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1. 发明授权

US5007927A Muscle-powered cardiac assist device 失效
标题翻译：肌肉动力心脏辅助装置
公开(公告)号：US5007927A
公开(公告)日：1991-04-16
申请号：US426301
申请日：1989-10-24
申请人： Stephen F. Badylak , Leslie A. Geddes , Jerry L. Wessale
发明人： Stephen F. Badylak , Leslie A. Geddes , Jerry L. Wessale
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1046 , A61M1/1003 , A61M1/1037 , A61M1/1089 , A61M1/1098 , A61M1/122
摘要： A method and apparatus is provided for enhancing blood circulation, and thereby reducing fatigue, in a skeletal muscle used for powering a cardiac assist device wherein the muscle is positioned to compress a blood reservoir in response to muscle contracting stimuli. Enhanced perfusion of the skeletal muscle is achieved by delaying blood flow into the reservoir for a period of time following each muscle contraction.
摘要翻译：提供了一种用于增强血液循环，从而减轻用于为心脏辅助装置供电的骨骼肌中的疲劳的方法和装置，其中肌肉定位为响应于肌肉收缩刺激而压缩血液储存器。骨骼肌的增强灌注是通过在每次肌肉收缩之后延迟血液进入储存器一段时间来实现的。

2. 发明授权

US5058583A Multiple monopolar system and method of measuring stroke volume of the heart 失效
标题翻译：多重单极系统和测量心脏搏动量的方法
公开(公告)号：US5058583A
公开(公告)日：1991-10-22
申请号：US553434
申请日：1990-07-13
申请人： Leslie A. Geddes , Neal E. Fearnot , Jerry L. Wessale
发明人： Leslie A. Geddes , Neal E. Fearnot , Jerry L. Wessale
IPC分类号： A61N1/365
CPC分类号： A61N1/3686 , A61N1/36514
摘要： A multiple monopolar system and method for measuring stroke volume of a patient's heart. An intracardiac impedance catheter is provided with a plurality of monopolar electrodes axially spaced along the surface of its distal end, and is used in conjunction with a distant reference electrode which may, for example, be incorporated into the conductive case of a pacemaker. The proximal end of the catheter is attached to the pacemaker, which, in addition to pulse generator circuitry and circuitry for sensing electrical activity of the heart and for controlling pacing rate, includes a constant-current source for current injection into the volume of blood in the patient's ventricle and an impedance processor for measuring the resultant voltage between one of the monopolar electrodes in the ventricle and the pacemaker case and for calculating stroke volume therefrom. A system and method are also disclosed for generating a three-phase relationship between cardiac output and heart rate for an individual patient at a particular workload, for purposes of determining optimal heart rate, as is a method of using the monopolar electrode configuration to detect ventricular fibrillation.
摘要翻译：用于测量患者心脏的搏动体积的多重单极系统和方法。心内阻塞导管设置有沿着其远端的表面轴向间隔开的多个单极电极，并且与远程参考电极结合使用，其可以例如并入到起搏器的导电壳体中。导管的近端附接到起搏器，除了用于感测心脏的电活动和用于控制起搏速率的脉冲发生器电路和电路之外，还包括用于当前注入血液体积的恒流源患者的心室和阻抗处理器，用于测量心室中的一个单极电极和起搏器壳体之间的所得电压，并用于计算其中的冲程容量。还公开了一种系统和方法，用于在特定工作负载下为个体患者产生心输出量和心率之间的三相关系，以便确定最佳心率，正如使用单极电极配置来检测心室的方法一样颤动。

3. 发明授权

US06187039B1 Tubular submucosal graft constructs 有权
标题翻译：管状粘膜下移植物构建体
公开(公告)号：US06187039B1
公开(公告)日：2001-02-13
申请号：US09297620
申请日：1999-05-04
申请人： Michael C. Hiles , Umesh H. Patel , Leslie A. Geddes , Stephen F. Badylak
发明人： Michael C. Hiles , Umesh H. Patel , Leslie A. Geddes , Stephen F. Badylak
IPC分类号： A60F206
CPC分类号： A61L27/3604 , A61F2/06 , A61F2310/00365 , A61L27/24 , A61L27/3629 , A61L27/3687
摘要： An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the submucosal tissue prosthesis generally involves wrapping a first sheet of submucosal tissue (60) and a second sheet of submucosal tissue (70) around a mandrel (50), wherein the first end (74) and the second opposite end (76) of the second sheet of submucosal tissue (70) are sutured together with sutures (78). The submucosal tissue is compressed and dried on the mandrel (50) before removing the construct by pulling on a first end (54) and a second end (56) of a water permeable tape to unwind the tape and thus release the construct for eventual use.
摘要翻译：已经开发了可植入的粘膜下组织的容易制造和机械强度的管，其以任何期望的长度，壁厚或直径制造。通过本发明的方法生产的构造体可以用作动脉，静脉，输尿管，尿道，分流器的移植物，或者在需要顺应的组织相容管的任何应用中。粘膜下组织假体的制造通常包括围绕心轴（50）缠绕第一片粘膜下组织（60）和第二片粘膜下组织（70），其中第一端（74）和第二相对端（76））的第二片粘膜下组织（70）与缝合线（78）缝合在一起。在通过拉动透水性带的第一端（54）和第二端（56）去除构造物之前，在心轴（50）上压缩并干燥粘膜下组织以展开带，并因此释放结构以最终使用。

4. 发明授权

US5281422A Graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的移植物
公开(公告)号：US5281422A
公开(公告)日：1994-01-25
申请号：US764818
申请日：1991-09-24
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, muscularis mucosa and stratum compactum delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括肠壁粘膜下层，肌层粘膜和从肌层分泌的层状结节和中膜粘膜的腔内部分。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

5. 发明授权

US5573784A Graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的移植物
公开(公告)号：US5573784A
公开(公告)日：1996-11-12
申请号：US423411
申请日：1995-04-18
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括从中膜肌层和至少中膜粘膜的腔部分离的肠粘膜粘膜下层。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

6. 发明授权

US6096347A Myocardial graft constructs 有权
标题翻译：心肌移植物构建体
公开(公告)号：US6096347A
公开(公告)日：2000-08-01
申请号：US297621
申请日：1999-05-04
申请人： Leslie A. Geddes , Stephen F. Badylak , Robert G. Matheny , William E. Schoenlein , Fred J. Obermiller , William J. Havel
发明人： Leslie A. Geddes , Stephen F. Badylak , Robert G. Matheny , William E. Schoenlein , Fred J. Obermiller , William J. Havel
IPC分类号： C12N5/06 , A61K35/12 , A61K35/24 , A61K35/38 , A61L27/00 , A61L27/36 , A61P9/00
CPC分类号： A61L27/3695 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/367 , A61L27/3683
摘要： The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac tissues with the manufactured composition.
摘要翻译： PCT No.PCT / US97 / 20240 Sec。 371日期1999年5月4日 102（e）1999年5月4日PCT PCT 1997年11月4日PCT公布。第WO98 / 19719号公报日期1998年5月14日使用温血脊椎动物的粘膜下组织来制造组织移植组合物，其在心脏组织与所制造的组合物接触时在体内诱导内源性心脏组织的形成。

7. 发明授权

US5372821A Graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的移植物
公开(公告)号：US5372821A
公开(公告)日：1994-12-13
申请号：US168026
申请日：1993-12-15
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括肠粘膜下层和从肌层剥离的基底膜粘膜组织和粘膜的腔内部分。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

8. 发明授权

US5445833A Tendon or ligament graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的肌腱或韧带移植物
公开(公告)号：US5445833A
公开(公告)日：1995-08-29
申请号：US167579
申请日：1993-12-15
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, and basilar mucosa tissue delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括肠中膜粘膜下层和从肌层分泌的基底膜粘膜组织和中膜粘膜的腔内部分。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

9. 发明授权

US4902508A Tissue graft composition 失效
标题翻译：组织移植物组成
公开(公告)号：US4902508A
公开(公告)日：1990-02-20
申请号：US217299
申请日：1988-07-11
申请人： Stephen F. Badylak , Leslie A. Geddes , Gary Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , Gary Lantz , Arthur C. Coffey
IPC分类号： E04B2/86 , A61F2/02 , A61K35/38 , A61L27/00 , A61L27/36 , A61L27/50 , E02D5/08 , E04C2/20 , E04G11/06
CPC分类号： E02D5/08 , A61L27/3629 , A61L27/507 , Y10T428/139 , Y10T428/24008
摘要： This invention relates to a method for preparation of a tissue graft composition from a segment of small intestine. A tissue graft composition is described which comprises the tunica submucosa of a segment of small intestine of a warm-blooded vertebrate wherein the tunica submucosa is delaminated from the tunica muscularis and at least the luminal portion of the tunica mucosa. The tissue graft composition has been shown to have excellent mechanical characteristics, as well as non-allergenicity and non-thrombogenicity in applications as vascular autografts, vascular allografts, and vascular heterografts.
摘要翻译：本发明涉及从小肠段制备组织移植组合物的方法。描述了一种组织移植组合物，其包括温血脊椎动物的小肠段的中膜粘膜下层，其中粘膜下层从肌层和至少中膜粘膜的腔部分离。已显示组织移植组合物具有优异的机械特性，以及作为血管自体移植物，血管同种异体移植物和血管异种移植物的应用中的非致敏性和非血栓形成性。

10. 发明授权

US6126686A Artificial vascular valves 失效
标题翻译：人造血管瓣
公开(公告)号：US6126686A
公开(公告)日：2000-10-03
申请号：US319653
申请日：1999-06-10
申请人： Stephen F. Badylak , Arthur C. Coffey , Leslie A. Geddes , Michael C. Hiles , James Hong , Rebecca Roeder
发明人： Stephen F. Badylak , Arthur C. Coffey , Leslie A. Geddes , Michael C. Hiles , James Hong , Rebecca Roeder
IPC分类号： A61L27/00 , A61F2/06 , A61F2/24 , A61L27/36
CPC分类号： A61F2/2412 , A61F2/2415 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3645 , A61L27/3691 , A61L27/3886 , A61L27/507 , A61F2/06 , A61F2/2409 , A61F2220/0075 , Y10S623/91 , Y10S623/918 , Y10S623/925
摘要： A method for preparing vascular valves from submucosal tissue is described. Both bicuspid and tricuspid valve constructs are described. The bicuspid constructs can be formed with or without a supporting stent. The tricuspid constructs are formed by fixing submucosal tissue to a supporting stent, folding the submucosal tissue, and forming the valve commissures from the folded submucosal tissue by cutting along the folds. The artificial vascular valves are useful for replacing damaged or diseased valves of a warm-blooded vertebrate.
摘要翻译： PCT No.PCT / US97 / 22728 Sec。 371日期1999年6月10日第 102（e）1999年6月10日PCT 1997年12月10日PCT公布。第WO98 / 25549号公报日期：1998年6月18日描述了从粘膜下组织制备血管瓣膜的方法。描述了双尖瓣和三尖瓣构造。二尖瓣构建体可以形成有或不具有支撑支架。通过将粘膜下组织固定到支撑支架，折叠粘膜下组织以及通过沿着折痕切割从折叠的粘膜下组织形成瓣膜连合而形成三尖瓣构造。人造血管瓣可用于更换温血脊椎动物的受损或患病瓣膜。

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