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1. 发明申请

WO2008067377A3 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 审中-公开
标题翻译：新型医疗方法与系统无线监控
公开(公告)号：WO2008067377A3
公开(公告)日：2009-01-29
申请号：PCT/US2007085761
申请日：2007-11-28
申请人： MEDTRONIC INC , HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
发明人： HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
IPC分类号： A61B5/07 , A61B5/00 , A61B5/11 , A61B19/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法包括至少两个植入标记的监测，每个植入标记适于响应于无线发送的激励信号无线地发送信号; 响应信号被转换成两个标记的位置信息。所述系统和方法还包括植入的感测构件和/或植入的治疗递送装置中的一个或其中之一。从感测构件接收到的信号可以与位置信息进行整理。可以根据位置信息调整从治疗输送装置输送的治疗。

2. 发明申请

WO2008067377A9 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 审中-公开
标题翻译：结合无线监测的新型医疗方法和系统
公开(公告)号：WO2008067377A9
公开(公告)日：2008-08-14
申请号：PCT/US2007085761
申请日：2007-11-28
申请人： MEDTRONIC INC , HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
发明人： HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
IPC分类号： A61B5/00 , A61B5/06 , A61B5/07 , A61B5/11
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法结合了对至少两个植入标记的监视，每个植入标记适于响应于无线发送的激励信号而无线发送信号; 响应信号被转换成两个标记的位置信息。该系统和方法进一步结合了植入的感测构件和/或植入的治疗输送装置两者或一者。从传感构件接收到的信号可以与位置信息进行比较。根据位置信息可以调整从治疗传递装置传递的治疗。

3. 发明申请

WO2008067377A2 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 审中-公开
标题翻译：新型医疗方法与系统无线监控
公开(公告)号：WO2008067377A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085761
申请日：2007-11-28
申请人： MEDTRONIC, INC , HETTRICK, Douglas, A. , MARKOWITZ, H., Toby , SOWELAM, Sameh , GARDESKI, Kenneth, C.
发明人： HETTRICK, Douglas, A. , MARKOWITZ, H., Toby , SOWELAM, Sameh , GARDESKI, Kenneth, C.
IPC分类号： A61B5/00 , A61B5/06 , A61B5/07 , A61B5/11
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法包括至少两个植入标记的监测，每个植入标记适于响应于无线发送的激励信号无线地发送信号; 响应信号被转换成两个标记的位置信息。所述系统和方法还包括植入的感测构件和/或植入的治疗递送装置中的一个或其中之一。从感测构件接收到的信号可以与位置信息进行整理。可以根据位置信息调整从治疗输送装置输送的治疗。

4. 发明申请

WO2011090621A1 CATHETER WITH A DETACHABLE IMPLANTABLE MEDICAL DEVICE COMMUNICATIVELY COUPLED TO THE CATHETER 审中-公开
标题翻译：带有可拆卸式可插拔医疗设备的导管与传导器通信
公开(公告)号：WO2011090621A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/060752
申请日：2010-12-16
申请人： MEDTRONIC, INC. , MARKOWITZ, H., Toby , CINBIS, Can
发明人： MARKOWITZ, H., Toby , CINBIS, Can
IPC分类号： A61N1/372
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for delivering an implantable medical device (14) in a patient and through a catheter (20). The delivery catheter comprises telemetry means (22) for communicatively coupling the implantable medical device with an external instrumentation (18) during implantation.
摘要翻译：描述了用于将可植入医疗装置（14）输送到患者体内并通过导管（20）的系统和方法。递送导管包括遥测装置（22），用于在植入期间将可植入医疗装置与外部装置（18）通信地联接。

5. 发明申请

WO2008108901A8 CHRONICALLY-IMPLANTABLE ACTIVE FIXATION MEDICAL ELECTRICAL LEADS AND RELATED METHODS FOR NON-FLUOROSCOPIC IMPLANTATION 审中-公开
标题翻译：慢性植入式有源固定型医用电线及相关方法非手术植入
公开(公告)号：WO2008108901A8
公开(公告)日：2010-02-18
申请号：PCT/US2007089087
申请日：2007-12-28
申请人： MEDTRONIC INC , MARKOWITZ H TOBY , GIESE CHAD , WALDHAUSER STEVEN
发明人： MARKOWITZ H TOBY , GIESE CHAD , WALDHAUSER STEVEN
IPC分类号： A61B5/053 , A61N1/05
CPC分类号： A61N1/0573 , A61B2034/2053 , A61N1/3627
摘要： Bio-impedance may be used for navigation systems to chronically implant pacing and defibrillation leads in the heart using a non-fluoroscopic position sensing unit (PSU), such as a modified LocaLisa® system from Medtronic Inc., which allows for variable frequency sampling of the position of electrode of a catheter. The PSU injects small AC signals via surface electrodes in three orthogonal axes, each on a slightly different frequency (e.g., near 30 KHz). Indwelling electrodes electrically connected to the PSU resolves the magnitude of induced voltage for each of the three frequencies, thus measuring voltage for each of the three axes. Voltages are divided by induced current to yield impedance in each axis for each electrode. Impedance is proportional to position within the body. Such a system requires that a conductive material, such as a retractable helical tip-electrode, be exposed during implantation. Since the tip is retracted during implantation, this disclosure provides a modified distal portion employing at least one aperture (or 'window') for fluid exposure of the helix-electrode and a deployable internal sleeve for covering the aperture(s) when the helix-electrode is extended.
摘要翻译：生物阻抗可用于导航系统，以使用非荧光位置感测单元（PSU）长期地在心脏中植入起搏和除颤引线，例如来自Medtronic Inc.的经修改的LocaLisa系统，该系统允许对导管电极的位置。 PSU通过三个正交轴中的表面电极注入小的AC信号，每个在稍微不同的频率（例如，接近30KHz）处。电连接到PSU的留置电极解决三个频率中的每一个的感应电压的大小，从而测量三个轴中的每一个的电压。电压被感应电流除以每个电极的每个轴线产生阻抗。阻抗与体内的位置成比例。这样的系统需要在植入期间露出诸如可伸缩螺旋尖端电极的导电材料。由于尖端在植入期间缩回，所以本公开提供了一种修改的远端部分，其采用用于螺旋电极的流体暴露的至少一个孔口（或“窗口”）和可展开的内部套筒，电极延长。

6. 发明申请

WO2009129477A1 METHOD AND APPARATUS FOR MAPPING A STRUCTURE 审中-公开
标题翻译：用于绘制结构的方法和装置
公开(公告)号：WO2009129477A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040984
申请日：2009-04-17
申请人： MEDTRONIC, INC. , REGENTS OF THE UNIVERSITY OF MINNESOTA , MARKOWITZ, H., Toby , CAMPBELL-MASSA, Sean , FALKNER, Phillip , FLEMING, Ioana , GIESE, Chad , KARAMANOGLU, Mustafa , KRYGER, Michael , NOWAK, Karl, Evan , MEHTA, Pooja , STEEVES, James , PHILLIPS, Lane, A. , ZHANG, Shangqian, Peter , WALDHAUSER, Steven, L. , SCANLON, David, A. , CRAIG, Brian, Houston , WARMAN, Eduardo, N. , MICHELS, Koen , SMITH, Marie, P. , HURTIG, Noelle, Christine , EICK, Olaf, J. , RECEVEUR, Rogier , LARIK, Vincent , CHELGREN, Brent , INTERRANTE, Victoria
发明人： MARKOWITZ, H., Toby , CAMPBELL-MASSA, Sean , FALKNER, Phillip , FLEMING, Ioana , GIESE, Chad , KARAMANOGLU, Mustafa , KRYGER, Michael , NOWAK, Karl, Evan , MEHTA, Pooja , STEEVES, James , PHILLIPS, Lane, A. , ZHANG, Shangqian, Peter , WALDHAUSER, Steven, L. , SCANLON, David, A. , CRAIG, Brian, Houston , WARMAN, Eduardo, N. , MICHELS, Koen , SMITH, Marie, P. , HURTIG, Noelle, Christine , EICK, Olaf, J. , RECEVEUR, Rogier , LARIK, Vincent , CHELGREN, Brent , INTERRANTE, Victoria
IPC分类号： A61B5/042
CPC分类号： A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

7. 发明申请

WO2009129475A1 METHOD AND APPARATUS FOR MAPPING A STRUCTURE 审中-公开
标题翻译：用于绘制结构的方法和装置
公开(公告)号：WO2009129475A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040979
申请日：2009-04-17
申请人： MEDTRONIC, INC. , MARKOWITZ, H., Toby , KARAMANOGLU, Mustafa , MEHTA, Pooja , FLEMING, Ioana , SCANLON, David, A. , KRYGER, Michael , CAMPBELL-MASSA, Sean , GIESE, Chad , WALDHAUSER, Steven, L. , ZHANG, Shangqian, Peter , JANNICKE, Jeff , FALKNER, Phillip , HEFNER, Don , WARMAN, Eduardo, N. , STEEVES, James , RECEVEUR, Rogier , MICHELS, Koen , EICK, Olaf , LARIK, Vincent
发明人： MARKOWITZ, H., Toby , KARAMANOGLU, Mustafa , MEHTA, Pooja , FLEMING, Ioana , SCANLON, David, A. , KRYGER, Michael , CAMPBELL-MASSA, Sean , GIESE, Chad , WALDHAUSER, Steven, L. , ZHANG, Shangqian, Peter , JANNICKE, Jeff , FALKNER, Phillip , HEFNER, Don , WARMAN, Eduardo, N. , STEEVES, James , RECEVEUR, Rogier , MICHELS, Koen , EICK, Olaf , LARIK, Vincent
IPC分类号： A61B5/042 , A61B5/06
CPC分类号： A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

8. 发明申请

WO2006060806A2 PATIENT MANAGEMENT NETWORK 审中-公开
标题翻译：患者管理网络
公开(公告)号：WO2006060806A2
公开(公告)日：2006-06-08
申请号：PCT/US2005044034
申请日：2005-12-02
申请人： MEDTRONIC INC , GOTTESMAN JANELL M , MARKOWITZ H TOBY , WILLENBRING JAMES E , MANRODT CHRISTOPHER M , VANDANACKER JOHN P , BURNES JOHN E , RUETER JOHN C , DVORAK DAVID P , AUDET SARAH A , CARNEY JAMES K , HILL GERALD J
发明人： GOTTESMAN JANELL M , MARKOWITZ H TOBY , WILLENBRING JAMES E , MANRODT CHRISTOPHER M , VANDANACKER JOHN P , BURNES JOHN E , RUETER JOHN C , DVORAK DAVID P , AUDET SARAH A , CARNEY JAMES K , HILL GERALD J
IPC分类号： G06F19/00
CPC分类号： G06F19/3418 , G06Q50/22 , G16H80/00
摘要： An intelligent patient management system collects data from a variety of sources, processes that information, and provides relevant information to an appropriate caregiver in context at the proper time. The system has multiple information sources available from which to gather additional information based upon conclusions drawn or issues identified from the patient data.
摘要翻译：智能患者管理系统从各种来源收集数据，处理这些信息，并在适当的时候向适当的护理人员提供相关信息。该系统具有多种信息来源，可根据患者数据识别的结论或问题收集附加信息。

9. 发明申请

WO2011059642A1 IDENTIFICATION AND TREATMENT OF JUNCTIONAL RHYTHMS 审中-公开
标题翻译：识别和治疗结节性红斑狼疮
公开(公告)号：WO2011059642A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/053184
申请日：2010-10-19
申请人： MEDTRONIC, INC. , SHELDON, Todd, J. , MARKOWITZ, H., Toby
发明人： SHELDON, Todd, J. , MARKOWITZ, H., Toby
IPC分类号： A61N1/368 , A61N1/372
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/37264
摘要： An implantable medical device and associated method provide atrial pacing and measure intervals between atrial pacing pulses and subsequently sensed ventricular events. A decreasing trend in the of intervals indicative of a pre-junctional rhythm is detected. The atrial pacing pulse is delivered at a shortened atrial pacing pulse interval in response to detecting the decreasing trend to reduce the likelihood of a junctional rhythm.
摘要翻译：可植入医疗装置和相关方法提供心房起搏并测量心房起搏脉冲与随后检测到的心室事件之间的间隔。检测到指示连接前节律的间隔的下降趋势。响应于检测到降低趋势以减少连接节律的可能性，心房起搏脉冲以缩短的心房起搏脉冲间隔递送。

10. 发明申请

WO2006115815A2 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 审中-公开
标题翻译：远程启动的遥控器和可植入的辅助放大器/除颤器系统
公开(公告)号：WO2006115815A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013956
申请日：2006-04-12
申请人： MEDTRONIC. INC. , MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
发明人： MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.
摘要翻译：皮下植入式心律转复除颤器（SubQ ICD）被公开，其完全可植入皮下，以最小的手术入侵患者体内，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法必要。 SubQ ICD与其他植入式和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。

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