摘要翻译：提供了用于确定生理样品中分析物浓度的方法和装置。在本方法中，将生理样品引入具有工作参比电极的电化学电池中。对单元施加第一电位，并测量在一段时间内产生的单元电流以确定第一时间 - 电流瞬变。然后施加相反极性的第二电位，并且确定第二个时间电流瞬变。然后从第一和/或第二时间电流瞬态计算分析物的初步浓度。然后将较少背景值的初步分析物浓度乘以血细胞比容校正因子以获得样品中的分析物浓度，其中血细胞比容校正因子是初步分析物浓度和电化学电池的可变γ的函数。本发明的方法和装置适用于多种样品中多种分析物的测定，特别适用于测定全血或其衍生物中的分析物，其中特别感兴趣的分析物是葡萄糖。

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