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1. 发明授权

US06801798B2 Body-member-illuminating pressure cuff for use in optical noninvasive measurement of blood parameters 失效
标题翻译：身体成员照明压力袖带，用于光学无创测量血液参数
公开(公告)号：US06801798B2
公开(公告)日：2004-10-05
申请号：US10176186
申请日：2002-06-20
申请人： Leslie A. Geddes , Kirk S. Foster , William E. Schoenlein , Rebecca A. Roeder , Claude B. Harrington
发明人： Leslie A. Geddes , Kirk S. Foster , William E. Schoenlein , Rebecca A. Roeder , Claude B. Harrington
IPC分类号： A61B500
CPC分类号： A61B5/6826 , A61B5/02233 , A61B5/14552 , A61B5/6838
摘要： A member-illuminating cuff for measurement of systolic, mean and diastolic pressure, oxygen saturation, pulse and respiratory rate in small body members, comprising a hinged cuff housing, one or more light sources mounted on a first section of the housing, a photodetector mounted on a second section of the housing, and a disposable, inflatable cuff adapted to fit within the cuff housing and around a body member placed therein.
摘要翻译：用于测量小身体构件中的收缩压，平均值和舒张压，氧饱和度，脉搏和呼吸频率的成员照明袖带，包括铰接的袖套，安装在壳体的第一部分上的一个或多个光源，安装在在壳体的第二部分上，以及适于装配在袖带壳体内并围绕放置在其中的身体构件的一次性的可充气套箍。

2. 发明授权

US06546287B1 Controlled-power defibrillator and method of defibrillation 失效
标题翻译：控制功率除颤器和除颤方法
公开(公告)号：US06546287B1
公开(公告)日：2003-04-08
申请号：US09680790
申请日：2000-10-06
申请人： William J. Havel , Joe D. Bourland , Leslie A. Geddes , Willis A. Tacker , Darrell O. Wagner
发明人： William J. Havel , Joe D. Bourland , Leslie A. Geddes , Willis A. Tacker , Darrell O. Wagner
IPC分类号： A61N136
CPC分类号： A61N1/3937 , A61N1/3912
摘要： A controlled-power defibrillator and method of defibrillation for automatically compensating for changes in patient resistance during delivery of a defibrillation pulse. A switching power converter is connected between a storage capacitor and a pair of electrodes adapted for connection to a patient's body, either internally or externally. A closed-loop power control circuit is operatively connected to the power converter for control of the power delivered to the patient, the power control circuit generating a target voltage signal for the storage capacitor, the target voltage signal having a defined relationship with the waveform of the power desired to be delivered to the patient. The power control circuit monitors the actual voltage on the storage capacitor and adjusts the delivery of power to the patient as a function of the difference between desired and actual storage capacitor voltage. The power converter is adapted to capture energy from the discharge of an existing defibrillator and to convert captured energy from the existing defibrillator to a waveform different from that generated by the existing defibrillator.
摘要翻译：一种控制功率除颤器和除颤方法，用于在除颤脉冲输送期间自动补偿患者阻力的变化。开关功率转换器连接在存储电容器和适于连接到患者身体的一对电极之间，内部或外部。闭环功率控制电路可操作地连接到功率转换器，用于控制传递给患者的功率，功率控制电路产生用于存储电容器的目标电压信号，目标电压信号与期望输送给患者的功率。功率控制电路监视存储电容器上的实际电压，并根据期望的和实际的存储电容器电压之间的差异来调整向患者的电力输送。功率转换器适于从现有除颤器的放电中捕获能量，并且将来自现有除颤器的捕获能量转换为与现有除颤器产生的波形不同的波形。

3. 发明授权

US06475232B1 Stent with reduced thrombogenicity 有权
标题翻译：支架具有降低的血栓形成
公开(公告)号：US06475232B1
公开(公告)日：2002-11-05
申请号：US09319718
申请日：1999-06-10
申请人： Charles F. Babbs , Neal F. Fearnot , Stephen F. Badylak , Leslie A Geddes , Michael C. Hiles , Joe D. Bourland
发明人： Charles F. Babbs , Neal F. Fearnot , Stephen F. Badylak , Leslie A Geddes , Michael C. Hiles , Joe D. Bourland
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/07 , A61F2/86 , A61F2/885 , A61F2/90 , A61F2/91 , A61F2/95 , A61F2/958 , A61F2002/072 , A61F2002/075 , A61F2002/9583 , A61F2220/0008 , A61F2220/005 , A61F2220/0075 , A61F2240/001 , A61F2250/0067 , A61L31/005 , A61L31/10 , A61L33/18 , A61M25/0045 , A61M29/02 , C08L89/06
摘要： A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent (3) covered with submucosal tissue (4) wherein the stent (3) is formed for receiving the distal end of a catheter (1) having an inflatable balloon (2).
摘要翻译：描述了用于修复受损或患病的脊椎动物血管的内衬的组织移植物构建体和方法。该方法包括以下步骤：将组织移植物构建体定位在需要修复的部位的血管内。组织移植物构件包括覆盖有粘膜下组织（4）的支架（3），其中支架（3）被形成用于接纳具有可膨胀气囊（2）的导管（1）的远端。

4. 发明授权

US5445833A Tendon or ligament graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的肌腱或韧带移植物
公开(公告)号：US5445833A
公开(公告)日：1995-08-29
申请号：US167579
申请日：1993-12-15
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括肠中膜粘膜下层和从肌层分泌的基底膜粘膜组织和中膜粘膜的腔内部分。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

5. 发明授权

US5058583A Multiple monopolar system and method of measuring stroke volume of the heart 失效
标题翻译：多重单极系统和测量心脏搏动量的方法
公开(公告)号：US5058583A
公开(公告)日：1991-10-22
申请号：US553434
申请日：1990-07-13
申请人： Leslie A. Geddes , Neal E. Fearnot , Jerry L. Wessale
发明人： Leslie A. Geddes , Neal E. Fearnot , Jerry L. Wessale
IPC分类号： A61N1/365
CPC分类号： A61N1/3686 , A61N1/36514
摘要： A multiple monopolar system and method for measuring stroke volume of a patient's heart. An intracardiac impedance catheter is provided with a plurality of monopolar electrodes axially spaced along the surface of its distal end, and is used in conjunction with a distant reference electrode which may, for example, be incorporated into the conductive case of a pacemaker. The proximal end of the catheter is attached to the pacemaker, which, in addition to pulse generator circuitry and circuitry for sensing electrical activity of the heart and for controlling pacing rate, includes a constant-current source for current injection into the volume of blood in the patient's ventricle and an impedance processor for measuring the resultant voltage between one of the monopolar electrodes in the ventricle and the pacemaker case and for calculating stroke volume therefrom. A system and method are also disclosed for generating a three-phase relationship between cardiac output and heart rate for an individual patient at a particular workload, for purposes of determining optimal heart rate, as is a method of using the monopolar electrode configuration to detect ventricular fibrillation.
摘要翻译：用于测量患者心脏的搏动体积的多重单极系统和方法。心内阻塞导管设置有沿着其远端的表面轴向间隔开的多个单极电极，并且与远程参考电极结合使用，其可以例如并入到起搏器的导电壳体中。导管的近端附接到起搏器，除了用于感测心脏的电活动和用于控制起搏速率的脉冲发生器电路和电路之外，还包括用于当前注入血液体积的恒流源患者的心室和阻抗处理器，用于测量心室中的一个单极电极和起搏器壳体之间的所得电压，并用于计算其中的冲程容量。还公开了一种系统和方法，用于在特定工作负载下为个体患者产生心输出量和心率之间的三相关系，以便确定最佳心率，正如使用单极电极配置来检测心室的方法一样颤动。

6. 发明授权

US5007927A Muscle-powered cardiac assist device 失效
标题翻译：肌肉动力心脏辅助装置
公开(公告)号：US5007927A
公开(公告)日：1991-04-16
申请号：US426301
申请日：1989-10-24
申请人： Stephen F. Badylak , Leslie A. Geddes , Jerry L. Wessale
发明人： Stephen F. Badylak , Leslie A. Geddes , Jerry L. Wessale
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1046 , A61M1/1003 , A61M1/1037 , A61M1/1089 , A61M1/1098 , A61M1/122
摘要： A method and apparatus is provided for enhancing blood circulation, and thereby reducing fatigue, in a skeletal muscle used for powering a cardiac assist device wherein the muscle is positioned to compress a blood reservoir in response to muscle contracting stimuli. Enhanced perfusion of the skeletal muscle is achieved by delaying blood flow into the reservoir for a period of time following each muscle contraction.
摘要翻译：提供了一种用于增强血液循环，从而减轻用于为心脏辅助装置供电的骨骼肌中的疲劳的方法和装置，其中肌肉定位为响应于肌肉收缩刺激而压缩血液储存器。骨骼肌的增强灌注是通过在每次肌肉收缩之后延迟血液进入储存器一段时间来实现的。

7. 发明授权

US4902508A Tissue graft composition 失效
标题翻译：组织移植物组成
公开(公告)号：US4902508A
公开(公告)日：1990-02-20
申请号：US217299
申请日：1988-07-11
申请人： Stephen F. Badylak , Leslie A. Geddes , Gary Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , Gary Lantz , Arthur C. Coffey
IPC分类号： E04B2/86 , A61F2/02 , A61K35/38 , A61L27/00 , A61L27/36 , A61L27/50 , E02D5/08 , E04C2/20 , E04G11/06
CPC分类号： E02D5/08 , A61L27/3629 , A61L27/507 , Y10T428/139 , Y10T428/24008
摘要： This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.
摘要翻译：本发明涉及从小肠段制备组织移植组合物的方法。描述了一种组织移植组合物，其包括温血脊椎动物的小肠段的中膜粘膜下层，其中粘膜下层从肌层和至少中膜粘膜的腔部分离。已显示组织移植组合物具有优异的机械特性，以及作为血管自体移植物，血管同种异体移植物和血管异种移植物的应用中的非致敏性和非血栓形成性。

8. 发明授权

US07014611B1 Oscillometric noninvasive blood pressure monitor 有权
标题翻译：示波非侵入性血压计
公开(公告)号：US07014611B1
公开(公告)日：2006-03-21
申请号：US10876308
申请日：2004-06-24
申请人： Leslie A. Geddes , Rebecca A. Roeder
发明人： Leslie A. Geddes , Rebecca A. Roeder
IPC分类号： A61B5/02
CPC分类号： A61B5/02225 , A61B5/0225 , A61B5/1455
摘要： An oscillometric, noninvasive blood pressure monitor comprising an inflatable cuff adapted for placement around a body member, a pump for cuff inflation, a pressure transducer connected to the cuff, means for detecting oscillations in arterial pressure occurring during a transition in cuff pressure between a pressure greater than normal systolic pressure and a pressure less than normal diastolic pressure, and a blood pressure measurement circuit which is capable of determining the maximum amplitude (Am) of the oscillations, identifying mean cuff pressure (Pm) as the coincident value of the cuff-pressure signal from the pressure transducer, and determining systolic pressure as a function of both Am and Pm. In accordance with one aspect of the invention, the blood pressure monitor has an optical sensor including a light source and photodetector optically coupled to the body member proximate to the cuff. Oscillations in the output signal of the photodetector are detected, and the blood pressure measurement circuit determines the oscillation amplitude corresponding to systolic pressure (As) as a function of both Am and Pm.
摘要翻译：一种示波器，无创血压监测器，包括适于放置在身体构件周围的可充气袖带，用于袖带充气的泵，连接到袖带的压力传感器的装置，用于检测在袖带压力的转变期间发生的动脉压的振荡，大于正常的收缩压和小于正常舒张压的压力，以及血压测量电路，其能够确定振荡的最大振幅（A> M），识别平均袖带压（P < 作为来自压力传感器的袖带压信号的一致值，并且确定收缩压作为A＆lt; m＆gt;和＆lt; >。根据本发明的一个方面，血压监测器具有光学传感器，该光学传感器包括光学源和光学检测器，其光学耦合到靠近袖带的身体构件。检测光检测器的输出信号中的振荡，并且血压测量电路确定与收缩压相对应的振荡振幅（A SUB）作为两个A / 和P＆lt; m＆gt;。

9. 发明授权

US6096347A Myocardial graft constructs 有权
标题翻译：心肌移植物构建体
公开(公告)号：US6096347A
公开(公告)日：2000-08-01
申请号：US297621
申请日：1999-05-04
申请人： Leslie A. Geddes , Stephen F. Badylak , Robert G. Matheny , William E. Schoenlein , Fred J. Obermiller , William J. Havel
发明人： Leslie A. Geddes , Stephen F. Badylak , Robert G. Matheny , William E. Schoenlein , Fred J. Obermiller , William J. Havel
IPC分类号： C12N5/06 , A61K35/12 , A61K35/24 , A61K35/38 , A61L27/00 , A61L27/36 , A61P9/00
CPC分类号： A61L27/3695 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/367 , A61L27/3683
摘要： The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac tissues with the manufactured composition.
摘要翻译： PCT No.PCT / US97 / 20240 Sec。 371日期1999年5月4日 102（e）1999年5月4日PCT PCT 1997年11月4日PCT公布。第WO98 / 19719号公报日期1998年5月14日使用温血脊椎动物的粘膜下组织来制造组织移植组合物，其在心脏组织与所制造的组合物接触时在体内诱导内源性心脏组织的形成。

10. 发明授权

US5372821A Graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的移植物
公开(公告)号：US5372821A
公开(公告)日：1994-12-13
申请号：US168026
申请日：1993-12-15
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括肠粘膜下层和从肌层剥离的基底膜粘膜组织和粘膜的腔内部分。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

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