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1. 发明申请

WO2007030155A3 METHOD AND APPARATUS FOR DETECTING ANALYTES USING AN ACOUSTIC DEVICE 审中-公开
标题翻译：使用声学装置检测分析物的方法和装置
公开(公告)号：WO2007030155A3
公开(公告)日：2007-05-10
申请号：PCT/US2006016809
申请日：2006-05-02
申请人： BIOSCALE INC , SRIVASTANA ALOK , WANG WAYNE , MILLER MICHAEL , MASTERS BRETT P , GULATI VISHAL K , LUNSTROM MARK
发明人： SRIVASTANA ALOK , WANG WAYNE , MILLER MICHAEL , MASTERS BRETT P , GULATI VISHAL K , LUNSTROM MARK
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324
摘要： Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte particle complexes that are bound to the sensor surface.
摘要翻译：提供了用于检测样品中的分析物的方法。将各自用对分析物具有亲和力的捕获剂涂覆的多个颗粒与样品结合以形成多个分析物颗粒复合物。该系统还包括用于将样品和/或颗粒传送到传感器表面的传送装置，以及可选的磁场感应结构，其被构造和布置成在传感器表面处并在传感器表面附近建立磁场。谐振传感器产生对应于结合到传感器表面的分析物颗粒复合物的量的信号。

2. 发明申请

WO2008067206A3 FLUID PATHS IN ETCHABLE MATERIALS 审中-公开
标题翻译：可蚀刻材料中的流体路径
公开(公告)号：WO2008067206A3
公开(公告)日：2008-11-27
申请号：PCT/US2007085086
申请日：2007-11-19
申请人： BIOSCALE INC , MILLER MICHAEL , MASTERS BRETT P , SCHMIDT MARTIN
发明人： MILLER MICHAEL , MASTERS BRETT P , SCHMIDT MARTIN
IPC分类号： B01L3/00 , B81C1/00
CPC分类号： B81C1/00714 , B81B2201/058 , B81B2203/033 , B81C2201/0112
摘要： The invention relates to fluid paths in etchable materials. Fluid paths are formed by forming a cavity through a substrate material with a first dry removal process to produce a first surface of the cavity. The first surface of the cavity is associated with a first roughness. The first surface of the cavity is etched with a second wet removal process to reduce the first roughness and produce a second roughness associated with the first surface of the cavity. A coating is applied to the first surface of the cavity to produce a second surface to improve wettability of the first or second surface of the cavity, reduce in size or number gas nucleation sites in the first or second surface of the cavity, reduce the amount of debris associated with the first roughness carried by the fluid flow, and/or improve hydrophilicity of the first or second surface.
摘要翻译：本发明涉及可蚀刻材料中的流体路径。流体路径通过利用第一干法去除工艺形成穿过基底材料的腔来形成，以产生腔的第一表面。空腔的第一表面与第一粗糙度相关联。用第二湿去除工艺蚀刻腔的第一表面以减小第一粗糙度并产生与腔的第一表面相关的第二粗糙度。将涂层施加到空腔的第一表面以产生第二表面以改善空腔的第一或第二表面的润湿性，减小空腔的第一或第二表面中的气体成核位置的尺寸或数量，与由流体流携带的第一粗糙度相关的碎片，和/或改善第一或第二表面的亲水性。

3. 发明申请

WO2006119308A3 METHOD AND APPARATUS FOR DETECTING ANALYTES USING AN ACOUSTIC DEVICE 审中-公开
标题翻译：用于使用声学设备检测分析仪的方法和装置
公开(公告)号：WO2006119308A3
公开(公告)日：2007-04-12
申请号：PCT/US2006016874
申请日：2006-05-02
申请人： BIOSCALE INC , SAUER-BUDGE ALEXIS F , FITCH ERIC , MASTERS BRETT P , MILLER MICHAEL , LUNDSTROM MARK
发明人： SAUER-BUDGE ALEXIS F , FITCH ERIC , MASTERS BRETT P , MILLER MICHAEL , LUNDSTROM MARK
IPC分类号： G01N33/543
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324
摘要： Methods for detecting analytes are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译：提供了检测分析物的方法。多个颗粒，每个颗粒被涂覆有对分析物具有亲和性的捕获剂与样品组合以形成多个分析物 - 颗粒复合物。该系统还包括用于将样品传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

4. 发明专利

JP2013015533A Method and apparatus for detection of analyte using acoustic device 审中-公开
标题翻译：用于使用声学设备检测分析仪的方法和装置
公开(公告)号：JP2013015533A
公开(公告)日：2013-01-24
申请号：JP2012198586
申请日：2012-09-10
申请人： Bioscale Inc , バイオスケール・インコーポレーテッド
发明人： ALEXIS F SAUER BUDGE , ERIC FITCH , BRET P MASTERS , MILLER MICHAEL , MARK RANSTROM
IPC分类号： G01N33/553 , G01N33/53
CPC分类号： G01N33/54313 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/1822 , B01L2400/043 , B01L2400/0487 , B82Y15/00 , B82Y30/00 , G01N29/022 , G01N29/036 , G01N29/4418 , G01N33/56911 , G01N2291/0256 , G01N2291/02836 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/324
摘要： PROBLEM TO BE SOLVED: To provide methods for detecting analytes.SOLUTION: A plurality of particles, each of which is coated with a capture agent having an affinity for an analyte, is combined with a sample to form a plurality of analyte-particle complexes. A system of the present invention also includes a transport means for transporting the sample to a sensor surface, and optionally a magnetic field inducing means arranged to generate a magnetic field at and adjacent to the sensor surface. In the configuration above, the sensor produces a signal corresponding to the amount of analyte-particle complexes that are bound to the sensor surface.
摘要翻译：要解决的问题：提供检测分析物的方法。解决方案：将多个颗粒（每个颗粒涂覆有对分析物具有亲和性的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。本发明的系统还包括用于将样品传送到传感器表面的传送装置，以及可选地设置成在传感器表面处和邻近传感器表面产生磁场的磁场感应装置。在上述配置中，传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。版权所有（C）2013，JPO＆INPIT

5. 发明专利

AU2003299534A1 RESONANT SENSOR AND SENSING SYSTEM 未知
公开(公告)号：AU2003299534A1
公开(公告)日：2004-05-13
申请号：AU2003299534
申请日：2003-08-28
申请人： BIOSCALE INC
发明人： LUNDSTROM MARK , MASTERS BRETT , SRIVASTAVA ALOK , SCHMIDT MARTIN , MILLER MICHAEL , CRAWLEY ED
IPC分类号： G01N5/02 , B81B3/00 , B81C1/00 , G01L1/10 , G01N27/00

6. 发明专利

CA2496777A1 RESONANT SENSOR AND SENSING SYSTEM 未知
公开(公告)号：CA2496777A1
公开(公告)日：2004-05-06
申请号：CA2496777
申请日：2003-08-28
申请人： BIOSCALE INC
发明人： LUNDSTROM MARK , CRAWLEY ED , MASTERS BRETT , SRIVASTAVA ALOK , SCHMIDT MARTIN , MILLER MICHAEL
IPC分类号： G01N5/02 , B81B3/00 , B81C1/00 , G01L1/10 , G01N27/00 , H01G5/00 , H01G7/00
摘要： The disclosed sensor chip (120) includes a substrate (126) and a moving memb er (132) coupled to the substrate and disposed for movement relative to the substrate. The moving member (132) moves relative to the substrate in a firs t direction and in a second direction in response to movement of the substrate . The first direction is different than the second direction. The moving membe r includes a plurality of receptors (140). The receptors are configured for selectively binding to a first measurement.

7. 发明申请

WO2004038354A2 RESONANT SENSOR AND SENSING SYSTEM 审中-公开
标题翻译：谐振传感器和感应系统
公开(公告)号：WO2004038354A2
公开(公告)日：2004-05-06
申请号：PCT/US0326927
申请日：2003-08-28
申请人： BIOSCALE INC
发明人： CRAWLEY ED , LUNDSTROM MARK , MASTERS BRETT , SRIVASTAVA ALOK , SCHMIDT MARTIN , MILLER MICHAEL
IPC分类号： G01N5/02 , B81B3/00 , B81C1/00 , G01L1/10 , G01N27/00 , G01L
CPC分类号： G01N29/036 , B81B3/0089 , B81B2201/0214 , B82Y30/00 , B82Y35/00 , B82Y40/00 , G01L1/10 , G01N2291/0257 , G01N2291/0427
摘要： The disclosed sensor chip includes a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate. The moving member moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors. The receptors are configured for selectively binding to a first measurand.
摘要翻译：所公开的传感器芯片包括衬底和耦合到衬底并被设置为相对于衬底移动的移动构件。移动构件响应于衬底的移动而在第一方向和第二方向上相对于衬底移动。第一方向与第二方向不同。移动构件包括多个受体。受体被配置为选择性地结合第一被测量。

8. 发明专利

AU2015396962B2 On-board re-inflatable containment boom system and method 未知
公开(公告)号：AU2015396962B2
公开(公告)日：2020-07-16
申请号：AU2015396962
申请日：2015-11-09
申请人： HALL TERRY , MILLER MICHAEL
发明人： MILLER MICHAEL , HALL TERRY
IPC分类号： E02B15/00
摘要： An on-board re-inflatable containment boom system for a waterborne vessel providing an on-board re-inflatable containment boom that lies substantially flat and capable of being spooled when deflated and floats in the proper orientation when inflated, that has re-inflatable float sections which are sequentially inflated during deployment and sequentially deflated during recovery, that can be repeatedly deployed and recovered for the purposes of training and testing, and that can be deployed immediately upon occurrence of an oil spill from a waterborne vessel because of its on-board location and its rapid deployment, providing controlled inflation and deflation during deployment and recovery, and a method for containment of an oil spill from a waterborne vessel using an on-board re-inflatable containment boom system.

9. 发明专利

CA2988271A1 ON-BOARD RE-INFLATABLE CONTAINMENT BOOM SYSTEM AND METHOD 未知
公开(公告)号：CA2988271A1
公开(公告)日：2016-12-08
申请号：CA2988271
申请日：2015-11-09
申请人： MILLER MICHAEL , HALL TERRY
发明人： MILLER MICHAEL , HALL TERRY
IPC分类号： E02B15/00
摘要： An on-board re-inflatable containment boom system for a waterborne vessel providing an on-board re-inflatable containment boom that lies substantially flat and capable of being spooled when deflated and floats in the proper orientation when inflated, that has re-inflatable float sections which are sequentially inflated during deployment and sequentially deflated during recovery, that can be repeatedly deployed and recovered for the purposes of training and testing, and that can be deployed immediately upon occurrence of an oil spill from a waterborne vessel because of its on-board location and its rapid deployment, providing controlled inflation and deflation during deployment and recovery, and a method for containment of an oil spill from a waterborne vessel using an on-board re-inflatable containment boom system.

10. 发明专利

CA3131881A1 INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS 未知
公开(公告)号：CA3131881A1
公开(公告)日：2020-09-17
申请号：CA3131881
申请日：2020-03-12
申请人： TOMITA DAISUKE , LAMA LODOE , TUSCHL THOMAS , PATEL DINSHAW , GLICKMAN J FRASER , KAMEI TAKU , MILLER MICHAEL , ASANO YASUTOMI , OKAMOTO REI , HASHIZUME SHOGO , AIDA JUMPEI , IMAEDA TOSHIHIRO , MICHINO MAYAKO , KUROITA TAKANOBU
发明人： TOMITA DAISUKE , LAMA LODOE , TUSCHL THOMAS , PATEL DINSHAW , GLICKMAN J FRASER , KAMEI TAKU , MILLER MICHAEL , ASANO YASUTOMI , OKAMOTO REI , HASHIZUME SHOGO , AIDA JUMPEI , IMAEDA TOSHIHIRO , MICHINO MAYAKO , KUROITA TAKANOBU
IPC分类号： A61K31/437 , C07D471/04
摘要： Tri-cyclyl nitrogen-containing heterocyclic compounds are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.

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