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    • 2. 发明申请
    • NOVEL TETRAHYDRONAPHTHOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
    • 新的四氢呋喃酮衍生物及其制备方法
    • WO1997030040A1
    • 1997-08-21
    • PCT/JP1997000451
    • 1997-02-19
    • MEIJI SEIKA KABUSHIKI KAISHAKURIHARA, KenichiSHINEI, RieTANABE, KiyoshiYAMAMOTO, YasuoAJITO, KeiichiMIYAJIMA, KaoriTABATA, YujiYASUDA, ShoheiTATSUTA, KuniakiOKONOGI, Tsuneo
    • MEIJI SEIKA KABUSHIKI KAISHA
    • C07D307/92
    • C07D307/92C07D407/12C07D407/14C07D409/12C07D417/12
    • Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof, which have progesterone receptor binding inhibitory activities and so are used as remedies and preventives for diseases in which progesterone participates, more particularly, as anticancer agents against mammary and ovarian cancers, remedies for uterine myoma, endometriosis, meningioma and myeloma, abortifacient, peroral contraceptive, and remedies and preventives for osteoporosis and climacteric disturbance, wherein R and R represent each hydroxy, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, oxygenous cycloalkyloxy, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, or aromatic carbamoyloxy, the R optionally representing hydrogen alkyl, alkenyl, or alkynyl; and R , R , and R represent each independently hydrogen, alkyl, or alkenyl.
    • 具有孕酮受体结合抑制活性的由通式(I)表示的化合物及其药学上可接受的盐等用作对孕激素参与的疾病的补救措施和预防药物,更特别地,作为抗乳腺癌和卵巢癌的抗癌剂, 子宫肌瘤,子宫内膜异位症,脑膜瘤和骨髓瘤,流产,口服避孕药,以及骨质疏松症和更年期障碍的治疗和预防药物,其中R 1和R 2代表各羟基,烷氧基,烯氧基,炔氧基,环烷氧基,烷氧基烷氧基, 芳烷氧基,烷基羰基氧基,链烯基羰基氧基,炔基羰基氧基,环烷基羰基氧基,烷氧基羰基氧基,芳氧基羰基氧基,芳烷基羰基氧基,芳香族酰氧基,杂芳基酰氧基,饱和杂环羰基氧基,烷基磺酰氧基,芳香族磺酰氧基,烷基氨基甲酰氧基或芳族氨基甲酰氧基,R 1任选代表氢 烷基,烯基或炔基; R 3,R 4和R 5各自独立地表示氢,烷基或链烯基。
    • 4. 发明申请
    • NOVEL TETRAHYDROBENZINDOLONE DERIVATIVES
    • 新型四氢苯并恶唑衍生物
    • WO1998027059A1
    • 1998-06-25
    • PCT/JP1997004683
    • 1997-12-18
    • MEIJI SEIKA KAISHA, LTD.KURIHARA, KenichiSHINEI, RieKURATA, YasushiTABATA, YujiTANABE, KiyoshiOKONOGI, Tsuneo
    • MEIJI SEIKA KAISHA, LTD.
    • C07D209/60
    • C07D231/12C07D209/60C07D233/56C07D249/08C07D401/12C07D403/12C07D405/12C07D409/12
    • Compounds represented by general formula (I) or pharmaceutically acceptable salts thereof and a process for producing the same. Because of having an inhibitory activity on the bonding of progesterone to its receptor, these compounds are usable as remedies and preventives for diseases in which progesterone participates. In particular, these compounds are useful as anticancer agents for mammary cancer and ovarian cancer, remedies for uterus myoma, endometriosis, meningioma and myeloma, abortifacients, oral contraceptives, and remedies and preventives for osteoporosis and menopausual symptoms. In said formula, R represents alkyl or aralkyl; R represents hydrogen, alkylcarbonyl, cycloalkyl- carbonyl, aromatic acyl, saturated heterocyclic acyl, alkyl, alkenyl, aralkyl, carbamoyl, alkylcarbamoyl, aromatic carbamoyl, aralkylcarbamoyl, alkylamino-carbonyl, cycloalkylcarbamoyl, alkoxycarbonyl, aryloxycarbonyl, heteroaromatic thiocarbonyl, saturated heterocyclic thiocarbonyl or alkylthiocarbamoyl; and R represents hydrogen, hydroxy, alkyloxy, alkylcarbonyloxy, alkylthio or arylthio.
    • 由通式(I)表示的化合物或其药学上可接受的盐及其制备方法。 由于对孕酮与其受体的结合具有抑制活性,这些化合物可用作孕酮参与的疾病的补救措施和预防药物。 特别地,这些化合物可用作乳腺癌和卵巢癌的抗癌剂,子宫肌瘤,子宫内膜异位症,脑膜瘤和骨髓瘤的补救剂,流产者,口服避孕药以及用于骨质疏松症和更年期症状的治疗剂和预防剂。 在所述式中,R 1表示烷基或芳烷基; R 2表示氢,烷基羰基,环烷基 - 羰基,芳族酰基,饱和杂环酰基,烷基,烯基,芳烷基,氨基甲酰基,烷基氨基甲酰基,芳族氨基甲酰基,芳烷基氨基甲酰基,烷基氨基 - 羰基,环烷基氨基甲酰基,烷氧基羰基,芳氧基羰基,杂芳硫基羰基,饱和杂环 硫代羰基或烷硫基氨基甲酰基; R 3表示氢,羟基,烷氧基,烷基羰氧基,烷硫基或芳硫基。
    • 9. 发明专利
    • Screen device
    • 屏幕设备
    • JP2013024020A
    • 2013-02-04
    • JP2011170521
    • 2011-07-18
    • Tomomichi Chigusa智道 千種Kurihara Kenichi栗原 健一
    • CHIGUSA TOMOMICHI
    • E06B9/06
    • PROBLEM TO BE SOLVED: To solve the problem that, a rigid band body is distorted by the weight of a pleated screen to damage horizontality at an upper end edge of the pleated screen, pleats are protruded, expanded or disordered by rigidity or plastic deformation of the pleated screen in approach of a post to increase air pressure between posts disposed oppositely especially when reducing the distance between the posts, so that considerable protrusion or disorder may occur and the pleated screen may become extremely bad in appearance.SOLUTION: In a screen device, between an inner right slope of one of pleated screens which are disposed while being opposed to each other and integrally formed in a pleated shape with an arbitrary length, and an inner left slope of the other pleated screen, an upper screen setter disposed in an upper part and a lower screen setter disposed in a lower part are installed while being divided vertically, and the pleated screens are spread over a first post and a second post which are opposed to each other.
    • 要解决的问题为了解决刚性带体被褶皱筛网的重量扭曲以破坏褶皱筛网的上端边缘处的水平度的问题,褶皱由于刚度而突出,膨胀或无序, 在接近柱子时褶皱筛网的塑性变形,以增加相对设置的柱之间的空气压力,特别是当减小柱之间的距离时,可能发生相当大的突起或紊乱,并且打褶的筛网在外观上可能变得非常差。 解决方案:在屏幕装置中,在彼此相对并一体地形成为具有任意长度的打褶形状并且另一个褶皱的内部左斜面之间布置的打褶屏幕之一的内右斜面之间 屏幕,布置在上部的上屏幕设置器和设置在下部的下屏幕设置器被安装在垂直分割处,并且打褶的屏幕分布在彼此相对的第一柱和第二柱上。 版权所有(C)2013,JPO&INPIT