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1. 发明授权

US06498043B1 Substrate sensor 有权
标题翻译：基板传感器
公开(公告)号：US06498043B1
公开(公告)日：2002-12-24
申请号：US09718782
申请日：2000-11-22
申请人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
发明人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
IPC分类号： H01L2100
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensors may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
摘要翻译：可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。其上形成有电子电路和电极的基板是形成有集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。在一个实施例中，两个这样的衬底传感器可以背对背放置，电极面向外。根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。

2. 发明授权

US06259937B1 Implantable substrate sensor 失效
标题翻译：可植入基片传感器
公开(公告)号：US06259937B1
公开(公告)日：2001-07-10
申请号：US09100310
申请日：1998-06-19
申请人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
发明人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
IPC分类号： A61N105
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensors may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
摘要翻译：可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。其上形成有电子电路和电极的基板是与其上形成有集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。在一个实施例中，两个这样的衬底传感器可以背对背放置，电极面向外。根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。

3. 发明授权

US6081736A Implantable enzyme-based monitoring systems adapted for long term use 失效
标题翻译：适用于长期使用的基于植入式酶的监测系统
公开(公告)号：US6081736A
公开(公告)日：2000-06-27
申请号：US953817
申请日：1997-10-20
申请人： Michael S. Colvin , Joseph H. Schulman , Lyle Dean Canfield , Rajiv Shah
发明人： Michael S. Colvin , Joseph H. Schulman , Lyle Dean Canfield , Rajiv Shah
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0031
摘要： Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution including microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution. Also provided herein is a method of extending the useful life of an implantable enzyme-based monitoring system, which method includes providing means, within the system, to replenish the enzyme and/or electrolyte solution.
摘要翻译：本文描述了适于长期体内使用的改进的可植入监测系统以测量一种或多种规定物质如葡萄糖的浓度。特别地，描述了可植入酶的葡萄糖监测系统，其包括以下至少一个：用于在酶反应消耗的时候补充酶溶液的装置; 用于补充洗涤电极组件的电解液的装置; 并且微处理装置近似于电极组件。在优选实施例中，微处理器组件与固定电极组件的基底密封相关。此外，监测系统采用与酶和电解质室流体连通的一个或多个储存器系统，其中使用酶和电解质溶液。在另一个实施方案中，监测系统使用分别与酶和电解质储存器流体连通并且定位在皮肤表面附近的酶和电解质储存器灯泡，从而提供对酶和电解质溶液的准备进入，而不需要移除设备。本文还提供了包含与酶结合的微球的酶溶液; 由此通过微球固定酶，并且微球体处于流动的可流动溶液中。本文还提供了延长可植入酶的监测系统的使用寿命的方法，该方法包括在系统内提供补充酶和/或电解质溶液的装置。

4. 发明授权

US5750926A Hermetically sealed electrical feedthrough for use with implantable electronic devices 失效
标题翻译：密封电气馈通用于可植入电子设备
公开(公告)号：US5750926A
公开(公告)日：1998-05-12
申请号：US515559
申请日：1995-08-16
申请人： Joseph H. Schulman , Lyle Dean Canfield
发明人： Joseph H. Schulman , Lyle Dean Canfield
IPC分类号： A61N1/375 , H01L23/057 , H05K1/03 , H05K3/28 , H05K3/40 , H05K5/00 , H05K5/06
CPC分类号： H01L23/057 , A61N1/3754 , H05K5/0095 , H01L2224/16 , H01L2924/01078 , H01L2924/01079 , H01L2924/09701 , H01L2924/10253 , H01L2924/16152 , H05K1/0306 , H05K3/28 , H05K3/4007
摘要： A thin hermetically sealed electrical feedthrough suitable for implantation within living tissue permits electrical connection between electronic circuits sealed within an hermetically sealed case and electrical terminals or contacts on the outside of the case. The hermetically sealed case is made by hermetically bonding a cover to an insulating layer. The hermetically sealed electrical feedthrough is made by depositing a conductive trace on the insulating layer and then depositing another insulating layer thereover, so that the conductive trace is hermetically encapsulated within the insulating layers. At least two spaced-apart openings are formed in the insulating layers before bonding the cover thereto, exposing the conductive trace. Additional conductive material is then inserted within each of the openings or holes so as to form conductive vias that make electrical contact with the conductive trace. The cover is then hermetically sealed to the insulating layer so that at least one conductive via resides inside of an hermetically sealed cavity formed under the cover, and the other conductive via resides outside of the hermetically sealed cavity. An electrical feedthrough is thus formed through the respective conductive vias and conductive trace so that electrical contact may be made between the outside and inside of the hermetically sealed cavity.
摘要翻译：适于植入生物组织的薄密封电馈电允许密封在密封的壳体内的电子电路与壳体外部的电气端子或触点之间的电连接。密封的壳体通过将盖子密封地粘合到绝缘层上而制成。密封电馈通通过在绝缘层上沉积导电迹线然后在其上沉积另一绝缘层而制成，使得导电迹线气密地封装在绝缘层内。在将盖接合到其之前，在绝缘层中形成至少两个间隔开的开口，暴露导电迹线。然后将另外的导电材料插入每个开口或孔中，以便形成与导电迹线电接触的导电通孔。然后将盖密封到绝缘层，使得至少一个导电通孔位于形成在盖下方的密封空腔的内部，而另一个导电通孔位于密封腔的外部。因此，通过相应的导电通孔和导电迹线形成电馈通，使得可以在气密密封腔的外部和内部之间进行电接触。

5. 发明授权

US07079881B2 Substrate sensor 有权
公开(公告)号：US07079881B2
公开(公告)日：2006-07-18
申请号：US10288038
申请日：2002-11-04
申请人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
发明人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
IPC分类号： A61N5/00
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensors may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.

6. 发明授权

US06512939B1 Implantable enzyme-based monitoring systems adapted for long term use 有权
标题翻译：适用于长期使用的基于植入式酶的监测系统
公开(公告)号：US06512939B1
公开(公告)日：2003-01-28
申请号：US09604179
申请日：2000-06-27
申请人： Michael S. Colvin , Joseph H. Schulman , Lyle Dean Canfield , Rajiv Shah
发明人： Michael S. Colvin , Joseph H. Schulman , Lyle Dean Canfield , Rajiv Shah
IPC分类号： A61B505
CPC分类号： A61B5/14865 , A61B5/0031
摘要： Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose, are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments, a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution comprising microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution. Also provided herein is a method of extending the useful life of an implantable enzyme-based monitoring system, which method comprises providing means, within the system, to replenish the enzyme and/or electrolyte solution.
摘要翻译：本文描述了适于长期体内使用的改进的可植入监测系统，以测量一种或多种规定物质如葡萄糖的浓度。特别地，描述了可植入酶的葡萄糖监测系统，其包括以下至少一个：用于在酶反应消耗的时候补充酶溶液的装置; 用于补充洗涤电极组件的电解液的装置; 并且微处理装置近似于电极组件。在优选实施例中，微处理器组件与固定电极组件的基板气密地相关联。此外，监测系统采用与酶和电解质室流体连通的一个或多个储存器系统，其中使用酶和电解质溶液。在另一个实施方案中，监测系统使用分别与酶和电解质储存器流体连通并且定位在皮肤表面附近的酶和电解质储存器灯泡，从而提供对酶和电解质溶液的准备进入，而不需要移除设备。本文进一步提供了包含与酶结合的微球的酶溶液; 由此通过微球固定酶，并且微球体处于流动的可流动溶液中。本文还提供了延长可植入酶的监测系统的使用寿命的方法，该方法包括在系统内提供补充酶和/或电解质溶液的装置。

7. 发明授权

US07555328B2 Implantable substrate sensor with back-to-back electrodes 有权
标题翻译：具有背对背电极的可植入衬底传感器
公开(公告)号：US07555328B2
公开(公告)日：2009-06-30
申请号：US11392163
申请日：2006-03-29
申请人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
发明人： Joseph H. Schulman , Charles L. Byers , John C. Gord , Rajiv Shah , Lyle Dean Canfield
IPC分类号： A61B5/145
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensor may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
摘要翻译：可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。其上形成有电子电路和电极的基板是与其上形成有集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。在一个实施例中，两个这样的衬底传感器可以背靠背放置，电极面向外。根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。

8. 发明授权

US5999849A Low power rectifier circuit for implantable medical device 失效
标题翻译：用于植入式医疗设备的低功率整流电路
公开(公告)号：US5999849A
公开(公告)日：1999-12-07
申请号：US928871
申请日：1997-09-12
申请人： John C. Gord , Lyle Dean Canfield
发明人： John C. Gord , Lyle Dean Canfield
IPC分类号： H02M7/12 , H02M7/21 , H02M7/219 , A61N1/08 , H02M7/217
CPC分类号： H02M7/219 , A61N1/378
摘要： A low power switched rectifier circuit is realized using P-MOS and N-MOS FET switches that are turned ON/OFF at just the right time by a detector and inverter circuit (which form an integral part of the rectifier circuit) to rectify an incoming ac signal in a highly efficient manner. Parasitic diodes and transistors that form an integral part of the FET circuitry respond to and rectify the incoming signal during start up, i.e., when no supply voltage is yet present, thereby providing sufficient operating voltage for the FET switches to begin to perform their intended rectifying function. In the absence of an incoming ac signal, i.e., during the time between biphasic pulses, the rectifier circuit is biased with an extremely small static bias current; but in the presence of an incoming ac signal, at a time when the positive and negative phases of the incoming signal are to be connected to positive and negative supply lines, a much larger dynamic bias current is automatically triggered.
摘要翻译：使用由适当的时间在检测器和逆变器电路（其形成整流电路的组成部分）的ON / OFF中的P-MOS和N-MOS FET开关来实现低功率开关整流电路，以纠正输入交流信号以高效的方式。形成FET电路的组成部分的寄生二极管和晶体管在启动期间响应并整流输入信号，即当没有电源电压时，从而为FET开关提供足够的工作电压，开始执行其预期的整流功能。在没有输入交流信号的情况下，即在双相脉冲之间的时间期间，整流电路以非常小的静态偏置电流偏置; 但是在存在进入的交流信号的情况下，在输入信号的正相和负相连接到正和负电源线的时候，自动触发大得多的动态偏置电流。

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