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1. 发明申请

WO1994003436A1 NOVEL PIPRAZINE CARBOXAMIDES 审中-公开
标题翻译：新型哌嗪羧酰胺
公开(公告)号：WO1994003436A1
公开(公告)日：1994-02-17
申请号：PCT/SE1993000639
申请日：1993-07-22
申请人： KABI PHARMACIA AB , ABRAMO, Lisbeth , NORDVI, Curt , LUNDSTEDT, Torbjörn , OLSSON, Knut, Gunnar , BRODSZKI, Martin
发明人： KABI PHARMACIA AB
IPC分类号： C07D241/04
CPC分类号： C07D295/215 , C07D213/74
摘要： The present invention concerns novel compounds of general formula (I) wherein R1 and R2 are the same or different and selected from hydrogen or lower alkyl; wherein Ar are the same or different and selected from (II) and (III) wherein R3 is halogen or hydrogen. n is 2 or 3, X is nitrogen or methine. When X is nitrogen Y is methylene. When X is methine Y is selected from nitrogen or oxygen. A is selected from the carboxylic derivatives (IV) and (V) wherein R4 and R5 are the same or different and selected from hydrogen, alkyl, cycloalkyl or aryl. Z is selected from sulfur or oxygen. R6 is selected from (VI) and (VII) wherein m is 1, 2, 3 or 4. R7 is selected from hydrogen or lower alkyl, and the pharmacologically active salts thereof. The new compounds are useful for treating mental disorders.
摘要翻译：本发明涉及通式（I）的新化合物，其中R 1和R 2相同或不同并选自氢或低级烷基; 其中Ar相同或不同，并且选自（II）和（III），其中R 3是卤素或氢。 n为2或3，X为氮或次甲基。当X是氮时，Y是亚甲基。当X为次甲基时，Y选自氮或氧。 A选自羧酸衍生物（IV）和（V），其中R 4和R 5相同或不同，并且选自氢，烷基，环烷基或芳基。 Z选自硫或氧。 R6选自（VI）和（VII）其中m为1,2,3或4.R 7选自氢或低级烷基，及其药理学活性盐。新化合物可用于治疗精神障碍。

2. 发明申请

WO1994000434A1 NOVEL NICOTINIC ACID ESTERS 审中-公开
标题翻译：新颖的酸甜味
公开(公告)号：WO1994000434A1
公开(公告)日：1994-01-06
申请号：PCT/SE1993000565
申请日：1993-06-23
申请人： KABI PHARMACIA AB , LUNDSTEDT, Torbjörn , ABRAMO, Lisbeth , BJÖRK, Anders , PETTERSSON, Göran , ANDERSSON, Gunnar , NORDVI, Curt , CHANG WU, Jin , LUDWIG, Catarina , SEIFERT, Elisabeth , NILSSON, Arne
发明人： KABI PHARMACIA AB
IPC分类号： C07D213/80
CPC分类号： C07D213/80
摘要： The present invention concerns novel compounds of formula (II) wherein R is selected from saturated or unsaturated alkyls, saturated or unsaturated cycloalkyls, heterocyclic compounds or from (a) or (b) wherein G is carbon or nitrogen; m is 0-10; wherein R1, R2 and R3 are the same or different and selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl and the pharmacologically active salts thereof. The new compounds can be used for treating disorder in the central nervous system.
摘要翻译：本发明涉及式（II）的新型化合物，其中R选自饱和或不饱和的烷基，饱和或不饱和环烷基，杂环化合物或（a）或（b）其中G是碳或氮; m为0-10; 其中R1，R2和R3相同或不同，选自氢，卤素，具有1-5个碳原子的烷基，电子给体基团如具有1-5个碳原子的烷氧基或羟基，选自氰基，硝基，三氟烷基及其药理学活性盐。新化合物可用于治疗中枢神经系统疾病。

3. 发明申请

WO1994003430A1 NOVEL PYRIDYL- AND PYRIMIDYLPIPERAZINE DERIVATIVES 审中-公开
标题翻译：新颖的吡啶并吡啶并吡啶衍生物
公开(公告)号：WO1994003430A1
公开(公告)日：1994-02-17
申请号：PCT/SE1993000632
申请日：1993-07-16
申请人： KABI PHARMACIA AB , NORDVI, Curt , ABRAMO, Lisbeth , LUNDSTEDT, Torbjörn , OLSSON, Knut, Gunnar , BRODSZKI, Martin
发明人： KABI PHARMACIA AB
IPC分类号： C07D213/72
CPC分类号： C07D213/80 , C07D213/74
摘要： The present invention concerns novel compounds of general formula (I) wherein Ar are the same or different and selected from (a), (b) wherein R3 is fluoro or hydrogen, R1 and R2 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3, X is nitrogen or methine. When X is nitrogen Y is methylene. When X is methine Y is selected from nitrogen or oxygen. A is selected from pyrimidyl or pyridyl derivatives: (c), (d), (e), (f). The new compounds are useful for treating mental disorders.
摘要翻译：本发明涉及通式（I）的新化合物，其中Ar相同或不同并且选自（a），（b）其中R 3为氟或氢，R 1和R 2相同或不同并选自氢或低级烷基; n为2或3，X为氮或次甲基。当X是氮时，Y是亚甲基。当X为次甲基时，Y选自氮或氧。 A选自嘧啶基或吡啶基衍生物：（c），（d），（e），（f）。新化合物可用于治疗精神障碍。

4. 发明专利

SK279393B6 ESTERS OF BISPHENYL PIPERAZINE NICOTINIC ACID, METHOD FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEM CONTAINING 未知
公开(公告)号：SK279393B6
公开(公告)日：1998-11-04
申请号：SK158594
申请日：1993-06-23
申请人： LUNDSTEDT TORBJORN , ABRAMO LISBETH , BJORK ANDERS , PETTERSSON GORAN , ANDERSSON GUNNAR , NORDVI CURT , CHANG WU JIN , LUDWIG CATARINA , SEIFERT ELISABETH , NILSSON ARNE
发明人： LUNDSTEDT TORBJORN , ABRAMO LISBETH , BJORK ANDERS , PETTERSSON GORAN , ANDERSSON GUNNAR , NORDVI CURT , CHANG WU JIN , LUDWIG CATARINA , SEIFERT ELISABETH , NILSSON ARNE
IPC分类号： C07D401/04 , A61K31/44 , A61K31/4418 , A61K31/455 , A61K31/495 , A61K31/496 , A61K31/497 , A61P9/10 , A61P25/00 , A61P25/24 , A61P25/26 , A61P43/00 , C07D213/80 , C07D213/803 , C07D295/03
摘要： The present invention concerns novel compounds of the formula (II) wherein R is a group of the formula (a); wherein G is a carbon or nitrogen; m is an integer between 0 - 10; wherein R1, R2 and R3 are the same or different and selected from the group containing hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl and the pharmacologically active salts thereof. The new compounds can be used for treating disorders in the central nervous system.

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