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1. 发明授权

US5058583A Multiple monopolar system and method of measuring stroke volume of the heart 失效
标题翻译：多重单极系统和测量心脏搏动量的方法
公开(公告)号：US5058583A
公开(公告)日：1991-10-22
申请号：US553434
申请日：1990-07-13
申请人： Leslie A. Geddes , Neal E. Fearnot , Jerry L. Wessale
发明人： Leslie A. Geddes , Neal E. Fearnot , Jerry L. Wessale
IPC分类号： A61N1/365
CPC分类号： A61N1/3686 , A61N1/36514
摘要： A multiple monopolar system and method for measuring stroke volume of a patient's heart. An intracardiac impedance catheter is provided with a plurality of monopolar electrodes axially spaced along the surface of its distal end, and is used in conjunction with a distant reference electrode which may, for example, be incorporated into the conductive case of a pacemaker. The proximal end of the catheter is attached to the pacemaker, which, in addition to pulse generator circuitry and circuitry for sensing electrical activity of the heart and for controlling pacing rate, includes a constant-current source for current injection into the volume of blood in the patient's ventricle and an impedance processor for measuring the resultant voltage between one of the monopolar electrodes in the ventricle and the pacemaker case and for calculating stroke volume therefrom. A system and method are also disclosed for generating a three-phase relationship between cardiac output and heart rate for an individual patient at a particular workload, for purposes of determining optimal heart rate, as is a method of using the monopolar electrode configuration to detect ventricular fibrillation.
摘要翻译：用于测量患者心脏的搏动体积的多重单极系统和方法。心内阻塞导管设置有沿着其远端的表面轴向间隔开的多个单极电极，并且与远程参考电极结合使用，其可以例如并入到起搏器的导电壳体中。导管的近端附接到起搏器，除了用于感测心脏的电活动和用于控制起搏速率的脉冲发生器电路和电路之外，还包括用于当前注入血液体积的恒流源患者的心室和阻抗处理器，用于测量心室中的一个单极电极和起搏器壳体之间的所得电压，并用于计算其中的冲程容量。还公开了一种系统和方法，用于在特定工作负载下为个体患者产生心输出量和心率之间的三相关系，以便确定最佳心率，正如使用单极电极配置来检测心室的方法一样颤动。

2. 发明授权

US5007927A Muscle-powered cardiac assist device 失效
标题翻译：肌肉动力心脏辅助装置
公开(公告)号：US5007927A
公开(公告)日：1991-04-16
申请号：US426301
申请日：1989-10-24
申请人： Stephen F. Badylak , Leslie A. Geddes , Jerry L. Wessale
发明人： Stephen F. Badylak , Leslie A. Geddes , Jerry L. Wessale
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1046 , A61M1/1003 , A61M1/1037 , A61M1/1089 , A61M1/1098 , A61M1/122
摘要： A method and apparatus is provided for enhancing blood circulation, and thereby reducing fatigue, in a skeletal muscle used for powering a cardiac assist device wherein the muscle is positioned to compress a blood reservoir in response to muscle contracting stimuli. Enhanced perfusion of the skeletal muscle is achieved by delaying blood flow into the reservoir for a period of time following each muscle contraction.
摘要翻译：提供了一种用于增强血液循环，从而减轻用于为心脏辅助装置供电的骨骼肌中的疲劳的方法和装置，其中肌肉定位为响应于肌肉收缩刺激而压缩血液储存器。骨骼肌的增强灌注是通过在每次肌肉收缩之后延迟血液进入储存器一段时间来实现的。

3. 发明授权

US5092339A Method and apparatus for electrically compensated measurement of cardiac output 失效
标题翻译：用于电补偿测量心输出量的方法和装置
公开(公告)号：US5092339A
公开(公告)日：1992-03-03
申请号：US557135
申请日：1990-07-23
申请人： Leslie A. Geddes , Joe D. Bourland , William D. Voorhees, III , Neal E. Fearnot , Anthony C. Raghep , Frederick J. Shipko
发明人： Leslie A. Geddes , Joe D. Bourland , William D. Voorhees, III , Neal E. Fearnot , Anthony C. Raghep , Frederick J. Shipko
IPC分类号： A61B5/0275 , A61B5/029
CPC分类号： A61B5/029 , A61B5/0275
摘要： Cardiac output is measured using an injected substance (indicator) that changes the conducting property (electrical resistivity) of blood, provided the indicator has a different resistivity from that of blood. A new type of electrically compensated tetrapolar conductivity cell located at the distal end of an intravascular catheter is disclosed. The conductivity cell consists of four electrodes arranged across the end of a catheter at its tip. The outer electrodes used for current injection are enlarged to reduce the electrode-electrolyte interface impedance. Capacitance compensation of the cather/tetrapolar conductivity cell provides reliable and repeatable blood resistivity measurements. The catheter further includes a calibration resistor thereby eliminating a calibration step previously necessary in using such a catheter for measuring cardiac output.
摘要翻译：使用改变血液的导电性（电阻率）的注射物质（指示剂）来测量心输出量，只要该指示器与血液具有不同的电阻率即可。公开了位于血管内导管远端的新型电补充四极导电电池。导电细胞由四个电极组成，四个电极在导管末端排列。用于电流注入的外部电极被放大以减少电极 - 电解质界面阻抗。电流/四极电导率电池的电容补偿提供可靠和可重复的血液电阻率测量。导管还包括校准电阻器，从而消除了使用这种导管测量心输出量所必需的校准步骤。

4. 发明授权

US4995390A Exercise responsive cardiac pacemaker 失效
标题翻译：运动反应性心脏起搏器
公开(公告)号：US4995390A
公开(公告)日：1991-02-26
申请号：US158402
申请日：1988-02-22
申请人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
发明人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
IPC分类号： A61N1/365
CPC分类号： A61N1/3655
摘要： An exercise-responsive cardiac pacemaker is provided which physiologically controls the stimulation rate of a heart by sensing the venous blood temperature in the right ventricle of the heart. A temperature sensing means which includes a thermistor produces an output signal which is sent to an algorithm implementing means for implementing the output signal by an algorithm which represents the mathematical function between venous blood temperature in the right ventricle and heart rate in a normally functioning heart. The algorithm implementing means produces an output signal which is variable between a maximum and minimum level corresponding to the desired maximum and minimum levels of heart rate in a normally functioning heart. The algorithm implementing means is also programmable by telemetry after implantation. A cardiac pacemaker is connected to the algorithm implementing means and is responsive thereto in order to variably control the stimulation rate of the heart.
摘要翻译：提供运动反应性心脏起搏器，其通过感测心脏右心室中的静脉血液温度来生理地控制心脏的刺激速率。包括热敏电阻的温度检测装置产生一个输出信号，该输出信号被发送到实现用于通过表示右心室静脉血温与正常功能心脏心率之间的数学函数的算法来实现输出信号的算法实现装置。算法实现装置产生一个输出信号，该输出信号在正常运行的心脏中对应于期望的最大和最小心率水平的最大和最小水平之间是变化的。算法实现手段也可以通过植入后的遥测进行编程。心脏起搏器连接到算法实现装置并且对其进行响应以便可变地控制心脏的刺激速率。

5. 发明授权

US4726383A Exercise-responsive cardiac pacemaker lead 失效
标题翻译：运动反应心脏起搏器导联
公开(公告)号：US4726383A
公开(公告)日：1988-02-23
申请号：US915887
申请日：1986-10-02
申请人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
发明人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
IPC分类号： A61N1/365 , A61N1/04
CPC分类号： A61N1/3655
摘要： An exercise-responsive cardiac pacemaker is provided which physiologically controls the stimulation rate of a heart by sensing the venous blood temperature in the right ventricle of the heart. A temperature sensing means which includes a thermistor produces an output signal which is sent to an algorithm implementing means for implementing the output signal by an algorithm which represents the mathematical function between venous blood temperature in the right ventricle and heart rate in a normally functioning heart. The algorithm implementing means produces an output signal which is variable between a maximum and minimum level corresponding to the desired maximum and minimum levels of heart rate in a normally functioning heart. The algorithm implementing means is also programmable by telemetry after implantation. A cardiac pacemaker is connected to the algorithm implementing means and is responsive thereto in order to variably control the stimulation rate of the heart.
摘要翻译：提供运动反应性心脏起搏器，其通过感测心脏右心室中的静脉血液温度来生理地控制心脏的刺激速率。包括热敏电阻的温度检测装置产生一个输出信号，该输出信号被发送到实现用于通过表示右心室静脉血温与正常功能心脏心率之间的数学函数的算法来实现输出信号的算法实现装置。算法实现装置产生一个输出信号，该输出信号在正常运行的心脏中对应于期望的最大和最小心率水平的最大和最小水平之间是变化的。算法实现手段也可以通过植入后的遥测进行编程。心脏起搏器连接到算法实现装置并且对其进行响应以便可变地控制心脏的刺激速率。

6. 发明授权

US5081988A Exercise responive cardiac pacemaker 失效
标题翻译：锻炼呼吸心脏起搏器
公开(公告)号：US5081988A
公开(公告)日：1992-01-21
申请号：US661402
申请日：1991-02-26
申请人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
发明人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
IPC分类号： A61N1/365
CPC分类号： A61N1/3655
摘要： An exercise-responsive cardiac pacemaker is provided which physiologically controls the stimulation rate of a heart by sensing the venous blood temperature in the right ventricle of the heart. A temperature sensing means which includes a thermistor produces an output signal which is sent to an algorithm implementing means for implementing the output signal by an algorithm which represents the mathematical function between venous blood temperature in the right ventricle and heart rate in a normally functioning heart. The algorithm implementing means produces an output signal which is variable between a maximum and minimum level corresponding to the desired maximum and minimum levels of heart rate in a normally functioning heart. The algorithm implementing means is also programmable by telemetry after implantation. A cardiac pacemaker is connected to the algorithm implementing means and is responsive thereto in order to variably control the stimulation rate of the heart.
摘要翻译：提供运动反应性心脏起搏器，其通过感测心脏右心室中的静脉血液温度来生理地控制心脏的刺激速率。包括热敏电阻的温度检测装置产生一个输出信号，该输出信号被发送到实现用于通过表示右心室静脉血温与正常功能心脏心率之间的数学函数的算法来实现输出信号的算法实现装置。算法实现装置产生一个输出信号，该输出信号在正常运行的心脏中对应于期望的最大和最小心率水平的最大和最小水平之间是变化的。算法实现手段也可以通过植入后的遥测进行编程。心脏起搏器连接到算法实现装置并且对其进行响应以便可变地控制心脏的刺激速率。

7. 发明授权

US4606352A Personal electrocardiogram monitor 失效
标题翻译：个人心电图监护仪
公开(公告)号：US4606352A
公开(公告)日：1986-08-19
申请号：US630589
申请日：1984-07-13
申请人： Leslie A. Geddes , Neal E. Fearnot
发明人： Leslie A. Geddes , Neal E. Fearnot
IPC分类号： A61B5/0404 , A61B5/0408 , A61B5/044 , G06F17/00 , A61B5/04
CPC分类号： A61B5/044 , A61B5/0404
摘要： A pocket-sized, self-contained electrocardiogram monitor with a dot-matrix, liquid-crystal display. The monitor uses dry electrodes and is suitable for direct placement against the patient's chest without the use of paste or gel to insure electrical contact. An A/D converter converts an ECG signal to a digital signal which is then processed by a microprocessor and then displayed on the liquid-crystal display in real time. The microprocessor is programmed to select the maximum and minimum digital values from four consecutive samples from the A/D converter and to supply data representative of the maximum and minimum values to the display at one-fourth the conversion sampling rate.
摘要翻译：袖珍尺寸，独立的心电图监护仪，带点阵式液晶显示器。显示器使用干电极，适合直接放置在患者胸部，而不使用糊或凝胶来确保电接触。 A / D转换器将ECG信号转换为数字信号，然后由微处理器处理，然后实时显示在液晶显示器上。微处理器被编程为从A / D转换器的四个连续采样中选择最大和最小数字值，并以四分之一的转换采样率向显示器提供表示最大值和最小值的数据。

8. 发明授权

US4436092A Exercise responsive cardiac pacemaker 失效
标题翻译：运动反应性心脏起搏器
公开(公告)号：US4436092A
公开(公告)日：1984-03-13
申请号：US379667
申请日：1982-05-19
申请人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
发明人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/3655
摘要： An exercise-responsive cardiac pacemaker is provided which physiologically controls the stimulation rate of a heart by sensing the venous blood temperature in the right ventricle of the heart. A temperature sensing means which includes a thermistor produces an output signal which is sent to an algorithm implementing means for implementing the output signal by an algorithm which represents the mathematical function between venous blood temperature in the right ventricle and heart rate in a normally functioning heart. The algorithm implementing means produces an output signal which is variable between a maximum and minimum level corresponding to the desired maximum and minimum levels of heart rate in a normally functioning heart. The algorithm implementing means is also programmable by telemetry after implantation. A cardiac pacemaker is connected to the algorithm implementing means and is responsive thereto in order to variably control the stimulation rate of the heart.
摘要翻译：提供运动反应性心脏起搏器，其通过感测心脏右心室中的静脉血液温度来生理地控制心脏的刺激速率。包括热敏电阻的温度检测装置产生一个输出信号，该输出信号被发送到实现用于通过表示右心室静脉血温与正常功能心脏心率之间的数学函数的算法来实现输出信号的算法实现装置。算法实现装置产生一个输出信号，该输出信号在正常运行的心脏中对应于期望的最大和最小心率水平的最大和最小水平之间是变化的。算法实现手段也可以通过植入后的遥测进行编程。心脏起搏器连接到算法实现装置并且对其进行响应以便可变地控制心脏的刺激速率。

9. 发明授权

US4543954A Exercise responsive cardiac pacemaker 失效
标题翻译：运动反应性心脏起搏器
公开(公告)号：US4543954A
公开(公告)日：1985-10-01
申请号：US542590
申请日：1983-10-17
申请人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
发明人： William A. Cook , Neal E. Fearnot , Leslie A. Geddes
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/3655
摘要： An exercise-responsive cardiac pacemaker is provided which physiologically controls the stimulation rate of a heart by sensing the venous blood temperature in the right ventricle of the heart. A temperature sensing means which includes a thermistor produces an output signal which is sent to an algorithm implementing means for implementing the output signal by an algorithm which represents the mathematical function between venous blood temperature in the right ventricle and heart rate in a normally functioning heart. The algorithm implementing means produces an output signal which is variable between a maximum and minimum level corresponding to the desired maximum and minimum levels of heart rate in a normally functioning heart. The algorithm implementing means is also programmable by telemetry after implantation. A cardiac pacemaker is connected to the algorithm implementing means and is responsive thereto in order to variably control the stimulation rate of the heart.
摘要翻译：提供运动反应性心脏起搏器，其通过感测心脏右心室中的静脉血液温度来生理地控制心脏的刺激速率。包括热敏电阻的温度检测装置产生一个输出信号，该输出信号被发送到实现用于通过表示右心室静脉血温与正常功能心脏心率之间的数学函数的算法来实现输出信号的算法实现装置。算法实现装置产生一个输出信号，该输出信号在正常运行的心脏中对应于期望的最大和最小心率水平的最大和最小水平之间是变化的。算法实现手段也可以通过植入后的遥测进行编程。心脏起搏器连接到算法实现装置并且对其进行响应以便可变地控制心脏的刺激速率。

10. 发明授权

US07096059B2 Device and method for electrocardiography on freely moving animals 失效
标题翻译：自由移动动物心电图的装置和方法
公开(公告)号：US07096059B2
公开(公告)日：2006-08-22
申请号：US10612126
申请日：2003-07-02
申请人： Leslie A. Geddes , Candice B. Kissinger , Joseph A. Bougher , Stephen J. Clevenger
发明人： Leslie A. Geddes , Candice B. Kissinger , Joseph A. Bougher , Stephen J. Clevenger
IPC分类号： A61B5/402
CPC分类号： A61B5/4839 , A61B5/04026 , A61B5/042 , A61B5/150022 , A61B5/15003 , A61B5/150862 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B2503/40
摘要： An electrocardiography device and method that is able to obtain the electrocardiogram of a freely moving animal. The device and method utilizes at least two catheters to obtain the electrical signals from the heart of the animal being tested. The catheters are filled with an electrically-conductive, physiological solution and are used in combination with at least two test leads that are able to transfer the electrical signals from the animal to an ECG monitoring device. The device and method also allows for fluids to flow through the catheters to other devices such as a blood sampler controller and/or an infusion pump.
摘要翻译：一种能够获得自由移动的动物的心电图的心电图设备和方法。该装置和方法利用至少两个导管从被测动物的心脏获得电信号。导管填充有导电的生理溶液，并且与能够将电信号从动物转移到ECG监测装置的至少两个测试引线组合使用。该装置和方法还允许流体流过导管到其它装置，例如血液取样器控制器和/或输液泵。

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