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1. 发明申请

WO2012154719A1 PHRENIC NERVE STIMULATION DURING CARDIAC REFRACTORY PERIOD 审中-公开
标题翻译：心脏炎症期间的神经性神经刺激
公开(公告)号：WO2012154719A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036895
申请日：2012-05-08
申请人： MEDTRONIC, INC. , KARAMANOGLU, Mustafa , SPLETT, Vincent, E.
发明人： KARAMANOGLU, Mustafa , SPLETT, Vincent, E.
IPC分类号： A61N1/36 , A61B5/0452
CPC分类号： A61N1/3611 , A61B5/0452 , A61B5/0826 , A61B5/4836 , A61B5/686 , A61N1/3601 , F04C2270/0421
摘要： A method includes estimating a cardiac signal of a patient, estimating a length of a cardiac refractory period based in part on the cardiac signal and selectively adjusting the length of phrenic nerve electrical stimulation to be delivered to the patient based on the estimated length of the cardiac refractory period. In some examples the method includes delivering phrenic nerve stimulation for approximately the entire refractory period. The phrenic nerve stimulation may be used to treat a variety of breathing disorders.
摘要翻译：一种方法包括估计患者的心脏信号，部分地基于心脏信号估计心脏不应期的长度，并且基于估计的心脏长度来选择性地调节要递送给患者的膈神经电刺激的长度不应期。在一些实例中，该方法包括在大约整个不应期内输送膈神经刺激。膈神经刺激可用于治疗各种呼吸障碍。

2. 发明申请

WO2011090552A1 OPTIMIZATION OF AV DELAY USING VENTRICULAR PRESSURE SIGNAL 审中-公开
标题翻译：使用心室压力信号优化AV延迟
公开(公告)号：WO2011090552A1
公开(公告)日：2011-07-28
申请号：PCT/US2010/058303
申请日：2010-11-30
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , KARAMANOGLU, Mustafa
发明人： GREENHUT, Saul, E. , KARAMANOGLU, Mustafa
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36564 , A61N1/3682
摘要： An implantable medical device system including an intraventricular pressure sensor controls an atrioventricular (AV) delay based on the intraventricular pressure signal. An atrial kick pressure waveform corresponding to active contraction of an atrial chamber is detected from the intraventricular pressure signal. In one embodiment, a time interval corresponding to the atrial kick pressure waveform is measured. An AV delay is set in response to the measured time interval..
摘要翻译：包括心室内压力传感器的可植入医疗装置系统基于心室内压力信号来控制房室（AV）延迟。从心室内压力信号检测与心房的主动收缩对应的心房踢压力波形。在一个实施例中，测量对应于心房踢压力波形的时间间隔。响应于测量的时间间隔设置AV延迟。

3. 发明申请

WO2010051155A1 SYSTEM AND METHOD FOR SIMULTANEOUS CENTRAL AND BRACHIAL ARTERIAL PRESSURE MONITORING 审中-公开
标题翻译：同时中央和手持式压力监测的系统和方法
公开(公告)号：WO2010051155A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/060318
申请日：2009-10-12
申请人： MEDTRONIC, INC. , BURNES, John E. , KARAMANOGLU, Mustafa
发明人： BURNES, John E. , KARAMANOGLU, Mustafa
IPC分类号： A61B5/00 , A61B5/021 , A61N1/36 , A61B5/0215 , A61M5/14 , A61N1/365
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/02125 , A61B5/02156 , A61B5/6846 , A61N1/36564
摘要： An implantable medical device system and corresponding method to monitor blood pressure by transforming a measured pressure signal to estimate a blood pressure metric or waveform corresponding to a target site. An implantable sensor generates a signal corresponding to blood pressure at a first arterial branch location and a processor receiving the signal applies a transfer function to the signal to derive a blood pressure metric or waveform at a target site.
摘要翻译：一种可植入医疗装置系统和相应的方法，用于通过变换测量的压力信号来估计对应于目标部位的血压量度或波形来监测血压。可植入传感器产生对应于第一动脉分支位置处的血压的信号，并且接收信号的处理器对信号施加传递函数以导出目标位置处的血压度量或波形。

4. 发明申请

WO2009129477A1 METHOD AND APPARATUS FOR MAPPING A STRUCTURE 审中-公开
标题翻译：用于绘制结构的方法和装置
公开(公告)号：WO2009129477A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040984
申请日：2009-04-17
申请人： MEDTRONIC, INC. , REGENTS OF THE UNIVERSITY OF MINNESOTA , MARKOWITZ, H., Toby , CAMPBELL-MASSA, Sean , FALKNER, Phillip , FLEMING, Ioana , GIESE, Chad , KARAMANOGLU, Mustafa , KRYGER, Michael , NOWAK, Karl, Evan , MEHTA, Pooja , STEEVES, James , PHILLIPS, Lane, A. , ZHANG, Shangqian, Peter , WALDHAUSER, Steven, L. , SCANLON, David, A. , CRAIG, Brian, Houston , WARMAN, Eduardo, N. , MICHELS, Koen , SMITH, Marie, P. , HURTIG, Noelle, Christine , EICK, Olaf, J. , RECEVEUR, Rogier , LARIK, Vincent , CHELGREN, Brent , INTERRANTE, Victoria
发明人： MARKOWITZ, H., Toby , CAMPBELL-MASSA, Sean , FALKNER, Phillip , FLEMING, Ioana , GIESE, Chad , KARAMANOGLU, Mustafa , KRYGER, Michael , NOWAK, Karl, Evan , MEHTA, Pooja , STEEVES, James , PHILLIPS, Lane, A. , ZHANG, Shangqian, Peter , WALDHAUSER, Steven, L. , SCANLON, David, A. , CRAIG, Brian, Houston , WARMAN, Eduardo, N. , MICHELS, Koen , SMITH, Marie, P. , HURTIG, Noelle, Christine , EICK, Olaf, J. , RECEVEUR, Rogier , LARIK, Vincent , CHELGREN, Brent , INTERRANTE, Victoria
IPC分类号： A61B5/042
CPC分类号： A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

5. 发明申请

WO2009129475A1 METHOD AND APPARATUS FOR MAPPING A STRUCTURE 审中-公开
标题翻译：用于绘制结构的方法和装置
公开(公告)号：WO2009129475A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040979
申请日：2009-04-17
申请人： MEDTRONIC, INC. , MARKOWITZ, H., Toby , KARAMANOGLU, Mustafa , MEHTA, Pooja , FLEMING, Ioana , SCANLON, David, A. , KRYGER, Michael , CAMPBELL-MASSA, Sean , GIESE, Chad , WALDHAUSER, Steven, L. , ZHANG, Shangqian, Peter , JANNICKE, Jeff , FALKNER, Phillip , HEFNER, Don , WARMAN, Eduardo, N. , STEEVES, James , RECEVEUR, Rogier , MICHELS, Koen , EICK, Olaf , LARIK, Vincent
发明人： MARKOWITZ, H., Toby , KARAMANOGLU, Mustafa , MEHTA, Pooja , FLEMING, Ioana , SCANLON, David, A. , KRYGER, Michael , CAMPBELL-MASSA, Sean , GIESE, Chad , WALDHAUSER, Steven, L. , ZHANG, Shangqian, Peter , JANNICKE, Jeff , FALKNER, Phillip , HEFNER, Don , WARMAN, Eduardo, N. , STEEVES, James , RECEVEUR, Rogier , MICHELS, Koen , EICK, Olaf , LARIK, Vincent
IPC分类号： A61B5/042 , A61B5/06
CPC分类号： A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378
摘要： A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以利用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

6. 发明申请

WO2011087581A3 METHOD AND APPARATUS FOR BLOOD PRESSURE WAVEFORM BASELINE ESTIMATION AND REMOVAL 审中-公开
标题翻译：血压波形基线估计和去除方法与装置
公开(公告)号：WO2011087581A3
公开(公告)日：2011-09-09
申请号：PCT/US2010057785
申请日：2010-11-23
申请人： MEDTRONIC INC , GREENHUT SAUL E , KARAMANOGLU MUSTAFA
发明人： GREENHUT SAUL E , KARAMANOGLU MUSTAFA
IPC分类号： A61B5/0215 , A61M25/00 , A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61B5/0215 , A61B5/0402 , A61B5/686 , A61B5/7239 , A61B5/7246 , A61B5/7282 , A61N1/36564
摘要： An implantable medical device system including an implantable blood pressure sensor extracts a baseline signal from the sensed blood pressure signal and subtracts the extracted baseline signal from the sensed blood pressure signal to obtain a corrected pressure monitoring signal. The corrected pressure signal is monitored to detect a cardiac-related condition.
摘要翻译：包括可植入血压传感器的可植入医疗装置系统从感测的血压信号中提取基线信号，并从感测到的血压信号中减去提取的基线信号，以获得校正的压力监测信号。监视校正的压力信号以检测心脏相关状况。

7. 发明申请

WO2009134585A1 SYSTEM AND METHOD OF DETERMINING ARTERIAL BLOOD PRESSURE AND VENTRICULAR FILL PARAMETERS FROM VENTRICULAR BLOOD PRESSURE WAVEFORM DATA 审中-公开
标题翻译：从血管内血压波形数据确定血管内血压和静脉灌注参数的系统和方法
公开(公告)号：WO2009134585A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/039402
申请日：2009-04-03
申请人： MEDTRONIC, INC. , KARAMANOGLU, Mustafa , BENNETT, Tommy, D.
发明人： KARAMANOGLU, Mustafa , BENNETT, Tommy, D.
IPC分类号： A61B5/0215 , A61N1/365
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/02108 , A61B5/0456 , A61B5/7239 , A61N1/36564
摘要： A system and method of determining hemodynamic parameters uses sensed ventricular blood pressure during a portion of ventricular pressure waveform following peak pressure. An estimated arterial diastolic pressure is based upon an amplitude of the sensed ventricular pressure corresponding to a time at which a first derivative of ventricular pressure as a function of time is at a minimum (dP/dt min ). Fill parameters such as isovolumetric relaxation constant, ventricular suction pressure, atrial kick pressure, and transvalve pressure gradient are derived from measured pressures representing minimum ventricular pressure, ventricular diastolic pressure, and diastasis pressure.
摘要翻译：确定血液动力学参数的系统和方法在峰值压力之后的心室压力波形的一部分期间使用感测到的心室血压。估计的动脉舒张压基于对应于作为时间的函数的心室压力的一阶导数在最小（dP / dtmin）的时间的感测的心室压力的幅度。从表示最小心室压力，心室舒张压和舒张压的测量压力导出填充参数，例如等容舒张常数，心室吸入压力，心房踢压力和转化压力梯度。

8. 发明申请

WO2006081366A1 METHOD AND APPARATUS FOR MUSCLE FUNCTION MEASUREMENT 审中-公开
标题翻译：用于肌肉功能测量的方法和装置
公开(公告)号：WO2006081366A1
公开(公告)日：2006-08-03
申请号：PCT/US2006/002813
申请日：2006-01-26
申请人： MEDTRONIC, INC. , KARAMANOGLU, Mustafa , SPLETT, Vincent, E. , BENNETT, Tommy, D.
发明人： KARAMANOGLU, Mustafa , SPLETT, Vincent, E. , BENNETT, Tommy, D.
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/4519 , A61B5/7239
摘要： The present invention provides an apparatus and method for monitoring muscle function based on an index derived from a pressure or force signal. The muscle function index is derived from an instantaneous muscle stiffness ratio computed as the ratio of the first time derivative of the pressure or force waveform to the corresponding instantaneous pressure or force. The instantaneous stiffness ratio, Ė/E(t), is in units of 1/sec and relates to the rate of strong bond formation and will be influenced by calcium handling properties of the muscle fibers and the intracellular calcium concentration. As such, an index derived from Ė/E(t) provides a measure of the inotropic status of the muscle.
摘要翻译：本发明提供了一种基于从压力或力信号导出的指标来监测肌肉功能的装置和方法。肌肉功能指数来源于以压力或力波形的第一次导数与相应的瞬时压力或力的比值计算的瞬时肌肉僵直比。瞬时刚度比E / E（t）以1 /秒为单位，与强键形成速率有关，并受肌肉纤维钙处理性能和细胞内钙浓度的影响。因此，从E / E（t）得到的指数提供肌肉肌力状态的量度。

9. 发明申请

WO2011053543A1 DETECTION OF WAVEFORM ARTIFACT 审中-公开
标题翻译：检测波浪文艺
公开(公告)号：WO2011053543A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053910
申请日：2010-10-25
申请人： MEDTRONIC, INC. , GREENHUT, Saul, E. , KARAMANOGLU, Mustafa , KLECKNER, Karin, J. , BENNETT, Tommy, D. , DAVIE, Scott, W.
发明人： GREENHUT, Saul, E. , KARAMANOGLU, Mustafa , KLECKNER, Karin, J. , BENNETT, Tommy, D. , DAVIE, Scott, W.
IPC分类号： A61N1/37
CPC分类号： A61N1/3702
摘要： An implantable medical device system including a physiological sensor detects signal artifact in a signal waveform acquired by the sensor. Features of individual waveforms in the sensor signal are extracted. Sample waveforms are classified by expert observation into at least two classes including an artifact class. A distribution range for each of the extracted features from the sample waveforms is determined for each of the classes. Waveform classification criteria are established in response to the determined distribution ranges.
摘要翻译：包括生理传感器的可植入医疗装置系统检测由传感器获取的信号波形中的信号伪影。提取传感器信号中各波形的特征。通过专家观察将样本波形分类为至少两个类，包括神器类。为每个类别确定来自采样波形的每个提取特征的分布范围。响应于确定的分布范围建立波形分类标准。

10. 发明申请

WO2009148798A1 ESTIMATING PULMONARY ARTERY DIASTOLIC PRESSURE 审中-公开
标题翻译：估计脉搏动脉硬化压力
公开(公告)号：WO2009148798A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/044074
申请日：2009-05-15
申请人： MEDTRONIC, INC. , CARNEY, James, K. , BENNETT, Tommy, D. , KARAMANOGLU, Mustafa
发明人： CARNEY, James, K. , BENNETT, Tommy, D. , KARAMANOGLU, Mustafa
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028
摘要： A method for estimating pulmonary artery diastolic pressure, for a single heart beat, includes establishing a time window for sampling and storing pressure data points from a right ventricular pressure transducer. The time window may be established according to predetermined parameters and/or according to one or more triggering events. An approximate time at which the pulmonary artery valve opens is determined, either via the sampled pressure data points, or via another form of more direct monitoring, during the time window, in order to estimate the pulmonary artery diastolic pressure. A plurality of sets of N pressure data points may be collected, from the sampled data, and, for each collected set, a weighted sum is calculated. Each weighted sum may be employed to evaluate a quality of the sampled data and/or to estimate the pulmonary artery diastolic pressure, if the more direct monitoring of the pulmonary artery valve is not employed.
摘要翻译：用于估计单次心跳的肺动脉舒张压的方法包括建立用于从右心室压力传感器采样和存储压力数据点的时间窗口。可以根据预定参数和/或根据一个或多个触发事件建立时间窗口。通过采样的压力数据点或在时间窗口期间通过另一种形式的更直接的监测来确定肺动脉瓣打开的大致时间，以便估计肺动脉舒张压。可以从采样数据收集多组N个压力数据点，并且对于每个收集的集合，计算加权和。如果不采用更直接的肺动脉瓣监测，则每个加权和可用于评估采样数据的质量和/或估计肺动脉舒张压。

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