专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008071980A1 NOVEL AMINOGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS. 审中-公开
标题翻译：新的氨基葡萄糖作为MELANOCORTIN受体配体。
公开(公告)号：WO2008071980A1
公开(公告)日：2008-06-19
申请号：PCT/GB2007/004793
申请日：2007-12-13
申请人： ACURE PHARMA AB , PETT, Christopher, Phineas , LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
发明人： LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： C07C281/18 , C07D339/08 , A61K31/155 , A61K31/385 , A61P29/00
CPC分类号： C07D339/08 , C07C281/18 , C07C323/48
摘要： There are described compounds of general formula (I) and isomeric forms thereof wherein n is 0,1,2 or 3, saturated or unsaturated; most preferably at least one of R 1 to R 5 represents halogen; at least one of R 1 , R 2 , R 3 , R 4 and R 5 is selected from -S-R or -COOR, or two or more Of R 1 -R 5 comprise a linking group such as -S-(CH2) m S-, where m is 1, 2 or 3 and R is selected from alkyl having 1 to 5 carbon atoms, cycloalkyl having 3-6 carbon atoms, hydroxy, and aryl having 6 to 10 carbon atoms, such groups being optionally substituted, and when R 1 is selected from -S-R, then at least one of R 2 , R 3 and R 5 is most preferably selected from halogen; and R 1 , R 2 , R 3 , R 4 and R 5 are otherwise the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and pharmacologically acceptable salts thereof. Compounds described have activity on the melanocortin receptors and have application in the treatment of a wide range of inflammatory, arthritic or central nerve regeneration conditions.
摘要翻译：描述了通式（I）的化合物及其异构体形式，其中n为0,1,2或3，饱和或不饱和; 最优选R 1至R 5中的至少一个表示卤素; R 1，R 2，R 3，R 4和R 5中的至少一个， / SUB>选自-SR或-COOR，或者R 1 -R 5中的两个或更多个包含连接基团，例如-S-（CH 2）_{5 <>最优选选自卤素; 和R 1，R 2，R 3，R 4和R 5，选自氢，卤素，具有1-5个碳原子的烷基，电子给体基团如具有1-5个碳原子的烷氧基或羟基，选自氰基，硝基，三氟烷基或酰胺的电子受体基团; 烷基氨基，苯甲酰氧基，硝酰基，苯基或磺基; 及其药理学上可接受的盐。所描述的化合物对黑皮质素受体具有活性，并且可用于治疗广泛的炎性，关节炎或中枢神经再生条件。}

2. 发明申请

WO2006092619A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DAMAGE 审中-公开
标题翻译：用于治疗神经损伤的方法和药物组合物
公开(公告)号：WO2006092619A1
公开(公告)日：2006-09-08
申请号：PCT/GB2006/000774
申请日：2006-03-06
申请人： ACURE PHARMA AB , BAILEY, Lindsey , LUNDSTEDT, Torbjörn , SKOTTNER, Anna , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
发明人： LUNDSTEDT, Torbjörn , SKOTTNER, Anna , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： A61K31/155 , A61P25/00
CPC分类号： A61K31/155
摘要： The invention relates to a method of treating neurological damage, preferably spinal chord injury, said treatment comprising the topical administration of guanabenz. The invention also relates to the use of guanabenz for the preparation of a medicament for the treatment of neurological damage, preferably spinal chord injury, wherein said treatment comprises the topical administration of guanabenz to the site of said neurological damage. The invention is also directed to pharmaceutical compositions comprising guanabenz wherein said compositions are in the form of an aqueous gel or non-aqueous ointment.
摘要翻译：本发明涉及一种治疗神经损伤的方法，优选脊髓损伤，所述治疗包括局部给予胍那苯。本发明还涉及胍苯醌用于制备用于治疗神经损伤（优选脊髓损伤）的药物的用途，其中所述治疗包括将神经系统局部施用于所述神经损伤部位。本发明还涉及包含胍苯甲酸酯的药物组合物，其中所述组合物为水性凝胶或非水性软膏剂的形式。

3. 发明申请

WO2008058679A3 NOVEL AMIDES ACTING ON THE ADENOSINE RECEPTORS 审中-公开
公开(公告)号：WO2008058679A3
公开(公告)日：2008-05-22
申请号：PCT/EP2007/009721
申请日：2007-11-09
申请人： ACURE PHARMA AB , LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
发明人： LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： C07K5/023 , C07K5/027 , A61K38/05 , A61P19/02
摘要： There are described compounds of formula (I) in which R 3 to R 8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide; R 1 is an optionally substituted phenyl, benzyl or cyclohexyl group; R 2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C 1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.

4. 发明申请

WO2011012868A1 COMPOUNDS FOR TREATMENT OF INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的化合物
公开(公告)号：WO2011012868A1
公开(公告)日：2011-02-03
申请号：PCT/GB2010/001457
申请日：2010-07-30
申请人： ANAMAR AB , PALMQVIST, Niklas , SJÖDIN, Anders , WENGLÉN, Christina , FLOOD, Christofer , LUNDBERG, Lennart , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne , WEBBER, Philip, Michael
发明人： PALMQVIST, Niklas , SJÖDIN, Anders , WENGLÉN, Christina , FLOOD, Christofer , LUNDBERG, Lennart , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： A61P29/00 , A61K31/155 , A61K31/36 , A61K31/385
CPC分类号： A61K31/385 , A61K31/155 , A61K31/36
摘要： The present invention relates to the use of benzylideneaminoguanidines for the treatment of inflammation and pain. In one preferred embodiment, the invention relates to the use of N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidine for the treatment of rheumatoid arthritis.
摘要翻译：本发明涉及用于治疗炎症和疼痛的亚苄氨基鸟嘌呤的用途。在一个优选的实施方案中，本发明涉及N-（2-氯-3,4-二甲氧基亚苄基氨基）胍用于治疗类风湿性关节炎的用途。

5. 发明公开

EP2121585A1 NOVEL AMINOGUANIDINES AS MELANOCORTIN RECEPTOR LIGANDS. 有权
标题翻译：新型氨基胍作为黑色素受体配体。
公开(公告)号：EP2121585A1
公开(公告)日：2009-11-25
申请号：EP07848535.6
申请日：2007-12-13
申请人： Acure Pharma AB
发明人： LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： C07C281/18 , C07D339/08 , A61K31/155 , A61K31/385 , A61P29/00
CPC分类号： C07D339/08 , C07C281/18 , C07C323/48
摘要： There are described compounds of general formula (I) and isomeric forms thereof wherein n is 0, 1, 2 or 3, saturated or unsaturated; most preferably at least one of R1 to R5 represents halogen; at least one of R1, R2, R3, R4 and R5 is selected from —S—R or —COOR, or two or more Of R1-R5 comprise a linking group such as —S—(CH2)mS—, where m is 1, 2 or 3 and R is selected from alkyl having 1 to 5 carbon atoms, cycloalkyl having 3-6 carbon atoms, hydroxy, and aryl having 6 to 10 carbon atoms, such groups being optionally substituted, and when R1 is selected from —S—R, then at least one of R2, R3 and R5 is most preferably selected from halogen; and R1, R2, R3, R4 and R5 are otherwise the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and pharmacologically acceptable salts thereof. Compounds described have activity on the melanocortin receptors and have application in the treatment of a wide range of inflammatory, arthritic or central nerve regeneration conditions.
摘要翻译：描述了通式（I）的化合物及其异构体形式，其中n是0,1,2或3，饱和或不饱和的; 最优选R1至R5中的至少一个表示卤素; R 1，R 2，R 3，R 4和R 5中的至少一个选自-S-，R或-COOR，或者两个或更多个R 1 -R 5包含连接基团，例如-S-（CH 2）m -S m- 其中m为1,2或3，R选自具有1-5个碳原子的烷基，具有3-6个碳原子的环烷基，羟基和具有6-10个碳原子的芳基，这些基团任选被取代，并且当R1是选自-S-，R，则R 2，R 3和R 5中的至少一个最优选选自卤素; 并且R 1，R 2，R 3，R 4和R 5可以相同或不同，并且选自氢，卤素，具有1-5个碳原子的烷基，电子给体基团如具有1-5个碳原子的烷氧基或羟基，电子受体基团选自氰基，硝基，三氟烷基或酰胺; 烷基氨基，苯甲酰氧基，硝酰基，苯基或磺基; 及其药理学上可接受的盐。所述化合物对黑皮质素受体具有活性，并可用于治疗各种炎症，关节炎或中枢神经再生病症。

6. 发明公开

EP1858502A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DAMAGE 审中-公开
标题翻译：方法和药物组合物，神经系统损害的治疗
公开(公告)号：EP1858502A1
公开(公告)日：2007-11-28
申请号：EP06709997.8
申请日：2006-03-06
申请人： Acure Pharma AB
发明人： LUNDSTEDT, Torbjörn , SKOTTNER, Anna , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： A61K31/155 , A61P25/00
CPC分类号： A61K31/155
摘要： The invention relates to a method of treating neurological damage, preferably spinal chord injury, said treatment comprising the topical administration of guanabenz. The invention also relates to the use of guanabenz for the preparation of a medicament for the treatment of neurological damage, preferably spinal chord injury, wherein said treatment comprises the topical administration of guanabenz to the site of said neurological damage. The invention is also directed to pharmaceutical compositions comprising guanabenz wherein said compositions are in the form of an aqueous gel or non-aqueous ointment.

7. 发明公开

EP2099815A2 NOVEL AMIDES ACTING ON THE ADENOSINE RECEPTORS 有权
标题翻译：腺苷受体发挥作用的新酰胺
公开(公告)号：EP2099815A2
公开(公告)日：2009-09-16
申请号：EP07846549.9
申请日：2007-11-09
申请人： Acure Pharma AB
发明人： LUNDSTEDT, Torbjörn , SEIFERT, Elisabeth , LEK, Per , BOMAN, Arne
IPC分类号： C07K5/023 , C07K5/027 , A61K38/05 , A61P19/02
CPC分类号： C07D209/14
摘要： There are described compounds of formula (I) in which R3 to R8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide; R1 is an optionally substituted phenyl, benzyl or cyclohexyl group; R2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.

8. 发明授权

EP1309544B1 COMPOUNDS ACTING AS MELANOCORTIN RECEPTOR LIGANDS 有权
标题翻译：化合物作为黑皮素受体ACT的配位体
公开(公告)号：EP1309544B1
公开(公告)日：2008-11-05
申请号：EP01954195.2
申请日：2001-08-07
申请人： Acure Pharma AB
发明人： LUNDSTEDT, Torbjörn , SKOTTNER, Anna , BOMAN, Arne , LEK, Per , ANDRIANOV, Victor , KALVINS, Ivars
IPC分类号： C07C281/18 , C07D213/36 , C07D209/14 , C07D207/335 , A61K31/155 , A61K31/40 , A61K31/44 , A61P25/00 , A61P29/00
CPC分类号： C07D213/53 , A61K31/155 , A61K31/40 , A61K31/44 , C07C281/18 , C07D209/14 , C07D209/40 , C07D213/74 , C07D401/12 , C07D405/12
摘要： The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen from O, N, S and (CH2)n, where n is 0, 1, 2, 3, 4 or 5, or a combination of these and may contain carbon-carbon multiple bonds and branched chains as well as alicyclic and heterocyclic groups; Q is H or OH; R1 and R2 can be either the same or different and are chosen from hydrogen or the residue of an aromatic group as listed in Scheme 1 and the pharmacologically active salts thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式