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1. 发明申请

WO2008067377A3 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 审中-公开
标题翻译：新型医疗方法与系统无线监控
公开(公告)号：WO2008067377A3
公开(公告)日：2009-01-29
申请号：PCT/US2007085761
申请日：2007-11-28
申请人： MEDTRONIC INC , HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
发明人： HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
IPC分类号： A61B5/07 , A61B5/00 , A61B5/11 , A61B19/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法包括至少两个植入标记的监测，每个植入标记适于响应于无线发送的激励信号无线地发送信号; 响应信号被转换成两个标记的位置信息。所述系统和方法还包括植入的感测构件和/或植入的治疗递送装置中的一个或其中之一。从感测构件接收到的信号可以与位置信息进行整理。可以根据位置信息调整从治疗输送装置输送的治疗。

2. 发明申请

WO2008067377A9 NOVEL MEDICAL METHODS AND SYSTEMS INCORPORATING WIRELESS MONITORING 审中-公开
标题翻译：结合无线监测的新型医疗方法和系统
公开(公告)号：WO2008067377A9
公开(公告)日：2008-08-14
申请号：PCT/US2007085761
申请日：2007-11-28
申请人： MEDTRONIC INC , HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
发明人： HETTRICK DOUGLAS A , MARKOWITZ H TOBY , SOWELAM SAMEH , GARDESKI KENNETH C
IPC分类号： A61B5/00 , A61B5/06 , A61B5/07 , A61B5/11
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1107 , A61B5/686 , A61B90/39 , A61B2017/00411 , A61B2090/3908 , A61B2090/397 , A61B2090/3975 , A61B2562/0209 , A61B2562/046
摘要： Medical systems and methods incorporate monitoring of at least two implanted markers, each of which is adapted to wirelessly transmit a signal in response to a wirelessly transmitted excitation signal; the response signals are converted into positional information for the two markers. The systems and methods further incorporate both, or one of, an implanted sensing member and/or an implanted therapy delivery device. Signals received from the sensing member may be collated with the positional information. A therapy delivered from the therapy delivery device may be adjusted according to the positional information.
摘要翻译：医疗系统和方法结合了对至少两个植入标记的监视，每个植入标记适于响应于无线发送的激励信号而无线发送信号; 响应信号被转换成两个标记的位置信息。该系统和方法进一步结合了植入的感测构件和/或植入的治疗输送装置两者或一者。从传感构件接收到的信号可以与位置信息进行比较。根据位置信息可以调整从治疗传递装置传递的治疗。

3. 发明申请

WO2008094816A3 SYSTEMS AND METHODS FOR MONITORING EFFECTIVENESS OF CONGESTIVE HEART FAILURE THERAPY 审中-公开
标题翻译：用于监测充血性心力衰竭疗法的有效性的系统和方法
公开(公告)号：WO2008094816A3
公开(公告)日：2008-10-16
申请号：PCT/US2008051978
申请日：2008-01-25
申请人： MEDTRONIC INC , SOWELAM SAMEH , MARKOWITZ H TOBY
发明人： SOWELAM SAMEH , MARKOWITZ H TOBY
IPC分类号： A61B5/042 , A61B5/0285
CPC分类号： A61B5/6826 , A61B5/0285 , A61B5/042 , A61B5/053 , A61B5/08 , A61B5/14551 , A61B5/4818 , A61B5/6838
摘要： A method for monitoring a patient includes measuring a series of consecutive pulse transit times (PTT's) of the patient, and processing the resulting PTT signal to detect a presence or absence of central sleep apnea (CSA). The method further includes determining an effectiveness of congestive heart failure therapy, which is being provided to the patient, based on the detected presence or absence of CSA. A system incorporating the method includes an electrode of an implantable medical device, which is adapted to pick up the patient's ventricular depolarization signals, a sensor, which is adapted to pick up peripheral arterial pulse signals of the patient, and a signal processor, which is adapted to receive the two types of signals and to process the signals according to the method. The system may provide the therapy via cardiac resynchronization pacing and, upon detection of CSA, the system may adjust at least one pacing parameter.
摘要翻译：用于监测患者的方法包括测量患者的一系列连续脉搏传播时间（PTT），并且处理所得到的PTT信号以检测中枢性睡眠呼吸暂停（CSA）的存在或不存在。该方法进一步包括基于检测到的CSA的存在或不存在来确定提供给患者的充血性心力衰竭治疗的有效性。结合该方法的系统包括适于拾取患者的心室去极化信号的可植入医疗设备的电极，适于拾取患者的外周动脉脉搏信号的传感器，以及信号处理器，其为适于接收两种类型的信号并根据该方法处理信号。系统可以通过心脏再同步起搏来提供治疗，并且在检测到CSA时，系统可以调整至少一个起搏参数。

4. 发明申请

WO2006115815A3 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 审中-公开
标题翻译：远程启动的遥控器和可植入的辅助放大器/除颤器系统
公开(公告)号：WO2006115815A3
公开(公告)日：2008-03-27
申请号：PCT/US2006013956
申请日：2006-04-12
申请人： MEDTRONIC INC , MARKOWITZ H TOBY , HETTRICK DOUGLAS A , COMBS WILLIAM J , SHELDON TODD J , THOMPSON DAVID L , GHANEM RAJA N , WANASEK KEVIN A
发明人： MARKOWITZ H TOBY , HETTRICK DOUGLAS A , COMBS WILLIAM J , SHELDON TODD J , THOMPSON DAVID L , GHANEM RAJA N , WANASEK KEVIN A
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.
摘要翻译：皮下植入式心脏复律除颤器（SubQ ICD）被公开，其完全可植入皮下，以最小的手术入侵患者身体，并提供分布式心脏复律除颤感和刺激电极，用于在整个心脏中递送心脏复律除颤休克和起搏疗法必要。 SubQ ICD与其他可植入和外部医疗设备一起实施，并以协调和协同的方式进行通信以提供药物和治疗。

5. 发明申请

WO2011026077A3 COMBINATION LOCALIZATION SYSTEM 审中-公开
标题翻译：组合本地化系统
公开(公告)号：WO2011026077A3
公开(公告)日：2011-09-22
申请号：PCT/US2010047241
申请日：2010-08-31
申请人： MEDTRONIC INC , UNIV MINNESOTA , MARKOWITZ H TOBY , GARDESKI KENNETH , CARVER JEAN , YASGER KENDRA , NEIDERT MICHAEL R , PHILLIPS LANE A , VERARD LAURENT , HARTMANN STEVEN L , BZOSTEK ANDREW , JASCOB BRADLEY A
发明人： MARKOWITZ H TOBY , GARDESKI KENNETH , CARVER JEAN , YASGER KENDRA , NEIDERT MICHAEL R , PHILLIPS LANE A , VERARD LAURENT , HARTMANN STEVEN L , BZOSTEK ANDREW , JASCOB BRADLEY A
IPC分类号： A61B19/00
CPC分类号： G01S5/0263 , A61B34/20 , A61B2017/00725 , A61B2034/2051 , A61B2034/2053 , A61B2090/0818
摘要： A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.
摘要翻译：可以使用导航系统或导航系统的组合来提供两个或多个导航模式来导航卷中的单个乐器。例如，可以使用电磁（EM）和电动（EP）导航系统来导航音量内的乐器。图像数据也可以相对于用于导航的体积中的仪器的跟踪位置被示出。

6. 发明申请

WO2008108901A8 CHRONICALLY-IMPLANTABLE ACTIVE FIXATION MEDICAL ELECTRICAL LEADS AND RELATED METHODS FOR NON-FLUOROSCOPIC IMPLANTATION 审中-公开
标题翻译：慢性植入式有源固定型医用电线及相关方法非手术植入
公开(公告)号：WO2008108901A8
公开(公告)日：2010-02-18
申请号：PCT/US2007089087
申请日：2007-12-28
申请人： MEDTRONIC INC , MARKOWITZ H TOBY , GIESE CHAD , WALDHAUSER STEVEN
发明人： MARKOWITZ H TOBY , GIESE CHAD , WALDHAUSER STEVEN
IPC分类号： A61B5/053 , A61N1/05
CPC分类号： A61N1/0573 , A61B2034/2053 , A61N1/3627
摘要： Bio-impedance may be used for navigation systems to chronically implant pacing and defibrillation leads in the heart using a non-fluoroscopic position sensing unit (PSU), such as a modified LocaLisa® system from Medtronic Inc., which allows for variable frequency sampling of the position of electrode of a catheter. The PSU injects small AC signals via surface electrodes in three orthogonal axes, each on a slightly different frequency (e.g., near 30 KHz). Indwelling electrodes electrically connected to the PSU resolves the magnitude of induced voltage for each of the three frequencies, thus measuring voltage for each of the three axes. Voltages are divided by induced current to yield impedance in each axis for each electrode. Impedance is proportional to position within the body. Such a system requires that a conductive material, such as a retractable helical tip-electrode, be exposed during implantation. Since the tip is retracted during implantation, this disclosure provides a modified distal portion employing at least one aperture (or 'window') for fluid exposure of the helix-electrode and a deployable internal sleeve for covering the aperture(s) when the helix-electrode is extended.
摘要翻译：生物阻抗可用于导航系统，以使用非荧光位置感测单元（PSU）长期地在心脏中植入起搏和除颤引线，例如来自Medtronic Inc.的经修改的LocaLisa系统，该系统允许对导管电极的位置。 PSU通过三个正交轴中的表面电极注入小的AC信号，每个在稍微不同的频率（例如，接近30KHz）处。电连接到PSU的留置电极解决三个频率中的每一个的感应电压的大小，从而测量三个轴中的每一个的电压。电压被感应电流除以每个电极的每个轴线产生阻抗。阻抗与体内的位置成比例。这样的系统需要在植入期间露出诸如可伸缩螺旋尖端电极的导电材料。由于尖端在植入期间缩回，所以本公开提供了一种修改的远端部分，其采用用于螺旋电极的流体暴露的至少一个孔口（或“窗口”）和可展开的内部套筒，电极延长。

7. 发明申请

WO2006060806A2 PATIENT MANAGEMENT NETWORK 审中-公开
标题翻译：患者管理网络
公开(公告)号：WO2006060806A2
公开(公告)日：2006-06-08
申请号：PCT/US2005044034
申请日：2005-12-02
申请人： MEDTRONIC INC , GOTTESMAN JANELL M , MARKOWITZ H TOBY , WILLENBRING JAMES E , MANRODT CHRISTOPHER M , VANDANACKER JOHN P , BURNES JOHN E , RUETER JOHN C , DVORAK DAVID P , AUDET SARAH A , CARNEY JAMES K , HILL GERALD J
发明人： GOTTESMAN JANELL M , MARKOWITZ H TOBY , WILLENBRING JAMES E , MANRODT CHRISTOPHER M , VANDANACKER JOHN P , BURNES JOHN E , RUETER JOHN C , DVORAK DAVID P , AUDET SARAH A , CARNEY JAMES K , HILL GERALD J
IPC分类号： G06F19/00
CPC分类号： G06F19/3418 , G06Q50/22 , G16H80/00
摘要： An intelligent patient management system collects data from a variety of sources, processes that information, and provides relevant information to an appropriate caregiver in context at the proper time. The system has multiple information sources available from which to gather additional information based upon conclusions drawn or issues identified from the patient data.
摘要翻译：智能患者管理系统从各种来源收集数据，处理这些信息，并在适当的时候向适当的护理人员提供相关信息。该系统具有多种信息来源，可根据患者数据识别的结论或问题收集附加信息。

8. 发明专利

JP2006272028A Pacemaker 有权
标题翻译：起搏器
公开(公告)号：JP2006272028A
公开(公告)日：2006-10-12
申请号：JP2006199245
申请日：2006-07-21
申请人： Medtronic Inc , メドトロニック・インコーポレーテッド
发明人： HESS MICHAEL F , MARKOWITZ H TOBY , BUSACKER JAMES W
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： PROBLEM TO BE SOLVED: To provide a pacemaker including an adjusting means for automatically adjusting ventricle atrial refractory period (PVARP) between heart rates.
SOLUTION: This pacemaker includes the adjusting means for automatically adjusting PVARP between heart rates, and retains a value to 2:1 block point and an interval value corresponding to the 2:1 block point, and also AV interval value, wherein the adjusting means includes a means for determining the 2:1 block point to the sequence between the given heart rates; and means for setting the PVARP equal to an interval value obtained by subtracting one of the AV interval values from the interval value corresponding to the 2:1 block point.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种起搏器，其包括用于自动调节心率之间的心室心房不应期（PVARP）的调节装置。解决方案：该起搏器包括用于在心率之间自动调节PVARP的调节装置，并且将值保持为2：1的阻挡点和对应于2：1阻挡点的间隔值，以及AV间隔值，其中调整装置包括用于确定给定心率之间的序列的2:1块的装置; 以及用于将PVARP设置为等于通过从对应于2：1块点的间隔值中减去一个AV间隔值而获得的间隔值的装置。版权所有（C）2007，JPO＆INPIT

9. 发明专利

CA2539066A1 DELIVERING GENETIC MATERIAL TO A STIMULATION SITE 未知
公开(公告)号：CA2539066A1
公开(公告)日：2005-03-31
申请号：CA2539066
申请日：2004-09-15
申请人： MEDTRONIC INC
发明人： LASKE TIMOTHY G , BLUM JANELLE , EBERT MICHAEL , CASAS-BEJAR JESUS , MONGEON LUC R , CROSS DAISY P , MARKOWITZ H TOBY
IPC分类号： A61N1/05 , A61K48/00 , C12N15/63 , C12N15/87
摘要： Delivery of genetic material to a stimulation site causes transgene expressi on by tissue at the stimulation site. In some embodiments, the delivered geneti c material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at t he stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation si te via a stimulation lead. A stimulation lead for delivering genetic material t o a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.

10. 发明专利

DE69630912T2 未知
公开(公告)号：DE69630912T2
公开(公告)日：2004-09-02
申请号：DE69630912
申请日：1996-09-13
申请人： MEDTRONIC INC
发明人： HESS MICHAEL F , MARKOWITZ H TOBY
IPC分类号： A61N1/368 , A61N1/362

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