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1. 发明申请

WO2009131883A2 METHOD AND APPARATUS FOR ANALYTE PROCESSING 审中-公开
标题翻译：分析方法和装置
公开(公告)号：WO2009131883A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/040716
申请日：2009-04-15
申请人： BIOSCALE, INC. , FALB, Peter, W. , BRANCAZIO, David , FRANCE, Eric , MASTERS, Brett, P. , MILLER, Michael, F. , ORMSBY, Joshua, R. , SLOAN, Walker
发明人： FALB, Peter, W. , BRANCAZIO, David , FRANCE, Eric , MASTERS, Brett, P. , MILLER, Michael, F. , ORMSBY, Joshua, R. , SLOAN, Walker
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： G01N35/00029 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , B01L2400/0655 , G01N2035/00148 , Y10T29/49
摘要： A system for processing analytes in samples includes an instrument and a cartridge. The cartridge includes fluid inputs, input and output valve assemblies, processing devices, fluid reservoirs, and channels for carrying samples from the fluid inputs to the fluid reservoirs. The valve assemblies include valves adapted to form a sealed fluid chamber in response to force applied by a movable head assembly of the instrument. Each fluid reservoir is adapted to mate and align with an air displacement pump interface member. A valve assembly includes a recess wall surrounding a recess and a valve assembly wall surrounding both the recess and the recess wall. The recess wall and the valve assembly walls are adapted to mate with and seal against a flexible sheet covering the recess, the recess wall, and the valve assembly wall. The cartridge and instrument include complementary features for finely and coarsely aligning instrument assemblies with portions of the cartridge.
摘要翻译：用于处理样品中分析物的系统包括仪器和墨盒。墨盒包括流体输入，输入和输出阀组件，处理装置，流体储存器和用于将样品从流体输入传送到流体储存器的通道。阀组件包括适于响应由仪器的可移动头组件施加的力而形成密封流体室的阀。每个流体储存器适于与排气泵接口构件配合和对准。阀组件包括围绕凹部的凹陷壁和围绕凹部和凹陷壁的阀组件壁。凹陷壁和阀组件壁适于与覆盖凹部，凹陷壁和阀组件壁的柔性薄片配合并密封。墨盒和仪器包括用于精细和粗略地对准具有部分墨盒的仪器组件的互补特征。

2. 发明申请

WO2007030155A3 METHOD AND APPARATUS FOR DETECTING ANALYTES USING AN ACOUSTIC DEVICE 审中-公开
标题翻译：使用声学装置检测分析物的方法和装置
公开(公告)号：WO2007030155A3
公开(公告)日：2007-05-10
申请号：PCT/US2006016809
申请日：2006-05-02
申请人： BIOSCALE INC , SRIVASTANA ALOK , WANG WAYNE , MILLER MICHAEL , MASTERS BRETT P , GULATI VISHAL K , LUNSTROM MARK
发明人： SRIVASTANA ALOK , WANG WAYNE , MILLER MICHAEL , MASTERS BRETT P , GULATI VISHAL K , LUNSTROM MARK
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324
摘要： Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte particle complexes that are bound to the sensor surface.
摘要翻译：提供了用于检测样品中的分析物的方法。将各自用对分析物具有亲和力的捕获剂涂覆的多个颗粒与样品结合以形成多个分析物颗粒复合物。该系统还包括用于将样品和/或颗粒传送到传感器表面的传送装置，以及可选的磁场感应结构，其被构造和布置成在传感器表面处并在传感器表面附近建立磁场。谐振传感器产生对应于结合到传感器表面的分析物颗粒复合物的量的信号。

3. 发明申请

WO2007030155A2 METHOD AND APPARATUS FOR DETECTING ANALYTES USING AN ACOUSTIC DEVICE 审中-公开
标题翻译：用于使用声学设备检测分析仪的方法和装置
公开(公告)号：WO2007030155A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/016809
申请日：2006-05-02
申请人： BIOSCALE, INC. , SRIVASTANA, Alok , WANG, Wayne , MILLER, Michael , MASTERS, Brett, P. , GULATI, Vishal, K. , LUNSTROM, Mark
发明人： SRIVASTANA, Alok , WANG, Wayne , MILLER, Michael , MASTERS, Brett, P. , GULATI, Vishal, K. , LUNSTROM, Mark
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324 , Y02A50/52 , Y02A50/57
摘要： Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte particle complexes that are bound to the sensor surface.
摘要翻译：提供了检测样品中分析物的方法。多个颗粒，每个颗粒被涂覆有对分析物具有亲和性的捕获剂，与样品组合以形成多个分析物颗粒复合物。该系统还包括用于将样品和/或颗粒传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。谐振传感器产生对应于结合到传感器表面的分析物颗粒复合物的量的信号。

4. 发明申请

WO2006119308A2 METHOD AND APPARATUS FOR DETECTING ANALYTES USING AN ACOUSTIC DEVICE 审中-公开
标题翻译：用于使用声学设备检测分析仪的方法和装置
公开(公告)号：WO2006119308A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016874
申请日：2006-05-02
申请人： BIOSCALE, INC. , SAUER-BUDGE, Alexis, F. , FITCH, Eric , MASTERS, Brett, P. , MILLER, Michael , LUNDSTROM, Mark
发明人： SAUER-BUDGE, Alexis, F. , FITCH, Eric , MASTERS, Brett, P. , MILLER, Michael , LUNDSTROM, Mark
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324 , Y02A50/52 , Y02A50/57
摘要： Methods for detecting analytes are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译：提供检测分析物的方法。将多个颗粒，每个颗粒涂覆有对分析物具有亲和性的捕获剂与样品组合以形成多个分析物 - 颗粒复合物。该系统还包括用于将样品传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

5. 发明申请

WO2009131883A3 METHOD AND APPARATUS FOR ANALYTE PROCESSING 审中-公开
标题翻译：分析方法和装置
公开(公告)号：WO2009131883A3
公开(公告)日：2010-05-06
申请号：PCT/US2009040716
申请日：2009-04-15
申请人： BIOSCALE INC , FALB PETER W , BRANCAZIO DAVID , FRANCE ERIC , MASTERS BRETT P , MILLER MICHAEL F , ORMSBY JOSHUA R , SLOAN WALKER
发明人： FALB PETER W , BRANCAZIO DAVID , FRANCE ERIC , MASTERS BRETT P , MILLER MICHAEL F , ORMSBY JOSHUA R , SLOAN WALKER
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： G01N35/00029 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2200/025 , B01L2200/16 , B01L2300/0654 , B01L2300/0816 , B01L2400/0487 , B01L2400/0655 , G01N2035/00148 , Y10T29/49
摘要： A system for processing analytes in samples includes an instrument and a cartridge. The cartridge includes fluid inputs, input and output valve assemblies, processing devices, fluid reservoirs, and channels for carrying samples from the fluid inputs to the fluid reservoirs. The valve assemblies include valves adapted to form a sealed fluid chamber in response to force applied by a movable head assembly of the instrument. Each fluid reservoir is adapted to mate and align with an air displacement pump interface member. A valve assembly includes a recess wall surrounding a recess and a valve assembly wall surrounding both the recess and the recess wall. The recess wall and the valve assembly walls are adapted to mate with and seal against a flexible sheet covering the recess, the recess wall, and the valve assembly wall. The cartridge and instrument include complementary features for finely and coarsely aligning instrument assemblies with portions of the cartridge.
摘要翻译：用于处理样品中分析物的系统包括仪器和墨盒。墨盒包括流体输入，输入和输出阀组件，处理装置，流体储存器和用于将样品从流体输入传送到流体储存器的通道。阀组件包括适于响应由仪器的可移动头组件施加的力而形成密封流体室的阀。每个流体储存器适于与排气泵接口构件配合和对准。阀组件包括围绕凹部的凹陷壁和围绕凹部和凹陷壁的阀组件壁。凹陷壁和阀组件壁适于与覆盖凹部，凹陷壁和阀组件壁的柔性薄片配合并密封。墨盒和仪器包括用于精细和粗略地对准具有部分墨盒的仪器组件的互补特征。

6. 发明申请

WO2009033056A1 REUSABLE DETECTION SURFACES AND METHODS OF USING SAME 审中-公开
标题翻译：可重复使用的检测表面及其使用方法
公开(公告)号：WO2009033056A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075448
申请日：2008-09-05
申请人： BIOSCALE, INC. , ARENAS, Jaime, E. , CHOI, Hyun-Goo , DICKERSON, William, Matthew , HEMBREE, Sarah, Beth , MADISON, Lara, Louise , MASTERS, Brett, P. , MILLER, Michael, F. , WANG, Wayne, U.
发明人： ARENAS, Jaime, E. , CHOI, Hyun-Goo , DICKERSON, William, Matthew , HEMBREE, Sarah, Beth , MADISON, Lara, Louise , MASTERS, Brett, P. , MILLER, Michael, F. , WANG, Wayne, U.
IPC分类号： G01N33/543 , G01N29/02
CPC分类号： G01N29/022 , B01L9/52 , G01N33/54373 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2291/02836 , G01N2291/0427
摘要： The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte. In particular, the present application relates to a detection surface of an acoustic device, like flexural plate wave (FPW) device, wherein a first capture agent capable of binding an analyte is linked to the detection surface and remains linked to the detection surface upon removal of the bound analyte by chemical wash. Thus the detection surface can be reused in further assays. Furthermore the application claims a kit and a reusable cartridge with a fluid chamber, an acoustic device with detection surface and a first capturing agent.
摘要翻译：本文提供的技术通常涉及可重复使用的检测表面和用于在分析物的测定中使用检测表面后重新使用检测表面的方法。特别地，本申请涉及一种声学装置的检测表面，例如弯曲板波（FPW）装置，其中能够将分析物结合的第一捕获剂与检测表面连接，并且在去除时保持与检测表面的连接的化学洗涤结合的分析物。因此，检测表面可以再次用于进一步的检测。此外，本申请要求具有流体室的套件和可重复使用的盒，具有检测表面的声学装置和第一捕获剂。

7. 发明申请

WO2008067206A2 FLUID PATHS IN ETCHABLE MATERIALS 审中-公开
标题翻译：可蚀性材料中的流体状态
公开(公告)号：WO2008067206A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085086
申请日：2007-11-19
申请人： BIOSCALE, INC. , MILLER, Michael , MASTERS, Brett, P. , SCHMIDT, Martin
发明人： MILLER, Michael , MASTERS, Brett, P. , SCHMIDT, Martin
IPC分类号： B81C1/00
CPC分类号： B81C1/00714 , B81B2201/058 , B81B2203/033 , B81C2201/0112
摘要： The invention relates to fluid paths in etchable materials. Fluid paths are formed by forming a cavity through a substrate material with a first dry removal process to produce a first surface of the cavity. The first surface of the cavity is associated with a first roughness. The first surface of the cavity is etched with a second wet removal process to reduce the first roughness and produce a second roughness associated with the first surface of the cavity. A coating is applied to the first surface of the cavity to produce a second surface to improve wettability of the first or second surface of the cavity, reduce in size or number gas nucleation sites in the first or second surface of the cavity, reduce the amount of debris associated with the first roughness carried by the fluid flow, and/or improve hydrophilicity of the first or second surface.
摘要翻译：本发明涉及可蚀刻材料中的流体路径。通过用第一干燥去除工艺通过基底材料形成空腔来形成流体路径，以产生空腔的第一表面。空腔的第一表面与第一粗糙度相关联。通过第二湿去除工艺蚀刻空腔的第一表面，以减少第一粗糙度并产生与空腔的第一表面相关联的第二粗糙度。将涂层施加到空腔的第一表面以产生第二表面以改善空腔的第一或第二表面的润湿性，减小空腔的第一或第二表面中的气体成核位置的尺寸或数量，减少量与由流体流动携带的第一粗糙度相关联的碎屑和/或改善第一或第二表面的亲水性。

8. 发明申请

WO2006107961A2 ELECTRICALLY RESPONSIVE DEVICE 审中-公开
标题翻译：电动响应装置
公开(公告)号：WO2006107961A2
公开(公告)日：2006-10-12
申请号：PCT/US2006012491
申请日：2006-04-05
申请人： BIOSCALE INC , MASTERS BRETT P , MILLER MICHAEL F
发明人： MASTERS BRETT P , MILLER MICHAEL F
IPC分类号： H03H3/00 , H03H3/04 , H03H3/10 , H03H9/02
CPC分类号： G01N29/036 , G01N9/002 , G01N2291/0256
摘要： Electrically responsive devices and methods for fabricating electrically responsive devices involves applying an electrically responsive material (e.g., an electroactive material) over at least a portion of a surface of a substrate material and applying an electrode material over at least a portion of a surface of the electrically responsive material. At least one region of the electrode material is selectively removed exposing the electrically responsive material. At least some of the electrically responsive material is selectively removed in a region corresponding to the at least one region of the electrode material.
摘要翻译：用于制造电响应装置的电响应装置和方法包括在基底材料的表面的至少一部分上施加电响应材料（例如，电活性材料），并将电极材料施加到至少一部分表面上电响应材料。选择性地去除电极材料的至少一个区域，暴露出电响应材料。在对应于电极材料的至少一个区域的区域中选择性地去除至少一些电响应材料。

9. 发明申请

WO2007021907A2 RESONANT SENSOR SYSTEMS AND METHODS WITH REDUCED GAS INTERFERENCE 审中-公开
标题翻译：谐波传感器系统和减少气体干扰的方法
公开(公告)号：WO2007021907A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031329
申请日：2006-08-10
申请人： BIOSCALE, INC. , MASTERS, Brett, P. , MILLER, Michael, F.
发明人： MASTERS, Brett, P. , MILLER, Michael, F.
IPC分类号： G01N30/96
CPC分类号： G01N29/036 , B82Y15/00 , B82Y30/00 , G01N2291/0256 , G01N2291/0257
摘要： A system having reduced gas interference that includes a fluid chamber and a resonant sensor device in fluid communication with a fluid in the fluid chamber. The system includes a fluid control device adapted to change at least one of the fluid flow or pressure within the fluid chamber to achieve substantial wetting of surfaces in proximity to the resonant sensor device. Fluid surfaces of the system can include a material to increase the wettability (e.g., hydrophilicity) of the fluid surfaces.
摘要翻译：具有减小的气体干扰的系统，其包括与流体室中的流体流体连通的流体室和谐振传感器装置。该系统包括流体控制装置，其适于改变流体室内的流体流动或压力中的至少一个，以实现靠近谐振传感器装置的表面的实质润湿。系统的流体表面可以包括增加流体表面的润湿性（例如亲水性）的材料。

10. 发明申请

WO2009099733A1 FLUIDIC SYSTEM WITH IMPROVED FLOW CHARACTERISTICS 审中-公开
标题翻译：具有改进流动特性的流体系统
公开(公告)号：WO2009099733A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/031060
申请日：2009-01-15
申请人： BIOSCALE, INC. , MASTERS, Brett, P. , FALB, Peter, W. , MILLER, Michael, F.
发明人： MASTERS, Brett, P. , FALB, Peter, W. , MILLER, Michael, F.
IPC分类号： B01L3/00 , G01N29/02
CPC分类号： G01N29/222 , B01L3/502707 , B01L3/502746 , B01L2200/027 , B01L2200/0668 , B01L2300/0627 , B01L2300/0877 , B01L2400/0487 , B01L2400/084 , G01N29/022 , G01N2291/014 , G01N2291/0423 , G01N2291/0427 , Y10T137/2082 , Y10T137/2191 , Y10T137/2224
摘要： The invention relates to a fluidic system (200) that includes a body structure having a chamber (264) disposed therein. The fluidic system (200) includes at least one fluid input (268) at a first end (276) of the chamber (264) and at least one fluid output (274) at a second end ( (280) of the chamber (264). The fluidic system also includes a sensor device (260) (e.g., an acoustic device) having a surface (284) defining a portion of a surface of the chamber (264). The fluidic system (200) also includes a first surface (222a) at the first end (276) of the chamber (264) oriented at an oblique or arcuate (e.g., curved) angle relative to the surface (284) of the sensor device (260) to direct fluid through the chamber (264).
摘要翻译：本发明涉及一种流体系统（200），其包括具有设置在其中的室（264）的主体结构。流体系统（200）包括在腔室（264）的第一端（276）处的至少一个流体输入（268）和在腔室（264）的第二端（280）处的至少一个流体输出（274）流体系统还包括具有限定腔室（264）表面的一部分的表面（284）的传感器装置（例如，声学装置），流体系统（200）还包括第一表面（260）的表面（284）以倾斜或弓形（例如，弯曲）的角度定向的腔室（264）的第一端（276）处的导管（222a），以引导流体通过腔室）。

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