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1. 发明专利

IL290331A Rna-targeting ligands, compositions thereof, and methods of making and using the same 未知
公开(公告)号：IL290331A
公开(公告)日：2022-04-01
申请号：IL29033122
申请日：2022-02-03
申请人： UNIV NORTH CAROLINA CHAPEL HILL , WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
发明人： WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
摘要： The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity 5 binding ligand compared to compounds that only bind to a single RNA binding site.

2. 发明专利

IL290331D0 Rna-targeting ligands, compositions thereof, and methods of making and using the same 未知
公开(公告)号：IL290331D0
公开(公告)日：2022-04-01
申请号：IL29033122
申请日：2022-02-03
申请人： UNIV NORTH CAROLINA CHAPEL HILL , WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
发明人： WEEKS KEVIN , AUBE JEFFREY , LI KELIN , ZELLER MEREDITH
IPC分类号： A61K31/498 , A61P43/00
摘要： The disclosure is directed to compounds that bind to a target RNA molecule, such as a TPP riboswitch, compositions comprising the compounds, and methods of making and using the same. The compounds contain two structurally different fragments that allow for binding with the target RNA at two different binding sites thereby producing a higher affinity 5 binding ligand compared to compounds that only bind to a single RNA binding site.

3. 发明申请

WO2011140527A3 METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 审中-公开
标题翻译：用于抑制过渡性内皮细胞ATPase的方法和组合物
公开(公告)号：WO2011140527A3
公开(公告)日：2012-03-29
申请号：PCT/US2011035654
申请日：2011-05-06
申请人： CALIFORNIA INST OF TECHN , DESHAIES RAYMOND J , CHOU TSUI-FEN , SCHOENEN FRANK J , LI KELIN , FRANKOWSKI KEVIN J , AUBE JEFFREY , GERRITZ SAMUEL W , ZHOU HAN-JIE
发明人： DESHAIES RAYMOND J , CHOU TSUI-FEN , SCHOENEN FRANK J , LI KELIN , FRANKOWSKI KEVIN J , AUBE JEFFREY , GERRITZ SAMUEL W , ZHOU HAN-JIE
IPC分类号： A61K31/517 , A61K31/4184 , A61K31/53 , A61P35/00
CPC分类号： A61K31/517 , A61K31/4184 , A61K31/53 , A61K31/538 , C12Q1/42 , C12Q1/485 , G01N2500/02
摘要： Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.
摘要翻译：式I-XLIII的化合物被鉴定为p97 ATPase的直接抑制剂或p97依赖性泛素 - 蛋白酶体系统（UPS）底物的降解。公开了用于抑制p97 ATP酶和p97依赖性UPS底物的降解以及鉴定其抑制剂的方法和组合物。

4. 发明申请

WO2011140527A2 METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 审中-公开
标题翻译：用于抑制过渡性内皮细胞ATPase的方法和组合物
公开(公告)号：WO2011140527A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/035654
申请日：2011-05-06
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS , DESHAIES, Raymond, J. , CHOU, Tsui-fen , SCHOENEN, Frank, J. , LI, Kelin , FRANKOWSKI, Kevin, J. , AUBE, Jeffrey , GERRITZ, Samuel, W. , ZHOU, Han-jie
发明人： DESHAIES, Raymond, J. , CHOU, Tsui-fen , SCHOENEN, Frank, J. , LI, Kelin , FRANKOWSKI, Kevin, J. , AUBE, Jeffrey , GERRITZ, Samuel, W. , ZHOU, Han-jie
IPC分类号： A61K31/517 , A61K31/53 , A61K31/4184 , A61P35/00
CPC分类号： A61K31/517 , A61K31/4184 , A61K31/53 , A61K31/538 , C12Q1/42 , C12Q1/485 , G01N2500/02
摘要： Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.
摘要翻译：式I-XLIII的化合物被鉴定为p97 ATPase的直接抑制剂或p97依赖性泛素 - 蛋白酶体系统（UPS）底物的降解。公开了用于抑制p97 ATP酶和p97依赖性UPS底物的降解以及鉴定其抑制剂的方法和组合物。

5. 发明申请

WO2011103833A3 BATTERY, BATTERY COMPONENT AND USER EQUIPMENT 审中-公开
标题翻译：电池，电池组件和用户设备
公开(公告)号：WO2011103833A3
公开(公告)日：2012-03-22
申请号：PCT/CN2011072946
申请日：2011-04-18
申请人： HUAWEI DEVICE CO LTD , LI CHANGQI , YU JIANBING , LI KELIN
发明人： LI CHANGQI , YU JIANBING , LI KELIN
IPC分类号： H01M2/20
CPC分类号： H01M10/4257 , G01R31/3658 , H01M2/0215 , H01M2/1027 , H01M2/204 , H01M2/30 , H01M10/0436 , H01M10/425 , H01M10/441 , H01M10/482 , H01M10/486 , H01M2010/4278 , H01M2220/30 , H02J7/0013 , H02J7/0032 , H02J7/007
摘要： A battery, a battery component and a user equipment are provided. The battery comprises a circuit board and an electric core(11). The circuit board comprises a first contact(101), a second contact(102), a third contact(103), a forth contact(104), a battery management module(105) and a control switch(106). The first contact(101) is used to report the capacity of the electric core(11) in the battery of the battery management module(105) or the capacity of the electric core(11) in battery and the capacity of the electric core(11) in a cascade battery behind the battery to a previous battery or an electricity load. The second contact(102) is used to receive and output the capacity of the electric core(11) in a cascade battery behind the battery. The third contact(103) is used to connect with the electric core(11) in the battery for the electric core(11) in the battery to charge or discharge, when the control switch(106) is turned on. The forth contact(104) is used to connect with the third contact(103) for a next battery to execute the corresponding processing, when the control switch(106) is turned off. The battery management module(105) is used to trigger the control switch(106) to turn on or turn off, according to the obtained capacity of the electric core(11) in the battery and/or the obtained capacity of the electric core(11) in the cascade battery behind the battery.
摘要翻译：提供电池，电池组件和用户设备。电池包括电路板和电芯（11）。电路板包括第一触点（101），第二触点（102），第三触点（103），第四触点（104），电池管理模块（105）和控制开关（106）。第一触点（101）用于报告电池管理模块（105）的电池中的电芯（11）的容量或电池中的电芯（11）的容量和电芯的容量（ 11）将电池后面的级联电池连接到先前的电池或电力负载。第二触点（102）用于在电池后面的级联电池中接收和输出电芯（11）的容量。当控制开关（106）接通时，第三触点（103）用于与用于电池中的电芯（11）的电池中的电芯（11）连接以进行充电或放电。当控制开关（106）关闭时，第四触点（104）用于与下一个电池的第三触点（103）连接以执行相应的处理。电池管理模块（105）用于根据获得的电池中的电芯（11）的容量和/或所获得的电芯的容量来触发控制开关（106）导通或关断 11）在电池后面的级联电池。

6. 发明申请

WO2013036749A1 HCV HELICASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： HCV HELICASE抑制剂及其使用方法
公开(公告)号：WO2013036749A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054130
申请日：2012-09-07
申请人： UNIVERSITY OF KANSAS , UWM RESEARCH FOUNDATION, INC. , AUBE, Jeffrey , BLAGG, Brian, Scott Jonathan , FRANKOWSKI, Kevin, John , FRICK, David, Norman , LI, Kelin , SCHOENEN, Frank, John
发明人： AUBE, Jeffrey , BLAGG, Brian, Scott Jonathan , FRANKOWSKI, Kevin, John , FRICK, David, Norman , LI, Kelin , SCHOENEN, Frank, John
IPC分类号： A01N43/52
CPC分类号： C07D277/66 , A61K31/13 , A61K31/428 , A61K31/4439 , A61K31/7056 , A61K45/06 , C07D417/04 , C07D417/14 , C12Q1/6806 , C12Q2563/173 , G01N1/30 , G01N33/6896 , G01N2001/302 , Y02A50/385 , A61K2300/00
摘要： The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are useful as antiviral agents. The present invention further relates to pharmaceutical compositions containing the aforementioned compounds and methods of treating an HCV infection.
摘要翻译：本发明公开了抑制丙型肝炎病毒解旋酶和蛋白酶活性的硫黄素S和起始衍生物。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，可用作抗病毒剂。本发明还涉及含有上述化合物的药物组合物和治疗HCV感染的方法。

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