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1. 发明公开

EP1281047A1 SPATIOTEMPORAL AND GEOMETRIC OPTIMIZATION OF SENSOR ARRAYS FOR DETECTING ANALYTES IN FLUIDS 审中-公开
标题翻译：时空和分析物在流体中检测传感器阵列的几何优化
公开(公告)号：EP1281047A1
公开(公告)日：2003-02-05
申请号：EP01932624.8
申请日：2001-04-24
申请人： Lewis, Nathan S. , Freund, Michael S. , Briglin, Shawn M. , Tokumaru, Phil , Martin, Charles R. , Mitchell, David T.
发明人： Lewis, Nathan S. , Freund, Michael S. , Briglin, Shawn M. , Tokumaru, Phil , Martin, Charles R. , Mitchell, David T.
IPC分类号： G01D18/00 , G01N3/62 , G01R35/00 , G01S7/40 , G01W1/18 , G01B13/00
CPC分类号： G01N33/0031
摘要： Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors (530) configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one more surfaces/faces (540) relative to one or more fluid channels (500) in a array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels (500) can be formed between one or more substrate plates. Sensor (530) can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

2. 发明公开

EP1281047A4 SPATIOTEMPORAL AND GEOMETRIC OPTIMIZATION OF SENSOR ARRAYS FOR DETECTING ANALYTES IN FLUIDS 审中-公开
标题翻译：时空和分析物在流体中检测传感器阵列的几何优化
公开(公告)号：EP1281047A4
公开(公告)日：2004-03-24
申请号：EP01932624
申请日：2001-04-24
申请人： LEWIS NATHAN S , FREUND MICHAEL S , BRIGLIN SHAWN M , TOKUMARU PHIL , MARTIN CHARLES R , MITCHELL DAVID T
发明人： LEWIS NATHAN S , FREUND MICHAEL S , BRIGLIN SHAWN M , TOKUMARU PHIL , MARTIN CHARLES R , MITCHELL DAVID T
IPC分类号： B81B1/00 , G01N33/00 , G01N27/12 , G01N33/497
CPC分类号： G01N33/0031
摘要： Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors (530) configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one more surfaces/faces (540) relative to one or more fluid channels (500) in a array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels (500) can be formed between one or more substrate plates. Sensor (530) can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

3. 发明申请

WO2006122175A1 TEMPLATE-SYNTHESIZED DNA NANOTUBES 审中-公开
标题翻译：模板合成DNA纳米颗粒
公开(公告)号：WO2006122175A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/018044
申请日：2006-05-09
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MARTIN, Charles, R. , HOU, Shifeng
发明人： MARTIN, Charles, R. , HOU, Shifeng
IPC分类号： B82B3/00
CPC分类号： C12Q1/6806 , A61K9/0092 , A61K48/00 , B82Y5/00 , B82Y30/00 , C12N15/10 , C12N15/1068 , D01F4/00 , Y10S977/704 , Y10S977/742 , Y10S977/745 , Y10S977/746
摘要： A method of forming DNA nanotubes composed entirely or predominantly from DNA that the methods of the present invention form single layer or multilayer template-synthesized nanotubes where the bulk of the tube is composed of DNA, and the layers are held together by hybridization of complementary DNA strands. The DNA molecules making up these tubes may be varied as desired, and the DNA is capable of being released from the tube.
摘要翻译：形成完全或主要由DNA构成的DNA纳米管的方法，本发明的方法形成单层或多层模板合成的纳米管，其中管的主体由DNA组成，并且层通过互补DNA杂交而保持在一起链。构成这些管的DNA分子可以根据需要变化，并且DNA能够从管中释放。

4. 发明申请

WO2005098429A3 SYSTEM AND METHOD FOR REAL-TIME DIAGNOSIS, TREATMENT, AND THERAPEUTIC DRUG MONITORING 审中-公开
标题翻译：用于实时诊断，治疗和治疗药物监测的系统和方法
公开(公告)号：WO2005098429A3
公开(公告)日：2006-05-26
申请号：PCT/US2005006355
申请日：2005-02-28
申请人： UNIV FLORIDA , MELKER RICHARD J , SACKELLARES JAMES CHRIS , GOLD MARK S , DENNIS DONN MICHAEL , MARTIN CHARLES R , STEWART JON D
发明人： MELKER RICHARD J , SACKELLARES JAMES CHRIS , GOLD MARK S , DENNIS DONN MICHAEL , MARTIN CHARLES R , STEWART JON D
IPC分类号： G01N33/543 , A61B5/08 , A61B5/083 , A61K9/51 , A61M5/142 , A61M5/172 , A61M16/01 , A61M16/10 , G01N33/53
CPC分类号： G01N33/5432 , A61B5/082 , A61B5/411 , A61B5/4821 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M2016/1035 , A61M2230/437 , B82Y5/00 , G01N33/50 , G01N33/5308
摘要： Systems and methods for diagnosing and/or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and/or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and/or monitoring disease treatment.
摘要翻译：用于诊断和/或治疗疾病以及监测疾病治疗的系统和方法。为了诊断，本发明使用纳米颗粒基组件，其包含纳米颗粒; 替代标记以及用于检测特定化学实体的手段。在某些实施方案中，基于纳米颗粒的组件包括用于同时诊断和治疗疾病的有效载荷。在另外的实施方案中，向患者施用治疗药物和治疗药物标记物以监测疾病治疗。使用传感器技术分析体液样品以检测替代物和/或治疗药物标记物的存在，以提供用于诊断疾病和/或监测疾病治疗的有效和准确的手段。

5. 发明申请

WO2004037316A2 NANOPARTICLE DELIVERY SYSTEM 审中-公开
标题翻译：纳米粒子递送系统
公开(公告)号：WO2004037316A2
公开(公告)日：2004-05-06
申请号：PCT/US2003/032355
申请日：2003-10-10
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MARTIN, Charles, R. , ROGERS, Richard, J. , STEWART, Jon, D.
发明人： DENNIS, Donn, M. , MARTIN, Charles, R. , ROGERS, Richard, J. , STEWART, Jon, D.
IPC分类号： A61M
CPC分类号： A61K9/0092 , A61K47/6849 , A61K47/6923 , B82Y5/00 , Y10T428/2984 , Y10T428/2987
摘要： The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials . The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.
摘要翻译：本发明涉及各种尺寸的纳米管，并且由各种材料或材料的组合组成。本发明还描述了这种纳米管用于递送各种有效载荷的用途，特别是用于生物活性物质的体内递送。

6. 发明申请

WO02080885B1 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO02080885B1
公开(公告)日：2003-01-03
申请号：PCT/US0206114
申请日：2002-02-28
申请人： UNIV FLORIDA , DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
发明人： DENNIS DONN M , MARTIN CHARLES R , MOREY TIMOTHY E , PARTCH RICHARD E , SHAH DINESH O
IPC分类号： A61K9/51 , A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for removing a target chemical from a region comprising the steps of: adding nanoparticle to the region and partitioning at least a portion of the target chemical into or onto the bioparticle. A composition comprising bioparticles having a surface adopted for toxic drug attachment is also provided.
摘要翻译：一种用于从区域除去目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

7. 发明申请

WO2013095456A1 POWER MANAGEMENT IN A DISCRETE MEMORY PORTION 审中-公开
标题翻译：分离存储器部分的电源管理
公开(公告)号：WO2013095456A1
公开(公告)日：2013-06-27
申请号：PCT/US2011/066582
申请日：2011-12-21
申请人： INTEL CORPORATION , MOZIPO, Aurelien T. , MARTIN, Charles R. , SCHOCK, John D.
发明人： MOZIPO, Aurelien T. , MARTIN, Charles R. , SCHOCK, John D.
IPC分类号： G06F1/26 , G06F13/14
CPC分类号： G06F1/26 , G06F1/266 , G06F1/3275 , Y02D10/14 , Y02D50/20
摘要： Systems and methods of operating a computing system may involve receiving, at a control interface, an instruction to alter a power state at a memory device, and directing, by the control interface, a controller to control a power supply to a memory device channel to alter the power state in the memory device.
摘要翻译：操作计算系统的系统和方法可以包括在控制接口处接收改变存储设备处的功率状态的指令，以及通过控制接口指示控制器来控制对存储器件通道的电源改变存储设备中的电源状态。

8. 发明申请

WO2009052021A2 SYSTEM AND METHOD FOR SECURE STORAGE OF DATA 审中-公开
标题翻译：用于安全存储数据的系统和方法
公开(公告)号：WO2009052021A2
公开(公告)日：2009-04-23
申请号：PCT/US2008/079462
申请日：2008-10-10
申请人： SUN MICROSYSTEMS, INC. , MADISON, Carl, T. , MARTIN, Charles, R.
发明人： MADISON, Carl, T. , MARTIN, Charles, R.
IPC分类号： H03M99/00 , H04L9/06
CPC分类号： H04L9/0894
摘要： A method of securely storing a data item including obtaining the data item; translating the data item into a first plurality of data blocks using an erasure code associated with a rate; and storing at least a subset of the first plurality of data blocks, where a size of the subset exceeds a product of the rate and a size of the first plurality of data blocks.
摘要翻译：一种安全地存储包括获得数据项的数据项的方法; 使用与速率相关联的擦除码将所述数据项转换成第一多个数据块; 以及存储所述第一多个数据块的至少一个子集，其中所述子集的大小超过所述速率与所述第一多个数据块的大小的乘积。

9. 发明申请

WO2002080885A1 DETOXIFICATION AND DECONTAMINATION USING NANOTECHNOLOGY THERAPY 审中-公开
标题翻译：使用纳米技术治疗的脱氧和去除
公开(公告)号：WO2002080885A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/006114
申请日：2002-02-28
申请人： UNIVERSITY OF FLORIDA , DENNIS, Donn, M. , MARTIN, Charles, R. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O.
发明人： DENNIS, Donn, M. , MARTIN, Charles, R. , MOREY, Timothy, E. , PARTCH, Richard, E. , SHAH, Dinesh, O.
IPC分类号： A61K9/14
CPC分类号： A61K9/0092 , A61K9/1075 , A61K9/51
摘要： A method for detoxification and decontamination comprising the steps of: adding nanoparticle size bioparticles having at least one enzyme incorporated therein to a solution and biotransforming the target chemical into inactive metabolites.
摘要翻译：一种用于从区域去除目标化学物质的方法，包括以下步骤：向该区域添加纳米颗粒尺寸的生物颗粒并将至少一部分目标化学品分配到生物颗粒中或其上。还提供了包含具有用于有毒药物附着的表面的生物颗粒的组合物。

10. 发明申请

WO1993025300A1 ULTRATHIN COMPOSITE MEMBRANES 审中-公开
标题翻译：超薄复合膜
公开(公告)号：WO1993025300A1
公开(公告)日：1993-12-23
申请号：PCT/US1993005384
申请日：1993-06-07
申请人： RESEARCH CORPORATION TECHNOLOGIES, INC. , MARTIN, Charles, R. , LIU, Chao
发明人： RESEARCH CORPORATION TECHNOLOGIES, INC.
IPC分类号： B01D69/12
CPC分类号： B01D69/125 , B01D69/02 , G01N27/40
摘要： The present invention relates to a method of forming defect-free ultrathin film composite membranes by the photochemical synthesis of an ultrathin polymer film on the surface of a microporous support membrane. In one particular embodiment, the method entails placing a support membrane on a filter paper which is saturated with a solution of the desired monomer(s). The solution then wicks to the top of the membrane, covering the surface with a thin solution film, where it is subjected to irradiation by ultraviolet (UV) light to initiate the polymerization of the ultrathin polymer film. The rate of polymerization can be enhanced by adding a photoinitiator to the gas phase above the membrane or into solution with the monomer or monomers to induce radical polymerization. The method results in a defect-free ultrathin composite membrane. In addition, to minimize photon penetration depth and confine the polymerization predominantly to the membrane surface, the incident at which the UV light strikes the membrane surface is kept at an acute angle. The ultrathin film composite membranes can be used in a vast number of chemical separation processes, bioreactors and sensors, energy conversion and drug delivery systems.
摘要翻译：本发明涉及通过微孔聚合物膜的光化学合成在微孔载体膜的表面上形成无缺陷的超薄膜复合膜的方法。在一个具体实施方案中，该方法需要将支撑膜放置在用所需单体的溶液饱和的滤纸上。然后将溶液吸到膜的顶部，用薄的溶液膜覆盖表面，在那里用紫外线（UV）光照射以引发超薄聚合物膜的聚合。通过向膜上方的气相或与单体或单体的溶液中加入光引发剂以引发自由基聚合，可以提高聚合速率。该方法产生无缺陷的超薄复合膜。此外，为了使光子穿透深度最小化并将聚合主要限制在膜表面，UV光照射到膜表面的入射处被保持为锐角。超薄膜复合膜可用于大量化学分离过程，生物反应器和传感器，能量转换和药物输送系统。

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