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1. 发明申请

WO2004064673A2 ARTIFICIAL NUCLEUS PULPOSUS AND METHOD OF INJECTING SAME 审中-公开
标题翻译：人造核素及其注射方法
公开(公告)号：WO2004064673A2
公开(公告)日：2004-08-05
申请号：PCT/US2004/001321
申请日：2004-01-16
申请人： PSINERGI CORPORATION , DULAK, Gary, R. , BHALANI, Anil , MOLLOY, Paul, A.
发明人： DULAK, Gary, R. , BHALANI, Anil , MOLLOY, Paul, A.
IPC分类号： A61F
CPC分类号： A61F2/4611 , A61B17/00234 , A61F2/441 , A61F2/4601 , A61F2002/30088 , A61F2002/30583 , A61F2002/444 , A61F2002/4635 , A61F2210/008 , A61F2210/0085 , A61L27/26
摘要： The present invention relates to an artificial nucleus pulposus implant that is injected minimally invasively into the nucleus cavity of the annulus fibrosus to restore the normal anatomical and physiological function of the spine in the affected disc segment. In one aspect of the invention, a device is disclosed for delivering a phase changing biomaterial to a tissue site, the device comprising a dispenser including (i) a plunger having a proximal portion and a distal portion, an inlet end and an outlet end, (ii) a dispensing actuator attached to the proximal portion of the plunger, and (iii) a cartridge adapted to be inserted into the inlet end of the plunger for containing the phase changing biomaterial in a fluid state. The dispenser may be mechanically, pneumatically or hydraulically actuated. The dispenser may further comprise a nozzle attached to the cartridge for dispensing the biomaterial to the tissue site. In another aspect, the device may further comprise a tissue cavity access unit providing a conduit having an inlet end in fluid communication with the nozzle, and an outlet end adapted to deliver the biomaterial to the tissue site. The biomaterial may transition from the fluid state to a solid state after a set amount of time, a temperature change or an exposure to an external stimuli such as radiation, UV light or an electrical stimuli. The cartridge may be a dual-chambered cartridge for storing different fluid biomaterials in the two chambers. In another aspect of the invention, a process for producing the artificial nucleus pulposus implant in the nucleus cavity of the annulus fibrosus is disclosed, the process comprising the steps of (a) obtaining access to the nucleus cavity; (b) injecting the artificial nucleus pulposus into the nucleus cavity; and (c) permitting the biomaterial to transition from a fluid state to a solid state in-situ after a given condition.
摘要翻译：本发明涉及一种人造髓核植入物，其被最小程度地侵入到纤维环的核腔中，以恢复受影响椎间盘段脊柱的正常解剖和生理功能。在本发明的一个方面，公开了一种用于将相变生物材料输送到组织部位的装置，该装置包括分配器，该分配器包括（i）具有近端部分和远端部分的柱塞，入口端和出口端，（ii）附接到柱塞的近端部分的分配致动器，以及（iii）适于插入到柱塞的入口端的筒，用于容纳处于流体状态的相变生物材料。分配器可以是机械的，气动的或液压致动的。分配器还可以包括连接到盒的喷嘴，用于将生物材料分配到组织部位。在另一方面，所述装置还可以包括组织腔进入单元，其提供具有与所述喷嘴流体连通的入口端的导管，以及适于将生物材料输送到组织部位的出口端。生物材料可以在经过一定时间，温度变化或暴露于诸如辐射，紫外光或电刺激的外部刺激之后从流体状态转变为固态。盒可以是用于在两个腔室中存储不同流体生物材料的双腔筒。在本发明的另一方面，公开了一种在纤维环的细胞腔内制备人造髓核植入物的方法，该方法包括以下步骤：（a）获得进入核腔的步骤; （b）将人造髓核注入核腔; 和（c）允许生物材料在给定条件之后从原位流体状态转变为固态。

2. 发明申请

WO2011011443A3 ADJUSTABLE ANNULOPLASTY RING WITH SUBCUTANEOUS ACTIVATION PORT 审中-公开
标题翻译：可调节ANNULOPLASTY环与辅助活动端口
公开(公告)号：WO2011011443A3
公开(公告)日：2011-04-28
申请号：PCT/US2010042644
申请日：2010-07-20
申请人： MICARDIA CORP , DUMONTELLE JEFFREY P , BUCHBINDER MAURICE , SHAOLIAN SAMUEL M , DANG NINH H , MOLLOY PAUL A , TSUKASHIMA ROSS , GRAY BRIAN C , ANDERSON DANIEL C
发明人： DUMONTELLE JEFFREY P , BUCHBINDER MAURICE , SHAOLIAN SAMUEL M , DANG NINH H , MOLLOY PAUL A , TSUKASHIMA ROSS , GRAY BRIAN C , ANDERSON DANIEL C
IPC分类号： A61F2/24 , A61F2/48 , A61L27/04 , H05B3/40
CPC分类号： A61L27/50 , A61F2/2445 , A61F2210/0023 , A61F2210/0033 , A61F2250/001 , A61L27/507
摘要： Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.
摘要翻译：使用瓣环成形术来治疗心脏瓣膜缺损，例如反流。将心脏组织同步到环将瓣膜开口恢复到其近似的原始尺寸和操作效率。可调环形成形术环允许在心脏开放心脏手术期间和患者生命周期内均匀适应程度的同步。皮下端口可以联接到可调节瓣环成形术环，使得可以使用外部激活能量发生器来加热可调节瓣环成形术环，从而调节瓣膜成形术环的尺寸。

3. 发明申请

WO2004064673A3 ARTIFICIAL NUCLEUS PULPOSUS AND METHOD OF INJECTING SAME 审中-公开
标题翻译：人造核素及其注射方法
公开(公告)号：WO2004064673A3
公开(公告)日：2005-03-10
申请号：PCT/US2004001321
申请日：2004-01-16
申请人： PSINERGI CORP , DULAK GARY R , BHALANI ANIL , MOLLOY PAUL A
发明人： DULAK GARY R , BHALANI ANIL , MOLLOY PAUL A
IPC分类号： A61B17/00 , A61F20060101 , A61F2/00 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/26
CPC分类号： A61F2/4611 , A61B17/00234 , A61F2/441 , A61F2/4601 , A61F2002/30088 , A61F2002/30583 , A61F2002/444 , A61F2002/4635 , A61F2210/008 , A61F2210/0085 , A61L27/26
摘要： An artificial nucleus pulposus implant (102, 104) is injected minimally invasively into the nucleus cavity (51) of the annulus fibrosus (12). A device (70) delivers a phase changing biomaterial in a fluid state (102) to a tissue site. The device (70) comprises a dispenser (72) including a plunger (76), a dispensing actuator (74), and a cartridge (80) insertable into an inlet of the plunger (76) for containing the phase changing biomaterial in a fluid state (102). The biomaterial is permitted to transition from the fluid state (102) to a solid state (104) in-situ after a given condition.
摘要翻译：人造髓核植入物（102,104）被最少侵入地注射到纤维环（12）的细胞腔（51）中。装置（70）将流体状态（102）中的相变生物材料输送到组织部位。装置（70）包括分配器（72），其包括柱塞（76），分配致动器（74）和可插入到柱塞（76）的入口中的筒（80），用于将相变生物材料容纳在流体州（102）。允许生物材料在给定条件之后原位从流体状态（102）转变为固态（104）。

4. 发明申请

WO2011011443A2 ADJUSTABLE ANNULOPLASTY RING WITH SUBCUTANEOUS ACTIVATION PORT 审中-公开
标题翻译：具有皮下活化端口的可调整的分泌周期环
公开(公告)号：WO2011011443A2
公开(公告)日：2011-01-27
申请号：PCT/US2010/042644
申请日：2010-07-20
申请人： MICARDIA CORPORATION , DUMONTELLE, Jeffrey P. , BUCHBINDER, Maurice , SHAOLIAN, Samuel M. , DANG, Ninh H. , MOLLOY, Paul A. , TSUKASHIMA, Ross , GRAY, Brian C. , ANDERSON, Daniel C.
发明人： DUMONTELLE, Jeffrey P. , BUCHBINDER, Maurice , SHAOLIAN, Samuel M. , DANG, Ninh H. , MOLLOY, Paul A. , TSUKASHIMA, Ross , GRAY, Brian C. , ANDERSON, Daniel C.
IPC分类号： A61F2/24 , A61F2/48 , A61L27/04 , H05B3/40
CPC分类号： A61L27/50 , A61F2/2445 , A61F2210/0023 , A61F2210/0033 , A61F2250/001 , A61L27/507
摘要： Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.
摘要翻译：采用瓣环成形术来治疗心脏瓣膜缺陷，如反流。将心脏组织同步到环上可将瓣膜开口恢复到其原始大小和操作效率。可调整的瓣环成形环可以在心脏直视手术期间和病人的一生中进行适当程度的同步。皮下端口可以连接到可调节瓣环成形术环上，使得外部激活能量发生器可以用于加热可调节瓣环成形术环并由此调节瓣环成形术环的尺寸。

5. 发明申请

WO2004064673A9 ARTIFICIAL NUCLEUS PULPOSUS AND METHOD OF INJECTING SAME 审中-公开
标题翻译：人造髓核及其注射方法
公开(公告)号：WO2004064673A9
公开(公告)日：2004-09-10
申请号：PCT/US2004001321
申请日：2004-01-16
申请人： PSINERGI CORP , DULAK GARY R , BHALANI ANIL , MOLLOY PAUL A
发明人： DULAK GARY R , BHALANI ANIL , MOLLOY PAUL A
IPC分类号： A61B17/00 , A61F20060101 , A61F2/00 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/26 , A61F
CPC分类号： A61F2/4611 , A61B17/00234 , A61F2/441 , A61F2/4601 , A61F2002/30088 , A61F2002/30583 , A61F2002/444 , A61F2002/4635 , A61F2210/008 , A61F2210/0085 , A61L27/26
摘要： The present invention relates to an artificial nucleus pulposus implant that is injected minimally invasively into the nucleus cavity of the annulus fibrosus to restore the normal anatomical and physiological function of the spine in the affected disc segment. In one aspect of the invention, a device is disclosed for delivering a phase changing biomaterial to a tissue site, the device comprising a dispenser including (i) a plunger having a proximal portion and a distal portion, an inlet end and an outlet end, (ii) a dispensing actuator attached to the proximal portion of the plunger, and (iii) a cartridge adapted to be inserted into the inlet end of the plunger for containing the phase changing biomaterial in a fluid state. The dispenser may be mechanically, pneumatically or hydraulically actuated. The dispenser may further comprise a nozzle attached to the cartridge for dispensing the biomaterial to the tissue site. In another aspect, the device may further comprise a tissue cavity access unit providing a conduit having an inlet end in fluid communication with the nozzle, and an outlet end adapted to deliver the biomaterial to the tissue site. The biomaterial may transition from the fluid state to a solid state after a set amount of time, a temperature change or an exposure to an external stimuli such as radiation, UV light or an electrical stimuli. The cartridge may be a dual-chambered cartridge for storing different fluid biomaterials in the two chambers. In another aspect of the invention, a process for producing the artificial nucleus pulposus implant in the nucleus cavity of the annulus fibrosus is disclosed, the process comprising the steps of (a) obtaining access to the nucleus cavity; (b) injecting the artificial nucleus pulposus into the nucleus cavity; and (c) permitting the biomaterial to transition from a fluid state to a solid state in-situ after a given condition.
摘要翻译：本发明涉及人造髓核植入物，其被微创地侵入到纤维环的髓核腔中，以恢复受影响的椎间盘节段中脊柱的正常解剖和生理功能。在本发明的一个方面中，公开了一种用于将相变生物材料递送至组织部位的装置，该装置包括分配器，该分配器包括（i）具有近端部分和远端部分，入口端和出口端的柱塞，（ii）连接到柱塞的近侧部分的分配致动器，以及（iii）适于插入柱塞的入口端以用于容纳处于流体状态的相变生物材料的筒。分配器可以机械地，气动地或液压地致动。分配器可进一步包括附接到药筒的喷嘴，用于将生物材料分配到组织部位。在另一方面，该装置可进一步包括组织空腔通路单元，其提供具有与喷嘴流体连通的入口端和适于将生物材料递送至组织部位的出口端的导管。在设定的时间量，温度变化或暴露于诸如辐射，UV光或电刺激的外部刺激之后，生物材料可以从流体状态转变为固态。盒可以是用于在两个腔室中存储不同的流体生物材料的双腔盒。在本发明的另一方面中，公开了一种用于在纤维环的髓核中产生人造髓核植入物的方法，该方法包括以下步骤：（a）进入髓核腔; （b）将人造髓核注入髓核腔; 和（c）允许生物材料在给定条件后原位从流体状态过渡到固态。

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