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1. 发明申请

WO1997031014A1 TRITERPENE DERIVATIVES AND REMEDIES FOR LIVER DISEASES 审中-公开
标题翻译： TRAILRPENE DIVIVATIVES AND REMIDIES FOR LIVER DISEASES
公开(公告)号：WO1997031014A1
公开(公告)日：1997-08-28
申请号：PCT/JP1997000555
申请日：1997-02-26
申请人： MEIJI SEIKA KABUSHIKI KAISHA , SASAKI, Kazue , MINOWA, Nobuto , NISHIYAMA, Shoji , KUZUHARA, Hiroyuki
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07J71/00
CPC分类号： C07J63/008 , C07J63/00 , Y10S514/893 , Y10S514/894
摘要： Triterpene derivatives efficacious in the treatment of liver diseases. The remedies contain as the active ingredient triterpene derivatives represented by general formula (I) or salts thereof: wherein R represents hydroxy, arylmethyloxy, lower alkoxy or lower alkanoyloxy; R represents lower alkyl, lower alkenyl, -CH2OR , formyl, -COOR or -CH2N(R )R , or R and R may form together -O-C(R )R -O-CH2-; R and R are the same or different and each represents hydrogen, hydroxy, lower alkyl, lower alkenyl, aryl, hydroxymethyl, -N(R )R , formyl, -COOR or -OR , or R and R may form together oxo, hydroxyimino or alkylidene; and X represents O, CH2 or NH.
摘要翻译：三萜衍生物有效治疗肝脏疾病。补救措施包含作为由通式（I）表示的活性成分三萜衍生物或其盐：其中R 1表示羟基，芳基甲氧基，低级烷氧基或低级烷酰氧基; R 2表示低级烷基，低级烯基，-CH 2 OR 5，甲酰基，-COOR 6或-CH 2 N（R 7）R 8，或R 1和R 2可以形成一起-OC（R 9）R 10 -O-CH 2 - ; R 3和R 4相同或不同，各自表示氢，羟基，低级烷基，低级烯基，芳基，羟甲基，-N（R 11）R 12，甲酰基，-COOR 6 或-OR 13，或R 3和R 4可以一起形成氧代，羟基亚氨基或亚烷基; X表示O，CH 2或NH。

2. 发明申请

WO1997003088A1 TRITERPENE DERIVATIVES AND REMEDY FOR LIVER DISEASES 审中-公开
标题翻译： TRAILRPENE DIVIVATIVES AND REMEDY FOR LIVER DISEASES
公开(公告)号：WO1997003088A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001891
申请日：1996-07-08
申请人： MEIJI SEIKA KABUSHIKI KAISHA , SASAKI, Kazue , MINOWA, Nobuto , NISHIYAMA, Shoji , KUZUHARA, Hiroyuki
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07J63/00
CPC分类号： C07J63/008 , C07J71/0005
摘要： A remedy for liver diseases which comprises a triterpene derivative represented by following general formula (I) or a pharmaceutically acceptable salt thereof wherein R represents hydroxy, alkoxy, alkylcarbonyloxy or aralkyloxy; R represents alkyl, -CH2O (wherein R represents hydrogen, alkyl, aralkyl or akylcarbonyl), formyl, -COOR (wherein R represents hydrogen or alkyl) or -CH2N(R )R , or R and R are bonded to each other to form -O-CR (R )-OCH2- (wherein R and R are the same or different and each represents hydrogen, alkyl or aryl); R and R are the same or different and each represents hydrogen, hydroxy, alkyl, hydroxyalkyl, formyl, -COOR (wherein R represents hydrogen or alkyl) or -OR (wherein R represents alkyl, aralkyl, C1-6 alkylcarbonyl, arylcarbonyl, alkenyl, alkenylcarbonyl or optionally substituted arylalkenylcarbonyl, or R and R together form methylene; and - - - represents a single or double bond, provided that when - - - is a double bond, then R is not present.
摘要翻译：一种肝病的治疗方法，其包含由以下通式（I）表示的三萜衍生物或其药学上可接受的盐，其中R 1表示羟基，烷氧基，烷基羰氧基或芳烷氧基; R 2表示烷基，-CH 2 O（其中R 5表示氢，烷基，芳烷基或烷基羰基），甲酰基，-COOR 6（其中R 6表示氢或烷基）或-CH 2 N（R 7 ）R 8或R 1和R 2彼此键合以形成-O-CR 9（R 10）-O 2 2-（其中R 9和R 10 >相同或不同，各自表示氢，烷基或芳基）; R 3和R 4相同或不同，各自表示氢，羟基，烷基，羟烷基，甲酰基，-COOR 11（其中R 11表示氢或烷基）或-OR 12（其中R 12表示烷基，芳烷基，C 1-6烷基羰基，芳基羰基，烯基，烯基羰基或任选取代的芳基烯基羰基，或R 3和R 4一起形成亚甲基;和 - 表示单键或双键，条件是当< - - - - 双键时，则不存在R 4。

3. 发明申请

WO1996037499A1 NOVEL CEPHEM DERIVATIVES 审中-公开
标题翻译：新的CEPHEM衍生物
公开(公告)号：WO1996037499A1
公开(公告)日：1996-11-28
申请号：PCT/JP1996001406
申请日：1996-05-24
申请人： MEIJI SEIKA KABUSHIKI KAISHA , UMEMURA, Eijiro , ATSUMI, Kunio , IWAMATSU, Katsuyoshi , TAMURA, Atsushi
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D519/00
CPC分类号： C07D501/00 , Y02P20/55
摘要： Compounds represented by general formula (I) and having a beta -(optionally substituted imidazo[5,1-b]thiazolyl)vinyl group at the 3-position of the cephem ring, and salts and esters thereof. These compounds have an extremely broad antimicrobial spectrum and exerts potent antimicrobial effects on Gram-positive bacteria, Gram-negative bacteria and even resistant bacteria. In formula (I) X represents CH or N; R represents hydrogen or an amino protecting group; R represents hydrogen, C1-6 alkyl, C3-7 cycloalkyl or a hydroxy protecting group; R is not present or represents hydrogen, a cation forming a salt or a carboxy protecting group; R , R and R may be the same or different and each represents hydrogen or C1-6 alkyl; R is not present or represents a cation of C1-6 alkyl; and n is an integer of 0 or 1.
摘要翻译：由通式（I）表示并在头孢烯环的3位具有β-（任选取代的咪唑并[5,1-b]噻唑基）乙烯基的化合物及其盐和酯。这些化合物具有非常宽的抗菌谱，对革兰氏阳性菌，革兰氏阴性细菌甚至抗性细菌都发挥有力的抗菌作用。在式（I）中，X表示CH或N; R 1表示氢或氨基保护基; R 2表示氢，C 1-6烷基，C 3-7环烷基或羟基保护基; R 3不存在或表示氢，形成盐或羧基保护基的阳离子; R 4，R 5和R 6可以相同或不同，各自表示氢或C 1-6烷基; R 7+不存在或表示C 1-6烷基的阳离子; n为0或1的整数。

4. 发明申请

WO1996016968A1 BICYCLIC THIAZOLE COMPOUND 审中-公开
标题翻译：双环噻唑化合物
公开(公告)号：WO1996016968A1
公开(公告)日：1996-06-06
申请号：PCT/JP1995002412
申请日：1995-11-27
申请人： MEIJI SEIKA KABUSHIKI KAISHA , FUKUDA, Yoshimasa , HASEGAWA, Toshifumi , NAKATANI, Yuuko , MURASE, Kenshi , FUJI, Kazuyuki
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D519/00
CPC分类号： C07D513/04
摘要： A compound having a psychotropic effect and represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein one of R and R represents W-(CH2)m-, wherein m is an integer of from 1 to 4, and another represents hydrogen or optionally substituted lower alkyl; W represents a group represented by formula (i) (wherein R represents hydrogen or halogeno; A represents oxygen or sulfur; B represents nitrogen or CH and Y represents CH or nitrogen); and the cyclic structure -D- represents one member selected from among those represented by formulae (a) to (d), wherein n represents an integer of 0 to 2; R independently represent hydrogen, lower alkyl, hydroxy, alkoxy, alkoxycarbonyl or aminocarbonyl; and the solid line accompanied by the dotted line represents either a single bond or a double bond.
摘要翻译：具有精神作用并由通式（I）表示的化合物及其药学上可接受的盐，其中R 1和R 2之一表示W-（CH 2）m - ，其中m为1的整数至4，另一个表示氢或任选取代的低级烷基; W表示由式（i）表示的基团（其中R 3表示氢或卤素; A表示氧或硫; B表示氮或CH，Y表示CH或氮）; 环状结构-D-表示选自由式（a）〜（d）表示的那些，其中，n表示0〜2的整数。 [R <4？和R 5>独立地表示氢，低级烷基，羟基，烷氧基，烷氧基羰基或氨基羰基; 伴随虚线的实线表示单键或双键。

5. 发明申请

WO1996005205A1 NOVEL CEPHEM DERIVATIVE 审中-公开
标题翻译：新闻CEPHEM DERIVATIVE
公开(公告)号：WO1996005205A1
公开(公告)日：1996-02-22
申请号：PCT/JP1995001627
申请日：1995-08-16
申请人： MEIJI SEIKA KABUSHIKI KAISHA , TSUSHIMA, Masaki , ATSUMI, Kunio , IWAMATSU, Katsuyoshi , TAMURA, Atsushi
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D519/381
CPC分类号： C07D501/00
摘要： A cephalosporin derivative represented by general formula (I) wherein an (un)substituted 3-(imidazo[5,1-b]thiazolium-6-yl)-1-propenyl group is present as a substituent at the 3-position of the cephem ring, having an excellent antibacterial activity, and being useful as a remedy for various microbisms.
摘要翻译：由通式（I）表示的头孢菌素衍生物，其中（（un）取代的3-（咪唑并[5,1-b]噻唑鎓-6-基）-1-丙烯基作为取代基在3- 头孢烯环，具有优异的抗菌活性，可用作各种微生物的补救剂。

6. 发明申请

WO1994021599A1 NOVEL COMPOUND WITH PLATELET AGGREGATION INHIBITOR ACTIVITY 审中-公开
标题翻译：新型化合物与平板聚集抑制剂活性
公开(公告)号：WO1994021599A1
公开(公告)日：1994-09-29
申请号：PCT/JP1994000437
申请日：1994-03-17
申请人： MEIJI SEIKA KABUSHIKI KAISHA , KATANO, Kiyoaki , OHUCHI, Shokichi , SHITARA, Eiki , SHIMIZU, Masaro , YAEGASHI, Kazue , MIURA, Tomoaki , ISOMURA, Yasuko , IIDA, Hiroyuki , ISHIKAWA, Midori , ASAI, Kenji , HATSUSHIBA, Emiko , KAWAGUCHI, Mami , TSURUOKA, Takashi
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07C237/24
CPC分类号： C07D413/06 , C07C237/24 , C07C257/16 , C07C257/18 , C07C279/14 , C07C279/16 , C07C2601/14 , C07D211/34 , C07D211/62 , C07D263/14 , C07D495/04 , C07D513/04
摘要： A compound with a platelet aggregation inhibitor activity, represented by the following general formula (I), and pharmacologically acceptable salt and solvate thereof. Examples of the compound are as in (II).
摘要翻译：具有下列通式（I）表示的具有血小板聚集抑制剂活性的化合物及其药理学上可接受的盐和溶剂合物。化合物的实例如（II）所示。

7. 发明申请

WO1995018130A1 TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES 审中-公开
标题翻译：三氯苯并苯并噻唑衍生物
公开(公告)号：WO1995018130A1
公开(公告)日：1995-07-06
申请号：PCT/JP1994002282
申请日：1994-12-28
申请人： MEIJI SEIKA KABUSHIKI KAISHA , OHTSUKA, Yasuo , SHISHIKURA, Takashi , OGINO, Hiroko , FUSHIHARA, Kenichi , KAWAGUCHI, Mami , TSUTSUMI, Seiji , IMAI, Megumi , SHITO, Keiko , TSUCHIYA, Koji , TANAKA, Junko , IWASAKI, Takako , HOSHIKO, Shigeru , TSURUOKA, Takashi
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D249/04 , C07D513/04 , Y02P20/55
摘要： Tricyclic benzazepine and benzothiazepine derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, wherein Z represents CO, -CR R - or -S(O)n; R represents hydrogen, alkyl, phenylalkyl or a triazole-protective group; and R to R represent each hydrogen, alkyl, alkenyl, alkoxy, amino, oxime or hydroxy. The compounds have an antiallergic activity and hence are useful for treating and preventing allergic diseases.
摘要翻译：由通式（I）表示的三环苯并吖庚因衍生物和苯并硫氮杂衍生物及其药理学上可接受的盐，其中Z表示CO，-CR 6 R 7或-S（O）n; R代表氢，烷基，苯基烷基或三唑保护基; R 1至R 5各自代表氢，烷基，烯基，烷氧基，氨基，肟或羟基。该化合物具有抗过敏活性，因此可用于治疗和预防过敏性疾病。

8. 发明申请

WO1995005171A1 ANTI-MRSA COMPOSITION 审中-公开
标题翻译：抗MRSA组合物
公开(公告)号：WO1995005171A1
公开(公告)日：1995-02-23
申请号：PCT/JP1994001353
申请日：1994-08-16
申请人： MEIJI SEIKA KABUSHIKI KAISHA , BIOMATERIAL CO., LTD. , YONETA, Toshio , FUJII, Naoyuki , OOISHI, Maki , IINUMA, Katsuharu , SATO, Atsuyuki , YASUDA, Kimiaki
发明人： MEIJI SEIKA KABUSHIKI KAISHA , BIOMATERIAL CO., LTD.
IPC分类号： A61K31/415
CPC分类号： D21H21/36 , A01N43/50 , A61K31/415 , A61L31/16 , A61L2300/204 , A61L2300/404 , D06M13/352 , D06M16/00 , D06N3/0059 , A01N25/34 , A01N2300/00
摘要： An anti-methicillin-resistant Staphylococcus aureus (MRSA) composition containing an imidazole derivative represented by general formula (I), wherein R , R , R and R represent each independently hydrogen or halogen. Since the above compound has an anti-MRSA activity, it can provide a composition efficacious in preventing infection with MRSA and a textile product bearing the composition.
摘要翻译：含有由通式（I）表示的咪唑衍生物的抗甲氧西林抗性金黄色葡萄球菌（MRSA）组合物，其中R 1，R 2，R 3和R 4各自独立地表示氢或卤素。由于上述化合物具有抗MRSA活性，因此可以提供有效预防感染MRSA的组合物和具有该组合物的纺织品。

9. 发明申请

WO1994001392A1 (-)-RITODRINE 审中-公开
标题翻译：（ - ） - 利托君
公开(公告)号：WO1994001392A1
公开(公告)日：1994-01-20
申请号：PCT/JP1993000896
申请日：1993-06-30
申请人： MEIJI SEIKA KABUSHIKI KAISHA , YAMAZAKI, Naoki , FUKUDA, Yoshimasa , SHIBAZAKI, Yoshiaki , NIIZATO, Tetsutarou , KOSUGI, Isao , YOSHIOKA, Shin
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07C215/60
CPC分类号： C07C215/60 , A61K31/135
摘要： (-)-Ritodrine, i.e. (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-pr opanol, which is substantially free from the (+)-isomer, or a salt thereof. This compound has a potent effect of inhibiting uterine contraction as compared with (+/-)-ritodrine and (+)-ritodrine and a toxicity comparable to those of the other ritodrines, and hence is usable as a highly safe remedy for threatened premature birth and abortion and a remedy for dysmenorrhea.
摘要翻译：（ - ） - 基本上不含（+） - 异构体的（ - ） - 赤 - 1-（对羟基苯基）-2- [2-（对羟基苯基）乙基氨基] ，或其盐。与（+/-） - 利培酮和（+） - 利培酮相比，该化合物具有抑制子宫收缩的有效作用，其毒性与其他孕妇相当，因此可用作威胁性早产的高度安全补救措施堕胎和痛经补救。

10. 发明申请

WO1997030040A1 NOVEL TETRAHYDRONAPHTHOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：新的四氢呋喃酮衍生物及其制备方法
公开(公告)号：WO1997030040A1
公开(公告)日：1997-08-21
申请号：PCT/JP1997000451
申请日：1997-02-19
申请人： MEIJI SEIKA KABUSHIKI KAISHA , KURIHARA, Kenichi , SHINEI, Rie , TANABE, Kiyoshi , YAMAMOTO, Yasuo , AJITO, Keiichi , MIYAJIMA, Kaori , TABATA, Yuji , YASUDA, Shohei , TATSUTA, Kuniaki , OKONOGI, Tsuneo
发明人： MEIJI SEIKA KABUSHIKI KAISHA
IPC分类号： C07D307/92
CPC分类号： C07D307/92 , C07D407/12 , C07D407/14 , C07D409/12 , C07D417/12
摘要： Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof, which have progesterone receptor binding inhibitory activities and so are used as remedies and preventives for diseases in which progesterone participates, more particularly, as anticancer agents against mammary and ovarian cancers, remedies for uterine myoma, endometriosis, meningioma and myeloma, abortifacient, peroral contraceptive, and remedies and preventives for osteoporosis and climacteric disturbance, wherein R and R represent each hydroxy, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, oxygenous cycloalkyloxy, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, or aromatic carbamoyloxy, the R optionally representing hydrogen alkyl, alkenyl, or alkynyl; and R , R , and R represent each independently hydrogen, alkyl, or alkenyl.
摘要翻译：具有孕酮受体结合抑制活性的由通式（I）表示的化合物及其药学上可接受的盐等用作对孕激素参与的疾病的补救措施和预防药物，更特别地，作为抗乳腺癌和卵巢癌的抗癌剂，子宫肌瘤，子宫内膜异位症，脑膜瘤和骨髓瘤，流产，口服避孕药，以及骨质疏松症和更年期障碍的治疗和预防药物，其中R 1和R 2代表各羟基，烷氧基，烯氧基，炔氧基，环烷氧基，烷氧基烷氧基，芳烷氧基，烷基羰基氧基，链烯基羰基氧基，炔基羰基氧基，环烷基羰基氧基，烷氧基羰基氧基，芳氧基羰基氧基，芳烷基羰基氧基，芳香族酰氧基，杂芳基酰氧基，饱和杂环羰基氧基，烷基磺酰氧基，芳香族磺酰氧基，烷基氨基甲酰氧基或芳族氨基甲酰氧基，R 1任选代表氢烷基，烯基或炔基; R 3，R 4和R 5各自独立地表示氢，烷基或链烯基。

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