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1. 发明申请

WO2002080896A1 USES OF BENZYLIDENEAMINO GUANIDINES AS LIGANDS TO THE MELANOCORTIIN RECEPTORS 审中-公开
标题翻译：苯并噻吩类化合物作为MILANOCORTIIN受体配体的使用
公开(公告)号：WO2002080896A1
公开(公告)日：2002-10-17
申请号：PCT/GB2002/001589
申请日：2002-04-05
申请人： MELACURE THERAPEUTICS AB , TOWLER, Philip, Dean , LUNDSTEDT, Torbjörn , ANDERSSON, Per , BOMAN, Arne , SEIFERT, Elisabeth , SKOTTNER, Anna
发明人： LUNDSTEDT, Torbjörn , ANDERSSON, Per , BOMAN, Arne , SEIFERT, Elisabeth , SKOTTNER, Anna
IPC分类号： A61K31/155
CPC分类号： A61K31/155
摘要： The present invention relates to the use of benzylideneamino guanidines of general formula (I) as melanocortin receptor agonists or antagonist, and in particular, the use of benzylideneamino guanidines which show selectivity to the MC1 and MC4 melanocortin receptors as argonists and/or antagonists.
摘要翻译：本发明涉及通式（I）的亚苄基氨基胍类作为黑皮质素受体激动剂或拮抗剂，特别是使用显示对MC1和MC4黑皮质素受体的选择性的亚苄基氨基胍类作为氩学和/或拮抗剂。

2. 发明申请

WO1994000434A1 NOVEL NICOTINIC ACID ESTERS 审中-公开
标题翻译：新颖的酸甜味
公开(公告)号：WO1994000434A1
公开(公告)日：1994-01-06
申请号：PCT/SE1993000565
申请日：1993-06-23
申请人： KABI PHARMACIA AB , LUNDSTEDT, Torbjörn , ABRAMO, Lisbeth , BJÖRK, Anders , PETTERSSON, Göran , ANDERSSON, Gunnar , NORDVI, Curt , CHANG WU, Jin , LUDWIG, Catarina , SEIFERT, Elisabeth , NILSSON, Arne
发明人： KABI PHARMACIA AB
IPC分类号： C07D213/80
CPC分类号： C07D213/80
摘要： The present invention concerns novel compounds of formula (II) wherein R is selected from saturated or unsaturated alkyls, saturated or unsaturated cycloalkyls, heterocyclic compounds or from (a) or (b) wherein G is carbon or nitrogen; m is 0-10; wherein R1, R2 and R3 are the same or different and selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl and the pharmacologically active salts thereof. The new compounds can be used for treating disorder in the central nervous system.
摘要翻译：本发明涉及式（II）的新型化合物，其中R选自饱和或不饱和的烷基，饱和或不饱和环烷基，杂环化合物或（a）或（b）其中G是碳或氮; m为0-10; 其中R1，R2和R3相同或不同，选自氢，卤素，具有1-5个碳原子的烷基，电子给体基团如具有1-5个碳原子的烷氧基或羟基，选自氰基，硝基，三氟烷基及其药理学活性盐。新化合物可用于治疗中枢神经系统疾病。

3. 发明申请

WO2006092619A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DAMAGE 审中-公开
标题翻译：用于治疗神经损伤的方法和药物组合物
公开(公告)号：WO2006092619A1
公开(公告)日：2006-09-08
申请号：PCT/GB2006/000774
申请日：2006-03-06
申请人： ACURE PHARMA AB , BAILEY, Lindsey , LUNDSTEDT, Torbjörn , SKOTTNER, Anna , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
发明人： LUNDSTEDT, Torbjörn , SKOTTNER, Anna , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： A61K31/155 , A61P25/00
CPC分类号： A61K31/155
摘要： The invention relates to a method of treating neurological damage, preferably spinal chord injury, said treatment comprising the topical administration of guanabenz. The invention also relates to the use of guanabenz for the preparation of a medicament for the treatment of neurological damage, preferably spinal chord injury, wherein said treatment comprises the topical administration of guanabenz to the site of said neurological damage. The invention is also directed to pharmaceutical compositions comprising guanabenz wherein said compositions are in the form of an aqueous gel or non-aqueous ointment.
摘要翻译：本发明涉及一种治疗神经损伤的方法，优选脊髓损伤，所述治疗包括局部给予胍那苯。本发明还涉及胍苯醌用于制备用于治疗神经损伤（优选脊髓损伤）的药物的用途，其中所述治疗包括将神经系统局部施用于所述神经损伤部位。本发明还涉及包含胍苯甲酸酯的药物组合物，其中所述组合物为水性凝胶或非水性软膏剂的形式。

4. 发明申请

WO2008071980A1 NOVEL AMINOGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS. 审中-公开
标题翻译：新的氨基葡萄糖作为MELANOCORTIN受体配体。
公开(公告)号：WO2008071980A1
公开(公告)日：2008-06-19
申请号：PCT/GB2007/004793
申请日：2007-12-13
申请人： ACURE PHARMA AB , PETT, Christopher, Phineas , LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
发明人： LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： C07C281/18 , C07D339/08 , A61K31/155 , A61K31/385 , A61P29/00
CPC分类号： C07D339/08 , C07C281/18 , C07C323/48
摘要： There are described compounds of general formula (I) and isomeric forms thereof wherein n is 0,1,2 or 3, saturated or unsaturated; most preferably at least one of R 1 to R 5 represents halogen; at least one of R 1 , R 2 , R 3 , R 4 and R 5 is selected from -S-R or -COOR, or two or more Of R 1 -R 5 comprise a linking group such as -S-(CH2) m S-, where m is 1, 2 or 3 and R is selected from alkyl having 1 to 5 carbon atoms, cycloalkyl having 3-6 carbon atoms, hydroxy, and aryl having 6 to 10 carbon atoms, such groups being optionally substituted, and when R 1 is selected from -S-R, then at least one of R 2 , R 3 and R 5 is most preferably selected from halogen; and R 1 , R 2 , R 3 , R 4 and R 5 are otherwise the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and pharmacologically acceptable salts thereof. Compounds described have activity on the melanocortin receptors and have application in the treatment of a wide range of inflammatory, arthritic or central nerve regeneration conditions.
摘要翻译：描述了通式（I）的化合物及其异构体形式，其中n为0,1,2或3，饱和或不饱和; 最优选R 1至R 5中的至少一个表示卤素; R 1，R 2，R 3，R 4和R 5中的至少一个， / SUB>选自-SR或-COOR，或者R 1 -R 5中的两个或更多个包含连接基团，例如-S-（CH 2）_{5 <>最优选选自卤素; 和R 1，R 2，R 3，R 4和R 5，选自氢，卤素，具有1-5个碳原子的烷基，电子给体基团如具有1-5个碳原子的烷氧基或羟基，选自氰基，硝基，三氟烷基或酰胺的电子受体基团; 烷基氨基，苯甲酰氧基，硝酰基，苯基或磺基; 及其药理学上可接受的盐。所描述的化合物对黑皮质素受体具有活性，并且可用于治疗广泛的炎性，关节炎或中枢神经再生条件。}

5. 发明申请

WO2003013509A1 N-PHENYLPYRROLE GUANIDINE DERIVATIVES AS MELANOCORTIN RECEPTION LIGANDS 审中-公开
标题翻译：作为MELANOCORTIN接收配体的N-苯基吡咯烷酮衍生物
公开(公告)号：WO2003013509A1
公开(公告)日：2003-02-20
申请号：PCT/GB2002/003620
申请日：2002-08-06
申请人： MELACURE THERAPEUTICS AB , LUNDSTEDT, Torbjörn , SKOTTNER, Anna , BOMAN, Arne , ANDERSSON, Per , SEIFERT, Elisabeth , ANDRIANOV, Victor
发明人： LUNDSTEDT, Torbjörn , SKOTTNER, Anna , BOMAN, Arne , ANDERSSON, Per , SEIFERT, Elisabeth , ANDRIANOV, Victor
IPC分类号： A61K31/402
CPC分类号： C07D207/335 , C07D207/34 , C07D207/36 , C07D207/38 , C07D207/42
摘要： The present invention provides novel compounds of the general Formula (I) as ligands to the melanocortin receptors and/or treatment of disorders in the melanocortin system: wherein the variables are as defined in the claims; and the pharmacologically active salts thereof.
摘要翻译：本发明提供作为黑皮质素受体的配体和/或黑皮质素系统中的疾病的治疗的通式（I）的新化合物：其中变量如权利要求中所定义; 及其药理学活性盐。

6. 发明申请

WO1994003430A1 NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES 审中-公开
标题翻译：新颖的吡啶并吡啶并吡啶衍生物
公开(公告)号：WO1994003430A1
公开(公告)日：1994-02-17
申请号：PCT/SE1993000632
申请日：1993-07-16
申请人： KABI PHARMACIA AB , NORDVI, Curt , ABRAMO, Lisbeth , LUNDSTEDT, Torbjörn , OLSSON, Knut, Gunnar , BRODSZKI, Martin
发明人： KABI PHARMACIA AB
IPC分类号： C07D213/72
CPC分类号： C07D213/80 , C07D213/74
摘要： The present invention concerns novel compounds of general formula (I) wherein Ar are the same or different and selected from (a), (b) wherein R3 is fluoro or hydrogen, R1 and R2 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3, X is nitrogen or methine. When X is nitrogen Y is methylene. When X is methine Y is selected from nitrogen or oxygen. A is selected from pyrimidyl or pyridyl derivatives: (c), (d), (e), (f). The new compounds are useful for treating mental disorders.
摘要翻译：本发明涉及通式（I）的新化合物，其中Ar相同或不同并且选自（a），（b）其中R 3为氟或氢，R 1和R 2相同或不同并选自氢或低级烷基; n为2或3，X为氮或次甲基。当X是氮时，Y是亚甲基。当X为次甲基时，Y选自氮或氧。 A选自嘧啶基或吡啶基衍生物：（c），（d），（e），（f）。新化合物可用于治疗精神障碍。

7. 发明申请

WO2008061647A1 USE OF A COMPOUND AS VEGF INHIBITOR 审中-公开
标题翻译：复合物作为VEGF抑制剂的用途
公开(公告)号：WO2008061647A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/009767
申请日：2007-11-12
申请人： ACURE PHARMA AB , LUNDSTEDT, Torbjörn , EKSTRÖM, Gunilla
发明人： LUNDSTEDT, Torbjörn , EKSTRÖM, Gunilla
IPC分类号： A61K31/155 , A61P35/00 , A61P29/00
CPC分类号： A61K31/155
摘要： There is disclosed the use of N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidine or a pharmacologically acceptable salt thereof as an agent for use in the inhibition of Vascular Endothelial Growth Factor (VEGF). Such an agent is likely to be of application in the treatment or prevention of undesired blood vessel formation during tumour growth and/or in inflammatory conditions.
摘要翻译：公开了N-（2-氯-3,4-二甲氧基亚苄基氨基）胍或其药理学上可接受的盐作为用于抑制血管内皮生长因子（VEGF）的药剂的用途，。这样的药剂可能用于治疗或预防肿瘤生长期间和/或炎性疾病期间不期望的血管形成。

8. 发明申请

WO2008058679A3 NOVEL AMIDES ACTING ON THE ADENOSINE RECEPTORS 审中-公开
公开(公告)号：WO2008058679A3
公开(公告)日：2008-05-22
申请号：PCT/EP2007/009721
申请日：2007-11-09
申请人： ACURE PHARMA AB , LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
发明人： LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： C07K5/023 , C07K5/027 , A61K38/05 , A61P19/02
摘要： There are described compounds of formula (I) in which R 3 to R 8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide; R 1 is an optionally substituted phenyl, benzyl or cyclohexyl group; R 2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C 1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.

9. 发明申请

WO2007141343A1 PHENYL PYRROLE AMINOGUANIDINE DERIVATIVES 审中-公开
标题翻译：苯胺微量氨基嘌呤衍生物
公开(公告)号：WO2007141343A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055715
申请日：2007-06-11
申请人： Action Pharma A/S , BOMAN, Arne , JONASSEN, Thomas Engelbrecht Norkild , LUNDSTEDT, Torbjörn
发明人： BOMAN, Arne , JONASSEN, Thomas Engelbrecht Norkild , LUNDSTEDT, Torbjörn
IPC分类号： C07D207/32 , C07D207/38 , C07D207/40 , C07D207/42 , C07D207/34 , C07D207/36 , A61K31/402 , A61P25/00
CPC分类号： C07D207/42 , C07D207/335 , C07D207/34 , C07D207/36 , C07D207/38 , C07D207/416
摘要： The present invention relates to phenyl pyrrole aminoguanidine derivatives of the general formula (I): (I) including tautomeric forms thereof, wherein n is 1, 2 or 3; or a pharmaceutically acceptable salt thereof. The present invention further relates to the use of such phenyl pyrrole aminoguanidine derivatives for the treatment of diseases associated with the melanocortin receptors or related systems, e.g. the melanocyte stimulating hormones.
摘要翻译：本发明涉及通式（I）的苯基吡咯氨基胍衍生物：（I）包括其互变异构形式，其中n为1,2或3; 或其药学上可接受的盐。本发明还涉及这种苯基吡咯氨基胍衍生物用于治疗与黑皮质素受体或相关系统有关的疾病的用途，例如，黑素细胞刺激激素。

10. 发明申请

WO2002081430A2 NOVEL BENZYLIDENEAMINO GUANIDINES AND THEIR USES AS LIGANDS TO THE MELANOCORTIN RECEPTORS 审中-公开
标题翻译：新戊酰胆碱酯酶及其作为MELANOCORTIN受体配体的用途
公开(公告)号：WO2002081430A2
公开(公告)日：2002-10-17
申请号：PCT/GB2002/001593
申请日：2002-04-05
申请人： MELACURE THERAPEUTICS AB , TOWLER, Philip, Dean , LUNDSTEDT, Torbjörn , ANDERSSON, Per , BOMAN, Arne , SEIFERT, Elisabeth , SKOTTNER, Anna
发明人： LUNDSTEDT, Torbjörn , ANDERSSON, Per , BOMAN, Arne , SEIFERT, Elisabeth , SKOTTNER, Anna
IPC分类号： C07C281/18
CPC分类号： A61K31/155
摘要： The present invention relates to novel benzylideneamino guanidines of general formula and to the use of these benzylideneamino guanidines as melanocortin receptor agonists or antagonists. The invention further relates to benzylideneamino guanidines which show selectivity to the MC1 and MC4 melanocortin receptors as agonists and/or antagonists.
摘要翻译：本发明涉及通式的新亚苄基氨基胍，以及这些亚苄基氨基胍用作黑皮质素受体激动剂或拮抗剂。本发明还涉及对MC1和MC4黑皮质素受体作为激动剂和/或拮抗剂显示选择性的亚苄基氨基胍。

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